ライフサイエンスコーパス: intratumoral injection

1 n nu/nu mouse xenograft models with a single intratumoral injection.

2 gnificantly inhibited tumor growth following intratumoral injection.

3 release of entrapped fluorophores following intratumoral injection.

4 ntry into the systemic circulation following intratumoral injection.

5 self-assembles into radionuclide seeds upon intratumoral injection.

6 efficacy in vivo was demonstrated only with intratumoral injection.

7 of virus throughout the tumor mass following intratumoral injection.

8 xpressing MCF7 xenografts in nude mice after intratumoral injection.

9 MHC/tumor peptide complexes to T cells after intratumoral injection.

10 ribution of exogenous p53 into gliomas after intratumoral injection and to determine the toxicity of

11 rding to the protocol for the ablation-only, intratumoral injection, and intravenous injection groups

12 Intratumoral injection arrested tumor growth within 1 we

13 iomas revealed peak Rluc activity 36 h after intratumoral injection as determined by coelenterazine i

14 ribute to tumor regression, and they support intratumoral injection as the optimal route for their de

15 orter vector was used as the DNA plasmid for intratumoral injection at 0.2 mg/ml tumor.

16 affect INGN 007 antitumor efficacy following intratumoral injection, but immunity prevents vector spi

17 of 1 x 10(10) plaque-forming units (pfu) via intratumoral injection for 5 days during week 1 of each

18 YX-015 at a dose of 2 x 10(11) particles via intratumoral injection for either 5 consecutive days (st

19 pread and gene transfer in vivo after direct intratumoral injection in a variety of primary cancer mo

20 earing the HSV1-tk gene were administered by intratumoral injection in separate groups of mice.

21 r, we tested the antitumor activity of local intratumoral injection in the setting of host lymphodepl

22 by serum and ribonucleases in vitro and upon intratumoral injection in vivo, confirming the stability

23 We initially considered three patterns of intratumoral injection in which a fixed fraction of cell

24 vivo and in ex vivo organ analysis following intratumoral injection into HT-1080 xenograft tumors.

25 Direct intratumoral injection of 100 microg of a IFN-omega pDNA

26 d CT26 (H-2(d), colon cancer) murine models, intratumoral injection of 2 x 10(6) AdmCD40L-modified DC

27 We show that intratumoral injection of a highly interferogenic TLR9 a

28 In a preclinical lymphoma model, intratumoral injection of a Toll-like receptor 9 (TLR9)

29 Intratumoral injection of Ad-101F6, Ad-FUS1, Ad-NPRL2, a

30 ection of breast cancer cells ex vivo and by intratumoral injection of Ad-IRF-1 into established tumo

31 Importantly, in vivo intratumoral injection of Ad-MyD88 into established tumo

32 Intratumoral injection of Ad-OC-TK into murine ROS osteo

33 Intratumoral injection of Ad-p53 allowed for exogenous t

34 Furthermore, a single intratumoral injection of Ad.HKBP into pre-established h

35 Furthermore, intratumoral injection of Ad.REST-VP16 in established me

36 ffect of IGFBP-6 was investigated in vivo by intratumoral injection of Ad5CMV-BP6 in NSCLC xenografts

37 inally, the therapeutic efficacy of a single intratumoral injection of AdCMVCD followed by systemic 5

38 In addition, intratumoral injection of adenovirus encoding the HIF-1a

39 were inoculated into syngeneic C57BL/6 mice, intratumoral injection of adenovirus vector expressing 1

40 Intratumoral injection of adenovirus vector expressing t

41 ablished MCA205 mouse fibrosarcoma by single intratumoral injection of AdIL-1H4 resulted in significa

42 In all four tumor models, intratumoral injection of AdMIP-3alpha induced the local

43 Intratumoral injection of AdStx1A1Do and AdStx1A1Ac into

44 r toxin from the site of injection following intratumoral injection of AdStx1A1Do and AdStx1A1Ac.

45 Intratumoral injection of Ag-loaded DCs also reactivated

46 ostate cancer, we have previously shown that intratumoral injection of Ag-loaded dendritic cells (DCs

47 tion of endogenous dendritic cells (DCs) and intratumoral injection of Ag-loaded mature DCs delayed t

48 se model was also significantly inhibited by intratumoral injection of Akt-DN virus.

49 d with allogeneic-IgG-coated tumour cells or intratumoral injection of allogeneic IgG in combination

50 Similar intratumoral injection of alpha-gal glycolipids in human

51 Intratumoral injection of alpha-gal glycolipids results

52 Intratumoral injection of an adenoviral vector containin

53 reated intradermal B16F10 murine melanoma by intratumoral injection of an attenuated strain of Toxopl

54 ve this response by combining radiation with intratumoral injection of an IL2-linked tumor-specific a

55 Intratumoral injection of an unmethylated cytosine guani

56 blished 100-mm3 s.c. tumors who received one intratumoral injection of antibody 38C2 followed by syst

57 ere systemic administration of GM-CSF and/or intratumoral injection of autologous dendritic cells, wh

58 We then determined the effects of intratumoral injection of bcl-xs adenovirus on solid MCF

59 t of tumor-bearing BALB/c mice with a single intratumoral injection of biodegradable polylactic acid

60 Intratumoral injection of bM24-TE significantly reduced

61 Intratumoral injection of both unmodified MV-Ed and a st

62 Intratumoral injection of CCL4 or CCL5 increased tumor-i

63 Intratumoral injection of chemerin also inhibited tumor

64 We have previously shown that intratumoral injection of CpG oligodeoxynucleotide plus

65 The combination of intratumoral injection of CpG with systemic treatment by

66 Direct intratumoral injection of cps has efficacy against an in

67 Combined intratumoral injection of CRAD and ad-IGF-1R/482 induced

68 Combined intratumoral injection of CRAD and ad-luc increased the

69 we find that enforced activation of STING by intratumoral injection of cyclic dinucleotide GMP-AMP (c

70 Intratumoral injection of DAPT with cisplatin treatment

71 the JCI, Zaini et al. report that, in mice, intratumoral injection of DCs genetically modified to ex

72 erapy (cyclophosphamide) combined with local intratumoral injection of DCs led to complete tumor regr

73 n cancer cells accompanied with virotherapy, intratumoral injection of Delta-24-RGDOX and an anti-PD-

74 However, the intratumoral injection of dendritic cells after chemothe

75 Histological analysis confirmed that intratumoral injection of Dox@PEG-HAuNS and laser treatm

76 After a single intratumoral injection of Dtxl-NP-Apt bioconjugates, com

77 n in immunodeficient mice, were treated with intratumoral injection of endostatin plasmid at 7-day in

78 No significant effect was observed after intratumoral injection of fumarate or PBS.

79 e intracerebral tumors generated by GBM-SCs, intratumoral injection of G47Delta significantly prolong

80 topic xenografts (MDA-MB-231 cells) received intratumoral injection of GLV-1h153 or PBS.

81 A single intratumoral injection of hrR3 into HT29 flank tumors si

82 ted into the flanks of nude mice followed by intratumoral injection of hrR3.

83 Direct intratumoral injection of HSVB7.1 and/or HSVrantes alone

84 In xenografted mice, intratumoral injection of ICOVIR-5 resulted in a signifi

85 In mouse models, intratumoral injection of ICP34.5-defective oncolytic HS

86 ong-term survival analysis demonstrated that intratumoral injection of IL-12 + GM-CSF-loaded microsph

87 A single intratumoral injection of IL-12 and GM-CSF-encapsulated

88 A single intratumoral injection of IL-12 and GM-CSF-loaded slow-r

89 Separately, we have shown that a direct intratumoral injection of immunocytokine (IC), an anti-G

90 Direct intratumoral injection of Leuvectin is a safe and possib

91 Intratumoral injection of lipidoid/CLDN3 siRNA into OVCA

92 d radiotherapy delivered selectively through intratumoral injection of lutetium-177 bound to core-cro

93 We investigated the efficacy of intratumoral injection of macrophages transduced with mu

94 1(+/-) female mice received a transauricular intratumoral injection of Men1.rAd5 or control treatment

95 grate and invade was impaired in vivo by the intratumoral injection of miR-19a-3p.

96 Intratumoral injection of Mobilan into subcutaneously gr

97 Intratumoral injection of MV resulted in significant tum

98 del, by the combination of chemotherapy plus intratumoral injection of oligodeoxynucleotides containi

99 Intratumoral injection of PMEA (75 microl of 2% solution

100 We find that the intratumoral injection of polyguanosine (poly-G) oligonu

101 red with diluent-treated tumor-bearing mice, intratumoral injection of recombinant ELC/CCL19 led to s

102 Intratumoral injection of recombinant SLC evidenced pote

103 In vivo, intratumoral injection of relatively large human melanom

104 or in each animal was accomplished by direct intratumoral injection of retroviral vector-producer cel

105 pe tumors was accomplished in vivo by direct intratumoral injection of retroviral vector-producer cel

106 The results support future plans for intratumoral injection of rF-mCD40L in patients with lym

107 Intratumoral injection of SFV-IL12 induced production of

108 Intratumoral injection of succinate significantly increa

109 y of conventional chemotherapy together with intratumoral injection of syngeneic bone marrow-derived

110 Intratumoral injection of TATp-liposome-DNA complexes in

111 Intratumoral injection of the adenovirus also induces gr

112 Intratumoral injection of the allogeneic histocompatibil

113 Further, intratumoral injection of the nanoparticle complexes con

114 f these tumors were significantly reduced by intratumoral injection of the P2X7 inhibitor-oxidized AT

115 sis of P2X7-expressing tumors was blocked by intratumoral injection of the VEGF-blocking antibody Ava

116 Notably, intratumoral injection of this cBiTE-expressing adenovir

117 In conjuncture, intratumoral injection of TNFSF15 significantly reduces

118 ts were observed with local radiotherapy and intratumoral injection of tumor-specific antibodies, ari

119 Intratumoral injection of tumors with VSV-12'GFP dramati

120 lytic Ad vector antitumor efficacy following intratumoral injection of vector as well as tumor-to-tis

121 Although their work focused on intratumoral injection of viral vectors, the findings ca

122 ic CD8 T lymphocytes expanded robustly after intratumoral injection of WT mice with SFV-IL12, this di

123 the brain; however, treatment with a single intratumoral injection of Y10 increased median survival

124 were established, which then received three intratumoral injections of 1 x 10(9) pfu AdCMVCD.

125 ore, we evaluated the safety and efficacy of intratumoral injections of a bacterial superantigen with

126 neous tumor growth in nude mice who received intratumoral injections of Ad-FHIT, at a total dose of 3

127 Mice treated with two intratumoral injections of AdCMVIFN-beta had a 68% reduc

128 re established in nude mice and treated with intratumoral injections of adenoviruses carrying the hum

129 F and anti-c-met U1snRNA/ribozymes by either intratumoral injections of adenoviruses expressing the t

130 ng was conducted in vivo with mice receiving intratumoral injections of AdSSTR2, AdSSTR2-EGFP, or AdE

131 nced transplanted syngeneic tumor were given intratumoral injections of bone marrow-derived dendritic

132 ne to increase the number of tumoral DCs and intratumoral injections of CG-rich motifs (CpGs) to acti

133 Following intratumoral injections of CpG-ODN, approximately 30% of

134 ty of using this potent strategy of combined intratumoral injections of DCs and systemic chemotherapy

135 Intratumoral injections of GAA peptide-loaded DC1s furth

136 Sixty percent of animals treated with intratumoral injections of IL4-Pseudomonas exotoxin A ex

137 a subcutaneous mouse model of human glioma, intratumoral injections of liposomes containing H-ferrit

138 Intratumoral injections of MCF-7-induced tumors by high

139 Low dosage, intratumoral injections of PEX inhibitor repressed tumor

140 Direct intratumoral injections of plasmid DNA expressing hpRNA

141 Intratumoral injections of plasmid vectors expressing hp

142 We demonstrated that intratumoral injections of recombinant adenovirus overex

143 The protocol involves intratumoral injections of replication-incompetent adeno

144 static A20 lymphoma tumors were treated with intratumoral injections of rF-mCD40L together with syste

145 Intratumoral injections of SLC inhibited tumor growth in

146 Intratumoral injections of SLC-expressing DCs resulted i

147 Intratumoral injections of syngeneic but not allogeneic

148 therapy tests in SCID mice demonstrated that intratumoral injections of the adenoviral vector encodin

149 ontrol groups of tumor-bearing mice received intratumoral injections of the control adenoviral vector

150 intravesical injection), brain gliosarcomas (intratumoral injection), or intrathecal gliosarcomas (in

151 livered with sufficient efficiency by direct intratumoral injection to mediate tumor regression as sh

152 ONYX-015 can be safely administered via intratumoral injection to patients with recurrent/refrac

153 ac damage during therapy and required direct intratumoral injection to yield similar levels of tumor

154 dicated that virus administration by U-87 MG intratumoral injection was inadequate, resulting in an e

155 A total of 284 intratumoral injections were performed, with a mean of 9

156 Intratumoral injection with Adp53 in combination with ci

157 Intratumoral injection with AdVp53, but not AdVluc, led

158 Importantly, intratumoral injection with DCs engineered to secrete bo

159 Intratumoral injection with dl309 resulted in markedly g

160 infiltration and efficacy were similar upon intratumoral injection with either dl704 or Ad5.

161 Intratumoral injection with IL-12 gene-modified BM-DCs r

162 Furthermore, intratumoral injection with IL-12-transduced dendritic c

163 In addition, our results demonstrated that intratumoral injection with the plasmid construct expres