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1 Shaker potassium (K+) channels normally lack intrasubunit and intersubunit disulfide bonds.
2 ctural findings are discussed in relation to intrasubunit and intersubunit interactions that may conf
3 odeling, identify important sites of dynamic intrasubunit and intersubunit interactions that regulate
4 tent with such an evolutionary trade between intrasubunit and intersubunit interactions, we showed in
5                        We conclude that both intrasubunit and intersubunit reaction mechanisms are ne
6          Residues in the GLIC TMD that frame intrasubunit and intersubunit water-accessible cavities
7  tRNAs trapped in transit, bound in chimeric intrasubunit ap/P and pe/E hybrid states.
8 t contains an independent active site (i.e., intrasubunit arrangement) or whether the active site res
9 3)H]S-mTFD-MPPB photolabeling of these nAChR intrasubunit binding sites.
10 date binding site to an intersubunit, not an intrasubunit, binding pocket is a novel conclusion that
11 topes into two binding regions at inter- and intrasubunit boundaries of the calcium-dependent trimer.
12 e and di-Fe(2+) forms of BFR showed that the intrasubunit catalytic center, known as the ferroxidase
13                   Key to this activity is an intrasubunit catalytic dinuclear iron center called the
14 n the virion assembly, probably involving an intrasubunit cation-pi interaction between the guanidini
15 ting state propofol does not bind in the TMD intrasubunit cavity as observed in the crystal structure
16  and P3 dictates intersubunit (trans) versus intrasubunit (cis) autophosphorylation, with the trans r
17 talytic domain in the sister subunit, but no intrasubunit collisions are detected.
18 irst transmembrane domain alter in inter- or intrasubunit communication.
19  suggest that the effects of dimerization on intrasubunit conformation reflect the need to adjust the
20 er831 decreases the activation energy for an intrasubunit conformational change that regulates the co
21 h I domains remain individually sensitive to intrasubunit conformational changes induced by allosteri
22  activation includes subunit rotation and/or intrasubunit conformational changes that move N170 to a
23 tition the restraints between explicit inter/intrasubunit contacts and a class wherein both were reta
24                                        These intrasubunit contacts as well as those between MD helix
25 distal loop does not contact Hsp70 but makes intrasubunit contacts with nucleotide-binding domain 2 (
26 t it may not exhibit the pronounced negative intrasubunit cooperativity in the absence of Mg2+ that i
27 ine-valine-proline (PVP) motif, Cd(2+) forms intrasubunit coordination with a native glutamate E321,
28                                          The intrasubunit correlated motions were decreased in the mo
29  long-range couplings across the ring, while intrasubunit couplings connected the motif to the conser
30                      In addition there is an intrasubunit covalent linkage between two tryptophan sid
31 ly inhibits the formation of both inter- and intrasubunit cross-links.
32 ural Zn2+ is coordinated in a highly stable, intrasubunit Cys4:Zn2+ site.
33 normally participate in the formation of the intrasubunit disulfide bond (Cys-57 to Cys-146) or are b
34 er by metal binding and the formation of the intrasubunit disulfide bond are mediated by independent
35 activity and resulted in the formation of an intrasubunit disulfide bond between Cys315 and Cys318.
36                  These results indicate that intrasubunit disulfide bond formation leads to a global
37 eroxide radical, and the connectivity of the intrasubunit disulfide bond in P. leiognathi CuZnSOD are
38 5) compromised CCS-mediated oxidation of the intrasubunit disulfide bond in vivo.
39 ubunit loop 2 and its end is "latched" by an intrasubunit disulfide bond to the beta-subunit core.
40 beled hBCATm showed that during labeling, an intrasubunit disulfide bond was formed in a significant
41                             Reduction of the intrasubunit disulfide bond within each SOD1 subunit by
42 lfide mechanism, Tpx contains a redox-active intrasubunit disulfide bond yet is homodimeric in soluti
43 mature form, lacking metal and a stabilizing intrasubunit disulfide bond, apoSOD1(2SH), is dynamic an
44 impaired metal ion binding, reduction of the intrasubunit disulfide bond, or oxidative modification.
45  of SOD1, a protein incapable of forming the intrasubunit disulfide bond, sediments as a monomer in t
46                                           An intrasubunit disulfide bond, seen in the crystal structu
47 tion of alpha-bungarotoxin-binding sites and intrasubunit disulfide bonding, apparently within the al
48  indicates that native as well as non-native intrasubunit disulfide bonds form in monomeric intermedi
49                                              Intrasubunit disulfide bonds formed between these Cys pa
50              Mutants of gp45 with inter- and intrasubunit disulfide bonds were created to alter the s
51    Mutation of two cysteines not involved in intrasubunit disulfide bonds, C49 and C146, had modest e
52                                    Among six intrasubunit disulfide bonds, Cys 48-Cys 139 and Cys' 48
53 hydrogenase (MADH) requires formation of six intrasubunit disulfide bonds, incorporation of two oxyge
54        The structure also reveals inter- and intrasubunit disulfide bonds, mostly in the extended N-t
55 on response, likely by formation of multiple intrasubunit disulfide bonds.
56 CL (gammaCys-7/gammaCys-16) that likely form intrasubunit disulfide bonds.
57 :Zn2+ site by H2O2 leads to the formation of intrasubunit disulfide bonds.
58 XC motif at the C terminus, and two pairs of intrasubunit disulfide bridges may play an important rol
59  domain (C289A), predicted to be involved in intrasubunit disulfide bridging, resulted in disulfide-l
60                                       For an intrasubunit disulfide mutant, the distance between thes
61 monstrate that Cys(429) and Cys(476) form an intrasubunit disulfide while the intersubunit disulfides
62 tersubunit disulfide formation by forming an intrasubunit disulfide with Cys578 and therefore mutated
63 globulin polypeptides largely accumulated as intrasubunit disulfide-linked polypeptides with apparent
64                      For the mutants without intrasubunit disulfides, the efficiency of fluorescence-
65  a combination of an ion pair cluster and an intrasubunit disulphide bond.
66 ely 20 A from the ligand binding site at the intrasubunit domain-domain interface.
67 robe the conformational heterogeneity at the intrasubunit domain-domain interface.
68 wn whether ligand binding is intersubunit or intrasubunit, either for agonists or for allosteric modu
69               Modeling studies imply that an intrasubunit electron transfer accounts for the reductio
70 ional as a homodimer and that it utilizes an intrasubunit electron transfer pathway through the singl
71 on-glucosylated glycogenin produced by dimer intrasubunit glucosylation was 16% of that produced by t
72 red fifth methylation site, E502, lies at an intrasubunit helix interface closest to the HAMP domain
73  intersubunit connection and the other is an intrasubunit hinge located between domains I and II.
74                              One point is an intrasubunit hinge point that sharply divides the struct
75 a lever-like swinging motion pivoting on the intrasubunit hinge, and the entire TM2 bundle undergoes
76 ke" sequential formation of intersubunit and intrasubunit hydrogen bonds between backbone atoms of se
77  that suggests that Ala-40 contributes to an intrasubunit hydrophobic core, the principal effect of t
78                The substrate-binding site is intrasubunit in P22 and HK620 tailspikes, but intersubun
79 increased the rate of modification of T254C (intrasubunit), indicating that propofol binding induces
80 ers in which 1) cis-allostery is mediated by intrasubunit interactions and 2) trans-allostery require
81 hese results highlight the distinct roles of intrasubunit interactions and intersubunit communication
82 he extracellular domain by short linkers and intrasubunit interactions between residues in the putati
83        Interestingly, cTnI-R145G blunted the intrasubunit interactions between the cTnI N-terminal ex
84 osphomimic mutations led to the formation of intrasubunit interactions between the N-terminus and the
85                     The 986-990 region holds intrasubunit interactions between the TRP domain and the
86    Here we investigate both intersubunit and intrasubunit interactions between TM helices of P2X rece
87   These findings indicate that inter- and/or intrasubunit interactions in the TRP domain are essentia
88 eutral pH structure through intersubunit and intrasubunit interactions that presumably inhibit the co
89                                    Extensive intrasubunit interactions were observed in the closed st
90 tions affect critical residues and inter- or intrasubunit interactions.
91 ily to intersubunit interactions rather than intrasubunit interactions.
92 well as a network of transitional inter- and intrasubunit interactions.
93 a fourth cross-linking pair that spanned the intrasubunit interface between transmembrane helix 1 (TM
94 ic phenoxyalkoxy side chains extend into the intrasubunit interfaces between helices S5 and S6.
95 ding and effector sites involving inter- and intrasubunit interfaces.
96  complete its autoglucosylation by the dimer intrasubunit mechanism.
97     The data imply some degree of inter- and intrasubunit negative cooperative interaction between si
98 erodimers able to glucosylate exclusively by intrasubunit or intersubunit reaction mechanisms.
99 hown to generate an approximately 1 angstrom intrasubunit piston-type movement of one transmembrane h
100  vestibule of the receptor, in a preexisting intrasubunit pocket opposite the agonist binding site an
101 l disulfide centers occurred as an inter- or intrasubunit process in dimeric AhpF.
102 ctron transfer between domains of AhpF is an intrasubunit process.
103 results identify for the first time a single intrasubunit propofol binding site in the nAChR transmem
104 GLIC via a membrane-embedded tunnel using an intrasubunit protein lumen as the conduit, an observatio
105 designed for examining both intersubunit and intrasubunit protein-protein interactions.
106 analysis of these mutant enzymes reveals the intrasubunit rearrangements that occur upon substrate bi
107 onovalent Fabs, while those that bind at the intrasubunit region require divalency.
108          Recent structural studies implicate intrasubunit rotation of the 30S head in translocation.
109 S-H groups increases, implying that specific intrasubunit S-H.X hydrogen bonds must be weakened to ef
110                 Here, we identify a critical intrasubunit salt bridge between conserved charged resid
111 s modification of Cys93(F9)beta disrupts the intrasubunit salt bridge between His146(HC3)beta and Asp
112 ther loop conformation favors an alternative intrasubunit salt bridge, similar to that found in the E
113 pH they form a complex network of inter- and intrasubunit salt bridges and hydrogen bonds near the bu
114 GAPDHs is also correlated with the number of intrasubunit salt links and total hydrogen bonds.
115 P and allow the identification of a possible intrasubunit signal transduction pathway that controls t
116 ithin the nAChR transmembrane domain: (i) an intrasubunit site in the delta subunit helix bundle, pho
117                                           An intrasubunit site is adjacent to the GABA-recognition si
118 d by molecular dynamics simulations revealed intrasubunit sites for most halothane binding and inters
119                 Rather, S-mTFD-MPPB binds to intrasubunit sites within the alpha and delta subunits,
120                               We find strong intrasubunit TM1-TM2 interactions, as well as TM1-TM1' a
121 gh the binding-gating coupling preferred the intrasubunit to intersubunit configuration within the C
122 ta[c]quinoline-8-sulfonamide) interact at an intrasubunit transmembrane site.
123 ly packed conformation with water-accessible intrasubunit vestibules penetrating from the extracellul

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