ライフサイエンスコーパス: intratracheally

1 (i.p.), or mucosally (i.e., intranasally or intratracheally).

2 posed to 1 x 10 cells/mouse of C. neoformans intratracheally.

3 ession in the lung (>42 days) when delivered intratracheally.

4 tion when administered systemically, but not intratracheally.

5 ory settings, 4 mL/kg of beractant was given intratracheally.

6 eak that occurs after administration of IL-1 intratracheally.

7 il chemoattractant levels as rats given IL-1 intratracheally.

8 (HNE) when the inhibitors were administered intratracheally.

9 scular leak that develops in rats given IL-1 intratracheally.

10 e in vivo when administered either orally or intratracheally.

11 attractant (CINC) levels, in rats given IL-1 intratracheally.

12 crease in peak airway pressure when measured intratracheally.

13 tein increases compared with rats given IL-1 intratracheally.

14 e and absent in hamsters who received quartz intratracheally.

15 nge only in monkeys given booster injections intratracheally.

16 then exposed these mice to PM(2.5) or saline intratracheally.

17 ount of normal saline (pH 5.3) was instilled intratracheally.

18 for 4 days followed by 1.2 x 108 Pseudomonas intratracheally.

19 Control mice received saline solution intratracheally (0.05 mL, pulmonary control) or intraper

20 received Escherichia coli lipopolysaccharide intratracheally (2 mg/kg in 0.05 mL of saline/mouse, pul

21 were sensitized to cockroach Ag, challenged intratracheally 21 days later, and compared with STAT4-c

22 The MAbs were administered intratracheally 24 h before the calves were challenged w

23 ed either Fas-, caspase-8-, or control-siRNA intratracheally 4 hours after hemorrhage.

24 nt with keratinocyte growth factor (injected intratracheally 48 hrs before the experiment) on alpha-n

25 volved effect, we administered KGF (5 mg/kg, intratracheally) 48 h prior to ANTU (50 mg/kg, intraperi

26 Moreover, GM-CSF applied intratracheally activated CD103+ DCs, inducing increased

27 ls were recruited to the lung in response to intratracheally administered A. fumigatus conidia.

28 mice were then pretreated with 10(9) PFU of intratracheally administered adenoviral vector containin

29 Intratracheally administered Cy-5-labeled Fas-siRNA loca

30 e lung injury in rats, we have compared four intratracheally administered cytokines for their protect

31 onse of the lung and systemic circulation to intratracheally administered Escherichia coli lipopolysa

32 the increase in white blood cells induced by intratracheally administered HNE (100 micrograms/hamster

33 We intratracheally administered Klebsiella pneumoniae to wi

34 Intratracheally administered NONOates result in selectiv

35 Exogenous, intratracheally administered PAI-1 prevented the inhibit

36 Intratracheally administered PEG-PLGA based optimized fo

37 e (WT) and transgenic mice were injured with intratracheally administered saline or bleomycin, and th

38 Intratracheally administered sildenafil particles elicit

39 Intratracheally administered TLR2 agonist caused increas

40 impact of sRAGE, the recombinant protein was intratracheally administered to mice, which demonstrated

41 g with wild-type C57BL/6 mice were immunized intratracheally against P. carinii, depleted of T cells

42 LPS-induced acute lung injury by delivering intratracheally an adenovirus construct that expressed M

43 nactivated white birch pollen extract (BPEx) intratracheally and injected with the antioxidants, N-ac

44 neration adenoviral (Ad) vector administered intratracheally and intravenously.

45 We injected elastase intratracheally and the RAGE antagonist FPS-ZM1 in mice,

46 In contrast, rats given IL-1 intratracheally and TNFbp intravenously had the same ele

47 ficient (BLT1(-/-)) BMDCs or wild-type BMDCs intratracheally and were then challenged with OVA for 3

48 e were challenged with Klebsiella pneumoniae intratracheally, and organs were harvested at 8, 24, and

49 a good pharmacokinetic property, when given intratracheally, and the blood cells from such pharmacok

50 When mutants were inoculated intratracheally, any receptor, except for GerX, was suff

51 duced by Escherichia coli lipopolysaccharide intratracheally (ARDSp) or intraperitoneally (ARDSexp).

52 nized orally and intranasally at 0 weeks and intratracheally at 12 weeks with an adenovirus type 5 ho

53 containing 8.5 mg/kg cHyp or tHyp instilled intratracheally at 7 and 14 d after bleo.

54 Recombinant IL-6 instilled intratracheally at commencement of injury led to substan

55 Pregnant rats were inoculated intratracheally at midterm using recombinant RSV express

56 T+P was administered intratracheally at the time of sensitization in three do

57 (n = 6) or O(2) combined with rhSOD (5 mg/kg intratracheally) at birth (n = 4), rhSOD at 4 h of age (

58 Exogenous SP-D administered intratracheally attenuated BLM-induced lung fibrosis in

59 H4R agonist 4-methylhistamine when delivered intratracheally before Ag challenge mitigated airway hyp

60 osis when low doses of HKL were administered intratracheally but did not support the proliferation of

61 model of lung injury, anti-C5a administered intratracheally (but not intravenously) reduced in a dos

62 The Syk inhibitor NVP-QAB-205 was nebulized intratracheally by using a treatment-based protocol 15 m

63 R4-, MyD88-deficient and WT BALB/c mice were intratracheally challenged with PM2.5 +/- ovalbumin (OVA

64 (100% mortality) to pulmonary infection when intratracheally challenged, at day 3 after CLP, with via

65 entrations were increased in rats given IL-1 intratracheally compared with sham-treated control rats.

66 trol mice (Healthy) received saline solution intratracheally (Cp) or intraperitoneally (Cexp).

67 aging techniques for real-time monitoring of intratracheally delivered cells.

68 the effect of FGF-10 on LR-MSCs, FGF-10 was intratracheally delivered into the lungs of rats.

69 In addition, we explored the effect of intratracheally delivered liposomally encapsulated CG/NE

70 We report on the transport and deposition of intratracheally delivered stem cells as well as strategi

71 h the murine IFN-gamma (mIFN-gamma) gene and intratracheally delivered the macrophages to express mIF

72 Mice were administered bleomycin intratracheally followed by intravenous injection of rec

73 ptor 1 knockout (IL-1R(-/-)) mice challenged intratracheally, fungal recovery on day 7 after infectio

74 We found that rats given IL-1 intratracheally had increased lung lavage fluid tumor ne

75 ncreases risk of mycobacterial infection, we intratracheally (I.T.) administered silica, a control du

76 ation of LT-HDM plus recombinant IL-33, were intratracheally (i.t.) administered to induce allergic a

77 tes neuropeptide stores, and then challenged intratracheally (i.t.) with hen egg lysozyme (HEL).

78 T), TLR2(-/-), TLR4(-/-), or MyD88(-/-) mice intratracheally (i.t.) with recombinant cHSP60 (50 micro

79 rst intranasally (i.n.) plus orally and then intratracheally (i.t.), followed by envelope protein boo

80 nged with 10(2) CFU of Klebsiella pneumoniae intratracheally (i.t.), resulting in the time-dependent

81 esothelioma) and LKR (lung cancer) tumors or intratracheally in a Kras orthotopic lung tumor model.

82 l accumulation, after administration of IL-1 intratracheally in rats.

83 more widespread in the respiratory tract for intratracheally infected guinea pigs.

84 In contrast, lungs from intratracheally infected mindin-deficient mice contained

85 Rats were intratracheally infected with 109 colony-forming units o

86 When pigs were intratracheally infected with A. pleuropneumoniae, pigs

87 Mice were intratracheally infected with either a wild-type P. aeru

88 rgeted (IL-12p40-/-) and wild-type mice were intratracheally infected with respiratory syncytial viru

89 ent (CCSP(-/-)) and wild-type (WT) mice were intratracheally infected with RSV and the lung inflammat

90 00-PPM (supplemented) alpha-Toc for 4 wk and intratracheally infected with S. pneumoniae.

91 The migration of intratracheally injected eosinophils into paratracheal l

92 ic mice, fluorescently labeled ex vivo, were intratracheally injected into ovalbumin-sensitized and o

93 L/6J wild-type (WT) and Mfge8(-/-) mice were intratracheally injected with LPS (5 mg/kg).

94 defective in acute lethality (24 to 48 h) to intratracheally inoculated A/J mice.

95 All three viruses replicated in lungs of intratracheally inoculated pigs, yet nasal shedding was

96 he lack of PPARgamma, PPARgamma KO mice were intratracheally inoculated with a PPARgamma lentivirus c

97 Albino C57 female mice were intratracheally inoculated with either live or dead Kleb

98 Mice were intratracheally inoculated with Klebsiella pneumoniae an

99 d of their TCR beta- and/or delta-chain were intratracheally inoculated with Klebsiella pneumoniae.

100 RAP-deficient and wild-type littermates were intratracheally inoculated with Kp or Pa.

101 thout selective CD4(+)-T-cell depletion were intratracheally inoculated with Pneumocystis organisms.

102 To do so, Escherichia coli was intratracheally instilled into C57BL/6 mice in the prese

103 The mIFN-gamma-producing macrophages were intratracheally instilled into mechanically ventilated s

104 Here, we describe an intratracheally instilled lentiviral system able to deli

105 cterial DNA in lower airway inflammation, we intratracheally instilled prokaryotic and eukaryotic DNA

106 (SH), and SH heart failure (SHHF) rats were intratracheally instilled with 0.0, 0.25, or 1.0 mg LA (

107 nflux by 93% and protein leak by 55% in mice intratracheally instilled with FMLP.

108 After challenge, mice were intratracheally instilled with saline vehicle or 3 mg/kg

109 fibrosing alveolitis, we instilled bleomycin intratracheally into gelatinase B-deficient mice and gel

110 of heat-killed Listeria (HKL) were injected intratracheally into Lewis rats.

111 These AMs were administered intratracheally into mechanically ventilated SCID mice.

112 Cryptococcus neoformans was inoculated intratracheally into mice lacking the IFN-gamma receptor

113 These labeled cells, instilled intratracheally into normal mice, migrated into draining

114 after 7 days of culture and were inoculated intratracheally into susceptible scid mice.

115 constitutively active form of Akt introduced intratracheally into the lungs of mice by adenovirus gen

116 n fluorescent protein-siRNA was administered intratracheally into transgenic mice overexpressing gree

117 7.2 x 105 or 1.9 x 107 cfu/mL) was instilled intratracheally into untreated C57Bl/6 mice, C57Bl/6 mic

118 carinii directly, organisms were inoculated intratracheally into wild-type mice and into three group

119 cubated with OVA Ag in vitro, were instilled intratracheally into wild-type recipient mice that adopt

120 , PCF alone, or RW alone and then challenged intratracheally, intranasally, and supraocularly with RW

121 ntrol, BALB/c (wild-type), mice were treated intratracheally, intraperitoneally, or intravenously, wi

122 45 virus, administered intranasally (in) and intratracheally (it) in the presence of high levels of P

123 A potent and selective Rip2 siRNA given intratracheally knocked down Rip2 expression in OVA-chal

124 Following intratracheally LPS treatment, CD44(-/-) mice demonstrat

125 se ragweed-immunized mice were given ragweed intratracheally on day 11.

126 e (5 mL/kg each) was administered as a bolus intratracheally or by aerosolization for 6 hrs.

127 ese studies, apoptotic thymocytes were given intratracheally or i.p. to normal mice, and then AMphi o

128 g injury, animals treated with anti-PcrV IgG intratracheally or i.v. had significant decreases in lun

129 ere given Escherichia coli or saline, either intratracheally or intravenously.

130 In the present studies, HMG-1 given intratracheally produced acute inflammatory injury to th

131 y Escherichia coli lipopolysaccharide either intratracheally (pulmonary acute lung injury) or intrape

132 erichia coli lipopolysaccharide administered intratracheally (pulmonary acute respiratory distress sy

133 ngeneic WT but not TLR9-/- mice administered intratracheally reconstituted antibacterial immunity in

134 nged with 10(2) CFU of Klebsiella pneumoniae intratracheally, resulting in the time-dependent express

135 For asthma induction, mice were intratracheally sensitized with OVA or cat dander extrac

136 can green monkeys immunized intranasally and intratracheally, the mean peak titer of the P chimera wa

137 vector in PBS, or PBS alone was administered intratracheally to ACI (RT1(a)) rats.

138 P. aeruginosa was administered intratracheally to determine the mortality rate at incre

139 t attenuating inflammation when administered intratracheally to mice challenged with LPS.

140 e proinflammatory, bombesin was administered intratracheally to mice.

141 after administration of interleukin-1 (IL-1) intratracheally to rats and tested this premise by using

142 ry distress syndrome, and administering IL-1 intratracheally to rats causes an acute, neutrophil-depe

143 IL-13 was delivered intratracheally to wild-type, signal transducer and acti

144 Alveolar-like macrophages were intratracheally transplanted to the injured animals and

145 I restimulation by lymphoid cells from three intratracheally treated mice showed an attenuation in th

146 ells isolated by bronchoalveolar lavage from intratracheally treated TRAF1-/- mice produced more TNF-

147 Rats were inoculated intratracheally with 1 of 6 S. aureus isolates from the

148 knockout (TLR9-/-) BALB/c mice were infected intratracheally with 10(4) C. neoformans 52D.

149 ations in IFN-gamma and IL-4 were inoculated intratracheally with 10(5) CAR bacillus organisms, and s

150 male BALB/c and C57BL/6 mice were inoculated intratracheally with 10(5) CAR bacillus organisms.

151 e of monoclonal antibodies, and rechallenged intratracheally with 10(7) viable P. carinii organisms.

152 erent routes such as i.m., intradermally, or intratracheally with a DNA vaccine to rabies virus devel

153 nockout (MIP-1alpha(-/-)) mice were infected intratracheally with a highly virulent strain of C. neof

154 duration of disease in naive rats challenged intratracheally with a lethal dose of the virulent type

155 C3H/HeN mice were inoculated intratracheally with a mouse-adapted clinical Ureaplasma

156 a study, in which we inoculated C57Bl/6 mice intratracheally with BLM or saline, and tested the anima

157 immune complexes were treated either i.v. or intratracheally with blocking Ab to murine IL-12, there

158 RA(+/+) mice and SRA(-/-) mice were infected intratracheally with C. neoformans.

159 ite rabbits were inoculated intranasally and intratracheally with C. pneumoniae, strain AR-39, and pr

160 Two groups of C. jacchus were inoculated intratracheally with cell culture supernatant containing

161 Mice infected intratracheally with Cryptococcus neoformans (Cne) requi

162 rted eosinophilic pneumonia in mice infected intratracheally with Cryptococcus neoformans.

163 Next, rats were instilled intratracheally with either saline (sal) or 1.2 U bleo,

164 onally, passive anti-PC IgM Abs administered intratracheally with HDMs decreased allergen uptake by e

165 ry immune response, Lewis rats were injected intratracheally with heat-killed Listeria (HKL), labeled

166 r proasthmatic effects, mice were inoculated intratracheally with IL-4 or IL-13, and pulmonary gene i

167 sodium arsenite for 5 wk and then challenged intratracheally with Klebsiella pneumoniae, Streptococcu

168 ella pneumophila infections, were inoculated intratracheally with L. pneumophila (10(6) bacteria per

169 pneumophila lung infections, were inoculated intratracheally with L. pneumophila AA100, AA488, or AA5

170 lung infection, were subsequently inoculated intratracheally with L. pneumophila-infected H. vermifor

171 A/J mice inoculated intratracheally with L. pneumophila-infected H. vermifor

172 l diet or a liquid control diet and infected intratracheally with low-dose M. tuberculosis H37Rv.

173 Rats treated intratracheally with LPS generate lipid-derived free rad

174 p. OVA sensitization (day 0) were challenged intratracheally with OVA on days 8, 15, 18, and 21.

175 When pretreated mice were challenged intratracheally with OVA, their bronchoalveolar lavage f

176 Finally, IFN-gamma-/- mice challenged intratracheally with P. carinii resolved their infection

177 CR(+) T-cell-deficient) mice were inoculated intratracheally with P. carinii.

178 ined immunodeficiency (scid) were inoculated intratracheally with P. carinii.

179 were depleted of CD4+ T cells and inoculated intratracheally with Pneumocystis.

180 Mice were challenged intratracheally with Pseudomonas aeruginosa, and on the

181 tein promoter (CCSP-IL-4 mice) were infected intratracheally with Pseudomonas aeruginosa.

182 Subjects were inoculated intratracheally with Streptococcus pneumoniae and contro

183 V-seronegative monkeys to monkeys inoculated intratracheally with SVV, in which viral DNA and RNA per

184 Mice immunized intranasally or intratracheally with the F1 antigen of Yersinia pestis a

185 X [n = 25]) were inoculated intranasally and intratracheally with the ISU-1 strain of PRCV (1 x 10(7)

186 ent BALB/c mice and GKO mice were inoculated intratracheally with virulent L. pneumophila (10(6) bact

187 Rabbits infected intratracheally with wild-type (wt) GBS developed focal

188 lfonic acid-sensitized cells and challenged (intratracheally) with the hapten developed pulmonary int

189 Syrian hamsters were treated, intratracheally, with clodronate-encapsulated liposomes

190 obilized onto polystyrene beads and injected intratracheally yielded comparable results to those obse