ライフサイエンスコーパス: intratumoral

1 wever, even with near complete inhibition of intratumoral 2-HG production, not all mutant glioma mode

2 s are noncytotoxic and have greater than 20% intratumoral accumulation and (b) systemic administratio

3 r T cell CCR/CXCR expression correlates with intratumoral accumulation, metastatic progression, and/o

4 d in Bach2-deficient mice and coincided with intratumoral activation of both innate and adaptive immu

5 t significantly delay tumour outgrowth after intratumoral activation.

6 o be developed as a new anticancer agent for intratumoral administration and is currently being evalu

7 attractive immunostimulatory properties, but intratumoral administration has been required to induce

8 Intratumoral administration of ISF35 in subcutaneous B16

9 In the bilateral flank tumour models, intratumoral administration of NDV-ICOSL results in enha

10 Intratumoral administration of STING agonists results in

11 with the best discriminating value, yielding intratumoral alpha, supratumoral k, and infratumoral mun

12 specific T cell responses than NoKT-SCC, and intratumoral and circulating FOXP3 + Treg cells were hig

13 cancer models, we discover that significant intratumoral and intertumoral genomic heterogeneity evol

14 Determination of intratumoral and intertumoral heterogeneity as well as t

15 ction and simultaneously allows the study of intratumoral and intertumoral heterogeneity.This review

16 ions that may contribute to the detection of intratumoral and intertumoral heterogenetic subclones.

17 herapeutic benefit and (2) determine whether intratumoral and peripheral blood T cell receptor (TCR)

18 S was used to image the pHe gradient between intratumoral and peritumoral regions (DeltapHe) in both

19 moral and recurrent GBMs relative to matched intratumoral and primary GBMs, respectively, supporting

20 (CRPC) is associated with the activation of intratumoral androgen biosynthesis and an increase in an

21 ografts express high levels of AR and retain intratumoral androgen concentrations similar to tumors g

22 nced prostate cancer R-profens could inhibit intratumoral androgen synthesis and act as analgesics fo

23 rostate cancer, which is otherwise driven by intratumoral androgen synthesis.

24 CaP tumors, indicating that the reduction in intratumoral androgens is a novel mechanism by which ant

25 We explored whether modulation of intratumoral antigen-presenting cells (APCs) could incre

26 se dual-specific T cells in combination with intratumoral bacteria injection to treat solid tumors in

27 Intratumoral basophils enhanced CD8(+) T-cell infiltrati

28 et al. indicate that chemokines produced by intratumoral Batf3 dendritic cells are critical for effe

29 Intratumoral BATF3-dependent DCs are critical determinan

30 sociated fibroblasts (CAFs) regulate diverse intratumoral biological programs and can promote or inhi

31 ncreased percentage of tumors with transient intratumoral bleeding was observed.

32 nhancement, outlines of lesions, presence of intratumoral bleeding, presence of calcifications.

33 es revealed decreased toxicity and efficient intratumoral bortezomib and doxorubicin delivery by nano

34 escent-labeled blood vessels showed enhanced intratumoral branching in xenografted E2f7/8-deficient n

35 down-regulation also promotes conversion of intratumoral but not systemic Tregs into T effector cell

36 t Treg blockade was a consequence of reduced intratumoral CCL22 levels caused by type I IFN.

37 score to independent expression profiling of intratumoral ccRCC regions demonstrated that average int

38 tion of cancer cells and the accumulation of intratumoral CD11b(+)/Gr1(+) myeloid cell infiltrates.

39 that selective instability and conversion of intratumoral CD4 Tregs through genetic or Ab-based targe

40 concept of systemic antitumor activity after intratumoral CD40 triggering with ISF35 in combination w

41 and secondary lymphoid structures as well as intratumoral CD8 T cells.

42 aring CD103 in mice or CD141 in humans drive intratumoral CD8(+) T cell activation.

43 With these changes in the Treg population, intratumoral CD8(+) T cells acquired a more functional p

44 immunofluorescence technique, we quantified intratumoral CD8(+) T cells coexpressing the inhibitory

45 s) specific for CD8 to track the presence of intratumoral CD8(+) T cells in the immunotherapy-suscept

46 ic CD8(+) T cells, and an increased ratio of intratumoral CD8(+) T cells to CD4(+) Tregs.

47 Intratumoral CD8(+) T-cell and mDC densities remained st

48 Intratumoral CD8(+) T-cell density was high in smokers (

49 Similar in vivo antitumor efficacy and intratumoral CD8(+)/regulatory T cells were also observe

50 pression through Treg-mediated inhibition of intratumoral CD8+ T cells and IFN-gamma.

51 t neo-antigens may be commonly recognized by intratumoral CD8+ T cells, but it is unclear whether neo

52 -dependent (GLUT1) metabolism with decreased intratumoral CD8/CD4 ratios.

53 secondary lymphoid organs and increased the intratumoral CD8/Treg ratio, B. intestinihominis accumul

54 ter administration, here we investigated the intratumoral CED infusions of PLGA BPNPs in animals bear

55 pontaneously in growing tumors or induced by intratumoral cGAMP injection was dependent on type I IFN

56 ptional propensity to metastasize early into intratumoral, chemokine-secreting nerves.

57 is study establishes the prognostic value of intratumoral cholesterol synthesis as measured via SQLE,

58 support trafficking despite the presence of intratumoral cognate chemokines.

59 imal study revealed that TTT-28 enhanced the intratumoral concentration of paclitaxel and promoted ap

60 zation on 30 pre-metastatic lesions, showing intratumoral concentration of relevant miRNAs.

61 Moreover, T cells from animals treated with intratumoral CpG and ibrutinib prevented the outgrowth o

62 cells led to significant reductions in both intratumoral CSCs and tumor burden.

63 tissue-resident memory T cells in promoting intratumoral CTL responses and support the rationale for

64 comitant with increased tumor saturation and intratumoral cytokine responses.

65 This combination therapy induces an intratumoral "cytokine storm" and extensive lymphocyte i

66 support the use of mathematical modeling of intratumoral Darwinian interactions of environmental sel

67 Strikingly, intratumoral delivery of Ad.Mda-5 led to regression of p

68 owing antiangiogenic therapy may also affect intratumoral delivery of concurrently administered chemo

69 Intratumoral delivery of HMGN1 and R848 plus Cytoxan era

70 Intratumoral delivery of HMGN1 with low dose of Cytoxan

71 ent of in-situ depot-forming gel systems for intratumoral delivery of immuno-oncology actives can enh

72 Intratumoral delivery of miR-890 mimetics prior to IR th

73 Intratumoral dendritic cells (DC) bearing CD103 in mice

74 ever, the relationship between heterogeneous intratumoral distribution and efficacy of ADCs is poorly

75 Intratumoral distribution in HT-29 tumors was studied us

76 The intratumoral distribution of (64)Cu-ATSM, but not (64)Cu

77 ibody ratio during treatment can improve the intratumoral distribution of a antibody-drug conjugate,

78 This work demonstrates that the intratumoral distribution of ADC, independent of payload

79 Better understanding intratumoral distribution of delivered drugs will be cru

80 extracellular matrix contributes to hindered intratumoral distribution of nanocarriers and that this

81 olid stress within tumors contribute to poor intratumoral distribution of nanomedicine.

82 eration, as well as tumor metabolism and the intratumoral distribution of specific molecular markers.

83 mined the effect of fibrin on the diffusion, intratumoral distribution, and therapeutic efficacy of n

84 o image drug uptake and retention, including intratumoral distribution, by PET.

85 f the current study was to determine whether intratumoral dosing of the 599 peptide-siCIP2A complex c

86 multiple tumor compartments to (i) increase intratumoral drug accumulation by >10-fold, (ii) increas

87 over conventional therapies, including high intratumoral drug delivery, reduced side effects, prolon

88 but also improve tumor perfusion to maintain intratumoral drug delivery.

89 Navigating intratumoral drug distribution has proven to be one of t

90 impact of the HIFU/nanobubble combination on intratumoral drug distribution.

91 impact of the HIFU/nanobubble combination on intratumoral drug distribution.

92 cruitment within epithelial tumor islets and intratumoral early T-cell signaling.

93 Importantly, iRGD enhanced intratumoral entry of intraperitoneally co-injected dext

94 t of a low-cost alternative therapy based on intratumoral ethanol injection suitable for resource-lim

95 Ongoing intratumoral evolution is apparent in molecular variatio

96 thods that attempt to understand and exploit intratumoral evolution to prolong response to therapy.

97 average intertumoral heterogeneity exceeded intratumoral expression heterogeneity.

98 mmunosuppression, characterized by increased intratumoral expression of the immune checkpoint inhibit

99 We recently reported that intratumoral expression of the programmed cell death 1 (

100 ACF treatment inhibited intratumoral expression of VEGF and tumor vascularizatio

101 However, the intratumoral factors that regulate the biology of gammad

102 Our findings suggest that intratumoral FoxP3 Tregs do not influence survival in pa

103 incided with a reduction in the frequency of intratumoral Foxp3+ Tregs.

104 active tumor microenvironment with increased intratumoral frequency of CD8(+) T cells with an effecto

105 the type I IFN/IL7 axis in the regulation of intratumoral gammadeltaT17-cell functions and in the dev

106 ers needs to be tuned for improved localized intratumoral gene delivery.

107 Recent evidence showing extensive inter- and intratumoral genetic diversity has given rise to the ide

108 Demonstrate intratumoral genetic heterogeneity in rectal cancer.

109 instability contributes to the phenomenon of intratumoral genetic heterogeneity, provides the genetic

110 absence of selective sweeps, uniformly high intratumoral heterogeneity (ITH) and subclone mixing in

111 ncies, but little is known about its spatial intratumoral heterogeneity (ITH) and temporal clonal evo

112 Investigation into intratumoral heterogeneity (ITH) of the epigenome is in

113 Intratumoral heterogeneity (ITH) represents an obstacle

114 he focus of this tool is to quantify spatial intratumoral heterogeneity (ITH), and the interactions b

115 ient and xenografted cells, we evaluated the intratumoral heterogeneity (n= 54) and reconstructed mut

116 Additionally, intratumoral heterogeneity and adaptations to therapeuti

117 as a single entity, insights from studies on intratumoral heterogeneity and cancer stem cells raise t

118 btype multiplicity correlated with increased intratumoral heterogeneity and presence of tumor microen

119 ranscriptomics are ideally placed to unravel intratumoral heterogeneity and selective resistance of c

120 We set out to investigate the emerging intratumoral heterogeneity and to determine the evolutio

121 discuss implications of TSSGs in generating intratumoral heterogeneity and tumor evolution and how T

122 , we report that MAPK signaling shows strong intratumoral heterogeneity and unexpectedly remains regu

123 Recent studies have revealed intratumoral heterogeneity as a source of therapeutic re

124 The extent of spatial and temporal intratumoral heterogeneity as medulloblastoma metastasiz

125 sessment, this approach can reveal inter- or intratumoral heterogeneity as well as variations in HER2

126 taEx16-derived tumors exhibit high degree of intratumoral heterogeneity co-expressing both basal and

127 textural features for the quantification of intratumoral heterogeneity concerns its added contributi

128 were reduced from baseline, and analysis of intratumoral heterogeneity during therapy demonstrated d

129 Intratumoral heterogeneity greatly complicates the study

130 Intratumoral heterogeneity hampers the success of marker

131 Intratumoral heterogeneity helps drive the selection for

132 ET imaging to address the important issue of intratumoral heterogeneity in breast cancer using both p

133 oximity was found to in part account for the intratumoral heterogeneity in EGFR activity observed.

134 cer, we demonstrated a significant degree of intratumoral heterogeneity in EGFR activity, as well as

135 Intratumoral heterogeneity is a major obstacle to cancer

136 Intratumoral heterogeneity is an inherent feature of mos

137 Elucidating this intratumoral heterogeneity is challenging but important.

138 erstanding of the functional significance of intratumoral heterogeneity is lacking.

139 ochastic nature of genetic alterations, this intratumoral heterogeneity is often viewed as chaotic.

140 Considerable intratumoral heterogeneity is present among naive rectal

141 Intratumoral heterogeneity is proposed as a major mechan

142 ved xenografts, which preserve, in part, the intratumoral heterogeneity known to exist in PC.

143 ell RNA sequencing (RNA-seq), we examine the intratumoral heterogeneity of a pair of primary renal ce

144 In order to overcome the potential bias of intratumoral heterogeneity of angiogenesis, this study i

145 scopy (FLIM)-based biosensing to demonstrate intratumoral heterogeneity of EGFR activity.

146 d regulation that gives rise to the observed intratumoral heterogeneity of EGFR signalling activity i

147 However, intratumoral heterogeneity of fluorescence intensity may

148 Intratumoral heterogeneity of signaling networks may con

149 We observed inter- and intratumoral heterogeneity of uptake, and (89)Zr-bevaciz

150 mmon signatures within the tumour as well as intratumoral heterogeneity regarding breast cancer subty

151 Mapping intratumoral heterogeneity such as vasculature and margi

152 A may be a better reflection of the inherent intratumoral heterogeneity than the biopsy of a single s

153 The approach may overcome intratumoral heterogeneity which hampers the success of

154 xtensive subclonal diversification, elevated intratumoral heterogeneity, and dismal disease outcome.

155 w human tumors progress, how they accumulate intratumoral heterogeneity, and ultimately how they may

156 However, in the setting of significant intratumoral heterogeneity, biopsies may not be represen

157 stoma (GBM), is characterized by significant intratumoral heterogeneity, microvascular proliferation,

158 ast cancer transcriptome has a wide range of intratumoral heterogeneity, which is shaped by the tumou

159 e in overcoming therapy resistance caused by intratumoral heterogeneity.

160 ngle tumor biopsy, fail to take into account intratumoral heterogeneity.

161 passenger mutations that are responsible for intratumoral heterogeneity.

162 minate between functional and non-functional intratumoral heterogeneity.

163 possibly represent a transition phenotype or intratumoral heterogeneity.

164 odels have been invoked to help explain this intratumoral heterogeneity.

165 ling tumors to adapt while maintaining their intratumoral heterogeneity.

166 issue repair and revascularization and treat intratumoral heterogeneity.

167 d functional consequences, accounted for all intratumoral heterogeneity.

168 ut-expressing T cells permitted detection of intratumoral homing.

169 Because intratumoral HPV oncoproteins upregulate immune checkpoi

170 Intratumoral hypoxia (reduced O2 availability) is a comm

171 d tumors and hematologic malignancies due to intratumoral hypoxia and emerging new layers of regulati

172 pression caused by the synergistic action of intratumoral hypoxia and HIF-1alpha activation.

173 al and experimental evidence indicating that intratumoral hypoxia is a critical microenvironmental fa

174 Intratumoral hypoxia is also associated with CRPC progre

175 r, in mouse models after sorafenib treatment intratumoral hypoxia is increased and may fuel evasive r

176 Intratumoral hypoxia may explain elevated CA in vivo bec

177 ions suggest that the induction of extensive intratumoral hypoxia plays a key role in GBM escape from

178 Intratumoral hypoxia stimulates enrichment of breast can

179 such as blood and lymphatic vessel density, intratumoral hypoxia, and the presence of infiltrating m

180 ation, normalized blood vessels, and reduced intratumoral hypoxia, culminating in suppressed tumor gr

181 ependent compensatory responses to increased intratumoral hypoxia.

182 Intratumoral IL-1beta and VEGF release were drastically

183 Limiting intratumoral IL-35 enhanced T cell proliferation, effect

184 Intratumoral immune cell densities (mDCs, CD8(+) T cells

185 atory tumor-associated macrophages (TAM) and intratumoral immune infiltration, thereby diminishing on

186 However, the drivers of intratumoral immune tolerance are uncertain.

187 our results show how combining radiation and intratumoral immunocytokine in murine tumor models can e

188 inated metastases, the triple-combination of intratumoral immunocytokine, radiation, and systemic ant

189 nse elicited by combined local radiation and intratumoral immunocytokine, we tested the potential ben

190 munity, although the appropriate targets for intratumoral immunomodulation using this strategy are no

191 These findings highlight that intratumoral immunomodulation with an oncolytic virus ex

192 ients with elevated CRT expression and dense intratumoral infiltration by DC or CD8(+) T lymphocytes

193 This effect was associated with increased intratumoral infiltration by TNFalpha(+) and CD80(+) mac

194 PD-L1 expression by either neoplastic or intratumoral inflammatory cells is related to tumor aggr

195 In addition, we find that intratumoral inhibition of macropinocytosis decreases am

196 by serum and ribonucleases in vitro and upon intratumoral injection in vivo, confirming the stability

197 We show that intratumoral injection of a highly interferogenic TLR9 a

198 d with allogeneic-IgG-coated tumour cells or intratumoral injection of allogeneic IgG in combination

199 ve this response by combining radiation with intratumoral injection of an IL2-linked tumor-specific a

200 we find that enforced activation of STING by intratumoral injection of cyclic dinucleotide GMP-AMP (c

201 n cancer cells accompanied with virotherapy, intratumoral injection of Delta-24-RGDOX and an anti-PD-

202 No significant effect was observed after intratumoral injection of fumarate or PBS.

203 Separately, we have shown that a direct intratumoral injection of immunocytokine (IC), an anti-G

204 d radiotherapy delivered selectively through intratumoral injection of lutetium-177 bound to core-cro

205 Intratumoral injection of Mobilan into subcutaneously gr

206 Intratumoral injection of succinate significantly increa

207 Notably, intratumoral injection of this cBiTE-expressing adenovir

208 ts were observed with local radiotherapy and intratumoral injection of tumor-specific antibodies, ari

209 ic CD8 T lymphocytes expanded robustly after intratumoral injection of WT mice with SFV-IL12, this di

210 de improved understanding of Th2 antibodies, intratumoral innate allergy effector cells and mediators

211 This indicates unstable intratumoral lineage relationships between CD271(-) and

212 e that lymphatic vessels both correlate with intratumoral lymphocytes and directly suppress immune fu

213 mbination with T cell clonal dominance among intratumoral lymphocytes prior to treatment or among per

214 Intratumoral macrophage density was low with EGFR mutati

215 investigated the association of densities of intratumoral mature dendritic cells (mDCs), CD8(+) T cel

216 Intratumoral mDC density was high with low pathological

217 lls (MECs) and that LPP expression levels in intratumoral MECs correlated with survival and chemoresi

218 expression of PGC1alpha resulted in superior intratumoral metabolic and effector function.

219 gle tail vein injection is capable of robust intratumoral MGMT protein knockdown in vivo, with persis

220 The intratumoral microenvironment, or stroma, is of major im

221 t model that stromal caveolin-1 remodels the intratumoral microenvironment, which is correlated with

222 taxel delivery to cancer cells by decreasing intratumoral microvessel leakiness.

223 Intratumoral MMAE concentrations consistently correlated

224 Here, we assessed the association of intratumoral mRNA expression of cholesterol synthesis en

225 terclonal circuitry mechanism established by intratumoral mutational heterogeneity.

226 e found that Tet2 expression is increased in intratumoral myeloid cells both in mouse models of melan

227 CP-dox treatment also repolarized intratumoral myeloid cells towards an antitumor phenotyp

228 y accumulate at the tumor site, transfecting intratumoral myeloid cells.

229 king antibody into PDAC-bearing mice reduced intratumoral nerve density, supporting a critical role f

230 d that LIF titers positively correlated with intratumoral nerve density.

231 eptors LIFR and gp130 were expressed only in intratumoral nerves.

232 Intratumoral neutrophil density was high and low with BR

233 We show that a high percentage of intratumoral NRP1(+) Tregs correlates with poor prognosi

234 vironment, we find that a high proportion of intratumoral Nrp1(-/-) Tregs produce interferon-gamma (I

235 ive potent tumor growth inhibition following intratumoral or intravenous administration in a mouse tu

236 oth alone and in the context of clinical and intratumoral parameters known to be predictive of surviv

237 Cotreatment with tPA resulted in greater intratumoral penetration of a model nanocarrier (Doxil),

238 or tissue but must be optimized to allow for intratumoral penetration.

239 Overall, our findings show how raising intratumoral pH through oral buffers therapy can improve

240 filtration, we hypothesized that imaging the intratumoral pHe in relation to the peritumoral pHe can

241 s were selected and tumor growth slowed when intratumoral pHe was increased.

242 s and hinders proliferation, also normalizes intratumoral pHe.

243 Intratumoral phenotypic heterogeneity has been described

244 istochemical staining against podoplanin and intratumoral platelet aggregates was performed in brain

245 ation of the growth factor FLT3L followed by intratumoral poly I:C injections expanded and activated

246 on to invasive adenocarcinoma, and augmented intratumoral proliferation.

247 Intratumoral radiation therapy - 'brachytherapy' - is a

248 ed rapid intratumoral uptake and significant intratumoral retention that increased the antitumor acti

249 olled ischemia and in the context of defined intratumoral sampling.

250 Anti-PD-1 plus intratumoral SD-101 promoted infiltration of activated,

251 Intratumoral SD-101 substantially increased leukocyte in

252 nit particularly in the endothelial cells of intratumoral small vessels.

253 Moreover, intratumoral spatial heterogeneity and pTyr dynamic resp

254 plasmatic sunitinib concentration (PSC) and intratumoral sunitinib concentration (ITSC) after transc

255 tor (ErbB) tyrosine kinase family to promote intratumoral survival and growth.

256 Degree of intratumoral susceptibility signal (ITSS) on SWI correla

257 ebral blood flow, cerebral blood volume, and intratumoral susceptibility signals.

258 However, the contribution of CD103 on intratumoral T cell distribution and functions and the p

259 tors (PD1, TIM3, LAG3), thereby facilitating intratumoral T cell exhaustion.

260 ssion in cancer and host cells, and baseline intratumoral T cell infiltration may improve response li

261 s increasing tumor antigenicity or promoting intratumoral T cell infiltration, provide a rationale fo

262 elanoma intrinsic beta-catenin signaling and intratumoral T cell infiltration, providing an explanati

263 in neoplastic and myeloid cells and PD-1 on intratumoral T cells limited tumor rejection, resulting

264 rs correlate with signatures of CD141(+) DC, intratumoral T cells, and better clinical outcomes.

265 y of the T-cell receptor (TCR) repertoire of intratumoral T cells.

266 ons suggest a novel "nonimmune" modality for intratumoral T reg and effector T cells in promoting tum

267 ctor family, was prominently up-regulated in intratumoral T reg cells.

268 ht to act by depleting and destabilizing the intratumoral T regulatory cell (Treg) population, the pr

269 elf, ICOS-L blockade reduced accumulation of intratumoral T regulatory cells (Treg), but it was insuf

270 expression, endothelial cell activation, and intratumoral T-cell infiltration.

271 Tumor control and intratumoral T-cell proliferation in response to the com

272 Temporal changes in intratumoral TCR repertoire revealed expansion of T cell

273 with Trp53(-/-) cells, with an appearance of intratumoral tertiary lymphoid structures rich in CD3(+)

274 9) significantly reduced (10-fold, P < 0.01) intratumoral testosterone and dihydrotestosterone concen

275 Here we find that intratumoral therapy with Newcastle disease virus (NDV),

276 Intratumoral therapy with pathogen-associated molecular

277 n 1 (PD-1) expression on stromal (sTILs) and intratumoral TILs.

278 Our findings establish intratumoral Tim-3(+)PD1(+)CD8(+) T cells as critical me

279 ditionally, these results support the use of intratumoral TNF-alpha, which is indicative of T cell fu

280 ated with an increase in the total amount of intratumoral TNF-alpha, which is indicative of tumor-spe

281 Correspondingly, TAM depletion reduces intratumoral TNP accumulation and efficacy.

282 Here we use single-cell imaging of intratumoral TNP pharmacokinetics and pharmacodynamics t

283 d vessel stain and methylene blue to analyze intratumoral transport.

284 ab-activated NK cells selectively eliminated intratumoral Treg but preserved effector T cells.

285 However, mechanisms of intratumoral Treg cell function remain to be elucidated.

286 However, properties of human intratumoral Treg cells and those present in correspondi

287 nt increased the frequency of CD4(+)FOXP3(+) intratumoral Treg expressing CTLA-4, CD39, and TGFbeta.

288 Neuropilin-1 (Nrp1) is required to maintain intratumoral Treg stability and function but is dispensa

289 red mouse models, the WDR4/PML axis elevates intratumoral Tregs and M2-like macrophages and reduces C

290 n of an unstable phenotype and conversion of intratumoral Tregs into T effector cells within the tumo

291 activated subpopulation of CD44(hi)ICOS(hi) intratumoral Tregs were preferentially targeted for elim

292 The intratumoral TSL and dox distribution were analyzed by s

293 ribution and pharmacokinetics revealed rapid intratumoral uptake and significant intratumoral retenti

294 Intratumoral uptake heterogeneity in (18)F-FDG PET has b

295 nomas demonstrated tortuous and disorganized intratumoral vasculature.

296 a patients was quantified using the ratio of intratumoral versus peritumoral T-cell densities (I/P ra

297 cells, indicating that E2F7/8 might inhibit intratumoral vessel branching via induction of DLL4.

298 s further improved owing to decompression of intratumoral vessels as a result of increased killing of

299 When mice had two brain tumors, intratumoral VSV-LASV-GPC injection in one tumor (glioma

300 alues) were extracted for three regions: the intratumoral zone, a 3-mm supratumoral zone, and a 5-mm