ライフサイエンスコーパス: intrinsically disordered

1 SilE is predicted to be intrinsically disordered.

2 All three peptides are intrinsically disordered.

3 h its three domains are poorly conserved and intrinsically disordered.

4 f its C-terminal domain, which is considered intrinsically disordered.

5 y revealed that UBXD1-N can be classified as intrinsically disordered.

6 1 that connects capsid to nucleocapsid, are intrinsically disordered.

7 yet understood for amorphous solids that are intrinsically disordered.

8 cal shifts showing [Formula: see text] to be intrinsically disordered.

9 the cortactin repeat region of cortactin is intrinsically disordered.

10 ion; and (3) that both the LU domain and the intrinsically disordered acidic domain of GPIHBP1 are re

11 es two functionally distinct domains: (1) an intrinsically disordered acidic N-terminal domain; and (

12 d our structure of Cdc42 bound to ACK via an intrinsically disordered ACK region to guide an analysis

13 f the N-terminal Ser(P)(118)-Pro(119) in the intrinsically disordered AF1 (activation function 1) dom

14 Several lysine residues in the intrinsically disordered AL are autoacetylated by the HA

15 he arginineserine (SR) di-repeats within the intrinsically disordered amino terminus of NP1 are requi

16 The intrinsically disordered and amyloidogenic protein alpha

17 proteins, which can interconvert between an intrinsically disordered and an aggregated prion state.

18 s showed that the N-terminal domain (NTD) is intrinsically disordered and binds presequence near a re

19 ially driving complete state changes between intrinsically disordered and folded states or dispersed

20 -R is a soluble extracellular domain that is intrinsically disordered and interacts with NGAL prefere

21 However, unbound soluble SAA is intrinsically disordered and is either rapidly degraded

22 these analyses, we show that the monomer is intrinsically disordered and that the dimer conformation

23 A substantial fraction of the proteome is intrinsically disordered, and even well-folded proteins

24 informatic analysis predicts that rSp0032 is intrinsically disordered, and its multiple binding chara

25 uctural domains, these were characterized as intrinsically disordered by NMR spectroscopy.

26 HI.SSB complex forms by RNase HI binding the intrinsically disordered C terminus of SSB (SSB-Ct), a m

27 Changing the length of the intrinsically disordered C-tail linker modifies the inte

28 Binding of the intrinsically disordered C-terminal arm of CcdA to the t

29 ch contain a folded N-terminal region and an intrinsically disordered C-terminal arm.

30 d to coarse-grained modeling reveal that the intrinsically disordered C-terminal arms are relatively

31 NA chaperone activity, the function of Hfq's intrinsically disordered C-terminal domain (CTD) has rem

32 Hfq possesses an intrinsically disordered C-terminal domain (CTD) that ma

33 lucidate the role(s) played by the protein's intrinsically disordered C-terminal domain and an incipi

34 We studied here the intrinsically disordered C-terminal domain of the Hendra

35 determine six pairwise distances within the intrinsically disordered C-terminal domain of the tropon

36 ObgE also contains an intrinsically disordered C-terminal domain, and we show

37 ligosaccharide binding fold (OB-fold) and an intrinsically disordered C-terminal domain.

38 de binding OB folds that bind ssDNA and four intrinsically disordered C-terminal domains of unknown s

39 Z comprises a polymerizing GTPase domain, an intrinsically disordered C-terminal linker (CTL), and a

40 operative binding requires the 56 amino acid intrinsically disordered C-terminal linker (IDL) that co

41 s a pentameric N-terminal core domain and an intrinsically disordered C-terminal tail domain.

42 -1 (HIF-1alpha), which interacts through its intrinsically disordered C-terminal transactivation doma

43 d gp19 with the former being mediated by the intrinsically disordered C-terminus of gp17.

44 RNA polymerase II contains a repetitive, intrinsically disordered, C-terminal domain (CTD) compos

45 Prostate-associated gene 4 (PAGE4) is an intrinsically disordered cancer/testis antigen that is u

46 zes" one of the conformational states of the intrinsically disordered Cdc25C protein partner and enha

47 the N-terminal 13 residues of capsid from an intrinsically disordered coil to a beta-hairpin upon cle

48 enesis abundant) proteins, which include the intrinsically disordered dehydrin (dehydration protein)

49 ats sample multiple conformations, including intrinsically disordered, dissociated, as well as two al

50 further understanding of the function of the intrinsically disordered domain 2 of HCV NS5A protein.

51 NS5B interacts with the intrinsically disordered domain 2 of NS5A (NS5A-D2), ano

52 satility of the interactions available to an intrinsically disordered domain containing bipartite int

53 r biophysical methods and show that it is an intrinsically disordered domain in sigma(54) alone.

54 ct activators stimulate Mec1 kinase using an intrinsically disordered domain of the protein.

55 ntly transport proteins entirely composed of intrinsically disordered domains (IDDs) or beta-strands.

56 hly structured domain 1 (D1), as well as two intrinsically disordered domains 2 (D2) and 3 (D3), repr

57 es both structurally stable (PX and BAR) and intrinsically disordered domains for its function.

58 This result is unexpected since intrinsically disordered domains lack a well-defined thr

59 GlcNAc onto serine and threonine residues in intrinsically disordered domains of key transcriptional

60 Here we report that intrinsically disordered domains of the endocytic adapto

61 in nucleic acid binding proteins with large intrinsically disordered domains that have been widely c

62 commonly interact with host proteins through intrinsically disordered domains.

63 hrough obligate folding cooperativity of the intrinsically disordered E domains that couple non-adjac

64 The intrinsically disordered eIF1A C-terminal tail (eIF1A-CT

65 her order structure self-assembly of the key intrinsically disordered EMPs, ameloblastin and amelogen

66 g domains (PFDs), which are generally large, intrinsically disordered, enriched in glutamines/asparag

67 Protein conformational states-from intrinsically disordered ensembles to amyloids that unde

68 lly further tunable by phosphorylation of an intrinsically disordered, extensible region of cMyBP-C's

69 C barrier in Xenopus relies primarily on the intrinsically disordered FG domain of Nup98.

70 cleosomal arrays induces condensation of the intrinsically disordered H1 CTD in a manner consistent w

71 how that LHP1 binds RNA in vitro through the intrinsically disordered hinge region.

72 The 2525 amino acid SMRT corepressor is an intrinsically disordered hub protein responsible for bin

73 imilar to their eukaryotic counterparts, use intrinsically disordered hub proteins for network assemb

74 The intrinsically disordered human protein alpha-Synuclein (

75 -called protein dynamical transition, in the intrinsically disordered human protein tau and the globu

76 paired helical filaments (PHF) formed by the intrinsically disordered human protein tau are one of th

77 Intrinsically disordered (ID) regions of the transcripti

78 While intrinsically disordered in isolation, p27 adopts second

79 n known to influence biological activity but intrinsically disordered in purified samples.

80 The prodomain region was found to be intrinsically disordered independent of the activation s

81 , a nuclear localization signal (NLS) and an intrinsically disordered linker encode the sorting signa

82 ID4 is the fourth intrinsically disordered linker of CREB-binding protein

83 from the complex but remains tethered by an intrinsically disordered linker.

84 h the last 9 amino acids (acidic tip) of the intrinsically disordered linkers (IDLs) within the four

85 distinct Gag cleavage sites, located in the intrinsically disordered linkers connecting the globular

86 or the cleavage sites of Gag (located within intrinsically disordered linkers connecting the globular

87 lymers to uncover the physical properties of intrinsically disordered linkers that determine the exte

88 sease, and it undergoes aggregation from its intrinsically disordered monomeric form to a cross-beta

89 The transition of intrinsically disordered, monomeric alpha-synuclein into

90 etal DHPR beta subunit beta1a Removal of the intrinsically disordered N and C termini and the hook re

91 es, showing a preference for substrates with intrinsically disordered N termini.

92 udy phase-separated droplets formed from the intrinsically disordered N-terminal 236 residues of the

93 Galectin-3 has an intrinsically disordered N-terminal domain and a canonic

94 ire a conserved 18-aa motif in its otherwise intrinsically disordered N-terminal domain.

95 erminal domain (the ball) preceded by a long intrinsically disordered N-terminal polypeptide chain.

96 ighest affinity interactions are between the intrinsically disordered N-terminal transactivation doma

97 broadly applied approach for overcoming the intrinsically disordered nature of linear peptides.

98 dated our method by measuring HX of CBP, the intrinsically disordered nuclear coactivator binding dom

99 ormation in solution and in real time to the intrinsically disordered, Parkinson disease related prot

100 e interactions between folded hubs and their intrinsically disordered partners.

101 Herein, we describe an intrinsically disordered peptide (CLIP6) that exclusivel

102 binding modes of phosphate anions by a small intrinsically disordered peptide.

103 eptide backbone conformational ensembles for intrinsically disordered peptides and proteins.

104 The dynamic nature of intrinsically disordered peptides makes them a challenge

105 study demonstrates a role for phosvitin, an intrinsically disordered phosphoprotein, in chick embryo

106 The interaction of the intrinsically disordered polypeptide islet amyloid polyp

107 emonstrated the region is a highly extended, intrinsically disordered polypeptide with unusually high

108 terpiece of NPC transport is the assembly of intrinsically disordered polypeptides, known as FG nucle

109 In contrast to many intrinsically disordered polypeptides, there was a minim

110 sition of kinase docking in rapidly evolving intrinsically disordered polypeptides.

111 Intrinsically disordered protein (IDP) conformers occupy

112 e than an N-terminal, arginine/glycine rich, intrinsically disordered protein (IDP) domain of LAF-1 i

113 Intrinsically disordered protein (IDP) duplexes composed

114 The intrinsically disordered protein (IDP), alpha-synuclein

115 Is), those involving a folded protein and an intrinsically disordered protein (IDP), are prevalent in

116 elongs to the BH3-only protein family, is an intrinsically disordered protein (IDP).

117 ded state of the spectrin domain R17 and the intrinsically disordered protein ACTR in two different d

118 guanidinium chloride on the structure of the intrinsically disordered protein ACTR, which can be stud

119 Participation of the small, intrinsically disordered protein alpha-synuclein (alpha-

120 Tau, an intrinsically disordered protein confined to neuronal ax

121 also the majority of experimental studies of intrinsically disordered protein coupled folding and bin

122 gment of Msm sigma(A), which may comprise an intrinsically disordered protein domain unique to mycoba

123 he case of the Abeta40 peptide, a 40-residue intrinsically disordered protein fragment associated wit

124 biophysical studies and show that SilE is an intrinsically disordered protein in its free apo-form bu

125 ) and hybrid proteins containing ordered and intrinsically disordered protein regions (IDPRs) constit

126 s) or partially disordered segments known as intrinsically disordered protein regions (IDPRs).

127 id-liquid phase separations (LLPS) driven by intrinsically disordered protein regions (IDR) of RNA bi

128 Phase transitions driven by intrinsically disordered protein regions (IDRs) have eme

129 Intrinsically disordered protein regions (IDRs) lack a w

130 any cell signaling events are coordinated by intrinsically disordered protein regions (IDRs) that und

131 teractions between prion-related domains and intrinsically disordered protein regions found in SG-nuc

132 exes, and the roles in the process played by intrinsically disordered protein segments.

133 MEG-3 is an intrinsically disordered protein that binds and phase se

134 mutational analyses show APLF is largely an intrinsically disordered protein that binds Ku, Ku/DNA-P

135 with the factors that induce LLPS, tau is an intrinsically disordered protein that complexes with RNA

136 One of them is COR15A, a small, intrinsically disordered protein that contributes to lea

137 alpha-synuclein is an intrinsically disordered protein that has the capacity t

138 alpha-Synuclein is an intrinsically disordered protein that is associated with

139 the 14-3-3-binding motifs are located, is an intrinsically disordered protein that reduces its flexib

140 alpha-synuclein (alphaS) is an intrinsically disordered protein whose fibrillar aggrega

141 Tau is an intrinsically disordered protein with a central role in

142 Tau is an intrinsically disordered protein with an important role

143 TaFROG is an intrinsically disordered protein, and it localized to th

144 LAT is an intrinsically disordered protein, and these data suggest

145 s the activation of nanoscale dynamics of an intrinsically disordered protein, controlling the bindin

146 hi-psi dihedral angle space, we used a model intrinsically disordered protein, namely, alpha-synuclei

147 n the cortactin repeats resemble a coil-like intrinsically disordered protein.

148 )DD) exhibits multiple characteristics of an intrinsically disordered protein.

149 These intrinsically disordered proteins (IDPs) and hybrid prot

150 Many intrinsically disordered proteins (IDPs) and protein reg

151 s requires elucidating the critical roles of intrinsically disordered proteins (IDPs) and regions (ID

152 Intrinsically disordered proteins (IDPs) are a set of pr

153 Intrinsically disordered proteins (IDPs) are a unique cl

154 Intrinsically disordered proteins (IDPs) are characteriz

155 Intrinsically disordered proteins (IDPs) are characteriz

156 Intrinsically disordered proteins (IDPs) are functional

157 Intrinsically disordered proteins (IDPs) are important f

158 Intrinsically disordered proteins (IDPs) are known to un

159 Intrinsically disordered proteins (IDPs) are proteins th

160 Intrinsically disordered proteins (IDPs) are ubiquitous

161 cant changes in the structural properties of intrinsically disordered proteins (IDPs) by affecting th

162 The study of intrinsically disordered proteins (IDPs) by NMR often su

163 ular structures that contain phase-separated intrinsically disordered proteins (IDPs) composed of seq

164 The dynamic modes and time scales sampled by intrinsically disordered proteins (IDPs) define their fu

165 ntitatively reproduce structural behavior in intrinsically disordered proteins (IDPs) has not been es

166 Intrinsically disordered proteins (IDPs) have roles in m

167 Measuring amide hydrogen exchange (HX) of intrinsically disordered proteins (IDPs) in solutions co

168 Liquid-liquid phase separation of intrinsically disordered proteins (IDPs) is a major unde

169 Characterization of intrinsically disordered proteins (IDPs) is challenging,

170 Intrinsically disordered proteins (IDPs) lack stable sec

171 A growing body of literature on intrinsically disordered proteins (IDPs) led scientists

172 less organelles form via phase separation of intrinsically disordered proteins (IDPs) or regions (IDR

173 Intrinsically disordered proteins (IDPs) perform their p

174 Intrinsically disordered proteins (IDPs) play central ro

175 lded states of proteins and native states of intrinsically disordered proteins (IDPs) populate hetero

176 Intrinsically disordered proteins (IDPs) present a funct

177 Intrinsically disordered proteins (IDPs) that lack a uni

178 ensemble model from candidate structures for intrinsically disordered proteins (IDPs) that takes full

179 be significantly more heterogeneous than on intrinsically disordered proteins (IDPs), peptides, and

180 o characterizing the structural ensembles of intrinsically disordered proteins (IDPs).

181 s six exciting articles on low complexity or intrinsically disordered proteins (IDPs).

182 argely unknown, in particular in the case of intrinsically disordered proteins (IDPs).

183 Here we show that tardigrade-specific intrinsically disordered proteins (TDPs) are essential f

184 of functionally and pathologically important intrinsically disordered proteins and disordered regions

185 Intrinsically disordered proteins and intrinsically diso

186 Intrinsically disordered proteins and intrinsically diso

187 ferent epitopes within three disease-related intrinsically disordered proteins and peptides (alpha-sy

188 flexibility and binding properties of these intrinsically disordered proteins and probably exemplifi

189 Intrinsically disordered proteins and regions (IDPs) rep

190 -third of the human proteome is comprised of intrinsically disordered proteins and regions (IDPs/IDRs

191 coupled folding and binding reaction of two intrinsically disordered proteins and the conformational

192 Protein-protein interactions involving intrinsically disordered proteins are important for cell

193 Intrinsically disordered proteins are ubiquitous in natu

194 Intrinsically disordered proteins can adopt multiple con

195 ditions has led to the realization that such intrinsically disordered proteins can be functional even

196 e of protein-based inheritance through which intrinsically disordered proteins can drive the emergenc

197 how very small structural motifs present in intrinsically disordered proteins can exert a specific f

198 The mechanisms by which intrinsically disordered proteins engage in rapid and hi

199 Like some other intrinsically disordered proteins in the solution state

200 A pre-structures motif in the intrinsically disordered proteins is thus important for

201 ifts suggest that new interactions involving intrinsically disordered proteins may evolve via a low-a

202 Intrinsically disordered proteins often become structure

203 on more than 800 entries of IDPs/IDRs, i.e. intrinsically disordered proteins or regions that exist

204 Intrinsically disordered proteins play important roles t

205 biology, molecular recognition mechanisms in intrinsically disordered proteins remain poorly understo

206 complexes (NPCs) contains a high density of intrinsically disordered proteins that are rich in pheny

207 Dehydrins are a group of intrinsically disordered proteins that protect plants fr

208 ese fuzzy interactions are characteristic of intrinsically disordered proteins to achieve liquid-liqu

209 this templated folding mechanism may enable intrinsically disordered proteins to achieve specific an

210 ing the detailed mechanism of interaction of intrinsically disordered proteins with their partners is

211 Like other intrinsically disordered proteins, dehydrins can gain st

212 other CRIB-family effectors and indeed other intrinsically disordered proteins, hydrophobic residues

213 Even in unfolded and intrinsically disordered proteins, internal friction has

214 ollective interactions among multivalent and intrinsically disordered proteins, is thought to mediate

215 Finally, we implicate intrinsically disordered proteins, key components in mRN

216 Intrinsically disordered proteins, like tau, are enriche

217 al studies of aggregation of short peptides, intrinsically disordered proteins, or proteins under den

218 As for many intrinsically disordered proteins, order-disorder transi

219 Example dark-matter species include intrinsically disordered proteins, posttranslational sta

220 tions that are close in energy, such as many intrinsically disordered proteins, residues distant from

221 hich has acquired a state similar to that of intrinsically disordered proteins, resulting in a predom

222 In intrinsically disordered proteins, slow transverse relax

223 Conformational behavior of intrinsically disordered proteins, such as Phe-Gly repea

224 Intrinsically disordered proteins, such as tau protein,

225 Upon analyzing intrinsically disordered proteins, we found a similar pa

226 are further strengthened by the finding that intrinsically disordered proteins, which have large hydr

227 us and dynamic complexes in the functions of intrinsically disordered proteins.

228 etheless poorly understood, particularly for intrinsically disordered proteins.

229 g and for the function of the large group of intrinsically disordered proteins.

230 roteins and is prevalent in the sequences of intrinsically disordered proteins.

231 and dynamics of functional de novo designed intrinsically disordered proteins.

232 ysis to probe the oligomerization process of intrinsically disordered proteins.

233 Intrinsically disordered proteins/regions (IDPs/IDRs) ar

234 enaturants on the dimensions of unfolded and intrinsically disordered proteins: A wide range of exper

235 d this interaction is mainly mediated by the intrinsically disordered PrP(C) N-terminal tail, which b

236 The NICD sequence includes an intrinsically disordered RAM region and a conserved anky

237 Interaction of the intrinsically disordered RBP-j-associated molecule (RAM)

238 interface and stabilizing the binding of an intrinsically disordered recognition motif to a rigid pa

239 actions between unphosphorylated PhyR and an intrinsically disordered region (IDR) of the anti-sigma

240 The intrinsically disordered region (IDR) on MBD2 both reduc

241 t eukaryotes, and feature a rapidly evolving intrinsically disordered region (IDR).

242 addition to the globular domain, a flanking intrinsically disordered region also recognizes DNA.

243 yltransferase activity and is composed of an intrinsically disordered region and a folded segment.

244 Lamtor2:Lamtor3 dimer and to the N-terminal intrinsically disordered region of Lamtor1.

245 a bipartite nuclear localization signal, an intrinsically disordered region overlapping arginine-ric

246 ronmentally sensitive folding pathway and an intrinsically disordered region, the yeast prion protein

247 X-isoleucine-proline) which exists within an intrinsically disordered region.

248 at histone chaperones are highly enriched in intrinsically disordered regions (IDRs) and acidic stret

249 Intrinsically disordered regions (IDRs) are characterize

250 Intrinsically disordered proteins and intrinsically disordered regions (IDRs) are ubiquitous i

251 ins are composed of both modular domains and intrinsically disordered regions (IDRs) having low amino

252 We characterized three intrinsically disordered regions (IDRs) in Arabidopsis W

253 Peptide motifs embedded within intrinsically disordered regions (IDRs) of proteins are

254 re enriched in transcript sequences encoding intrinsically disordered regions (IDRs) of proteins, in

255 mains, about half of the protein consists of intrinsically disordered regions (IDRs) of varying lengt

256 Protein intrinsically disordered regions (IDRs) play an importan

257 Intrinsically disordered regions (IDRs) play important r

258 able fraction of eukaryotic proteins contain intrinsically disordered regions (IDRs), which act in un

259 gomerization domain (Pcore) flanked by large intrinsically disordered regions (IDRs).

260 We show here that N- and C-terminal intrinsically disordered regions account for 80% of the

261 y motor and structural proteins that contain intrinsically disordered regions and coiled coil domains

262 Though intrinsically disordered regions are common among histon

263 Intrinsically disordered proteins and intrinsically disordered regions are implicated in many

264 o inactive, liquid-like droplets through its intrinsically disordered regions in the N-terminal domai

265 rties to protein structural properties, i.e. intrinsically disordered regions in the protein chain.

266 ions that encode protein domain junctions or intrinsically disordered regions may reflect increased R

267 ediated by NPCs are focused on properties of intrinsically disordered regions of nucleoporins that bi

268 Intrinsically disordered regions of proteins, which lack

269 , may generally promote interactions between intrinsically disordered regions of proteins.

270 y between folded domains, linear motifs, and intrinsically disordered regions regulates the formation

271 e mass spectrometry data, and on the role of intrinsically disordered regions to control protein moti

272 Intrinsically disordered regions within proteins are cri

273 Many human proteins contain intrinsically disordered regions, and disorder in these

274 the two domains, along with the presence of intrinsically disordered regions, controls this process.

275 secondary structure, transmembrane helices, intrinsically disordered regions, signal peptides and ot

276 Nearly half of the RNA-binding sites map to intrinsically disordered regions, uncovering unstructure

277 determine whether these C-terminal tails are intrinsically disordered regions, we conducted a battery

278 er DMS reactivity than regions that code for intrinsically disordered regions.

279 erent interacting partners that bind through intrinsically disordered regions.

280 transmembrane domains (TMDs) with or without intrinsically disordered regions.

281 ch has general applicability to the study of intrinsically disordered regions.

282 egions (PFRs), including protein domains and intrinsically disordered regions.

283 Here, by synthesizing intrinsically disordered, repeat proteins to test motifs

284 alysis of the RNA binding characteristics of intrinsically disordered RGG/RG domains from Fused in Sa

285 The intrinsically disordered scaffold proteins AFF1/4 and th

286 s are stabilized by depletion forces between intrinsically disordered sequences.

287 analysis of this region revealed that it is intrinsically disordered, similar to p53 and other hub p

288 etic resonance spectroscopy demonstrates the intrinsically disordered structure of FUS LC is preserve

289 and effects of single base mutations on the intrinsically disordered structure of the resulting poly

290 Intrinsically disordered substrates are typically recrui

291 m is the phosphorylation of S339/S340 in the intrinsically disordered tail of the multi-domain scaffo

292 s-links provide structural insights into the intrinsically disordered tetrameric tumor suppressor pro

293 ed atomistic conformational ensembles of the intrinsically disordered transactivation domain (TAD) of

294 process initiated by binding of MDM2 to the intrinsically disordered transactivation domain (TAD) of

295 ere we present a study of the folding of the intrinsically disordered transactivation domain of c-Myb

296 tes to genetically encoded glutamates in the intrinsically disordered tubulin C-terminal tails, are c

297 hat one subunit is very dynamic, potentially intrinsically disordered, whereas the other is considera

298 rsors of aggregation are partially folded or intrinsically disordered, which rules out structure-base

299 that the EGFR and HER3 C-terminal tails are intrinsically disordered with extended, non-globular str

300 at the N-terminal inhibitory domain (NID) is intrinsically disordered, yet utilizes transient intramo