ライフサイエンスコーパス: intrinsic activity

1 ) and Hsp90 cochaperone p23, despite a lower intrinsic activity.

2 e fields, and quantified the spectrum of the intrinsic activity.

3 containing NCT-E333A are indeed deficient in intrinsic activity.

4 effector (ERK) as well as an increase in PKB intrinsic activity.

5 eir density and accessibility but also their intrinsic activity.

6 specific protein microdomains in controlling intrinsic activity.

7 ylpiperazine ring can modulate functional or intrinsic activity.

8 , p38 MAPK-dependent process augmenting SERT intrinsic activity.

9 nt mutant, which showed extraordinarily high intrinsic activity.

10 rotein, interacts with NET and modulates NET intrinsic activity.

11 ute, a result typical for compounds with low intrinsic activity.

12 onist against 5HT(1B/1D) receptors, with low intrinsic activity.

13 repeat domain of the FSHR ECD and which had intrinsic activity.

14 e effect on 5-HT(2A/2C) receptor affinity or intrinsic activity.

15 to promoters of very different sequence and intrinsic activity.

16 as potential sites to modulate the level of intrinsic activity.

17 Thus, Delta9-THC was potent, but had low intrinsic activity.

18 nificant differences in binding affinity and intrinsic activity.

19 as potential sites to modulate the level of intrinsic activity.

20 r binding affinity and 1300-fold increase in intrinsic activity.

21 r local structures are crucial for enhancing intrinsic activity.

22 lic phospholipase A2, thereby increasing its intrinsic activity.

23 ctivity, with a Lys residue providing higher intrinsic activity.

24 as single-chain protein (scuPA) with little intrinsic activity.

25 strategies have been proposed to improve its intrinsic activity.

26 educing the energy barrier, and boosting the intrinsic activity.

27 ribe the brain's resting-state, baseline, or intrinsic activity.

28 two mutants exhibit constitutively enhanced intrinsic activity.

29 n the significance of the brain's ongoing or intrinsic activity.

30 opane (DAP), thereby turning on the latter's intrinsic activity.

31 rom full agonism to partial agonism with low intrinsic activity.

32 specially drugs that target proteins with no intrinsic activity.

33 lly diverse clinical candidates with varying intrinsic activities.

34 oxide perovskite catalysts with the highest intrinsic activities.

35 Thus, Pit-1 and TR amplify each other's intrinsic activities.

36 5-fold increase in agonist potency and full intrinsic activity (113%).

37 We detected the following primary intrinsic activities: 12-LOX (Alox12, Alox15), 15-LOX (A

38 The next day, intrinsic activity across the visual cortex is recorded

39 teric modulation of its nucleotide-dependent intrinsic activity: active K-Ras Switch-II region motion

40 ve cation exchange resin ablated most of the intrinsic activity against HIV-1.

41 esults confirm that SIVsmm Vif proteins show intrinsic activity against human APOBEC3 proteins but al

42 The lower intrinsic activity allowed a higher infusion rate with M

43 use of ChR2 current as a unique modulator of intrinsic activity, allowing for optical control of AP d

44 RS is evolutionarily conserved and that this intrinsic activity allows G4:U69-containing tRNAThr to e

45 What is unknown is if this intrinsic activity also contributes to variability in be

46 ving their RING finger domain but that their intrinsic activities and effects on endogenous and exoge

47 spliced isoforms which may exhibit different intrinsic activities and receptor specificities.

48 tion in multiple sclerosis (MS) through cell-intrinsic activities and their ability to recruit and ac

49 urface properties, as a result, enhances the intrinsic activity and availability of surface iridium s

50 residues near S500 mimics S500D, increasing intrinsic activity and CaM binding in vitro and enhancin

51 during synthesis can effectively improve the intrinsic activity and conductivity, and the disordered

52 d the potential for regulation by changes in intrinsic activity and in location.

53 a halogen into the aryl ring usually lowered intrinsic activity and in some cases led to full 5-HT(1A

54 for the hemagglutinin-hD(1) receptor and the intrinsic activity and potency of adenylate cyclase acti

55 he effects of electrolyte cation size on the intrinsic activity and selectivity of metal catalysts fo

56 n may contribute to the increased receptor's intrinsic activity and signal transduction.

57 hile providing a potential strategy to alter intrinsic activity and signaling modulation.

58 Enhancing the intrinsic activity and space time yield of Cu based hete

59 at its conduction band, exhibits a superior intrinsic activity and stability in CO(2) hydrogenation

60 The combination of the intrinsic activity and stability of single Co sites, alo

61 ired yet very challenging due to the limited intrinsic activity and their elusive evolution under har

62 M5 had a lower intrinsic activity and, therefore, remained stable in pl

63 iated by protein kinase A, a kinase with low intrinsic activity, and by the constitutively active gly

64 high utilization of active metal atoms, high intrinsic activity, and controllable coordination enviro

65 decreased LVDP in all hearts with return of intrinsic activity, and reperfusion with 155 mM [Na(+)](

66 ituents investigated effects on NOP binding, intrinsic activity, and selectivity and showed that whil

67 asis and protection from infections, but its intrinsic activities are untested.

68 progression by two mechanisms: first, via an intrinsic activity as an autocrine or paracrine growth f

69 he NH2-terminal PDZ domain of NHE-RF have no intrinsic activity as an inhibitor but appears to be req

70 oked phosphorylation that was not related to intrinsic activity as established by [(35)S]guanosine 5'

71 )O(3-delta) catalyst shows an extremely high intrinsic activity as reflected from its high turnover f

72 elative efficacy (on a scale of Log relative Intrinsic Activities) as the ordinates and Log(bias) as

73 Alterations in brain intrinsic activity-as organized in resting-state network

74 Analogues showed generally lower intrinsic activity at 5HT(1B/1D) receptors than their et

75 tment, whereas CY208,243 has relatively high intrinsic activity at adenylate cyclase, but much lower

76 receptors in native striatal tissue and full intrinsic activity at cloned human dopamine D1 receptors

77 therefore will be useful in determining how intrinsic activity at D3 receptors tested in vitro is re

78 eta(3) receptor, nearly completely abolished intrinsic activity at either the beta(1) or beta(2) rece

79 mpounds were tested for binding affinity and intrinsic activity at human MT1 and MT2 receptors.

80 unds of this naphthofuran series lacked high intrinsic activity at the 5-HT(2A) receptor as measured

81 Ovine CRF(9-33) that is devoid of intrinsic activity at the CRF receptors, was used as con

82 D2 and 5-HT1A receptors, were evaluated for intrinsic activity at these receptors, in vitro and in v

83 To understand the dynamics of neocortical intrinsic activity better, we performed two-photon calci

84 o non-natural environments can enhance their intrinsic activity beyond their natural performance, pav

85 primary cilia not only orchestrate beta-cell-intrinsic activity but also mediate cross talk both with

86 articles or to modulation of ORF19 protein's intrinsic activity by another viral component(s).

87 rtial agonists with the appropriate level of intrinsic activity can act to decrease dopamine synthesi

88 ingle-atom catalysts, further improvement of intrinsic activity can be hindered by the lack of neighb

89 et al. argue that homeostatic regulation of intrinsic activity can occur by an activity-independent

90 Over 40 years ago, an intrinsic activity capable of initiating this reparative

91 denylate cyclase functional potency and high intrinsic activity caused internalization.

92 Due to its low intrinsic activity, coincubation with anandamide effecti

93 phase, while others (Ni and Zn) increase its intrinsic activity compared to a monometallic Pd catalys

94 action potentials, increased levels of cell-intrinsic activity completely blocks cell death triggere

95 uption of the default network as measured by intrinsic activity correlations.

96 t properties of possessing a relatively high intrinsic activity coupled with a poor ability to produc

97 chemometric approach was used to predict the intrinsic activity (degree of agonism) at the receptor.

98 ern is believed to arise as a consequence of intrinsic activity-dependent changes in membrane potenti

99 Our results reveal that an increase in cell-intrinsic activity during maturation is sufficient to al

100 .935 muM), potency (pEC50 = 6.1 +/- 0.1) and intrinsic activity (E max = 26 +/- 2.0%) on 5-HT1A recep

101 the increased surface area and an unexpected intrinsic activity enhancement due possibly to a favoura

102 oying with Ag (e.g. Ag(0.1)Pd(0.9)) leads to intrinsic activity enhancements up to 5-fold at 0.9 V vs

103 asibility of measuring brain asymmetry using intrinsic activity fluctuations and suggest that multipl

104 Our results thus suggest that intrinsic activity fluctuations may act as a "traffic li

105 Imidazolines have wild-type potencies and intrinsic activities for both pathways.

106 gnificant role of surface steps in enhancing intrinsic activity for CO and methanol electro-oxidation

107 se regulated HBP1 protein levels but not the intrinsic activity for DNA binding or for transcriptiona

108 -14 and somatostatin-28, showed differential intrinsic activity for stimulation of [35S]GTPgammaS bin

109 like oxypropylene spacer possess significant intrinsic activity for the activation of Galpha(s), whil

110 using argon plasma exposure exhibited higher intrinsic activity for the electrochemical hydrogen evol

111 ine and noradrenaline which displayed higher intrinsic activity for the ERK phosphorylation than for

112 larger fraction of active sites and a higher intrinsic activity for the new sites.

113 ings demonstrate that overall levels of cell-intrinsic activity govern survival of new neurons and pr

114 ntifying non-peptide molecules which possess intrinsic activity has been a major obstacle in achievin

115 A zone of intrinsic activity has been identified for all of the ca

116 ever, in human resting state fMRI (rs-fMRI), intrinsic activity has been understood predominantly in

117 ns of whole-brain connectivity, derived from intrinsic activity, have been proposed as a general orga

118 Thus, the precise assessment of intrinsic activity highly depends on the reliable measur

119 1 M KOH without significantly perturbing the intrinsic activity (i.e., in the absence of an additive)

120 The brain's on-going intrinsic activity (i.e., the resting-state activity) is

121 ues 1-6, 1-7, and 1-8 led to gradual loss of intrinsic activity (IA) (from 50% IA to <10% IA) resulti

122 The intrinsic activity (IA) of quinpirole was unaffected by

123 By virtue of its low intrinsic activity, IDRA-21 elicits a free cytosolic Ca2

124 in atom-efficient catalysts with outstanding intrinsic activities; (ii) effective heterogenization of

125 alculations further elucidated the origin of intrinsic activity improvement associated with the optim

126 e full agonists with most of them possessing intrinsic activities in the range of 60-80%.

127 tingly, some ligands show considerably lower intrinsic activity in guanine nucleotide exchange experi

128 CoN(1) O(2) /Mn(3) O(4) exhibits high intrinsic activity in PMS activation and sulfamethoxazol

129 This nanostructure exhibits the intrinsic activity in selective CO(2) reduction that sim

130 Further, both 17c and 26 displayed high intrinsic activity in stimulating the release of [(3)H]d

131 Intrinsic activity in the brain is organized into networ

132 how synaptic plasticity may be regulated by intrinsic activity in the brain, much of which can invol

133 We hypothesize that Hsp90 has a higher intrinsic activity in the cell than in vitro.

134 rises a set of regions that exhibit ongoing, intrinsic activity in the resting state and task-related

135 e correlations in the visual system, whereby intrinsic activity in the same set of low-level areas wa

136 Does this synchrony result from intrinsic activity in visual cortex or from inputs from

137 ist activity in vitro and varying degrees of intrinsic activity in vivo.

138 strates that the odorant receptor's level of intrinsic activity-in the absence of activating odorant-

139 gies demonstrated effectiveness in improving intrinsic activity, increasing active site density, and

140 The enhanced intrinsic activity is attributed to the extra graphitic

141 The intrinsic activity is commonly defined as the specific a

142 oteins (cis-glutamine) that is essential for intrinsic activity is less important in the GAP-activate

143 synthesis of D2 partial agonists of varying intrinsic activity levels.

144 rich sequence of approximately 60 bp without intrinsic activity, located proximal to the repeats, act

145 amine D1 receptor ligands suggest that their intrinsic activity may depend on the conformational stat

146 observed post-treatment increase in striatal intrinsic activity may reflect counter-therapeutic funct

147 cell density provide a direct measure of the intrinsic activity (MIC0) of each homologue.

148 a is found to be very effective in enhancing intrinsic activity (normalized by the geometrical surfac

149 he task state, the brain: (1) controlled the intrinsic activity not only during the performance of a

150 This method allows the comparison of intrinsic activities of active sites and facilitates the

151 The intrinsic activities of all opioid peptide agonists and

152 We find that the intrinsic activities of Au-Pt nanoparticles with the sam

153 We showed that the intrinsic activities of beta(2)-AR ligands for stimulati

154 The structure and intrinsic activities of conserved STAS domains of the ub

155 cations had large effects on expression, the intrinsic activities of different classes of promoters w

156 The intrinsic activities of five GCAP1 promoter-luciferase c

157 Unlike the WT beta1-AR, intrinsic activities of full and partial agonists in act

158 Our data support a view that intrinsic activities of Hsp70 isoforms are comparable, a

159 Yet the intrinsic activities of such ligands are identical when

160 ocalize signaling complexes and modulate the intrinsic activities of the associated proteins.

161 We also found that the intrinsic activities of the BB-CK and the MM-CK isoenzym

162 e in a cell-free system, suggesting that the intrinsic activities of this small fragment, notably RNA

163 lted mainly from the discrepancy between the intrinsic activities of two groups of ligands for these

164 antagonist to weak partial agonist activity (intrinsic activity of 0-19% in comparison to quinpirole)

165 The intrinsic activity of 19-norD(2) on osteoclastogenesis a

166 /b: 0.66/12 nM) and act as partial agonists (intrinsic activity of 1a/b: 50/39%).

167 ost-derived molecules that are induced by an intrinsic activity of a pathogen-derived effector and ar

168 results suggest that the maintenance of the intrinsic activity of a RING finger E3 ubiquitin ligase

169 either the total cellular cholesterol or the intrinsic activity of ACAT, neither of which was changed

170 tion of a conserved threonine attenuates the intrinsic activity of activation-induced deaminase (Thr-

171 affinity sites also was proportional to the intrinsic activity of an agonist, and the coefficient of

172 In addition they demonstrate that the higher intrinsic activity of B-Raf cannot be explained simply b

173 This proved that the endonuclease is an intrinsic activity of baculovirus AN.

174 r cerebellar output caused by changes in the intrinsic activity of both Purkinje cells and neurons of

175 eptor complexes contributes to the increased intrinsic activity of C26 over time.

176 gested that the phenotype may result from an intrinsic activity of CED-4.

177 ation in TMDs and a methodology to boost the intrinsic activity of chalcogen atoms.

178 easure the effect RyR regulators have on the intrinsic activity of CRUs and on the coupling between t

179 other alkaloid antagonists and enhanced the intrinsic activity of documented alkaloid partial agonis

180 beta2AR-GFP redistribution reflective of the intrinsic activity of each agonist.

181 However, the intrinsic activity of each is superior to other catalyst

182 in the protein levels of Ras, p-ERK, and the intrinsic activity of ERK, illustrating TGF-beta3 appare

183 In contrast, the intrinsic activity of FeN(4) sites was only tunable by v

184 otion that the substrate specificity and the intrinsic activity of Glc-6-Pase in native membranes are

185 in fibroblasts, apparently by increasing the intrinsic activity of GLUT1.

186 of GLUT4 molecules and thus suggest that the intrinsic activity of GLUT4 is subject to regulation.

187 that indinavir inhibits the translocation or intrinsic activity of GLUT4 rather than insulin signalin

188 The intrinsic activity of hhG alpha h, was greatly decreased

189 edominantly by inhibiting the activation and intrinsic activity of IkappaB kinase-beta.

190 The intrinsic activity of in-plane chalcogen atoms plays a s

191 le application could only be possible if the intrinsic activity of Ir could be greatly enhanced.

192 In support of hematopoietic cell intrinsic activity of Itfg2, bone marrow transplantation

193 rmation and/or its change are needed for the intrinsic activity of KAI1/CD82.

194 of the mutant receptor enabled us to detect intrinsic activity of L-365,260, an established non-pept

195 ating residues beyond those required for the intrinsic activity of Mdm2 in vitro.

196 etrimentally affected affinity, potency, and intrinsic activity of nearly all compounds tested, altho

197 Synaptic dysfunction, death, and intrinsic activity of neurons are thought to contribute

198 nanohybrid, allowing the harness of the high intrinsic activity of NiFe-LDH due to (i) amorphous and

199 canonical NFkappaB, and de-repression of the intrinsic activity of non-canonical NFkappaB.

200 ant effect of the aromatic head group on the intrinsic activity of our ligands, as ligands with a car

201 nal studies revealed that PPM1D enhanced the intrinsic activity of p160 coactivators such as steroid

202 sting that SUMOylation regulates neither the intrinsic activity of PARP1 nor its localization.

203 constitutive activity (increased potency and intrinsic activity of partial agonists, increased effica

204 constitutive activity (increased potency and intrinsic activity of partial agonists, increased effica

205 e activation loop, which is regulated by the intrinsic activity of PDK-1, and 2) phosphorylation of t

206 nse studies demonstrate a higher potency and intrinsic activity of phenethylamines for polyphosphoino

207 We found that these mutations increase the intrinsic activity of PKCgamma.

208 tivation, indicating that H3K27M impairs the intrinsic activity of PRC2.

209 is a key structural determinant of the high intrinsic activity of pro-urokinase was confirmed by the

210 active position, thereby inducing the higher intrinsic activity of pro-urokinase.

211 hods to systematically characterize sequence-intrinsic activity of promoters have been limited by rel

212 Importantly, we find that the intrinsic activity of Pt in this Ru@Pt/C catalyst is dou

213 Central to this challenge is enhancing the intrinsic activity of Pt while ensuring the stability of

214 h non-canonical backside residues govern the intrinsic activity of Rad6.

215 Alterations in intrinsic activity of resting brain indicated that inges

216 The intrinsic activity of single-chain pro-urinary-type plas

217 In contrast, intrinsic activity of SV channels in vacuoles from young

218 These results indicate that the intrinsic activity of Tag1 is restricted to germinal exc

219 The intrinsic activity of the drugs at D1 receptors was asse

220 ome modification is largely dependent on the intrinsic activity of the engineered nucleases.

221 ition by the N-terminal extension, since the intrinsic activity of the enzyme is not sufficient for c

222 Thus, these compounds may enhance the intrinsic activity of the glucose transporter GLUT1 or G

223 llels between these "silent signals" and the intrinsic activity of the human brain, especially that a

224 o a robust material without compromising the intrinsic activity of the incorporated proteins.

225 f CD98 and ICAM-1 differentially affects the intrinsic activity of the LAT-2 transporter.

226 reduction of rs-FC was mainly a transfer in intrinsic activity of the left frontal operculum/anterio

227 catalytic site and were very critical to the intrinsic activity of the molecule.

228 xpensive electrocatalysts that lack the high intrinsic activity of the noble metals.

229 gonism by Nef, while it has no effect on the intrinsic activity of the protein as an inhibitor of inf

230 5' exonuclease activity of human NDK1 is an intrinsic activity of the protein.

231 and seem to result from an alteration in the intrinsic activity of the receptor itself.

232 Whereas activated RhoA does not modulate the intrinsic activity of the RhoGEFs, activated RhoA associ

233 The intrinsic activity of the single-site gold species is th

234 prisingly, the mutation does not enhance the intrinsic activity of the STAT2-containing transcription

235 this effect may be due to a decrease in the intrinsic activity of the transporter molecules, rather

236 Evaluation of the intrinsic activity of these analogs as topoisomerase I p

237 efficient C-C formation is restricted by the intrinsic activity of these catalysts often being compar

238 To study the intrinsic activity of these neurons and their responses

239 se particular surface sites, but probing the intrinsic activity of these sites is often beyond curren

240 tes to proguanil, thus providing evidence of intrinsic activity of this parent compound against a tar

241 ersisted when the synaptic input to, but not intrinsic activity of, Purkinje cells was manipulated.

242 y of opiate ligands of varying potencies and intrinsic activities on mu receptor phosphorylation and

243 titution in ring A reduced either potency or intrinsic activity on beta(3)-AR, the non-halogen-substi

244 ency for BSEP regulation correlates with the intrinsic activity on FXR.

245 tagonist, SB-269970, had no effect on either intrinsic activity or agonist responses.

246 Whether this is due to a change in Glut 1 intrinsic activity or targeting and/or to the appearance

247 cation, whereas high glucose impaired GLUT4 "intrinsic activity" or membrane intercalation.

248 Does the temporal congruity of intrinsic activity, or functional connectivity, between

249 he brain and spinal cord exhibit spontaneous intrinsic activity organised in a set of functionally re

250 and mouse dentate gyrus (DG) integrate their intrinsic activity over time and can turn into a persist

251 ) and D-Ins(1,4,6)PS(3) were shown to be low intrinsic activity partial agonists at the platelet myo-

252 techniques enable unprecedented control over intrinsic activity patterns and can effectively identify

253 The intrinsic activity patterns that characterize the matura

254 Presently, studies of the brain's intrinsic activity, popularly referred to as resting-sta

255 nist potency in the MVD but also shifted the intrinsic activity profile of 6c from an antagonist to t

256 al agonist activity at the D4 receptor, with intrinsic activities ranging from 0 to 35%.

257 s were antagonists, the D2 ligands displayed intrinsic activities ranging from full agonism to partia

258 onse relationships between binding affinity, intrinsic activity, receptor occupancy, drug exposure, a

259 cultures, which have high and low levels of intrinsic activity, respectively.

260 Analysis of intrinsic activity revealed the network comprises multip

261 is approximately 10 times higher and has an intrinsic activity significantly lower than that of cycl

262 p is attributable to ongoing fluctuations in intrinsic activity similar to those observed during rest

263 e catalytic subunits have been shown to have intrinsic activity, suggesting that noncatalytic subunit

264 gonists and second messengers can modify the intrinsic activity, surface expression or protein levels

265 al derivatives having roughly 4-fold greater intrinsic activity than diazepam as indicated by Cl- cur

266 roxybenzothi azolone), which displays higher intrinsic activity than the endogenous ligand adrenaline

267 ngly, we find that hantavirus N has multiple intrinsic activities that mimic and substitute for each

268 0.2)O(3-delta) (BSCF) catalyzes the OER with intrinsic activity that is at least an order of magnitud

269 atches, we further show that Trp3 has a high intrinsic activity that is suppressed by Ca(2+)/CaM unde

270 recombinant D10 fusion protein possesses an intrinsic activity that liberates m7GDP from capped RNA

271 This autoprocessing depends on intrinsic activity that resides in the zymogens of the i

272 orvinols that span across the full range of intrinsic activities, the antagonist diprenorphine, the

273 According to their intrinsic activities, the metal oxides can be classified

274 reducing IkappaB kinase-beta activation and intrinsic activity, thereby decreasing IkappaBalpha degr

275 onic nature of the C-3 substituents affected intrinsic activity to afford partial agonists with a ran

276 amine neurons are controlled by afferent and intrinsic activity to generate sensory cue and predictio

277 se findings suggest that neurons gauge their intrinsic activity to instruct homeostatic regulation of

278 Using intrinsic activity to measure asymmetry in 300 adults, w

279 change their abundance, localization, and/or intrinsic activity to mediate thermomorphogenesis.

280 In this study, we show that Jhd2 has intrinsic activity to remove all three states of H3K4 me

281 exes of soluble TWEAK and Fn14 have a higher intrinsic activity to stimulate the classical NFkappaB p

282 These studies indicate that Foxn4 has an intrinsic activity to suppress the alternative photorece

283 CD is devoid of any intrinsic activity toward the GABA(A) receptor before ir

284 arge injection in the nanosheets so that its intrinsic activity towards the HER can be measured.

285 Our study shows that the intrinsic activity trends could be established on the ba

286 s of approximately 2 nm can lead to enhanced intrinsic activity up to approximately 200% (current nor

287 There were no differences in transporter intrinsic activity (Vmax/Ro) among the three groups.

288 This high intrinsic activity was also observed in operating AEMFCs

289 -hour agonist incubation, at which point the intrinsic activity was determined to be 124.3 +/- 0.77%

290 ompounds tested, although a strong change in intrinsic activity was not seen with most N-aryl analogs

291 e found that, contrary to our intuition, the intrinsic activity was substantially larger than the tas

292 Reduced intrinsic activities were observed for CXC and CPX, but

293 etrimental effects on affinity, potency, and intrinsic activity were observed with the Phe339((6.51))

294 both in yeast and Escherichia coli, and has intrinsic activity when produced in the bacterium.

295 igands for the 5-HT1A/B/D receptors with low intrinsic activity, which represent a useful set of mole

296 In this study we compared the intrinsic activity with the activity evoked by tasks, an

297 ve, has alerted us to the ongoing and costly intrinsic activity within brain systems that most likely

298 erent input from the olfactory bulb but also intrinsic activity within the intracortical association

299 ors, but also on the ongoing and very costly intrinsic activity within these systems, for the latter

300 has an initiation site that lacks detectable intrinsic activity yet through coupling is translated at