ライフサイエンスコーパス: intrinsic binding

1 ons in which differences would depend on the intrinsic binding ability of the two groups.

2 iology is how this complex converts the weak intrinsic binding activity of the ectodomain into strong

3 of PfPuf1 expressed in bacteria demonstrated intrinsic binding activity of the PfPuf1 Puf domain to t

4 P protein can be uncoupled to determine the intrinsic binding affinities (K(a)'s) of the anionic lig

5 Whereas leucine reduced intrinsic binding affinities and interactions of Lrps bo

6 e lrp-1 mutation did not have much effect on intrinsic binding affinities but it decreased cooperativ

7 resulting relationships are consistent with intrinsic binding affinity (corrected for membrane inter

8 y 136 bp) but they have different effects on intrinsic binding affinity and binding cooperativity.

9 nities, PR-B in fact has a greatly increased intrinsic binding affinity and cooperative binding abili

10 ting a concentration-dependent transition in intrinsic binding affinity and in the topology of the DN

11 elements only as a preformed dimer, then its intrinsic binding affinity is not the typically observed

12 MCAT motif accounts for the majority of the intrinsic binding affinity of Purbeta with intersite coo

13 m trimer is greatly enhanced relative to the intrinsic binding affinity of the isolated EF-hand domai

14 In additional studies, we found that the intrinsic binding and functional potencies of structural

15 tion about cellular functions as well as the intrinsic binding capabilities of conserved folds.

16 perature decreased the magnitude of both the intrinsic binding constant and the inter-trimer was coop

17 The intrinsic binding constant for [MnOH]+ to apo-WOC was de

18 constant increased by a factor of 1.42, the intrinsic binding constant for ethidium increased by abo

19 The intrinsic binding constant for the formation of the (H-A

20 imately 1 order of magnitude higher than the intrinsic binding constant for the purine oligomers.

21 ons (pH 7.0, 10 degrees C, 100 mM NaCl), the intrinsic binding constant for the pyrimidine oligomers

22 0 degrees C, 100 mM NaCl, 5 mM MgCl2) by the intrinsic binding constant K = 6 +/- 2 x 10(6) M-1.

23 amined, the affinity is characterized by the intrinsic binding constant K=1.4(+/-0.5)x10(5)M(-1) and

24 Oscillations in intrinsic binding constant Ki and cooperativity factor o

25 The intrinsic binding constant of ATP is by a factor of appr

26 10(3) M(-1), which compares favorably to the intrinsic binding constant presented in the literature f

27 aged circles, both the torsion constant and intrinsic binding constant ratio lie close to the corres

28 Its affinity, K omega (the intrinsic binding constant times a cooperativity factor)

29 However, the binding affinity Komega (the intrinsic binding constant times a cooperativity factor)

30 equires only two interaction parameters, the intrinsic binding constant, K, and cooperativity paramet

31 and -23.4 kcal/mol, respectively) and their intrinsic binding constants (8780, 5040, and 3370 L/mol,

32 ntitative binding information in the form of intrinsic binding constants (K(obs)) and binding site si

33 g data further allowed determination of both intrinsic binding constants (K) and cooperativity factor

34 ion titrations has allowed us to extract the intrinsic binding constants and cooperativity parameters

35 m to favor the T state without affecting the intrinsic binding constants for the two Ca(2+) sites.

36 (the Ca2+-bound form), without affecting the intrinsic binding constants for the two Ca2+ sites.

37 Comparison of this constant with the intrinsic binding constants of the native protein allowe

38 mer binding accounts for the majority of the intrinsic binding energetics and cooperativity contribut

39 the active binding species demonstrate that intrinsic binding energetics are over an order of magnit

40 are in very good agreement with the measured intrinsic binding energetics.

41 d that this constitutively active mutant has intrinsic binding energies equal to that of the inactive

42 The intrinsic binding energies of the 5'-phosphate group of

43 e activation is equivalently described by an intrinsic binding energy (IBE) of 11.4 kcal/mol.

44 The intrinsic binding energy derived from the ground-state d

45 from protein to RNA enzymes, suggesting that intrinsic binding energy is a fundamental feature of bio

46 trinsic specificity by the topography of the intrinsic binding energy landscape and the kinetic speci

47 This intrinsic binding energy may be used to position reactan

48 Thus, the ribozyme appears to use the intrinsic binding energy of groups on the P1 duplex for

49 Interestingly, the intrinsic binding energy of NAD (+) differentially distr

50 hat this places an increased demand that the intrinsic binding energy of phosphite dianion be utilize

51 he transition state (Kd = 53 muM); the total intrinsic binding energy of phosphite dianion in the tra

52 These results show that the intrinsic binding energy of phosphite dianion is used in

53 hite dianion results from utilization of the intrinsic binding energy of phosphite dianion to stabili

54 abstraction from the substrate and that the intrinsic binding energy of substrate may be a significa

55 The 12 kcal/mol intrinsic binding energy of the phosphodianion is shown

56 ical model for catalysis by TIM in which the intrinsic binding energy of the substrate phosphodianion

57 he free aldehyde (1.7 kcal/mol) and (ii) the intrinsic binding energy of the terminal ethylene glycol

58 sts that T. thermophilus RNAP possesses less intrinsic binding energy than E. coli RNAP.

59 This extends the concept of "intrinsic binding energy" from protein to RNA enzymes, s

60 nto the active site that is paid for by the "intrinsic binding energy" of groups on the P1 duplex.

61 rategies that include the use of metal ions, intrinsic binding energy, and a novel example of general

62 acid residues contribute 54% and 44% of the intrinsic binding energy, respectively, despite the latt

63 hown to contribute at least 16.6 kcal/mol of intrinsic binding free energy to the stabilization of th

64 This analysis indicates that while intrinsic binding is similar to that observed with unmod

65 ing anti-CD3 mAbs mimic this force via their intrinsic binding mode.

66 Human IFNAR-1 has low intrinsic binding of human IFNs but strongly affects the

67 vided an estimate of Kd < or = 18 nM for the intrinsic binding of Lys-48-linked chains of linkage num

68 over, although phosphorylation increases the intrinsic binding of OmpR to a single OmpR-binding site,

69 The mechanism of the intrinsic binding of pol beta to the dsDNA is different

70 However, it remains possible that the intrinsic binding or signaling properties of the NCAM po

71 the nature of the adhesion system and of any intrinsic binding or signaling properties of the NCAM po

72 y for a particular ligand and that it is the intrinsic binding potential of the protein surface that

73 We find that Gd@C(82)(OH)(22) has an intrinsic binding preference to the binding groove, part

74 The intrinsic binding process is an entropy-driven reaction,

75 so that the differences were largely due to intrinsic binding properties.

76 gain, these differences arose primarily from intrinsic binding properties.

77 ted global cytidine deamination at deaminase intrinsic binding sites.

78 most important for function despite the low intrinsic binding specificity and the complete lack of e

79 We also drive the intrinsic binding specificity and which correlation with

80 ion, indicating that the isolated domain has intrinsic binding specificity determinants.

81 Since individual syntrophins do not have intrinsic binding specificity for dystrophin, dystrobrev

82 lting data allowed determination of both the intrinsic binding thermodynamics separated from the infl

83 Intrinsic binding to the dsDNA includes only two sequent