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2 ctural findings are discussed in relation to intrasubunit and intersubunit interactions that may conf
3 odeling, identify important sites of dynamic intrasubunit and intersubunit interactions that regulate
4 tent with such an evolutionary trade between intrasubunit and intersubunit interactions, we showed in
8 t contains an independent active site (i.e., intrasubunit arrangement) or whether the active site res
10 date binding site to an intersubunit, not an intrasubunit, binding pocket is a novel conclusion that
11 topes into two binding regions at inter- and intrasubunit boundaries of the calcium-dependent trimer.
12 e and di-Fe(2+) forms of BFR showed that the intrasubunit catalytic center, known as the ferroxidase
14 n the virion assembly, probably involving an intrasubunit cation-pi interaction between the guanidini
15 ting state propofol does not bind in the TMD intrasubunit cavity as observed in the crystal structure
16 and P3 dictates intersubunit (trans) versus intrasubunit (cis) autophosphorylation, with the trans r
19 suggest that the effects of dimerization on intrasubunit conformation reflect the need to adjust the
20 er831 decreases the activation energy for an intrasubunit conformational change that regulates the co
21 h I domains remain individually sensitive to intrasubunit conformational changes induced by allosteri
22 activation includes subunit rotation and/or intrasubunit conformational changes that move N170 to a
23 tition the restraints between explicit inter/intrasubunit contacts and a class wherein both were reta
25 distal loop does not contact Hsp70 but makes intrasubunit contacts with nucleotide-binding domain 2 (
26 t it may not exhibit the pronounced negative intrasubunit cooperativity in the absence of Mg2+ that i
27 ine-valine-proline (PVP) motif, Cd(2+) forms intrasubunit coordination with a native glutamate E321,
29 long-range couplings across the ring, while intrasubunit couplings connected the motif to the conser
33 normally participate in the formation of the intrasubunit disulfide bond (Cys-57 to Cys-146) or are b
34 er by metal binding and the formation of the intrasubunit disulfide bond are mediated by independent
35 activity and resulted in the formation of an intrasubunit disulfide bond between Cys315 and Cys318.
37 eroxide radical, and the connectivity of the intrasubunit disulfide bond in P. leiognathi CuZnSOD are
39 ubunit loop 2 and its end is "latched" by an intrasubunit disulfide bond to the beta-subunit core.
40 beled hBCATm showed that during labeling, an intrasubunit disulfide bond was formed in a significant
42 lfide mechanism, Tpx contains a redox-active intrasubunit disulfide bond yet is homodimeric in soluti
43 mature form, lacking metal and a stabilizing intrasubunit disulfide bond, apoSOD1(2SH), is dynamic an
44 impaired metal ion binding, reduction of the intrasubunit disulfide bond, or oxidative modification.
45 of SOD1, a protein incapable of forming the intrasubunit disulfide bond, sediments as a monomer in t
47 tion of alpha-bungarotoxin-binding sites and intrasubunit disulfide bonding, apparently within the al
48 indicates that native as well as non-native intrasubunit disulfide bonds form in monomeric intermedi
51 Mutation of two cysteines not involved in intrasubunit disulfide bonds, C49 and C146, had modest e
53 hydrogenase (MADH) requires formation of six intrasubunit disulfide bonds, incorporation of two oxyge
58 XC motif at the C terminus, and two pairs of intrasubunit disulfide bridges may play an important rol
59 domain (C289A), predicted to be involved in intrasubunit disulfide bridging, resulted in disulfide-l
61 monstrate that Cys(429) and Cys(476) form an intrasubunit disulfide while the intersubunit disulfides
62 tersubunit disulfide formation by forming an intrasubunit disulfide with Cys578 and therefore mutated
63 globulin polypeptides largely accumulated as intrasubunit disulfide-linked polypeptides with apparent
68 wn whether ligand binding is intersubunit or intrasubunit, either for agonists or for allosteric modu
70 ional as a homodimer and that it utilizes an intrasubunit electron transfer pathway through the singl
71 on-glucosylated glycogenin produced by dimer intrasubunit glucosylation was 16% of that produced by t
72 red fifth methylation site, E502, lies at an intrasubunit helix interface closest to the HAMP domain
75 a lever-like swinging motion pivoting on the intrasubunit hinge, and the entire TM2 bundle undergoes
76 ke" sequential formation of intersubunit and intrasubunit hydrogen bonds between backbone atoms of se
77 that suggests that Ala-40 contributes to an intrasubunit hydrophobic core, the principal effect of t
79 increased the rate of modification of T254C (intrasubunit), indicating that propofol binding induces
80 ers in which 1) cis-allostery is mediated by intrasubunit interactions and 2) trans-allostery require
81 hese results highlight the distinct roles of intrasubunit interactions and intersubunit communication
82 he extracellular domain by short linkers and intrasubunit interactions between residues in the putati
84 osphomimic mutations led to the formation of intrasubunit interactions between the N-terminus and the
86 Here we investigate both intersubunit and intrasubunit interactions between TM helices of P2X rece
87 These findings indicate that inter- and/or intrasubunit interactions in the TRP domain are essentia
88 eutral pH structure through intersubunit and intrasubunit interactions that presumably inhibit the co
93 a fourth cross-linking pair that spanned the intrasubunit interface between transmembrane helix 1 (TM
97 The data imply some degree of inter- and intrasubunit negative cooperative interaction between si
99 hown to generate an approximately 1 angstrom intrasubunit piston-type movement of one transmembrane h
100 vestibule of the receptor, in a preexisting intrasubunit pocket opposite the agonist binding site an
103 results identify for the first time a single intrasubunit propofol binding site in the nAChR transmem
104 GLIC via a membrane-embedded tunnel using an intrasubunit protein lumen as the conduit, an observatio
106 analysis of these mutant enzymes reveals the intrasubunit rearrangements that occur upon substrate bi
109 S-H groups increases, implying that specific intrasubunit S-H.X hydrogen bonds must be weakened to ef
111 s modification of Cys93(F9)beta disrupts the intrasubunit salt bridge between His146(HC3)beta and Asp
112 ther loop conformation favors an alternative intrasubunit salt bridge, similar to that found in the E
113 pH they form a complex network of inter- and intrasubunit salt bridges and hydrogen bonds near the bu
115 P and allow the identification of a possible intrasubunit signal transduction pathway that controls t
116 ithin the nAChR transmembrane domain: (i) an intrasubunit site in the delta subunit helix bundle, pho
118 d by molecular dynamics simulations revealed intrasubunit sites for most halothane binding and inters
121 gh the binding-gating coupling preferred the intrasubunit to intersubunit configuration within the C
123 ly packed conformation with water-accessible intrasubunit vestibules penetrating from the extracellul
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