ライフサイエンスコーパス: intrastriatal

1 tomical and behavioral protection against an intrastriatal 6-hydroxydopamine (6-OHDA) lesion in the c

2 compared the effects of a partial unilateral intrastriatal 6-hydroxydopamine (6-OHDA) lesion model of

3 y UOx manipulations were assessed in a mouse intrastriatal 6-hydroxydopamine (6-OHDA) model of hemipa

4 In the current studies, unilateral, intrastriatal 6-hydroxydopamine (6-OHDA) was used to inv

5 protective effects of the GDNF product in an intrastriatal 6-hydroxydopamine lesion model.

6 We made localized intrastriatal 6-hydroxydopamine lesions in rats and reco

7 loss of dopaminergic markers in response to intrastriatal 6-OHDA administration compared with wild-t

8 RO5166017 aggravated degeneration induced by intrastriatal 6-OHDA in WT mice.

9 These findings indicate that intrastriatal 6-OHDA lesion differentially affects dopam

10 hydroxylase-immunoreactive (TH-IR) axons in intrastriatal 6-OHDA lesioned rats, focusing on two calc

11 by the systemic (1 mg/kg, i.p.) or bilateral intrastriatal (7 microg/0.5 microl under halothane anaes

12 Fischer 344 rats bearing intrastriatal 9L tumors engineered to secrete SF/HGF (9L

13 Intrastriatal AAO, but not saline vehicle, caused a rapi

14 Daily intrastriatal administration for 1 week of > or = 50 ng

15 Intrastriatal administration of compounds structurally r

16 Previous work indicates that intrastriatal administration of MK-801 does not complete

17 cell death were significantly reduced by the intrastriatal administration of NF kappa B SN50, a cell-

18 ated responses, we determined the effects of intrastriatal administration of NMDA antagonists on imme

19 Unilateral intrastriatal administration of NMDA to rats resulted in

20 ndings from in vivo animal studies involving intrastriatal administration of pre-formed fibrils in mi

21 Intrastriatal administration of QA between 7 days and 21

22 Intrastriatal administration of the D1 antagonist inhibi

23 natomical and behavioral consequences of the intrastriatal administration of the NMDA agonist quinoli

24 nd associated behavioral deficits induced by intrastriatal administration of the NMDA receptor agonis

25 vides these beneficial effects, systemic and intrastriatal administration of the selective M1 and M4

26 In contrast, intrastriatal amphetamine administration to amphetamine-

27 ine-induced change in the effect of an acute intrastriatal amphetamine infusion on nigrostriatal term

28 Foxp2 deletion de-represses Mef2c, and both intrastriatal and global decrease of Mef2c rescue vocali

29 We compared the effectiveness of intrastriatal and intracerebroventricular administration

30 f the blood-brain barrier, intraventricular, intrastriatal, and intranigral routes of administration

31 s in modulating glutamate neurotransmission, intrastriatal application of RO5166017 prevented the inc

32 n neurons have been identified: 1) one whose intrastriatal arborization arises as a collateral of a p

33 In present study, intrastriatal autologous-blood injection was used to mim

34 Intrastriatal blood injection in rodents and primary mic

35 More than 70% of TH-positive intrastriatal cell bodies were found in the caudate nucl

36 ther confirmed by the study in which neither intrastriatal CHA nor DPCPX significantly altered the MI

37 uced MI but also blocked its accentuation by intrastriatal CHA.

38 at brain slices, we find that stimulation of intrastriatal cholinergic fibers evokes polysynaptic GAB

39 -state potentials, and they are modulated by intrastriatal cholinergic interneurons, providing a mech

40 new conceptualization of the organization of intrastriatal circuitry and their cortical and thalamic

41 Perspective will examine the organization of intrastriatal circuitry, review recent findings in this

42 ling in MSNs is critical for the function of intrastriatal circuits.

43 Intrastriatal co-infusion of hrIL-1beta (10 ng) with S-A

44 al properties and dopaminergic modulation of intrastriatal connections formed by striatopallidal neur

45 These results are in support of intrastriatal connections of D2R(+)-MSNs (iMSNs) with dM

46 With a rat model of intrastriatal DA injection, we studied the molecular eve

47 Intrastriatal delivery of anti-N-terminal htt scFv-C4 us

48 ty, tolerability, and efficacy of bilateral, intrastriatal delivery of ProSavin, a lentiviral vector-

49 Adult rats received chronic intrastriatal dialytic exposure to quinolinic acid (QUIN

50 rol over a cocaine-seeking habit by using an intrastriatal disconnection procedure that combined a se

51 gical correlates of the response to a single intrastriatal dispersed cell graft of fetal rat ventral

52 In a separate experiment, intrastriatal DNQX was shown to block kainic acid (KA)-i

53 The intrastriatal dopamine depletion severely affected the l

54 Intrastriatal dopaminergic neurons increase substantiall

55 t extrastriatal dopaminergic projections and intrastriatal dopaminergic neurons.

56 These data indicate that intrastriatal DORs modulate a calcium-dependent, ampheta

57 luR-dependent component of IPSCs elicited by intrastriatal electrical stimulation is almost exclusive

58 We show that intrastriatal expression of 97Q-GFP causes the rapid for

59 nesias have been a surprising side-effect of intrastriatal foetal ventral mesencephalic transplantati

60 Furthermore, we help to show how altered intrastriatal GABAergic signaling may produce aberrant n

61 Nonselectively reducing intrastriatal gamma-aminobutyric acid (GABA) receptor-A

62 Intrastriatal GFAP-hNGF-secreting implants also induced

63 Furthermore, intrastriatal glutamate antagonist infusions increased t

64 C57Bl/6J mice received an intrastriatal graft of MHP36 neural stem cells 3 days af

65 mplete recovery of motor functions following intrastriatal grafting of fetal ventral mesencephalon.

66 Intrastriatal grafts of embryonic mesencephalic tissue c

67 Two patients received intrastriatal grafts of human fetal ventral mesencephali

68 Finally, intrastriatal implants of engineered adenosine-releasing

69 We gave cynomolgus monkeys intrastriatal implants of polymer-encapsulated baby hams

70 Rats underwent intrastriatal infusion and were observed and then sacrif

71 Intrastriatal infusion of 1.6 or 8.1 mM oxotremorine did

72 adiol pellet were subjected to an unilateral intrastriatal infusion of 6-hydroxydopamine (6-OHDA).

73 Adult, male rats (n=10) underwent unilateral intrastriatal infusion of 6-OHDA (12.5mug).

74 gene expression is also downregulated by an intrastriatal infusion of a cholinergic muscarinic antag

75 Intrastriatal infusion of a neuronal NO synthase inhibit

76 Intrastriatal infusion of a NO scavenger also decreased

77 to amphetamine, we studied the effect of an intrastriatal infusion of amphetamine on nigrostriatal a

78 We investigated the effect of intrastriatal infusion of blood on hematoma volume, neur

79 inhibitor PD098059 or after a continuous 7 d intrastriatal infusion of ERK1/2 antisense oligodeoxynuc

80 nthine (DMPX) (A2a antagonist) 30 min before intrastriatal infusion of malonate (mitochondrial comple

81 reatment in mice which received a unilateral intrastriatal infusion of malonate, a metabolic inhibito

82 um or substantia nigra of rats 30 min before intrastriatal infusion of malonate.

83 ivity in a manner that was blocked following intrastriatal infusion of ODQ (50 mum).

84 ed gene expression in the barrel cortex, and intrastriatal infusion of SCH-23390 attenuated this effe

85 Intrastriatal infusion of the competitive NMDA receptor

86 Intrastriatal infusion of the neurokinin-1 receptor agon

87 Like the competitive antagonists, intrastriatal infusion of the non-competitive NMDA antag

88 Unilateral intrastriatal infusion of the selective D1 receptor anta

89 MDA receptor agonist quinolinic acid (QA) by intrastriatal infusion, and the role of NF-kappaB in the

90 sis, freely behaving rats received bilateral intrastriatal infusions of ascorbate oxidase (AAO) to in

91 MPTP was administered to mice which received intrastriatal infusions of saline or malonate.

92 Bilateral intrastriatal infusions of the full D1 agonist SKF 82958

93 vity in awake rats during quiet resting that intrastriatal inhibition maintains a low-correlation str

94 ions/min over 1 h) were randomly assigned to intrastriatal injection (ipsilateral to the lesion) of b

95 ncrease in zif/268 mRNA measured at 6 h post-intrastriatal injection in the pCPA/QA group as compared

96 Intrastriatal injection of 3-nitrotyrosine, which is a b

97 iglets, cerebral hyperemia was induced after intrastriatal injection of 5 mumol of N-methyl-D-asparti

98 sphorylation of Trk-type proteins 2 hr after intrastriatal injection of 50 ng of NGF.

99 l, lateral and caudal striatum 4 weeks after intrastriatal injection of 6-hydroxydopamine (6-OHDA), a

100 Intrastriatal injection of 6-hydroxydopamine results in

101 unilateral nigrostriatal lesion produced by intrastriatal injection of 6-hydroxydopamine was indisti

102 Twenty-four hours following an intrastriatal injection of [125I]GDNF, label was observe

103 Intrastriatal injection of a D1 receptor antagonist amel

104 Intrastriatal injection of a Tat-fusion and CaMKIIalpha-

105 The intrastriatal injection of a tyrosine kinase inhibitor,

106 does not seem to directly increase CNTF, as intrastriatal injection of an ischemic solution or expos

107 Intrastriatal injection of an mGluR agonist increases mo

108 sion of pioglitazone into gliomas induced by intrastriatal injection of C6 cells reduced tumor volume

109 nsplant for those animals pretreated with an intrastriatal injection of citrate buffer and subsequent

110 bsequently, transplanted animals received an intrastriatal injection of either GDNF (10 microg) or ci

111 Intrastriatal injection of either malonate or quinolinat

112 uced in Lewis rats (n = 24) via stereotactic intrastriatal injection of heat-killed bacillus Calmette

113 ogenous CCL2 exerted neuroprotection against intrastriatal injection of HIV-1 Tat.

114 ment with tACPD did not alter the effects of intrastriatal injection of KA.

115 were examined in adult rat striatum after an intrastriatal injection of low doses of quinolinic acid,

116 ter the acute systemic treatment of 3-NP and intrastriatal injection of malonate.

117 Furthermore, intrastriatal injection of neutralizing antibodies augme

118 p) and, after 20 min, by a single unilateral intrastriatal injection of NMDA (15 nmol, n = 12).

119 chanisms were probably also not involved, as intrastriatal injection of proinflammatory cytokines (IF

120 ntrol stem cells followed 9 days later by an intrastriatal injection of quinolinic acid (QA).

121 Selective neuronal loss caused by intrastriatal injection of quinolinic acid resulted in a

122 triatal output neurons from death induced by intrastriatal injection of quinolinic acid, an N-methyl-

123 xamined neuronal degeneration resulting from intrastriatal injection of quinolinic acid, an NMDA rece

124 We found that unilateral intrastriatal injection of rAAV resulting in the express

125 Intrastriatal injection of rAAV4betagal resulted again i

126 Consistent with our in vitro findings, intrastriatal injection of specific antisense against mi

127 Male rats were given an intrastriatal injection of Tat (25 micro g) or vehicle 2

128 The acute intrastriatal injection of the CaMKII inhibitor KN93 (1.

129 eloping dystonic movements after systemic or intrastriatal injection of the cholinergic agonist oxotr

130 signaling in dMSNs by cocaine is rescued by intrastriatal injection of the GABA antagonist, bicucull

131 athway was selectively inhibited by a single intrastriatal injection of the MAPK/ERK kinase inhibitor

132 optosis can be induced during development by intrastriatal injection of the neurotoxin 6-hydroxydopam

133 In pHSVpkcDelta-infected animals, intrastriatal injection of the PKC inhibitor NPC-15437 (

134 Here, using MRI, we demonstrate that a focal intrastriatal injection of TNF-alpha causes a significan

135 ssue water diffusion was apparent 24 h after intrastriatal injection of TNF-alpha injection, which ma

136 unilateral inhibition of striatal PTP by an intrastriatal injection of vanadate induced contralatera

137 At the time of the intrastriatal injection, 5-HT levels were depleted great

138 toxin 6-hydroxydopamine (6-OHDA) (unilateral intrastriatal injection, 64 nmol) were compared with fre

139 cts of the aminoglycoside neomycin following intrastriatal injection.

140 rAAV2betagal and rAAV5betagal intrastriatal injections led to beta-gal-positive parenc

141 d-type control mice (WT) received unilateral intrastriatal injections of 3-NP (200 nmol/microl) or QA

142 r GDNF or BDNF, or both vectors, followed by intrastriatal injections of 6-hydroxydopamine (6-OHDA).

143 lar superoxide dismutase received unilateral intrastriatal injections of 6-hydroxydopamine.

144 t microdialysis experiments after unilateral intrastriatal injections of a recombinant adeno-associat

145 Intrastriatal injections of AAV1-GFP-IC10 significantly

146 Intrastriatal injections of DA in amounts from 1 to 2 mi

147 Rats received unilateral intrastriatal injections of HSV-1 vectors that express e

148 Intrastriatal injections of malonate resulted in a signi

149 d adult neurons at different times following intrastriatal injections of non-NMDA and NMDA GluR agoni

150 2 and naive controls were tested with single intrastriatal injections of rAAV2 encoding human glial c

151 field by determining the capacity of direct intrastriatal injections of RY 008, a partial inverse ag

152 icrog/0.5 microl/side), as also were control intrastriatal injections of saline (0.5 microl/side).

153 Intrastriatal injections of the mamba snake toxin MT-7,

154 l dopamine neuron loss induced by unilateral intrastriatal injections of the toxin 6-hydroxydopamine.

155 Survival of rats with large intrastriatal inocula of C6trkA cells was significantly

156 at in wild-type nontransgenic mice, a single intrastriatal inoculation of synthetic alpha-Syn fibrils

157 In both mice and monkeys, intranigral or intrastriatal inoculations of PD-derived LB extracts res

158 out a framework for an updated model of the intrastriatal lateral inhibition, where we explore its c

159 /-) mice were more sensitive to NMDA-induced intrastriatal lesions than were wild-type animals.

160 values confirmed this finding and evidenced intrastriatal localization of seasonal effects to the ca

161 The combined treatment of intrastriatal malonate with systemic METH resulted in gr

162 Intrastriatal microinfusion of adenosine A1 receptor ago

163 the NPY (Y1R and Y2R) receptors infused via intrastriatal microinjection followed by a bolus of METH

164 Intrastriatal modulation of the moderate EtOH dose was s

165 We show that intrastriatal nitric oxide (NO) signaling elevates the e

166 tment for 21 days without the gene transfer, intrastriatal NPC-15437 had no effect on the response sh

167 of the limitations of this approach is that intrastriatal placement of implants fails to consistentl

168 To distinguish intrastriatal processing from loop dynamics, cortex-stri

169 adversely affect neuronal survival following intrastriatal QA exposure and lend support to the hypoth

170 Six months after intrastriatal rAAV transduction, TH staining was present

171 Intrastriatal release of dopamine and inhibition of inte

172 Previously, we have shown that intrastriatal Ro15-4513 not only significantly attenuate

173 Intrastriatal RY 008 (50, 500 ng) and SR 95531 (50 ng) a

174 Rats received unilateral or bilateral intrastriatal saline injections to disrupt the blood-bra

175 Compared to control rats injected with intrastriatal saline, rats depleted of dopamine displaye

176 Intrastriatal scopolamine at a concentration of 62 mM, b

177 s or whether impulsivity and cocaine-induced intrastriatal shifts are additive processes is unknown.

178 tly attenuated locomotor activity induced by intrastriatal SKF 82958 (12.0 nmol).

179 Excitotoxic lesions were produced by intrastriatal stereotactic NMDA microinjections (10-20 n

180 was depressed during repetitive 2 Hz firing, intrastriatal stimulation reliably evoked large polysyna

181 During periods of induced regular firing, intrastriatal stimuli were used to evoke pharmacological

182 ajority of neostriatal neurons and intrinsic intrastriatal synapses are GABAergic, the latter arising

183 At the electron microscopic level, the intrastriatal terminals of both corticostriatal neuron t

184 t only intratelencephalically (IT-type), the intrastriatal terminals of which are 0.41 microm in mean

185 ateral projection to striatum (PT-type), the intrastriatal terminals of which are 0.82 microm in mean

186 label PT-type neurons and their ipsilateral intrastriatal terminals retrogradely, BDA3k was injected

187 to the contralateral striatum, whereas their intrastriatal terminals were labeled anterogradely by bi

188 e cortex, and in the size and shape of their intrastriatal terminals, suggest that they may differ in

189 perikaryal size, and the morphology of their intrastriatal terminals.

190 Intrastriatal TGFalpha infusion induced significant prol

191 erentiate into dopaminergic neurons, survive intrastriatal transplantation and induce functional reco

192 Intrastriatal transplantation of dopaminergic neurones a

193 Intrastriatal transplantation of dopaminergic neurons ca

194 Intrastriatal transplantation of Gpc4 hypomorphic cells

195 d-brain barrier (BBB) permeability following intrastriatal transplantation of mouse bone marrow strom

196 middle cerebral artery occlusion (MCAo) and intrastriatal transplantation of mouse bone marrow strom

197 Furthermore, ARE preactivation by means of intrastriatal transplantation of Nrf2-overexpressing ast

198 Rats received intrastriatal transplants of GFAP-hNGF stem cells or con

199 Intrastriatal transplants of human foetal mesencephalic

200 ch block dopamine (DA) D2 receptors, showing intrastriatal variation in their effectiveness in modula

201 ne-induced rotational behavior 3 weeks after intrastriatal vector injection.