ライフサイエンスコーパス: intron-containing

1 uggest that there are at least two distinct, intron-containing 4CL genes, at least one of which is tr

2 When a shortened form of the intron containing all but the 3'-terminal six nucleotide

3 lleles, while minimizing cleavage at its own intron-containing allele.

4 donuclease from binding and cleaving its own intron-containing allele.

5 lts in unidirectional gene conversion to the intron-containing allele.

6 pts the endonucleases' recognition sequence, intron-containing alleles are immune to cleavage by thei

7 tic drift and weak mutation pressure against intron-containing alleles yields predictions consistent

8 efficiency and distinguishes intronless from intron-containing alleles.

9 U12-dependent introns containing alterations of the 3' splice site AC

10 his purpose two non-redundant samples of 719 intron-containing and 63 intron-lacking human genes were

11 a statistical analysis on these datasets of intron-containing and intron-lacking human coding sequen

12 inhibition was observed for mRNAs from both intron-containing and intronless histone genes.

13 an endothelial cells and megakaryocytes with intron-containing and intronless human vWF promoter-luci

14 I-BmoI binds intron-containing and intronless substrates with equal a

15 mes described here cleave one strand on both intron-containing and intronless targets at different di

16 ce with respect to the intron IS, binds both intron-containing and intronless TS-encoding substrates,

17 Eukaryotes have both 'intron containing' and 'intron less' genes.

18 by increasing the efficiency of splicing of introns containing branchpoint sequences with less than

19 AGO bind the nascent transcripts of not only intron-containing but also intronless genes on Drosophil

20 recruited to the export machinery or how the intron-containing but unspliced M1 mRNA bypasses the nor

21 In an enhancer assay, the first intron containing cat construct exhibited a 5.4-fold inc

22 Although nuclear export of intron-containing cellular transcripts is restricted in

23 rerequisite for translation initiation on an intron-containing chloroplast RNA; and (3) a feedback co

24 monocistronic clpP mRNA and accumulation of intron-containing clpP transcripts in the chlorotic leav

25 e lowers the levels of spliced products from intron-containing constructs and can functionally replac

26 One or more intron-containing copies are retained in the Ssty-defici

27 We have now identified an intron-containing copy that is also present in multiple

28 of the gene may exist, only one full-length intron-containing copy was identified.

29 defects by an RNA gel blot assay, using the intron- containing CRY1 and ACT1 genes as hybridization

30 have previously demonstrated that unspliced intron-containing CTE RNA is efficiently exported to the

31 originated from a retrotransposed copy of an intron-containing DUX gene, DUXC.

32 ucture of the d3' hairpin of the Sc.ai5gamma intron containing EBS1 in its 11-nucleotide loop in comp

33 an essential step for the expression of all intron-containing eukaryotic genes.

34 Intron-containing expression cassettes were transfected

35 Furthermore, imaging of intron-containing FIV RNA showed that hCRM1 increased RN

36 Intron-containing fragments also accumulated in mutants,

37 pendently evolved the ability to distinguish intron-containing from intronless alleles while maintain

38 splicing isoforms were derived from 128 667 intron-containing full-length FLNC reads, including a la

39 We designed an intron-containing full-length KCNH2 gene construct to st

40 The intron-containing gene for human ribosomal protein RPL23

41 however, how a defective spliceosome affects intron-containing gene transcripts in human cells is lar

42 f intron loss by replacement of an ancestral intron-containing gene with a reverse-transcribed DNA co

43 dent on its origin from an intron-free or an intron-containing gene.

44 ter expresses mitochondrial ferritin from an intron-containing gene.

45 at the last intervening sequence of multiple intron containing genes is a principal determinant of th

46 of U1 snRNP and its associated components to intron-containing genes (ICGs).

47 e that the SM protein inhibits expression of intron-containing genes and activates expression of intr

48 neral exon database comprising all available intron-containing genes and exon databases from 10 eukar

49 Gcn5 associates throughout intron-containing genes and, in the absence of the histo

50 We conclude that all multi-intron-containing genes are alternatively spliced and th

51 Intron-containing genes are generally expressed more eff

52 Intron-containing genes are often transcribed more effic

53 Yra1 associates with introns of intron-containing genes in a splicing-dependent manner.

54 suggests that at least approximately 42% of intron-containing genes in Arabidopsis are alternatively

55 Here we show that splicing of intron-containing genes in cells lacking H2A.Z is impair

56 The expression of intron-containing genes in eukaryotes requires generatio

57 decreases the expression of a subset of U12 intron-containing genes in mammalian cells and Drosophil

58 enerated by partial DNA-based duplication of intron-containing genes in the fruitfly genome.

59 to differential expression analysis of minor intron-containing genes is applicable to other diseases

60 the long production time required for large intron-containing genes is significant for the behavior

61 om genomewide studies on yeast revealed that intron-containing genes produce more RNA and more protei

62 hancing mRNA expression of hundreds of minor intron-containing genes that are otherwise suppressed by

63 large databases of animal, plant, and fungal intron-containing genes to a 20% similarity level and th

64 Pre-mRNAs from over 60% of intron-containing genes undergo AS to produce a vast rep

65 Whether metazoan species with long, intron-containing genes utilize a similar mechanism has

66 scent mRNAs and are retained specifically at intron-containing genes via RNA-dependent interactions.

67 Strikingly, intron-containing genes were most susceptible to CHD1 lo

68 Some intron-containing genes were not bound by the spliceosom

69 To extend these studies, we analyzed intron-containing genes with different second exon lengt

70 round of export if the tRNAs are encoded by intron-containing genes, and for these tRNAs Msn5 functi

71 We targeted other essential intron-containing genes, and observed a similar phenotyp

72 es was assessed by RT-PCR in a subset of 166 intron-containing genes, and those with confirmed testis

73 g enough to cover exon-exon junctions of the intron-containing genes, and thus intron loss events can

74 ntified debranched lariat intermediates from intron-containing genes, demonstrating a significant dis

75 s recruited similarly to both intronless and intron-containing genes, low Yra1p and Sub2p levels are

76 In intron-containing genes, R-loops are bounded between the

77 On some intron-containing genes, retention and/or transfer of Yr

78 ntronless genes, but not the CTE or RRE from intron-containing genes, significantly enhanced stabilit

79 Second, although most SARs are derived from intron-containing genes, surprisingly, 340 SARs are deri

80 Gs) are highly overrepresented in the set of intron-containing genes, we tested the hypothesis that s

81 and Sub2p levels are present on a subset of intron-containing genes.

82 ontrol the level of mRNA produced from these intron-containing genes.

83 e, which has been reported to harbor only 26 intron-containing genes.

84 tion causes a defect in the transcription of intron-containing genes.

85 About 20% of yeast tRNAs are encoded by intron-containing genes.

86 ate unspliced RNAs from the vast majority of intron-containing genes.

87 Several databases are available for 'intron containing' genes in eukaryotes.

88 gene evolution in a much simpler way unlike 'intron containing' genes.

89 er, analysis of EWG expression elicited from intron-containing genomic transgenes and cDNA minitransg

90 cognate cDNA revealed seven exons, with all introns containing GT/AG splicing donor/acceptor site.

91 An intron-containing hairpin RNA-mediated gene silencing wa

92 to examine the intranuclear distributions of intron-containing HIV RNAs and to determine their spatia

93 nt manner to enhance polysome association of intron-containing HIV-1 gag RNA and also nonviral luc RN

94 The nuclear export of intron-containing HIV-1 RNA is critically dependent on t

95 ellular cofactor for Rev-dependent export of intron-containing HIV-1 RNA.

96 In the absence of Rev, these intron-containing HIV-1 RNAs are retained in the nucleus

97 h have intronless homologues in bacteria and intron-containing homologues in the eukaryotes, with a c

98 intronless heat-shock protein 70 (HSP70) and intron-containing HSP83--and identify novel export facto

99 sive element (RRE)-independent expression of intron-containing human immunodeficiency virus type 1 (H

100 Nuclear export of intron-containing human immunodeficiency virus type 1 RN

101 expression and regulation of spliced versus intron-containing ICP0 transcripts in latently infected

102 riptase-PCR assays that detected spliced and intron-containing ICP0 transcripts in mouse ganglia late

103 There were fewer spliced than intron-containing ICP0 transcripts on average, with cons

104 however, appear to express reduced levels of intron-containing ICP0 transcripts.

105 ow that strong constitutive expression of an intron-containing JAZ10 genomic clone is sufficient to r

106 also needed for splicing of a small group of intron-containing lincRNAs.

107 Humans have a single intron-containing locus, EEF1B2, which maps to 2q33, and

108 The reporter, consisting of a destabilized, intron-containing luciferase expressed from a short-live

109 Bz2 seems to be specific: splicing of other intron-containing maize genes, including a maize actin g

110 The expression of intron-containing messages has been shown to occur in a

111 However, it is unknown whether these intron-containing messages result in protein production

112 is or in therapeutic intervention of group I intron-containing microorganisms.

113 Our studies indicate that (1) intron-containing miRNAs (inc-miRs) can be efficiently s

114 hlights variants preferentially occurring on intron-containing molecules, possibly resulting from alt

115 The intron-containing mRNA encodes a truncated 156-amino-aci

116 f an endogenous BK(Ca) channel alpha-subunit intron-containing mRNA in the cytoplasm of hippocampal n

117 We show that intron-containing mRNA precursors template siRNA synthes

118 estrict the nuclear export and expression of intron-containing mRNA.

119 an element that enables export of unspliced, intron-containing mRNA.

120 Intron-containing mRNAs are subject to restricted nuclea

121 ficiency virus type 1 (HIV-1) are encoded by intron-containing mRNAs that normally are retained in th

122 hCRM1 regulates the nuclear export of viral intron-containing mRNAs through the activity of the vira

123 Because maturation of 11 other intron-containing mRNAs was unaffected in the chlorotic

124 cycle by facilitating the nuclear export of intron-containing mRNAs, yet their activities have rarel

125 A retained intron containing multiple translation stop codons that

126 ut in the mutants in vivo both by monitoring intron-containing nascent transcript levels and (14)C-ur

127 This pathway furthermore protects most intron-containing nascent transcripts from the effects o

128 -like sequence may have been derived from an intron-containing nuclear tRNA gene or it may serve some

129 -like sequence may have been derived from an intron-containing nuclear tRNA gene or it may serve some

130 Furthermore, we propose that the intron-containing ORF 57 gene downregulates itself by th

131 Furthermore, each of a series of introns containing overlapping deletions that together s

132 een intronless genes and their corresponding intron-containing paralogs, we found that alignments do

133 n been considered to be retroposed copies of intron-containing paralogs.

134 wheat GstA1 promoter in combination with an intron-containing part of the wheat WIR1a gene was found

135 ycan hydrolase sequences, three new putative intron-containing phage endolysin genes were identified

136 rk reveals that nab2 mutant cells accumulate intron-containing pre-mRNA in vivo We extend this analys

137 ivo, with a preference for exon 2 regions of intron-containing pre-mRNAs and poly(A) proximal sites.

138 irect Prp8-binding sites on U5, U6 snRNA and intron-containing pre-mRNAs identified using site-direct

139 is of short-lived non-coding RNAs as well as intron-containing pre-mRNAs in wild-type yeast.

140 First, intron-containing pre-mRNAs in yeast are detectably boun

141 is associated with nad1 i4 and several other intron-containing pre-mRNAs.

142 cing Endonuclease (SEN) during processing of intron-containing pre-tRNAs and by Ire1 cleavage of HAC1

143 Both intron-containing pre-tRNAs and spliced tRNAs, regardles

144 Our studies of the location of intron-containing pre-tRNAs in the rna1-1 mutant rule ou

145 execute nuclear export of newly transcribed intron-containing pre-tRNAs.

146 f the transgene is inhibited at the level of intron-containing precursor mRNA.

147 enome assembly is comprised of nearly 14,000 intron-containing predicted genes, and 13,500 intron-les

148 er of the Pabp2 gene is not derived from its intron-containing progenitor, Pabp1.

149 ed these intronless amphibian IFNs and their intron-containing progenitors, and functionally characte

150 cteriophage T4 and is encoded adjacent to an intron-containing psbA gene [5, 6].

151 te spans the IIS, and it is unable to cleave intron-containing psbA genes.

152 tween the TIRs reside tail-to-tail-oriented, intron-containing RAG1-like and RAG2-like genes.

153 eved in a slow-growing mycobacterium with an intron-containing RecA.

154 ot spliced and six predictions identified an intron-containing region but failed to specify the corre

155 preferentially increased the translation of intron-containing reporters via the EJC, whereas silenci

156 d the efficacy of nanoparticle (NP)-mediated intron-containing rhodopsin (sgRho) vs. intronless cDNA

157 IF4E is readily detected in association with intron-containing RNA and the C-terminal domain of RNA p

158 ssion in all retroviruses is that unspliced, intron-containing RNA is exported to the cytoplasm despi

159 In complex retroviruses, the export of intron-containing RNA is mediated by specific viral regu

160 ate that Tap regulates expression of its own intron-containing RNA through a CTE-mediated mechanism.

161 F1 gene also regulates expression of its own intron-containing RNA through the use of a functional CT

162 t signal function and redirect the export of intron-containing RNA to a CRM1-independent pathway.

163 out the gamma-globin intron by targeting the intron-containing RNA via microRNA 30 (miR30)-based shor

164 ell restriction on cytoplasmic expression of intron-containing RNA.

165 by inducing the cytoplasmic accumulation of intron-containing RNA.

166 s as an autonomous nuclear export signal for intron-containing RNA.

167 t can also facilitate the export of cellular intron-containing RNA.

168 of spliceosomes from this abundant class of intron-containing RNAs (the ribosomal protein genes) to

169 Indeed, intron-containing RNAs are typically retained in the nuc

170 Together, our results show that binding to intron-containing RNAs stabilizes and regulates the acti

171 of spliceosomes from this abundant class of intron-containing RNAs to otherwise poorly spliced trans

172 Moreover, 144 minor intron-containing RNAs were differentially expressed, in

173 taining RNAs cofactors normally recruited to intron-containing RNAs.

174 The intron-containing RPL23A gene was mapped to cytogenetic

175 SR45 differentially regulates intronless and intron-containing SARs.

176 evious RNA analysis of lesions within the 15 intron-containing Sh2 (shrunken2) gene of maize (Zea may

177 rotein 1 gene (MKRN1), a highly transcribed, intron-containing source for this family of genes.

178 sition of a cDNA originating as mRNA from an intron-containing source gene.

179 ges in a unique BK(Ca) channel alpha-subunit intron-containing splice variant mRNA can greatly impact

180 The experiments reveal that these intron-containing splice variants remain within the nucl

181 56-bp region of the mouse alpha-actin first intron containing SRF, NFAT, and AP-1 sites (SNAP) acted

182 n the level of gene expression as long as an intron containing stimulatory sequences was included.

183 nt strategies to distinguish intronless from intron-containing substrates.

184 trotransposons, Ctr1 functions in processing intron-containing telomerase RNA.

185 a second, the beta form, in which a cryptic intron containing the potential DNA binding domain is sp

186 expression plasmids, we show that miniature introns containing the splice sites along with short ( a

187 f the glycoprotein hormone receptors and the intron-containing TM/C module of the CRFR is suggested b

188 educed endogenous cytoplasmic levels of this intron-containing transcript by RNA interference without

189 hat is not inhibited by LMB and programs the intron-containing transcript for translational enhanceme

190 d increase in the presence of the unspliced, intron-containing transcript.

191 Primer extension analysis of intron-containing transcripts in prp40 temperature-sensi

192 preliminary analysis of the splicing of all intron-containing transcripts in Saccharomyces cerevisia

193 After splicing of intron-containing transcripts, all three RLuc mRNAs had

194 RNAs but also inhibits expression of several intron-containing transcripts.

195 e and the cDNA of the transgene, but not the intron-containing transgene.

196 In Trypanosoma brucei, the single intron-containing tRNA (tRNA(Tyr)GUA) is responsible for

197 Splicing of eukaryal intron-containing tRNAs requires the action of the heter

198 protein complex, involved in the cleavage of intron-containing tRNAs.

199 in vivo splicing of the Haloferax volcanii, intron-containing tRNATrp RNA.

200 ependent U6atac modulation can control minor intron-containing tumor suppressor PTEN expression and c

201 ilitates the cytoplasmic accumulation of the intron-containing viral gag-pol and env mRNAs and is req

202 ion of both intronless viral ORF59 genes and intron-containing viral K8 and K8.1 genes.

203 tions are necessary for nuclear export of an intron-containing viral mRNA in vivo.

204 lls, the HIV-1 Rev protein recruits hCRM1 to intron-containing viral mRNAs encoding the Rev response

205 nuclear export steps to allow the export of intron-containing viral RNA transcripts to the cytoplasm

206 retroviruses act to facilitate the export of intron-containing viral RNAs.

207 s in the pdg coding regions (exons) from the intron-containing viruses are 84 to 100% identical.

208 lear ribonucleoprotein particles (snRNPs) to intron-containing yeast (S. cerevisiae) genes.

209 tinguish spliced from unspliced RNA for each intron-containing yeast gene and measured genomewide eff

210 dary structure bias in the coding regions of intron-containing yeast genes than in intronless genes,

211 method, we applied this approach to a set of intron-containing yeast genes, where we easily identifie