ライフサイエンスコーパス: intrinsic clearance

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1 ayed improved oral bioavailability and lower intrinsic clearance.

2 m and exhibited metabolic stability with low intrinsic clearance.

3 Despite its high in vitro metabolic intrinsic clearance, 23r (AMG 900) showed acceptable pha

4 , it was depleted by CYP26A1 (Km = 63 nM and intrinsic clearance = 90 mul/min per pmol).

5 Epelsiban has low levels of intrinsic clearance against the microsomes of four speci

6 e-NH2 resulted in high affinity and improved intrinsic clearance and intestinal epithelial permeabili

7 75 displayed excellent microsomal stability, intrinsic clearance, and hepatic extraction ratios with

8 In this article, we describe an in vitro intrinsic clearance-based approach to the optimization o

9 The estimated in vitro intrinsic clearance (Clint) of TBECH mixture was slower

10 These compounds have significantly reduced intrinsic clearance compared to our initial series of py

11 hile increasing polarity in order to improve intrinsic clearance culminated with the discovery of pur

12 Measured rates of intrinsic clearance determined using cryopreserved trout

13 ty-purified liver GST and GST-alpha 1-1, the intrinsic clearance for busulfan conjugation was 0.87 an

14 In vitro intrinsic clearances for CYP2C9*5, calculated as the rat

15 vatives with low cynomolgus monkey and human intrinsic clearance gave 2',6'-dimethyl-3'-pyridyl R-sec

16 Instead, low intrinsic clearance leads to high in vivo unbound plasma

17 previous study with determination of hepatic intrinsic clearance of (1)(8)F-FDGal (V*(max/K*(m)).

18 In HRN mice the in vitro metabolism and intrinsic clearance of CPA was over 6-fold lower than in

19 val kinetics of galactose, including hepatic intrinsic clearance of galactose (V(max)/K(m)) from meas

20 The intrinsic clearance of glutamate was reduced by 12.3-fol

21 and 6.2-fold (S457F, P < 0.01), whereas the intrinsic clearance of methotrexate was reduced by 4.2-f

22 tudy, three laboratories determined in vitro intrinsic clearance of six reference compounds (benzo[a]

23 To test if the higher intrinsic clearance of type II binding compounds relativ

24 ytes can be used to reliably obtain in vitro intrinsic clearance of xenobiotics, which provides suppo

25 tory variability (% CV) in measured in vitro intrinsic clearance values ranged from 4.1 to 30%, while

26 The intrinsic clearance (Vmax/K(m)) of busulfan conjugation

27 )C-CSar from blood to bile, as quantified by intrinsic clearance, was significantly lower in experime

28 By lowering the intrinsic clearance, we derived a set of imidazobenzoxaz

29 a stability but approximately 3-fold greater intrinsic clearance when compared to olaparib.

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