ライフサイエンスコーパス: intrinsically

1 casions, a test meal exclusively composed of intrinsically (15)N-labeled bovine meat (30 g protein),

2 membrane, indicating that HIV-1 envelope is intrinsically a low mobility environment, mainly due to

3 Gene expression is intrinsically a stochastic (noisy) process with importan

4 Recently, it was realized that BICs are intrinsically a wave phenomenon and are thus not restric

5 itively identified, reducing the activity of intrinsically 'abnormal' IgE, and decreasing in vitro co

6 Surprisingly, we discovered that intrinsically active MEK variants can both increase and

7 trophoresis (CE), using a routine method, is intrinsically affected by the generation of Joule heatin

8 provoke cutaneous inflammation, and because intrinsically aged skin displays compromised permeabilit

9 aggregated proteins revealed enrichment for intrinsically aggregation-prone proteins rather than pro

10 ession and electrical activity are generated intrinsically and can persist indefinitely in temporal i

11 iency and accuracy of the tool was evaluated intrinsically as well as extrinsically by case studies.

12 e developed an effective molecular method to intrinsically assimilate a chemiluminescence turn-ON mec

13 early development is necessarily dyadic and intrinsically associated with other aspects of social fu

14 Such a result is intrinsically associated with the unique ECL mechanism a

15 The majority of biomolecules are intrinsically atomically precise, an important character

16 e immune responses of HIV controllers showed intrinsically better helper activity than those of HIV p

17 Thus, promoter regions are intrinsically bidirectional and are shaped by evolution

18 to the synthetic systems, LDL particles are intrinsically biocompatible and biodegradable, together

19 The intrinsically blue-colored Ullman imidazolinyl nitronyl

20 edge that high-carbon martensitic steels are intrinsically brittle and thus are not expected to find

21 scopy faces a 'colour barrier', owing to the intrinsically broad (about 1,500 inverse centimetres) an

22 he mass of living mammalian cells fluctuates intrinsically by around one to four per cent over timesc

23 ally considered pathological but is produced intrinsically by these cells.

24 demonstrate that the immature epithelium is intrinsically capable of establishing a stable host-micr

25 produce autophagy-inducing peptides that are intrinsically cell-penetrant.

26 ial suspensions and actomyosin networks, are intrinsically chiral at a local scale, so that their act

27 applications in quantum information and are intrinsically compatible with industrial semiconductor p

28 urally and functionally conserved - but also intrinsically conformationally flexible - scaffolds for

29 of light-matter interaction because they are intrinsically connected to topological charges and repre

30 lus syringealis ventralis (VS) shortening is intrinsically constraint at maximally 12% strain.

31 D88 and its downstream effector kinase IRAK4 intrinsically control pericyte migration and conversion

32 network of hydrophilic polymer provides for intrinsically controlled swelling in the absence of an e

33 PD-1 intrinsically controls proliferation and cytokine produc

34 Magnetoelectric (ME) nanoparticles (MENs) intrinsically couple magnetic and electric fields.

35 can recapitulate the phenomenon because they intrinsically create a single-molecule threshold transie

36 ort the idea that synapses from AD brain are intrinsically defective in LTP.

37 ports the idea that AD-diseased synapses are intrinsically defective in LTP.

38 erized by different interaction energies and intrinsically different resulting structures.

39 Intrinsically disordaered proteins (IDPs) are a prevalen

40 y disordered proteins that are recognized as intrinsically disorder proteins (IDPs) or partially diso

41 Intrinsically disordered (ID) regions of the transcripti

42 d our structure of Cdc42 bound to ACK via an intrinsically disordered ACK region to guide an analysis

43 Several lysine residues in the intrinsically disordered AL are autoacetylated by the HA

44 s showed that the N-terminal domain (NTD) is intrinsically disordered and binds presequence near a re

45 However, unbound soluble SAA is intrinsically disordered and is either rapidly degraded

46 these analyses, we show that the monomer is intrinsically disordered and that the dimer conformation

47 uctural domains, these were characterized as intrinsically disordered by NMR spectroscopy.

48 Changing the length of the intrinsically disordered C-tail linker modifies the inte

49 Binding of the intrinsically disordered C-terminal arm of CcdA to the t

50 Hfq possesses an intrinsically disordered C-terminal domain (CTD) that ma

51 lucidate the role(s) played by the protein's intrinsically disordered C-terminal domain and an incipi

52 We studied here the intrinsically disordered C-terminal domain of the Hendra

53 ObgE also contains an intrinsically disordered C-terminal domain, and we show

54 Z comprises a polymerizing GTPase domain, an intrinsically disordered C-terminal linker (CTL), and a

55 operative binding requires the 56 amino acid intrinsically disordered C-terminal linker (IDL) that co

56 s a pentameric N-terminal core domain and an intrinsically disordered C-terminal tail domain.

57 zes" one of the conformational states of the intrinsically disordered Cdc25C protein partner and enha

58 NS5B interacts with the intrinsically disordered domain 2 of NS5A (NS5A-D2), ano

59 ntly transport proteins entirely composed of intrinsically disordered domains (IDDs) or beta-strands.

60 es both structurally stable (PX and BAR) and intrinsically disordered domains for its function.

61 her order structure self-assembly of the key intrinsically disordered EMPs, ameloblastin and amelogen

62 Protein conformational states-from intrinsically disordered ensembles to amyloids that unde

63 how that LHP1 binds RNA in vitro through the intrinsically disordered hinge region.

64 The 2525 amino acid SMRT corepressor is an intrinsically disordered hub protein responsible for bin

65 The intrinsically disordered human protein alpha-Synuclein (

66 While intrinsically disordered in isolation, p27 adopts second

67 The prodomain region was found to be intrinsically disordered independent of the activation s

68 from the complex but remains tethered by an intrinsically disordered linker.

69 distinct Gag cleavage sites, located in the intrinsically disordered linkers connecting the globular

70 lymers to uncover the physical properties of intrinsically disordered linkers that determine the exte

71 sease, and it undergoes aggregation from its intrinsically disordered monomeric form to a cross-beta

72 etal DHPR beta subunit beta1a Removal of the intrinsically disordered N and C termini and the hook re

73 udy phase-separated droplets formed from the intrinsically disordered N-terminal 236 residues of the

74 dated our method by measuring HX of CBP, the intrinsically disordered nuclear coactivator binding dom

75 e interactions between folded hubs and their intrinsically disordered partners.

76 eptide backbone conformational ensembles for intrinsically disordered peptides and proteins.

77 study demonstrates a role for phosvitin, an intrinsically disordered phosphoprotein, in chick embryo

78 The interaction of the intrinsically disordered polypeptide islet amyloid polyp

79 emonstrated the region is a highly extended, intrinsically disordered polypeptide with unusually high

80 Intrinsically disordered protein (IDP) conformers occupy

81 Is), those involving a folded protein and an intrinsically disordered protein (IDP), are prevalent in

82 elongs to the BH3-only protein family, is an intrinsically disordered protein (IDP).

83 gment of Msm sigma(A), which may comprise an intrinsically disordered protein domain unique to mycoba

84 s) or partially disordered segments known as intrinsically disordered protein regions (IDPRs).

85 Phase transitions driven by intrinsically disordered protein regions (IDRs) have eme

86 with the factors that induce LLPS, tau is an intrinsically disordered protein that complexes with RNA

87 One of them is COR15A, a small, intrinsically disordered protein that contributes to lea

88 Tau is an intrinsically disordered protein with a central role in

89 LAT is an intrinsically disordered protein, and these data suggest

90 s the activation of nanoscale dynamics of an intrinsically disordered protein, controlling the bindin

91 n the cortactin repeats resemble a coil-like intrinsically disordered protein.

92 Many intrinsically disordered proteins (IDPs) and protein reg

93 Intrinsically disordered proteins (IDPs) are characteriz

94 Intrinsically disordered proteins (IDPs) are functional

95 Intrinsically disordered proteins (IDPs) are known to un

96 Intrinsically disordered proteins (IDPs) are ubiquitous

97 ular structures that contain phase-separated intrinsically disordered proteins (IDPs) composed of seq

98 Intrinsically disordered proteins (IDPs) have roles in m

99 Measuring amide hydrogen exchange (HX) of intrinsically disordered proteins (IDPs) in solutions co

100 Liquid-liquid phase separation of intrinsically disordered proteins (IDPs) is a major unde

101 Characterization of intrinsically disordered proteins (IDPs) is challenging,

102 Intrinsically disordered proteins (IDPs) lack stable sec

103 A growing body of literature on intrinsically disordered proteins (IDPs) led scientists

104 less organelles form via phase separation of intrinsically disordered proteins (IDPs) or regions (IDR

105 lded states of proteins and native states of intrinsically disordered proteins (IDPs) populate hetero

106 Intrinsically disordered proteins (IDPs) present a funct

107 Intrinsically disordered proteins (IDPs) that lack a uni

108 be significantly more heterogeneous than on intrinsically disordered proteins (IDPs), peptides, and

109 Here we show that tardigrade-specific intrinsically disordered proteins (TDPs) are essential f

110 flexibility and binding properties of these intrinsically disordered proteins and probably exemplifi

111 Intrinsically disordered proteins and regions (IDPs) rep

112 coupled folding and binding reaction of two intrinsically disordered proteins and the conformational

113 Protein-protein interactions involving intrinsically disordered proteins are important for cell

114 Like some other intrinsically disordered proteins in the solution state

115 A pre-structures motif in the intrinsically disordered proteins is thus important for

116 ifts suggest that new interactions involving intrinsically disordered proteins may evolve via a low-a

117 on more than 800 entries of IDPs/IDRs, i.e. intrinsically disordered proteins or regions that exist

118 Intrinsically disordered proteins play important roles t

119 ese fuzzy interactions are characteristic of intrinsically disordered proteins to achieve liquid-liqu

120 ing the detailed mechanism of interaction of intrinsically disordered proteins with their partners is

121 other CRIB-family effectors and indeed other intrinsically disordered proteins, hydrophobic residues

122 Even in unfolded and intrinsically disordered proteins, internal friction has

123 Finally, we implicate intrinsically disordered proteins, key components in mRN

124 Intrinsically disordered proteins, like tau, are enriche

125 al studies of aggregation of short peptides, intrinsically disordered proteins, or proteins under den

126 hich has acquired a state similar to that of intrinsically disordered proteins, resulting in a predom

127 Intrinsically disordered proteins, such as tau protein,

128 are further strengthened by the finding that intrinsically disordered proteins, which have large hydr

129 ysis to probe the oligomerization process of intrinsically disordered proteins.

130 us and dynamic complexes in the functions of intrinsically disordered proteins.

131 etheless poorly understood, particularly for intrinsically disordered proteins.

132 The NICD sequence includes an intrinsically disordered RAM region and a conserved anky

133 interface and stabilizing the binding of an intrinsically disordered recognition motif to a rigid pa

134 actions between unphosphorylated PhyR and an intrinsically disordered region (IDR) of the anti-sigma

135 The intrinsically disordered region (IDR) on MBD2 both reduc

136 addition to the globular domain, a flanking intrinsically disordered region also recognizes DNA.

137 yltransferase activity and is composed of an intrinsically disordered region and a folded segment.

138 Lamtor2:Lamtor3 dimer and to the N-terminal intrinsically disordered region of Lamtor1.

139 a bipartite nuclear localization signal, an intrinsically disordered region overlapping arginine-ric

140 X-isoleucine-proline) which exists within an intrinsically disordered region.

141 at histone chaperones are highly enriched in intrinsically disordered regions (IDRs) and acidic stret

142 Intrinsically disordered regions (IDRs) are characterize

143 ins are composed of both modular domains and intrinsically disordered regions (IDRs) having low amino

144 re enriched in transcript sequences encoding intrinsically disordered regions (IDRs) of proteins, in

145 mains, about half of the protein consists of intrinsically disordered regions (IDRs) of varying lengt

146 Intrinsically disordered regions (IDRs) play important r

147 gomerization domain (Pcore) flanked by large intrinsically disordered regions (IDRs).

148 We show here that N- and C-terminal intrinsically disordered regions account for 80% of the

149 y motor and structural proteins that contain intrinsically disordered regions and coiled coil domains

150 Though intrinsically disordered regions are common among histon

151 , may generally promote interactions between intrinsically disordered regions of proteins.

152 e mass spectrometry data, and on the role of intrinsically disordered regions to control protein moti

153 Intrinsically disordered regions within proteins are cri

154 the two domains, along with the presence of intrinsically disordered regions, controls this process.

155 determine whether these C-terminal tails are intrinsically disordered regions, we conducted a battery

156 erent interacting partners that bind through intrinsically disordered regions.

157 alysis of the RNA binding characteristics of intrinsically disordered RGG/RG domains from Fused in Sa

158 The intrinsically disordered scaffold proteins AFF1/4 and th

159 s are stabilized by depletion forces between intrinsically disordered sequences.

160 etic resonance spectroscopy demonstrates the intrinsically disordered structure of FUS LC is preserve

161 m is the phosphorylation of S339/S340 in the intrinsically disordered tail of the multi-domain scaffo

162 process initiated by binding of MDM2 to the intrinsically disordered transactivation domain (TAD) of

163 A substantial fraction of the proteome is intrinsically disordered, and even well-folded proteins

164 informatic analysis predicts that rSp0032 is intrinsically disordered, and its multiple binding chara

165 RNA polymerase II contains a repetitive, intrinsically disordered, C-terminal domain (CTD) compos

166 The transition of intrinsically disordered, monomeric alpha-synuclein into

167 hat one subunit is very dynamic, potentially intrinsically disordered, whereas the other is considera

168 at the N-terminal inhibitory domain (NID) is intrinsically disordered, yet utilizes transient intramo

169 cal shifts showing [Formula: see text] to be intrinsically disordered.

170 the cortactin repeat region of cortactin is intrinsically disordered.

171 s, a clear epitaxial arrangement despite the intrinsically distinct symmetries and/or lattice constan

172 lasses of spinel-type oxide materials can be intrinsically doped by means of structural disorder and/

173 ective alignment of MA(+) cations within the intrinsically doped lattices, thus revealing the buildup

174 issing, and the driving forces governing the intrinsically driven self-assembly are yet to be fully u

175 rentiation, morphogenetic processes, and the intrinsically driven self-assembly of cells that mimics

176 demonstrated that metamaterials can undergo intrinsically driven self-assembly, metaphorically pulli

177 , which suggested that language switching is intrinsically effortful.

178 lar and multicellular life is visible in the intrinsically encoded nucleosome affinity.

179 We also show that the intrinsically enhanced freedom of motion of the iodine a

180 ialized translesion DNA polymerases that are intrinsically error prone and associated with mutagenesi

181 approximately 77.7 kHz fundamental mode and intrinsically exhibiting large optomechanical coupling o

182 Importantly, we show that intrinsically expressed ISGs protect stem cells against

183 Our findings indicate that IPF MPCs are intrinsically fibrogenic and that S100A4 confers MPCs wi

184 velop a simple and easy method that utilizes intrinsically flat two-dimensional (2D) plasmonic nanopa

185 lycan on the conformation and motions of the intrinsically flexible F-box-binding domain of Skp1.

186 erent genetic tags available, including both intrinsically fluorescent proteins and proteins that der

187 When these linker molecules are intrinsically fluorescent, they can pass on this propert

188 yte morphology, optimized for filtration, is intrinsically fragile, whereby local transient biochemic

189 PG04 maturation, as well as SHM hotspots and intrinsically frequent deletions associated with SHM.

190 interactions provides a SCO behavior that is intrinsically frustrated.

191 tion mechanism adapting gaze position during intrinsically generated disruptions to visual input.

192 Conclusion Prognostic discussion is not intrinsically harmful to the patient-physician relations

193 Combined with its intrinsically high charge mobility, the ferroelectric Sr

194 to harvest benefit from it for the design of intrinsically icephobic materials.

195 These two types of bonds are intrinsically immiscible without cosolvents.

196 NG, a critical innate sensor, also functions intrinsically in cells of the adaptive immune system to

197 en together, our data suggest that E(z) acts intrinsically in germ cells to activate dedifferentiatio

198 clinical imaging modalities available differ intrinsically in their detection principle and thus migh

199 that necroptotic stimuli activate NLRP3 cell-intrinsically, indicating that MLKL-induced NLRP3 inflam

200 o those observed when the nucleus is altered intrinsically, inducing chromatin decondensation or cell

201 In contrast, E46K alphaS fibrils are intrinsically inefficient at seeding alphaS inclusion pa

202 eroid dehydrogenase-1 (11beta-HSD1) converts intrinsically inert GCs into active GCs.

203 rry-phase term in an effective field theory, intrinsically intertwine the different order parameters.

204 After exercise, participants consumed intrinsically l-[5,5,5-(2)H3]leucine-labeled whole eggs

205 Here, we found that (64) Cu can be intrinsically labeled onto nanographene based on interac

206 proteins are unable to induce IFN-beta, are intrinsically less stable than wild-type IFIH1, and lack

207 ntimicrobial susceptibility testing (AST) is intrinsically limited by observation of cell colony grow

208 utility of X-ray fluorescence microscopy is intrinsically limited by the radiation damage it causes

209 that rely on genetic regulatory networks are intrinsically limited by the transcriptional response ti

210 iodes operating in the tunnelling regime are intrinsically limited to a maximum rectification ratio R

211 receptor tyrosine kinase (RTK) AXL has been intrinsically linked to epithelial-mesenchymal transitio

212 The regulation of NPQ is intrinsically linked to the cycling of xanthophylls that

213 Domain motion is intrinsically linked to the functionality of the enzyme,

214 istic of all living cells and tissues and is intrinsically linked with cell genotype, growth, and phy

215 ctor in the growth of autotrophic organisms, intrinsically linking the nitrogen and carbon cycles.

216 intensity close to one sun, highlighting the intrinsically long carrier recombination lifetime instea

217 Structure-function analysis reveals that the intrinsically low activity of Ubc15 largely results from

218 mbe Uba1 in complex with Ubc15, a Ub E2 with intrinsically low E1-E2 Ub thioester transfer activity.

219 However, the intrinsically low energy density inherent to traditional

220 drogel actuators, mostly osmotic-driven, are intrinsically low-speed and/or low-force; and their camo

221 Slower speeds might originate from intrinsically lower sprinting abilities of athletes with

222 izations, both resting and activated B-cells intrinsically maintain a high -frequency of single isola

223 in vitro and in vivo results show that CCR2 intrinsically mediates the expression of inflammatory T

224 fostered a conception of pluripotency as an intrinsically metastable and precarious state.

225 studies on medium-sized networks due to the intrinsically modular nature of cluster states, and pave

226 s rarely produce, rather than those that are intrinsically more difficult to produce.

227 capacity in the motor cortex counteracts an intrinsically more excitable motor system.

228 nce bias suggests that CpG dinucleotides are intrinsically more mutation prone.

229 ermodynamically favored, but chlorination is intrinsically more reactive due to the energy splitting

230 Tg(CJD) but not PrP KO mice were intrinsically more susceptible than WT controls to focal

231 hat antiviral-resistant (AVR) strains can be intrinsically more transmissible than their contemporane

232 that only certain vocal learning species are intrinsically motivated to do it.

233 and novel phases of matter that emerge under intrinsically non-equilibrium conditions.

234 to sensory input making the control process intrinsically non-linear.

235 l balance between pumping and losses, so the intrinsically nonequilibrium system may be described by

236 NMR dipolar couplings (DCs) depend intrinsically on both molecular shape and structural flu

237 t from carbene-alkene additions taking place intrinsically or extrinsically to decane solvent cage as

238 onging to a canonical IN type are determined intrinsically or extrinsically.

239 sible for fatigue, contain localized charges intrinsically or via defects, and present problems for d

240 er, our results support a highly dynamic yet intrinsically ordered enhanceosome assembly to maintain

241 The topological charges of OAM provide intrinsically orthogonal channels, offering a unique abi

242 growth of a family of 2D materials that are intrinsically patterned.

243 This new phase is intrinsically phase separated into insulating domains wi

244 nopsin-expressing retinal ganglion cells are intrinsically photosensitive cells that are involved in

245 s a photo-pigment found in a small subset of intrinsically photosensitive ganglion cells (ipRGCs) of

246 The intrinsically photosensitive M1 retinal ganglion cells (

247 Intrinsically photosensitive retinal ganglion cells (ipR

248 Intrinsically photosensitive retinal ganglion cells (ipR

249 Intrinsically photosensitive retinal ganglion cells (ipR

250 n of the circadian clock and discovered that intrinsically photosensitive retinal ganglion cells (ipR

251 e of photoreceptors in the mammalian retina, intrinsically photosensitive retinal ganglion cells (ipR

252 Intrinsically photosensitive retinal ganglion cells (ipR

253 pigment melanopsin [5], originally found in intrinsically photosensitive retinal ganglion cells (ipR

254 ed by rods, cones, and melanopsin-expressing intrinsically photosensitive retinal ganglion cells upon

255 er conditions that target the rod, cone, and intrinsically-photosensitive (melanopsin) retinal gangli

256 ton-electron transfer from TEMPOH, but is an intrinsically poor hydrogen atom abstractor (BDFE(OH) of

257 ideal building block for the construction of intrinsically porous framework materials by classifying

258 ugh the synthesis and characterization of an intrinsically porous hybrid glass processed from 1,3,5(t

259 es lineage-specific physiological demands to intrinsically primed MB-HSCs to enforce homeostasis.

260 sal epithelial cells from asthmatic patients intrinsically produced more lactate compared with cells

261 These results suggest an intrinsically programmed but nonsynchronous expression o

262 Our findings reveal that infant T cells are intrinsically programmed for short-term responses, and t

263 First, mechanisms that intrinsically regulate chloride secretion, centred on th

264 ffects of sunitinib in models of acquired or intrinsically resistant ccRCC.

265 sei and Candida glabrata, pathogens that are intrinsically resistant to fluconazole.

266 We found that CAFs are intrinsically resistant to gemcitabine, the chemotherape

267 Bcc pathogens are intrinsically resistant to multiple antibiotics, includi

268 tic, patient-derived xenograft model that is intrinsically resistant to the RTKi sunitinib, but not t

269 althy finches using an antibiotic that MG is intrinsically resistant to, then inoculated antibiotic-

270 is a fast dehydrative process; however it is intrinsically reversible in aqueous medium.

271 he unavoidable fact that metallic absorption intrinsically scales with field confinement.

272 4-34 (VH4-34) gene segment encodes in humans intrinsically self-reactive antibodies that recognize I/

273 element, was horizontally transferred to an intrinsically sensitive strain of S. aureus.

274 performance because these materials are not intrinsically similar to soft neural tissue.

275 lymerizing with NMIIB, NMIIA accelerates the intrinsically slow NMIIB dynamics, thus increasing cell

276 ffer from moderately low quantum efficiency, intrinsically small absorption cross-section, and gradua

277 Such performance far exceeds all reported intrinsically stretchable LEDs based on electroluminesce

278 Intrinsically stretchable light-emitting diodes (LEDs) a

279 onductor devices in which every component is intrinsically stretchable or highly flexible.

280 Cellular networks are intrinsically subject to stochastic fluctuations, but an

281 toimmunity, helps Ptpn22 (-/-) T cells to be intrinsically superior at clearing established tumors th

282 These results indicate that T. tabaci is an intrinsically superior competitor to F. occidentalis, bu

283 olytes, where the van der Waals structure is intrinsically superior in hosting charge-dense ions.

284 Intrinsically, the column combines the efficiency of a 7

285 cture varies throughout the thickness and is intrinsically three dimensional, determining the complex

286 ve high levels of Wnt activation but respond intrinsically to decreases in Wnt signaling by rapidly p

287 vel behavior of a reaction network is linked intrinsically to its topology and the functional connect

288 Domain walls, which are intrinsically two dimensional nano-objects exhibiting no

289 y aversion, a moral sense that inequality is intrinsically unfair, and cultural explanations such as

290 minal domains enhances the propensity of the intrinsically unfolded C-terminal domains to drive patho

291 lso indicates that the cortactin repeats are intrinsically unfolded, and the experimentally observed

292 e metformin-rescued P23H rhodopsin was still intrinsically unstable and led to increased structural i

293 The self-assembling building block is intrinsically unstable and spontaneously reverts to its

294 exert is hindered by the inaccessibility of intrinsically unstable poly-beta-ketones for in vitro st

295 nd self-adhesive hydrogels are designed with intrinsically unstructured proteins.

296 CTD dimer and CTD trimer interfaces are also intrinsically variable.

297 ronic devices, but is still limited by their intrinsically weak magnetoelectric effect.

298 acid, methionine, has been precluded by its intrinsically weaker nucleophilicity.

299 s crosslinked by solely reversible bonds are intrinsically weaker than common covalently crosslinked

300 understanding, they parametrize the dynamics intrinsically without explicit reference to fundamental