ライフサイエンスコーパス: intrinsic activity

1 effector (ERK) as well as an increase in PKB intrinsic activity.

2 specific protein microdomains in controlling intrinsic activity.

3 ylpiperazine ring can modulate functional or intrinsic activity.

4 , p38 MAPK-dependent process augmenting SERT intrinsic activity.

5 nt mutant, which showed extraordinarily high intrinsic activity.

6 rotein, interacts with NET and modulates NET intrinsic activity.

7 ute, a result typical for compounds with low intrinsic activity.

8 onist against 5HT(1B/1D) receptors, with low intrinsic activity.

9 repeat domain of the FSHR ECD and which had intrinsic activity.

10 two mutants exhibit constitutively enhanced intrinsic activity.

11 e effect on 5-HT(2A/2C) receptor affinity or intrinsic activity.

12 to promoters of very different sequence and intrinsic activity.

13 as potential sites to modulate the level of intrinsic activity.

14 Thus, Delta9-THC was potent, but had low intrinsic activity.

15 nificant differences in binding affinity and intrinsic activity.

16 as potential sites to modulate the level of intrinsic activity.

17 r binding affinity and 1300-fold increase in intrinsic activity.

18 lic phospholipase A2, thereby increasing its intrinsic activity.

19 ctivity, with a Lys residue providing higher intrinsic activity.

20 as single-chain protein (scuPA) with little intrinsic activity.

21 n the significance of the brain's ongoing or intrinsic activity.

22 opane (DAP), thereby turning on the latter's intrinsic activity.

23 rom full agonism to partial agonism with low intrinsic activity.

24 specially drugs that target proteins with no intrinsic activity.

25 ) and Hsp90 cochaperone p23, despite a lower intrinsic activity.

26 e fields, and quantified the spectrum of the intrinsic activity.

27 containing NCT-E333A are indeed deficient in intrinsic activity.

28 Thus, Pit-1 and TR amplify each other's intrinsic activities.

29 lly diverse clinical candidates with varying intrinsic activities.

30 5-fold increase in agonist potency and full intrinsic activity (113%).

31 We detected the following primary intrinsic activities: 12-LOX (Alox12, Alox15), 15-LOX (A

32 The next day, intrinsic activity across the visual cortex is recorded

33 teric modulation of its nucleotide-dependent intrinsic activity: active K-Ras Switch-II region motion

34 ve cation exchange resin ablated most of the intrinsic activity against HIV-1.

35 The lower intrinsic activity allowed a higher infusion rate with M

36 use of ChR2 current as a unique modulator of intrinsic activity, allowing for optical control of AP d

37 What is unknown is if this intrinsic activity also contributes to variability in be

38 ving their RING finger domain but that their intrinsic activities and effects on endogenous and exoge

39 spliced isoforms which may exhibit different intrinsic activities and receptor specificities.

40 during synthesis can effectively improve the intrinsic activity and conductivity, and the disordered

41 d the potential for regulation by changes in intrinsic activity and in location.

42 a halogen into the aryl ring usually lowered intrinsic activity and in some cases led to full 5-HT(1A

43 for the hemagglutinin-hD(1) receptor and the intrinsic activity and potency of adenylate cyclase acti

44 he effects of electrolyte cation size on the intrinsic activity and selectivity of metal catalysts fo

45 n may contribute to the increased receptor's intrinsic activity and signal transduction.

46 hile providing a potential strategy to alter intrinsic activity and signaling modulation.

47 M5 had a lower intrinsic activity and, therefore, remained stable in pl

48 iated by protein kinase A, a kinase with low intrinsic activity, and by the constitutively active gly

49 asis and protection from infections, but its intrinsic activities are untested.

50 progression by two mechanisms: first, via an intrinsic activity as an autocrine or paracrine growth f

51 he NH2-terminal PDZ domain of NHE-RF have no intrinsic activity as an inhibitor but appears to be req

52 oked phosphorylation that was not related to intrinsic activity as established by [(35)S]guanosine 5'

53 elative efficacy (on a scale of Log relative Intrinsic Activities) as the ordinates and Log(bias) as

54 Analogues showed generally lower intrinsic activity at 5HT(1B/1D) receptors than their et

55 receptors in native striatal tissue and full intrinsic activity at cloned human dopamine D1 receptors

56 therefore will be useful in determining how intrinsic activity at D3 receptors tested in vitro is re

57 eta(3) receptor, nearly completely abolished intrinsic activity at either the beta(1) or beta(2) rece

58 mpounds were tested for binding affinity and intrinsic activity at human MT1 and MT2 receptors.

59 unds of this naphthofuran series lacked high intrinsic activity at the 5-HT(2A) receptor as measured

60 Ovine CRF(9-33) that is devoid of intrinsic activity at the CRF receptors, was used as con

61 D2 and 5-HT1A receptors, were evaluated for intrinsic activity at these receptors, in vitro and in v

62 To understand the dynamics of neocortical intrinsic activity better, we performed two-photon calci

63 articles or to modulation of ORF19 protein's intrinsic activity by another viral component(s).

64 rtial agonists with the appropriate level of intrinsic activity can act to decrease dopamine synthesi

65 et al. argue that homeostatic regulation of intrinsic activity can occur by an activity-independent

66 Over 40 years ago, an intrinsic activity capable of initiating this reparative

67 denylate cyclase functional potency and high intrinsic activity caused internalization.

68 Due to its low intrinsic activity, coincubation with anandamide effecti

69 phase, while others (Ni and Zn) increase its intrinsic activity compared to a monometallic Pd catalys

70 action potentials, increased levels of cell-intrinsic activity completely blocks cell death triggere

71 uption of the default network as measured by intrinsic activity correlations.

72 t properties of possessing a relatively high intrinsic activity coupled with a poor ability to produc

73 chemometric approach was used to predict the intrinsic activity (degree of agonism) at the receptor.

74 ern is believed to arise as a consequence of intrinsic activity-dependent changes in membrane potenti

75 Our results reveal that an increase in cell-intrinsic activity during maturation is sufficient to al

76 .935 muM), potency (pEC50 = 6.1 +/- 0.1) and intrinsic activity (E max = 26 +/- 2.0%) on 5-HT1A recep

77 the increased surface area and an unexpected intrinsic activity enhancement due possibly to a favoura

78 asibility of measuring brain asymmetry using intrinsic activity fluctuations and suggest that multipl

79 Our results thus suggest that intrinsic activity fluctuations may act as a "traffic li

80 Imidazolines have wild-type potencies and intrinsic activities for both pathways.

81 gnificant role of surface steps in enhancing intrinsic activity for CO and methanol electro-oxidation

82 se regulated HBP1 protein levels but not the intrinsic activity for DNA binding or for transcriptiona

83 -14 and somatostatin-28, showed differential intrinsic activity for stimulation of [35S]GTPgammaS bin

84 using argon plasma exposure exhibited higher intrinsic activity for the electrochemical hydrogen evol

85 ine and noradrenaline which displayed higher intrinsic activity for the ERK phosphorylation than for

86 larger fraction of active sites and a higher intrinsic activity for the new sites.

87 ings demonstrate that overall levels of cell-intrinsic activity govern survival of new neurons and pr

88 ntifying non-peptide molecules which possess intrinsic activity has been a major obstacle in achievin

89 A zone of intrinsic activity has been identified for all of the ca

90 ever, in human resting state fMRI (rs-fMRI), intrinsic activity has been understood predominantly in

91 ues 1-6, 1-7, and 1-8 led to gradual loss of intrinsic activity (IA) (from 50% IA to <10% IA) resulti

92 The intrinsic activity (IA) of quinpirole was unaffected by

93 By virtue of its low intrinsic activity, IDRA-21 elicits a free cytosolic Ca2

94 e full agonists with most of them possessing intrinsic activities in the range of 60-80%.

95 tingly, some ligands show considerably lower intrinsic activity in guanine nucleotide exchange experi

96 Further, both 17c and 26 displayed high intrinsic activity in stimulating the release of [(3)H]d

97 Intrinsic activity in the brain is organized into networ

98 how synaptic plasticity may be regulated by intrinsic activity in the brain, much of which can invol

99 We hypothesize that Hsp90 has a higher intrinsic activity in the cell than in vitro.

100 rises a set of regions that exhibit ongoing, intrinsic activity in the resting state and task-related

101 e correlations in the visual system, whereby intrinsic activity in the same set of low-level areas wa

102 Does this synchrony result from intrinsic activity in visual cortex or from inputs from

103 ist activity in vitro and varying degrees of intrinsic activity in vivo.

104 strates that the odorant receptor's level of intrinsic activity-in the absence of activating odorant-

105 oteins (cis-glutamine) that is essential for intrinsic activity is less important in the GAP-activate

106 synthesis of D2 partial agonists of varying intrinsic activity levels.

107 synthesis of D2 partial agonists of varying intrinsic activity levels.

108 rich sequence of approximately 60 bp without intrinsic activity, located proximal to the repeats, act

109 amine D1 receptor ligands suggest that their intrinsic activity may depend on the conformational stat

110 observed post-treatment increase in striatal intrinsic activity may reflect counter-therapeutic funct

111 cell density provide a direct measure of the intrinsic activity (MIC0) of each homologue.

112 a is found to be very effective in enhancing intrinsic activity (normalized by the geometrical surfac

113 The intrinsic activities of all opioid peptide agonists and

114 We find that the intrinsic activities of Au-Pt nanoparticles with the sam

115 We showed that the intrinsic activities of beta(2)-AR ligands for stimulati

116 The structure and intrinsic activities of conserved STAS domains of the ub

117 The intrinsic activities of five GCAP1 promoter-luciferase c

118 Unlike the WT beta1-AR, intrinsic activities of full and partial agonists in act

119 Our data support a view that intrinsic activities of Hsp70 isoforms are comparable, a

120 Yet the intrinsic activities of such ligands are identical when

121 ocalize signaling complexes and modulate the intrinsic activities of the associated proteins.

122 We also found that the intrinsic activities of the BB-CK and the MM-CK isoenzym

123 e in a cell-free system, suggesting that the intrinsic activities of this small fragment, notably RNA

124 lted mainly from the discrepancy between the intrinsic activities of two groups of ligands for these

125 antagonist to weak partial agonist activity (intrinsic activity of 0-19% in comparison to quinpirole)

126 The intrinsic activity of 19-norD(2) on osteoclastogenesis a

127 ost-derived molecules that are induced by an intrinsic activity of a pathogen-derived effector and ar

128 results suggest that the maintenance of the intrinsic activity of a RING finger E3 ubiquitin ligase

129 either the total cellular cholesterol or the intrinsic activity of ACAT, neither of which was changed

130 tion of a conserved threonine attenuates the intrinsic activity of activation-induced deaminase (Thr-

131 affinity sites also was proportional to the intrinsic activity of an agonist, and the coefficient of

132 In addition they demonstrate that the higher intrinsic activity of B-Raf cannot be explained simply b

133 This proved that the endonuclease is an intrinsic activity of baculovirus AN.

134 r cerebellar output caused by changes in the intrinsic activity of both Purkinje cells and neurons of

135 eptor complexes contributes to the increased intrinsic activity of C26 over time.

136 gested that the phenotype may result from an intrinsic activity of CED-4.

137 easure the effect RyR regulators have on the intrinsic activity of CRUs and on the coupling between t

138 other alkaloid antagonists and enhanced the intrinsic activity of documented alkaloid partial agonis

139 beta2AR-GFP redistribution reflective of the intrinsic activity of each agonist.

140 However, the intrinsic activity of each is superior to other catalyst

141 in the protein levels of Ras, p-ERK, and the intrinsic activity of ERK, illustrating TGF-beta3 appare

142 otion that the substrate specificity and the intrinsic activity of Glc-6-Pase in native membranes are

143 in fibroblasts, apparently by increasing the intrinsic activity of GLUT1.

144 of GLUT4 molecules and thus suggest that the intrinsic activity of GLUT4 is subject to regulation.

145 that indinavir inhibits the translocation or intrinsic activity of GLUT4 rather than insulin signalin

146 The intrinsic activity of hhG alpha h, was greatly decreased

147 edominantly by inhibiting the activation and intrinsic activity of IkappaB kinase-beta.

148 In support of hematopoietic cell intrinsic activity of Itfg2, bone marrow transplantation

149 rmation and/or its change are needed for the intrinsic activity of KAI1/CD82.

150 of the mutant receptor enabled us to detect intrinsic activity of L-365,260, an established non-pept

151 ating residues beyond those required for the intrinsic activity of Mdm2 in vitro.

152 etrimentally affected affinity, potency, and intrinsic activity of nearly all compounds tested, altho

153 nanohybrid, allowing the harness of the high intrinsic activity of NiFe-LDH due to (i) amorphous and

154 canonical NFkappaB, and de-repression of the intrinsic activity of non-canonical NFkappaB.

155 nal studies revealed that PPM1D enhanced the intrinsic activity of p160 coactivators such as steroid

156 sting that SUMOylation regulates neither the intrinsic activity of PARP1 nor its localization.

157 constitutive activity (increased potency and intrinsic activity of partial agonists, increased effica

158 constitutive activity (increased potency and intrinsic activity of partial agonists, increased effica

159 e activation loop, which is regulated by the intrinsic activity of PDK-1, and 2) phosphorylation of t

160 nse studies demonstrate a higher potency and intrinsic activity of phenethylamines for polyphosphoino

161 We found that these mutations increase the intrinsic activity of PKCgamma.

162 is a key structural determinant of the high intrinsic activity of pro-urokinase was confirmed by the

163 active position, thereby inducing the higher intrinsic activity of pro-urokinase.

164 hods to systematically characterize sequence-intrinsic activity of promoters have been limited by rel

165 Importantly, we find that the intrinsic activity of Pt in this Ru@Pt/C catalyst is dou

166 h non-canonical backside residues govern the intrinsic activity of Rad6.

167 Alterations in intrinsic activity of resting brain indicated that inges

168 The intrinsic activity of single-chain pro-urinary-type plas

169 In contrast, intrinsic activity of SV channels in vacuoles from young

170 These results indicate that the intrinsic activity of Tag1 is restricted to germinal exc

171 The intrinsic activity of the drugs at D1 receptors was asse

172 ome modification is largely dependent on the intrinsic activity of the engineered nucleases.

173 ition by the N-terminal extension, since the intrinsic activity of the enzyme is not sufficient for c

174 Thus, these compounds may enhance the intrinsic activity of the glucose transporter GLUT1 or G

175 llels between these "silent signals" and the intrinsic activity of the human brain, especially that a

176 o a robust material without compromising the intrinsic activity of the incorporated proteins.

177 f CD98 and ICAM-1 differentially affects the intrinsic activity of the LAT-2 transporter.

178 reduction of rs-FC was mainly a transfer in intrinsic activity of the left frontal operculum/anterio

179 catalytic site and were very critical to the intrinsic activity of the molecule.

180 xpensive electrocatalysts that lack the high intrinsic activity of the noble metals.

181 5' exonuclease activity of human NDK1 is an intrinsic activity of the protein.

182 and seem to result from an alteration in the intrinsic activity of the receptor itself.

183 Whereas activated RhoA does not modulate the intrinsic activity of the RhoGEFs, activated RhoA associ

184 The intrinsic activity of the single-site gold species is th

185 this effect may be due to a decrease in the intrinsic activity of the transporter molecules, rather

186 Evaluation of the intrinsic activity of these analogs as topoisomerase I p

187 To study the intrinsic activity of these neurons and their responses

188 se particular surface sites, but probing the intrinsic activity of these sites is often beyond curren

189 tes to proguanil, thus providing evidence of intrinsic activity of this parent compound against a tar

190 ersisted when the synaptic input to, but not intrinsic activity of, Purkinje cells was manipulated.

191 y of opiate ligands of varying potencies and intrinsic activities on mu receptor phosphorylation and

192 titution in ring A reduced either potency or intrinsic activity on beta(3)-AR, the non-halogen-substi

193 ency for BSEP regulation correlates with the intrinsic activity on FXR.

194 tagonist, SB-269970, had no effect on either intrinsic activity or agonist responses.

195 Whether this is due to a change in Glut 1 intrinsic activity or targeting and/or to the appearance

196 cation, whereas high glucose impaired GLUT4 "intrinsic activity" or membrane intercalation.

197 Does the temporal congruity of intrinsic activity, or functional connectivity, between

198 and mouse dentate gyrus (DG) integrate their intrinsic activity over time and can turn into a persist

199 ) and D-Ins(1,4,6)PS(3) were shown to be low intrinsic activity partial agonists at the platelet myo-

200 The intrinsic activity patterns that characterize the matura

201 Presently, studies of the brain's intrinsic activity, popularly referred to as resting-sta

202 nist potency in the MVD but also shifted the intrinsic activity profile of 6c from an antagonist to t

203 al agonist activity at the D4 receptor, with intrinsic activities ranging from 0 to 35%.

204 s were antagonists, the D2 ligands displayed intrinsic activities ranging from full agonism to partia

205 onse relationships between binding affinity, intrinsic activity, receptor occupancy, drug exposure, a

206 cultures, which have high and low levels of intrinsic activity, respectively.

207 Analysis of intrinsic activity revealed the network comprises multip

208 is approximately 10 times higher and has an intrinsic activity significantly lower than that of cycl

209 p is attributable to ongoing fluctuations in intrinsic activity similar to those observed during rest

210 e catalytic subunits have been shown to have intrinsic activity, suggesting that noncatalytic subunit

211 gonists and second messengers can modify the intrinsic activity, surface expression or protein levels

212 al derivatives having roughly 4-fold greater intrinsic activity than diazepam as indicated by Cl- cur

213 roxybenzothi azolone), which displays higher intrinsic activity than the endogenous ligand adrenaline

214 ngly, we find that hantavirus N has multiple intrinsic activities that mimic and substitute for each

215 0.2)O(3-delta) (BSCF) catalyzes the OER with intrinsic activity that is at least an order of magnitud

216 atches, we further show that Trp3 has a high intrinsic activity that is suppressed by Ca(2+)/CaM unde

217 recombinant D10 fusion protein possesses an intrinsic activity that liberates m7GDP from capped RNA

218 This autoprocessing depends on intrinsic activity that resides in the zymogens of the i

219 orvinols that span across the full range of intrinsic activities, the antagonist diprenorphine, the

220 According to their intrinsic activities, the metal oxides can be classified

221 reducing IkappaB kinase-beta activation and intrinsic activity, thereby decreasing IkappaBalpha degr

222 se findings suggest that neurons gauge their intrinsic activity to instruct homeostatic regulation of

223 Using intrinsic activity to measure asymmetry in 300 adults, w

224 In this study, we show that Jhd2 has intrinsic activity to remove all three states of H3K4 me

225 exes of soluble TWEAK and Fn14 have a higher intrinsic activity to stimulate the classical NFkappaB p

226 These studies indicate that Foxn4 has an intrinsic activity to suppress the alternative photorece

227 arge injection in the nanosheets so that its intrinsic activity towards the HER can be measured.

228 s of approximately 2 nm can lead to enhanced intrinsic activity up to approximately 200% (current nor

229 There were no differences in transporter intrinsic activity (Vmax/Ro) among the three groups.

230 -hour agonist incubation, at which point the intrinsic activity was determined to be 124.3 +/- 0.77%

231 ompounds tested, although a strong change in intrinsic activity was not seen with most N-aryl analogs

232 Reduced intrinsic activities were observed for CXC and CPX, but

233 etrimental effects on affinity, potency, and intrinsic activity were observed with the Phe339((6.51))

234 both in yeast and Escherichia coli, and has intrinsic activity when produced in the bacterium.

235 igands for the 5-HT1A/B/D receptors with low intrinsic activity, which represent a useful set of mole

236 ve, has alerted us to the ongoing and costly intrinsic activity within brain systems that most likely

237 erent input from the olfactory bulb but also intrinsic activity within the intracortical association

238 ors, but also on the ongoing and very costly intrinsic activity within these systems, for the latter

239 has an initiation site that lacks detectable intrinsic activity yet through coupling is translated at