ライフサイエンスコーパス: intrinsic factor

1 of isolated rat parietal cells also contain intrinsic factor.

2 rate 16 +/- 3.6% of parietal cells contained intrinsic factor.

3 ies comparable with those of haptocorrin and intrinsic factor.

4 a complex network of multiple extrinsic and intrinsic factors.

5 c variation can be generated by two parasite-intrinsic factors.

6 fluenced by a variety of other extrinsic and intrinsic factors.

7 -renewal is controlled by both extrinsic and intrinsic factors.

8 ast, is controlled by both niche signals and intrinsic factors.

9 on of SOD1 seems to be largely determined by intrinsic factors.

10 ogenitors is regulated by both extrinsic and intrinsic factors.

11 require thalamic inputs and is regulated by intrinsic factors.

12 y divisions is probably under the control of intrinsic factors.

13 dulated both by environmental and by protein-intrinsic factors.

14 itment, which is influenced by extrinsic and intrinsic factors.

15 tion and is influenced by both extrinsic and intrinsic factors.

16 y dynamic process dependent on extrinsic and intrinsic factors.

17 eference is affected by myriad extrinsic and intrinsic factors.

18 e influence of both environmental and T cell-intrinsic factors.

19 s well as unrecognized brain-region-specific intrinsic factors.

20 ous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smokin

21 Among the intrinsic factors, a number of proteins termed axonal gr

22 We propose that intrinsic factors act synergistically with extrinsic fac

23 defects induced by environmental and lineage intrinsic factors act together to reduce responses to Ag

24 he socket cell and the inner pupal case--and intrinsic factors--actin cytoskeleton assembly.

25 e, and must instead be a consequence of cell-intrinsic factors, although we speculate that there may

26 was performed using antiserum against human intrinsic factor and H/K ATPase (a parietal cell marker)

27 llular and molecular characterization of the intrinsic factor and its receptor.

28 a higher shape complementarity than those of intrinsic factor and transcobalamin.

29 ion is stage dependent and regulated by both intrinsic factors and an extracellular signal, which is

30 ion is controlled by a combinatorial code of intrinsic factors and an extrinsic BMP signal.

31 perchlorate to examine the relative roles of intrinsic factors and axon-target interactions in the sp

32 ch reprogramming involves both extrinsic and intrinsic factors and can occur via three routes: pertur

33 tipotent progenitors is orchestrated by cell-intrinsic factors and cell-extrinsic environmental cues

34 pid heart growth during development, yet the intrinsic factors and environment governing these proces

35 Axon guidance is regulated by intrinsic factors and extrinsic cues provided by other n

36 egulatory network interactions between these intrinsic factors and extrinsic pathways, which ultimate

37 and temporally regulated through a number of intrinsic factors and extrinsic signaling pathways.

38 rolled by the interplay of neural crest cell-intrinsic factors and instructive cues from the surround

39 renewal and differentiation is controlled by intrinsic factors and niche signals.

40 Several cell intrinsic factors and signaling pathways have been impli

41 trolled by the concerted action of stem cell-intrinsic factors and signals within the niche.

42 em cells are under strict regulation by both intrinsic factors and the microenvironment.

43 neration of Tfh cells depends on both T-cell intrinsic factors and the supporting function of B cells

44 by three transport proteins: transcobalamin, intrinsic factor, and haptocorrin (HC).

45 ere examined for immunolocalization of TFF2, intrinsic factor, and Mist1, and morphologically with el

46 of different cobalamins for transcobalamin, intrinsic factor, and nonintrinsic factor.

47 ree cobalamin-binding proteins: haptocorrin, intrinsic factor, and transcobalamin.

48 Extrinsic and intrinsic factors appeared to interact to affect breedin

49 Many extrinsic and intrinsic factors are critical for oocyte development an

50 In addition to environmental factors, intrinsic factors are important for maintaining the rege

51 eactivity of His in proteins, especially the intrinsic factors are little known.

52 erable debate whether cell-extrinsic or cell-intrinsic factors are most important for triggering this

53 ce of stem or progenitor cell fate relies on intrinsic factors as well as local cues from the cellula

54 nding of the interplay between extrinsic and intrinsic factors at the molecular level is one promisin

55 AIG associated with both H(+)K(+)ATPase and intrinsic factor autoantibody responses.

56 suggest dysregulation of cell-extrinsic or -intrinsic factors can independently contribute to such i

57 ctor-Cobalamin receptor (IFCR), binds to the intrinsic factor-cobalamin (IFCbl) complex with an assoc

58 kDa consisting of CUB domains 6-8 bound both intrinsic factor-cobalamin (vitamin B(12); Cbl) (IF-Cbl)

59 eptor that mediates intestinal absorption of intrinsic factor-cobalamin and selective protein reabsor

60 hat purified gp280 from rat kidney, like the intrinsic factor-Cobalamin receptor (IFCR), binds to the

61 orward sensory pathways but also depend upon intrinsic factors (collectively known as the network sta

62 d parallels to yeast, in which extrinsic and intrinsic factors combine to restrict meiotic initiation

63 ceptor for both the intestinal vitamin B(12)-intrinsic factor complex and the tubular reabsorption of

64 In search of intrinsic factors contributing to the immunogenicity of

65 This could be because of intrinsic factors controlling differentiation or an inab

66 The crystal bending kinetics depends on intrinsic factors (crystal size) and external factors (e

67 within, healthy individuals, suggesting that intrinsic factors determine the magnitude of TLR4-mediat

68 Both extrinsic and intrinsic factors determine the severity of influenza.

69 However, unlike intracellular protein fate, intrinsic factors determining secreted protein aging and

70 roaches have provided fresh insight into the intrinsic factors determining the potency and duration o

71 -off, and how it is affected by latitude and intrinsic factors (development mode).

72 is more likely to occur (and progress) when intrinsic factor-driven absorption fails than when diet

73 factor family 2/spasmolytic polypeptide and intrinsic factor dual-immunostaining cells significantly

74 ze of dendritic fields is determined by cell-intrinsic factors during development remains primarily u

75 However, genetic manipulation of intrinsic factors during hematopoietic differentiation h

76 hile root waving has been attributed to both intrinsic factors (e.g. circumnutation) and growth respo

77 On the other hand, the intrinsic factors (e.g., a limited number of basic resid

78 pair are regulated by a complex interplay of intrinsic factors (e.g., transcription factors) and extr

79 e not been well-defined but may include both intrinsic factors (eg, the tendency to sickle) and extri

80 ressed by postmigratory germ cells, is a key intrinsic factor, enabling those cells to initiate meios

81 The intrinsic factors encompass regulators of cell cycle and

82 studies are consistent with the concept that intrinsic factor expression is both predetermined in chi

83 l conditions could alter the distribution of intrinsic factor expression, two rodent models of chroni

84 entified the bag-of-marbles (bam) gene as an intrinsic factor for cystoblast fate in Drosophila germl

85 results demonstrate that NF-L is a critical intrinsic factor for dendritic growth in large motoneuro

86 preimplantation mammalian embryo depends on intrinsic factors for its development, but there is also

87 or sex, we detected a direct effect of these intrinsic factors for the majority of immune genes.

88 Our results highlight the importance of intrinsic factors for triggering neurogenesis, but they

89 Although both extrinsic and intrinsic factors have been identified that orchestrate

90 We found that both extrinsic and intrinsic factors have comparable influence within a giv

91 acultative niche exploitation, extrinsic and intrinsic factors, host associations, seasonal distribut

92 in the coding region of the gene for gastric intrinsic factor (IF) in an 11-year-old girl with severe

93 The structure of intrinsic factor (IF) in complex with cobalamin (Cbl) wa

94 st, dietary and biliary Cbl bound to gastric intrinsic factor (IF) presented apically to the ileal ab

95 The intrinsic factor (IF) vitamin B(12) ileum anchored recep

96 A functional candidate gene encoding the intrinsic factor (IF)-B12 receptor, cubilin, was recentl

97 Cubilin recognizes intrinsic factor (IF)-cobalamin and various other protei

98 Loss of CUBN, the intestinal intrinsic factor (IF)-vitamin B12 receptor, results in h

99 stration of [(57)Co]Cbl complexed to gastric intrinsic factor (IF).

100 d and not corrected by the administration of intrinsic factor (IF); if untreated, the disease is fata

101 At the bases of glands, intrinsic factor immunoreactive cells also were costaine

102 Congenic controls expressed intrinsic factor in 8.9 +/- 3.8% (mean +/- SD) of pariet

103 It also resembled intrinsic factor in the composition of conserved residue

104 erted actions of extrinsic niche signals and intrinsic factors in a variety of systems.

105 ed by concerted actions of niche signals and intrinsic factors in a variety of systems.

106 tance of the interplay between extrinsic and intrinsic factors in determining disease dynamics is ill

107 ighlight the role of cell-extrinsic and cell-intrinsic factors in regulating the efficiency and kinet

108 To distinguish between extrinsic cues and intrinsic factors in the caudal migration of FBM neurone

109 ial skeleton depends on interactions between intrinsic factors in the skeletal precursors and extrins

110 eration, which depends on both extrinsic and intrinsic factors, including the PTEN-Akt pathway that i

111 messenger RNA were reduced, whereas those of intrinsic factor increased.

112 Knowledge about how intrinsic factors influence solubility is limited due to

113 ng apart the relative roles of extrinsic and intrinsic factors influencing transmission.

114 rrow chimerism experiments demonstrated that intrinsic factors inhibited the pathogenic activity of N

115 o quantify the extent to which extrinsic and intrinsic factors interact to influence owl reproductive

116 How extrinsic stimuli and intrinsic factors interact to regulate continuous neurog

117 rinsic factors (buffer environment) and cell-intrinsic factors (interferon-inducible transmembrane pr

118 Intrinsic factor is produced primarily by chief cells in

119 regulated by a combination of 1) mesodermal intrinsic factors MAB-5, HLH-1 and FOZI-1, 2) differenti

120 by broad synaptic blockade, suggesting that intrinsic factors may dominate the ISI distribution duri

121 Our results substantiate that COUP-TFI, an intrinsic factor, may work in concert with Pax6 and Emx2

122 te malabsorption engendered by disruption of intrinsic factor-mediated absorption.

123 ibitory CNS environment and the loss of cell-intrinsic factors necessary for regeneration.

124 this study supports the hypothesis that the intrinsic factors Neurog2 and Ascl1 regulate the tempora

125 ptides contained in complex Ags is due to an intrinsic factor of the peptide, based upon the affinity

126 ribes the combinatorial effect of lymphocyte-intrinsic factors on the homeostasis, activation and hom

127 ore the interactive effects of extrinsic and intrinsic factors on tool production and deployment.

128 However, how these intrinsic factors orchestrate the spatiotemporal express

129 Recently, two such intrinsic factors, Pax6 and Emx2, have been identified.

130 d in the absence of XBP1 induced ZC markers (intrinsic factor, pepsinogen C) but showed abnormal rete

131 lability and intra-specific competition) and intrinsic factors (population, sex and breeding outcome)

132 After 4 and 8 weeks of infection, intrinsic factor-positive parietal cells increased from

133 kin-1beta demonstrated a twofold increase in intrinsic factor-positive parietal cells.

134 rietal cell marker), counting the percent of intrinsic factor-positive parietal cells.

135 ucus-producing pit cells, and pepsinogen and intrinsic factor-producing zymogenic cells) is accuratel

136 In the Drosophila melanogaster ovary, some intrinsic factors promote germline stem cell (GSC) self-

137 onchial cell line, Calu-3, expresses the B12-intrinsic factor receptor, the transcobalamin II recepto

138 Many extracellular and intrinsic factors regulate oligodendrocyte development,

139 Although both extrinsic and intrinsic factors regulate this process, little is known

140 ntial utility of our system for the study of intrinsic factors regulating genetic variation in HCV.

141 cus on cancer metastasis has centered on the intrinsic factors regulating the cell autonomous homing

142 h cell-extrinsic stochastic factors and cell-intrinsic factors related to T cell antigen receptor (TC

143 The extent of contraction may be dictated by intrinsic factors related to the number of prior cell di

144 pecialized microenvironments, or niches, and intrinsic factors required for execution of context-appr

145 atostatin (SST)-expressing interneurons, the intrinsic factors required for the terminal differentiat

146 double-knockout implicated cardiac myocytes intrinsic factors responsible for observed phenotype.

147 hymus growth by provision of growth factors, intrinsic factors such as a proliferative restriction of

148 In recent years, intrinsic factors such as alignment, strength, laxity, a

149 s genotoxic and oxidative stress, as well as intrinsic factors such as mutations in DNA repair genes.

150 re expected to vary among individuals due to intrinsic factors such as sex, age or feeding proficienc

151 across the body, but the importance of cell intrinsic factors such as stem cell function in determin

152 Cigarette smoke (CS) exposure and intrinsic factors such as the NADPH oxidases produce hig

153 Cell intrinsic factors such as the proneural basic helix-loop

154 through single-file channels is affected by intrinsic factors such as their size and polarity and by

155 ors (such as perisynaptic astroglia) and the intrinsic factors (such as core subcellular organelles)

156 uch as signaling from neighboring cells, and intrinsic factors, such as chromatin structure.

157 The PNIR assessment model incorporates intrinsic factors, such as patient severity of illness,

158 Pest movement is affected by a suite of intrinsic factors, such as population age structure and

159 on of the aggregation process should include intrinsic factors, such as sequence variation, and extri

160 mbined activities of genes encoding mesoderm-intrinsic factors, such as Tinman (Tin), and spatially r

161 differentiated chief cell markers, Mist1 and intrinsic factor, suggesting that SPEM derived from tran

162 ts and controlled by extrinsic (but not cell-intrinsic) factors, suggesting that sepsis-induced chang

163 These results identify Lin-28 as a stem cell intrinsic factor that boosts insulin signaling in intest

164 istone demethylase UTX was an essential cell-intrinsic factor that controlled an iNKT-cell lineage-sp

165 sults indicate that MALT1 is a central, cell-intrinsic factor that determines the encephalitogenic po

166 the length of the C-terminus is an important intrinsic factor that directly correlates with the therm

167 he transcriptional repressor, Blimp-1, is an intrinsic factor that predisposes CD4(+) memory T cells

168 Our study identifies Pals1 as a novel intrinsic factor that regulates the generation of cerebe

169 However, our limited knowledge of the intrinsic factors that act along the secretory pathway,

170 gms of ENaC regulation include extrinsic and intrinsic factors that affect the expression, single-cha

171 how water sorption behavior is influenced by intrinsic factors that are related to structural propert

172 In search of intrinsic factors that contribute to the distinctively s

173 In search of intrinsic factors that control collateral branch develop

174 Little is known about common cell-intrinsic factors that control the development of such d

175 However, the extrinsic and intrinsic factors that control the recognition and rejec

176 The cell intrinsic factors that determine whether a neuron regene

177 e been implicated, little is known about the intrinsic factors that direct this process.

178 The intrinsic factors that drive reactive neutrophilias and

179 me host animal suggests that there are tumor-intrinsic factors that influence metastatic seeding.

180 purpose of this review is to highlight niche intrinsic factors that may promote or support malignant

181 This progression is mediated by clonal intrinsic factors that mediate tumor invasiveness as wel

182 The role of tissue-intrinsic factors that might contribute to regulation of

183 at can be initiated by numerous extrinsic or intrinsic factors that promote an unstable and hyperosmo

184 elta mice provide a model to identify B cell-intrinsic factors that promote T cell-dependent immune r

185 epted that the primary size determinants are intrinsic factors that regulate and coordinate cell prol

186 However, the intrinsic factors that regulate muscle pre-patterning re

187 nitrogen compounds in the environment and by intrinsic factors that regulate the frequency and patter

188 a complex microenvironment of extrinsic and intrinsic factors that regulate the self-renewing and as

189 Beyond cancer-cell intrinsic factors, the immune status of the host has a p

190 Like intrinsic factors, the trout cobalamin-binding protein w

191 cause holobionts are biologically different (intrinsic factors), they were exposed to different envir

192 specific rescue show that it functions as an intrinsic factor to control GSC self-renewal.

193 However, memory CD8+ T cells relied on intrinsic factors to control differentiation upon challe

194 uggest that early signals can modulate these intrinsic factors to influence the timing of neurogenesi

195 the relative contribution of synaptic versus intrinsic factors to the temporal dispersion of spikes i

196 strate that, in mouse embryos, extrinsic and intrinsic factors together regulate meiotic initiation.

197 increased numbers of cells that coexpressed intrinsic factor, trefoil factor 2, and Griffonia (Bande

198 (HSCs) is finely regulated by extrinsic and intrinsic factors via various signaling pathways.

199 nt study we investigated contribution of the intrinsic factor VIII (fVIII)-dependent pathway.

200 he recently described endocytic receptor for intrinsic factor-vitamin B(12).

201 The search for intrinsic factors, which account for a protein's capabil

202 ral, regulation of these elements depends on intrinsic factors with little direct input from the host

203 The remaining 60-80% is shaped by intrinsic factors, with age being the predominant factor

204 CMV control shaped by both viral and tissue-intrinsic factors, with global effects on homeostasis of

205 ults from interactions between extrinsic and intrinsic factors, with important implications for popul

206 t of the cellular respiratory rate is due to intrinsic factors within the myofibre.

207 Local intrinsic factors within the neighboring DNA that determ

208 hospholipid vesicles promote assembly of the intrinsic factor X (FX) activating complex by presenting

209 r of native Factor IXa for assembly into the intrinsic Factor X activation complex, Factor IXai, was

210 increase the affinity of factor IXa for the intrinsic factor X activation complex.

211 Intrinsic factor X activation is accelerated >10(7)-fold

212 been shown to be a specific inhibitor of the intrinsic factor X-(FX)-activating complex.

213 Activated platelets promote intrinsic factor X-activating complex assembly by presen

214 alue similar to its Ki for inhibition of the intrinsic factor Xase (105 microM).

215 The intrinsic factor Xase complex (FXase) is comprised of a

216 ith fIXa results in potent inhibition of the intrinsic factor Xase complex.

217 ivates the cofactor at two levels within the intrinsic factor Xase complex.

218 ly response; and 3) in normal hemostasis the intrinsic factor Xase function contributes to the durabi

219 activation after resupply; 2) impairments in intrinsic factor Xase function, i.e. hemophilias A and B