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1 t to be possibly vaccine-related (intestinal intussusception).
2 None of the infants had confirmed intussusception.
3 ds to assess the association between RV1 and intussusception.
4 increased the ability to diagnose or exclude intussusception.
5 as negative, positive, or indeterminate for intussusception.
6 ter studies showed a strong association with intussusception.
7 n and safe from the possible complication of intussusception.
8 thheld because of multiple reported cases of intussusception.
9 of a mouse model to study rotavirus-induced intussusception.
10 e risk of the association between RRV-TV and intussusception.
11 ation of the vaccine with the development of intussusception.
12 substantially greater than the rare risk of intussusception.
13 xplore here the effect of age on the risk of intussusception.
14 er cuff, the "pluck" technique, and ureteral intussusception.
15 s vaccine (OPV), may also be associated with intussusception.
16 tion between natural rotavirus infection and intussusception.
17 ism by which rotavirus infection could cause intussusception.
18 the rotavirus vaccine and the development of intussusception.
19 rtant benefits that outweigh risk related to intussusception.
20 ithdrawn after an association was found with intussusception.
21 en suspected of having abnormalities such as intussusception.
22 viruses has been found to be a rare cause of intussusception.
23 virus vaccine suggested an increased risk of intussusception.
24 born at the same hospital as the infant with intussusception.
25 of rotavirus vaccine (Rotashield) and infant intussusception.
26 here are 58 cases of surgically proven adult intussusception.
27 ignant colonic lesions associated with their intussusception.
28 pies, of which two also had small intestinal intussusception.
29 dered in the differential diagnosis of bowel intussusception.
30 contributes to less than 5% of all cases of intussusception.
31 at acted as a leading point to an ileo-ileal intussusception.
32 1 probable, 10 possible and 10 suspected for intussusception.
33 V5 and RV1 outweigh the small excess risk of intussusception.
34 was based on only 12 cases with both CD and intussusception.
35 There were 44 enteric and 14 colonic intussusceptions.
36 e small-bowel and 143 (71.5%) were ileocolic intussusceptions.
37 rentiation between ileocolic and small-bowel intussusceptions.
40 ed prolonged urine leak (10), infection (6), intussusception (2), and transient renal insufficiency (
43 but on AIN76A diet also developed intestinal intussusception, a tumor-associated pathology in patient
44 , at most, a 7% increase in the incidence of intussusception above the annual background incidence.
46 We found no evidence of increased infant intussusception admissions during the period of Rotashie
48 otashield dose), we estimated an increase in intussusception admissions of 1% (one excess admission)
50 tatistically significantly increased risk of intussusception after CD diagnosis (hazard ratio=1.95; 9
51 e possibility of a small increase in risk of intussusception after monovalent rotavirus vaccination.
52 7, 1999, after nine cases of infants who had intussusception after receiving the tetravalent rhesus-h
53 work was motivated by the documented risk of intussusception after RotaShield vaccination (Wyeth-Lede
55 new monovalent rotavirus vaccine (RV1) with intussusception after routine immunization of infants in
58 There was also an increase in the risk of intussusception after the second dose of the vaccine, bu
59 periods examined, the relative incidence of intussusception after vaccination was unchanged for 18,
61 studies have identified an increased risk of intussusception after vaccination with the second-genera
62 served a significant increase in the rate of intussusception after vaccination, a risk that must be w
63 ing receipt of OPV during the month prior to intussusception among 119 cases and 589 controls matched
64 ntial analyses, we then compared the risk of intussusception among children receiving monovalent rota
65 the potential association between RRV-TV and intussusception among infants at least 1 but less than 1
68 ociation between vaccination with RRV-TV and intussusception among otherwise healthy infants supports
69 ssibly cause a small increase in the risk of intussusception; an estimated 1-3 US infants out of 100
73 they assume high vaccine-associated risk of intussusception and do not account for potential herd im
76 , surgical reduction, or hospitalization for intussusception and had been enrolled in Medicaid for at
78 raise their awareness of imaging findings in intussusception and keep in their mind coexistent troubl
80 ted that it is well tolerated with regard to intussusception and other adverse events and is efficaci
81 avirus vaccine efficacy data, global natural intussusception and regional rotavirus vaccine-related r
83 idence intervals for the association between intussusception and RV5 by comparing the rates of intuss
85 s were reviewed to confirm the occurrence of intussusception and the status with respect to rotavirus
88 ckness was greater than 1.0 in all ileocolic intussusceptions and was less than 1.0 in all small-bowe
89 Revision, Clinical Modification code 560.0 (intussusception) and procedure codes and by review of me
92 described with reference to: the site of the intussusception, and the triggering lesion (either idiop
93 the rate of lipopolysaccharide (LPS)-induced intussusception, and this enhancement was replication de
94 ents 1% of all bowel obstructions, 5% of all intussusceptions, and 0.003%-0.02% of all hospital admis
96 unevaluable because of death at 3 weeks from intussusception; and 4 showed persisting mixed chimerism
104 = 90 days old accounted for 80% of cases of intussusception associated with a first dose but had rec
105 There was no significantly elevated risk of intussusception associated with receipt of OPV; 9.2% (11
106 at least significantly decrease the risk of intussusception associated with rotavirus vaccination.
107 inistered; this implies an increased risk of intussusception associated with RRV-TV at all ages studi
108 statistically significant increased risk of intussusception associated with RRV-TV for the exposure
110 uted disproportionately to the occurrence of intussusception associated with the use of RotaShield.
112 t patients with a postoperative diagnosis of intussusception at Mulago National Referral and Teaching
113 thin-walled blood vessels with sprouting or intussusception at the boundary of the ischemic lesion,
114 nd older with the postoperative diagnosis of intussusception at the Massachusetts General Hospital du
115 ion with RRV-TV, we estimated that 1 case of intussusception attributable to the vaccine would occur
116 cessary in a high percentage of infants with intussusception, but does not reduce the incidence of in
118 ciation between oral polio vaccine (OPV) and intussusception by linking Scottish vaccination and hosp
120 d the age-stratified background incidence of intussusception by use of Healthcare Cost and Utilizatio
122 n upper limit for the attributable risk of 1 intussusception case per 65,287 RV5 dose-1 recipients.
123 red during the study period, with 8 observed intussusception cases (7.11 expected), for a nonsignific
124 m policy considerations, we estimated excess intussusception cases and mortality potentially caused b
127 se of vaccination far exceeded the number of intussusception cases that may have been associated with
128 e two doses combined, the expected number of intussusception cases was 0.72, resulting in a significa
129 owing all RV5 doses, we observed 21 cases of intussusception compared with 20.9 expected cases (SIR,
130 were given OPV 0-28 days prior to the case's intussusception date (odds ratio=1.1, 95% confidence int
134 rotavirus deaths prevented and the number of intussusception deaths caused by vaccination when admini
135 3,700) and cause an additional 294 (161-471) intussusception deaths, for an incremental benefit-risk
137 and clinical records of all patients with an intussusception demonstrated on CT or MR images from Jan
140 n distinguishing the majority of small-bowel intussusceptions detected at CT that are self-limiting f
143 evidence for an association between OPV and intussusception, even when each dose is considered separ
144 ation at ages 2, 4, and 6 months projected 1 intussusception event/11,000-16,000 vaccine recipients;
145 beginning in the neonatal period projected 1 intussusception event/38,000-59,000 vaccine recipients.
146 s, in comparing rotavirus disease averted to intussusception events caused, the hospitalization ratio
147 n has been limited to young infants owing to intussusception events noted with a prior rotavirus vacc
148 ates, because of a temporal association with intussusception events that occurred in vaccinated infan
152 esus-human reassortant rotavirus vaccine and intussusception has increased the need to develop new va
154 ined age-specific trends in population-level intussusception hospitalization rates before (2000-2005)
155 evious rotavirus vaccine, RotaShield, caused intussusception in 1 of every 10,000 recipients, we asse
158 confidence interval: 1,551, 2,025) cases of intussusception in a fully vaccinated, national cohort o
160 RV1 was associated with a short-term risk of intussusception in approximately 1 of every 51,000 to 68
161 t of intussusception, we reviewed studies of intussusception in children <18 years of age published s
162 susception and RV5 by comparing the rates of intussusception in infants who had received RV5 with the
163 fants who had received RV5 with the rates of intussusception in infants who received other recommende
165 ere not associated with an increased risk of intussusception in large trials before licensure, recent
166 A combined annual excess of 96 cases of intussusception in Mexico (approximately 1 per 51,000 in
167 A radiographic modality was used to diagnose intussusception in over 95% of the cases in all regions
171 ors examined the association between OPV and intussusception in the Washington State Medicaid populat
172 nical data for children given a diagnosis of intussusception in the years 2007 through 2011 were eval
177 cribed; four died between 7 to 106 days with intussusception, infection, or GVHD, and five became lon
178 hospital (<365 days old) with any mention of intussusception (International Classification of Disease
179 lastic lead point, including all four of the intussusceptions involving the colon (benign mass, n = 3
189 ding the age period when naturally occurring intussusception is most prevalent (i.e., ages 3-4 months
190 ever, to address the hypothesis that risk of intussusception is related to receipt of a particular do
198 tepwise, logistic regression analysis showed intussusception length was the only variable that was in
199 The presence of an inner fatty core in the intussusception, lesion diameter, wall thickness, the ra
201 five surgically confirmed masses (carcinoid, intussusception, lymphangioma) were identified, but two
202 ortality by week of age from a recent study, intussusception mortality based on a literature review,
204 evious rotavirus vaccine was associated with intussusception, new rotavirus vaccines are monitored po
205 um schedule to avoid or significantly reduce intussusception, now reported to be associated in intern
206 a) and used worldwide spontaneous reports of intussusception occurring after Rotarix vaccination (Gla
208 helial polarity and proliferation leading to intussusception of endothelial cells and extensive remod
209 gation provide support for the idea that the intussusception of newly secreted pectin contributes to
210 There were 5 deaths due to pneumonia (n=1), intussusception of the graft (n=1), cardiorespiratory ar
212 and quiting imaging studies after finding an intussusception on ultrasound, may lead diagnostic error
217 l evaluation of patients suspected of having intussusception, particularly when the supine view is di
219 ely 1.5 (95% CI, 0.2 to 3.2) excess cases of intussusception per 100,000 recipients of the first dose
225 the induction of inflammatory mediators, and intussusception rates can be modified by inflammatory an
226 us vaccine introduction, a small increase in intussusception rates was seen among US infants aged 8-1
230 traperitoneal hemorrhage; the second died of intussusception-related bowel necrosis 10 days after TEP
233 Although US data have not documented an intussusception risk with current rotavirus vaccines, in
235 Ambulatory or nonhospital management of intussusception subjects the infant to the risk of a sig
236 this review relates to the heterogeneity in intussusception surveillance across different regions.
237 ion that should facilitate implementation of intussusception surveillance for monitoring the postlice
238 esection of the ureteral orifice (pluck) and intussusception techniques should be approached with cau
241 abdominal CT not only confirmed the enteric intussusception that was demonstrated on previos US, but
243 oviders should be aware of the small risk of intussusception, the signs and symptoms of intussuscepti
245 ants are relatively refractory to developing intussusception, thereby avoiding the age period when na
247 000 each in order to address questions about intussusception triggered by a third earlier vaccine.
248 ere seen in 128 (89.5%) of the 143 ileocolic intussusceptions versus in eight (14.0%) of the 57 small
249 rrent period and with the expected number of intussusception visits based on background rates assesse
250 .12%) individuals with CD had a diagnosis of intussusception vs. 143 (0.10%) reference individuals, s
251 CD in patients with at least two records of intussusception was 0.40 (95% CI=0.06-2.99).In contrast,
258 .10%) reference individuals, suggesting that intussusception was not a risk factor for later CD (OR=1
259 4 to 34 weeks who received RV5, the risk of intussusception was not increased compared with infants
261 ccination was associated with 1,400 cases of intussusception, was $36 (95% confidence interval: $28,
262 background rates and clinical management of intussusception, we reviewed studies of intussusception
263 dies and the ability to visualize or exclude intussusception were calculated to determine sensitivity
264 ratios (ORs) for future CD in patients with intussusception were estimated using conditional logisti
265 Thirty-seven cases of adult small-bowel intussusception were identified by a retrospective compu
271 drawn in 1999 due to a rare association with intussusception, which occurred disproportionately in in
272 vaccines are introduced globally, monitoring intussusception will be crucial for ensuring safety of t
273 nsure identification of an increased risk of intussusception with rotavirus vaccine, the 14 Latin Ame
274 statistically significant increased risk of intussusception with RV5 for either comparison group fol
277 We reviewed medical records and visits for intussusception within 7 days after monovalent rotavirus
279 1-3 US infants out of 100 000 might develop intussusception within 7 days of getting their first dos
281 126-293) and 10 deaths (90% CI, 6-17) due to intussusception, yielding benefit-risk ratios for hospit
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