ライフサイエンスコーパス: invariably

1 Electrode used in lithium-ion battery is invariably a composite of multifunctional components.

2 challenging problem because the receptor is invariably a membrane protein, which represents an Achil

3 Human perception is invariably accompanied by a graded feeling of confidence

4 A further increase in Lac density was invariably accompanied by a substantial decrease in aggl

5 With ionizing radiation, immortalization is invariably accompanied by efficient biallelic deletion o

6 Tissue injury and regeneration is invariably accompanied by macrophage infiltration, but t

7 lly significant since substrate reduction is invariably accompanied by proton uptake.

8 history of TBI, and survivors of TBI do not invariably acquire dementia later in life.

9 However, MM patients invariably acquire resistance to these drugs.

10 us auditory and visual signals yet they will invariably activate the brain asynchronously due to diff

11 Invariably, acute leukemia diagnosed in the first trimes

12 These errors invariably affect downstream analysis/application and sh

13 However, kinks invariably affect numerous interhelical interactions, qu

14 Invariably, approximately 85% of the transferred iTregs

15 in HPV-associated cancers in vivo, E6 and E7 invariably are coexpressed.

16 hibitor (PARPi) therapy; however, resistance invariably arises in these patients and is a major clini

17 ble smoke invariably in As(III) form and ash invariably as As(V).

18 These signalling patches are invariably associated with a ring of active SCAR/WAVE at

19 Infection and inflammation are invariably associated with activation of the blood coagu

20 Hepatocellular carcinoma (HCC) is almost invariably associated with an underlying inflammatory st

21 polymorphisms within this clade were almost invariably associated with antibiotic resistance, indica

22 nd reduced intra-abdominal adiposity are not invariably associated with liver fat depletion, whereas

23 Pancreatic cancer is almost invariably associated with mutations in the KRAS gene, m

24 ts for single words, on the other hand, were invariably associated with peak atrophy sites in the lef

25 Aneuploidy is invariably associated with poor proliferation of primary

26 assumption that chronic pain conditions are invariably associated with somatosensory cortex reorgani

27 M--mutations potentially arise first and are invariably associated with specific, high-fidelity oblig

28 ge cluster of genes in the E. coli genome is invariably associated with the high-pathogenicity island

29 the deadliest human malignancies, is almost invariably associated with the presence of an oncogenic

30 IVC-IAGPNA is invariably associated with VR reduction during AF.

31 in compounds, Group I elements, for example, invariably assume the +1 oxidation state, and their chem

32 y making a pair of transient staggered nicks invariably at 6-bp spacing as the reaction intermediate.

33 e doctrine that high-quality resonances must invariably be narrowband and providing the possibility o

34 of seizures with impaired awareness, as will invariably be the case in those having epilepsy surgery.

35 since large random ecological networks would invariably be unstable and thus should not be observed e

36 tatus epilepticus, the therapies have almost invariably been assessed in open studies only, and there

37 Primary epidemiological data have invariably been derived from cancer registries that are

38 However, the regulation of glycolysis has invariably been examined under conditions in which proli

39 tal effect approach has been applied, it has invariably been from a phytocentric perspective, focussi

40 isolates sequenced from these outbreaks have invariably been of genotypes distinct from those of vacc

41 ditionally, longitudinal studies have almost invariably been restricted to older adults, precluding t

42 ary adenomas expressing and secreting GH are invariably benign and exhibit DNA damage and a senescent

43 racterized by limited-stage presentation and invariably benign behavior despite often high-grade hist

44 mophores with acetylacetonate linking groups invariably bind in the chelate mode, whereas carboxylic

45 The methylation reactions are almost invariably catalyzed by enzymes that use S-adenosylmethi

46 ically acting immunosuppressive drugs, which invariably cause severe side effects.

47 ced hepatic arterial perfusion (HAP), and is invariably causing focal hepatic venous outflow obstruct

48 ) is an autosomal recessive disorder that is invariably characterized by severe growth retardation an

49 Although these disorders are invariably characterized by the degeneration of highly s

50 hat protein profiles of technical replicates invariably clustered; the protein profiles for distinct

51 ations of how the polarized structure arises invariably coalesce around somatic polarity, defined by

52 uggest that chemically unfolded polypeptides invariably collapse from an expanded random coil to more

53 ts point to an extended reading network that invariably comprises the occipitotemporal visual word-fo

54 However, asthma outcomes research has almost invariably concentrated on identifying and addressing pa

55 2s, yet this acidic loop (named for its four invariably conserved acidic residues) is critical for Cd

56 distal side of the loop collaborate with an invariably conserved histidine on the proximal side of t

57 minal residues of proapoptotic fragments was invariably conserved in evolution.

58 Photocatalysis has been invariably considered as an unselective process (especia

59 Instead, these proteins invariably contain a threonine residue at this position.

60 se clusters of up to 100 factors that almost invariably contain cohesins.

61 Is), aggregated assemblies of human PPI data invariably contain experiment-dependent noise.

62 notyped for thousands of genetic markers and invariably contain multiple errors in both the pedigree

63 antly, neurites undergoing active elongation invariably contained a bright F-actin patch at the tip,

64 We observed that nascent disks are invariably continuous with the ciliary plasma membrane,

65 With each chain-extension step, monolignols invariably couple at their beta-positions, generating ch

66 ions in natural and artificial settings, and invariably couples elastic deformation fluid flow.

67 However, its surface is invariably covered with a dense aluminum oxide film, whi

68 Functional Polycomb recruiter sequences are invariably CpG-rich but require protection against DNA m

69 d plant homeodomain (PHD) fingers, which are invariably deleted in oncogenic MLL1 fusion proteins in

70 However, because such efforts invariably depend upon mathematical modeling, mispercept

71 a human coronavirus (OC43), and this ability invariably depends upon the E3 ligase activity of TRIM56

72 patients with Lyme disease, the organism was invariably described as having spirochetal morphology.

73 trode sizes and current amplitudes, they are invariably described as small.

74 X-ray photoelectron spectroscopy invariably detected elemental contaminants associated wi

75 In frog hair cells, spectrin betaV was invariably detected near the apical junctional complex a

76 Even though TVCs normally migrate as an invariably determined leader-trailer polarized pair of a

77 mselves carry information, rather than being invariably detrimental.

78 atients with advanced prostate cancer almost invariably develop osseous metastasis.

79 Unfortunately, cancers invariably develop resistance, and overcoming or prevent

80 eated with crizotinib, although all patients invariably develop resistance.

81 fect of sorafenib is transient, and patients invariably develop sorafenib resistance (SR).

82 Thereafter, mutant mice invariably developed a rapidly fulminant neurological de

83 However, these mice invariably developed esophageal achalasia, and the enter

84 exerts a therapeutic effect, but resistance invariably develops through undefined mechanisms.

85 Resistance invariably develops to antiandrogen therapies used to tr

86 nase inhibitor (TKI) therapy, but resistance invariably develops, commonly within the CNS.

87 hibitors) such as crizotinib, but resistance invariably develops, often with progression in the brain

88 However, acquired resistance invariably develops.

89 Unfortunately, resistance almost invariably develops.

90 However, resistance invariably develops.

91 characterized by intracellular distributions invariably dictated by their hydrophilic/hydrophobic bal

92 However, mice with CHD invariably die prenatally/neonatally, causing CHD phenot

93 We found that null mutant animals invariably died at around the time of ecdysis, revealing

94 ones of the helices are in contact, and they invariably display networks of 4 to 8 weak hydrogen bond

95 hat people with this disorder often (but not invariably) do poorly on measures of learning and memory

96 , serum and cystic fluid CA 19-9 levels were invariably elevated and the CA 19-9 level in the cystic

97 tes or phenotypically normal hepatocytes are invariably elevated compared to normal health subjects.

98 ells give rise to Blimp1(-) progeny that are invariably Elf5(+)ERalpha(-)PR(-).

99 However, drug-resistant tumour cells invariably emerge leading to disease progression.

100 arget AR signaling, but secondary resistance invariably emerges, and new therapies are urgently neede

101 ns varied from 35 kbp to 80 kbp in size, but invariably encompassed or interrupted only two genes: TG

102 risk of genome instability, since replisomes invariably encounter DNA lesions or other structures tha

103 The DNA replication machinery invariably encounters obstacles that slow replication fo

104 nitially effective in cancer patients nearly invariably engender resistance at some stage, an inheren

105 on and mitochondrial protein acetylation are invariably enhanced in this dietary milieu.

106 formed by admixing of seawater, however, are invariably enriched in CH3SH (up to approximately 10(-6)

107 Tumor cells nearly invariably evolve sustained PI3K/Akt signaling as an eff

108 that complexin-deficient DKD and DKO neurons invariably exhibit a ~50% decrease in vesicle priming.

109 lighting from a large petrochemical complex invariably exhibited a visually based foraging behaviour

110 , once animal germ cells are specified, they invariably express a number of highly conserved genes.

111 third CDR (HCDR3), DANGMDV (motif-1), almost invariably express Ig L chains (IgL) encoded by IGLV3-21

112 stereotypic HCDR3, DPSFYSSSWTLFDY (motif-2), invariably express kappa-IgL encoded by IGKV3-20.

113 est ants are sufficient to kill raiders that invariably exterminate host nests without a cohabiting g

114 merging evidence indicates that OXT does not invariably facilitate social bonding but also produces n

115 th actual tumor mass shrinkage, this therapy invariably fails and the cancer reappears as castration-

116 ceptor (ER)-positive breast cancer, but this invariably fails with cancers becoming refractory to tre

117 g in amyotrophic lateral sclerosis (ALS), an invariably fatal and clinically heterogeneous neuromuscu

118 us protein-only infectious agents that cause invariably fatal brain diseases following silent incubat

119 Glioblastoma multiforme (GBM) remains almost invariably fatal despite optimal surgical and medical th

120 The transthyretin amyloidoses (ATTR) are invariably fatal diseases characterized by progressive n

121 a genomically diverse, prevalent, and almost invariably fatal malignancy.

122 reutzfeldt-Jakob disease (CJD) is a rare but invariably fatal neurodegenerative disease caused by mis

123 ey role in amyotrophic lateral sclerosis, an invariably fatal neurodegenerative disease.

124 treatment for a disease that was considered invariably fatal once clinical signs develop.

125 -Gilford progeria syndrome (HGPS) is a rare, invariably fatal premature aging disorder.

126 of rabbit PrP.IMPORTANCE Prion disorders are invariably fatal, untreatable diseases typically associa

127 ckable-turned-shockable OHCA is poor but not invariably fatal.

128 were used; however, significant differences invariably favored the bivalent vaccine.

129 The HFD was invariably followed by a DC voltage shift and a decrease

130 sults in dramatic tumor regression but it is invariably followed by drug resistance.

131 urvival rates, with initial responses nearly invariably followed by rapid recurrence of therapy-resis

132 ver, the clinical benefits are transient and invariably followed by tumor recurrence.

133 Aspartate release invariably follows that of a sodium ion located near the

134 beta-hairpin-containing conformers, instead, invariably form very stable dimers when their side chain

135 Products invariably formed in good yields, with rigorous chemo-,

136 ed into a small three-dimensional volume, it invariably forms a structure with a low volume fraction

137 ess, when examined, miRNA targeted mRNAs are invariably found to be polysome associated; observations

138 siRNA release occurred invariably from maturing endosomes within ~5-15 min of e

139 ession, they are currently thought to derive invariably from the cells lining the bile ducts, biliary

140 icient, whereas the wild-type allele of Tp53 invariably gained point mutations.

141 ne zipper (GILZ) is a rapidly, potently, and invariably GC-induced gene.

142 We find that asymmetric division invariably generates a basal self-renewing daughter and

143 rostate tumor xenografts, delta-catenin gene invariably gives rise to mutations, leading to sequence

144 As fatigue limits are invariably governed by the local arrest of microscopical

145 -cell ontogeny develop thymic lymphomas that invariably harbor a reciprocal translocation involving t

146 that colorectal cancer progression specimens invariably harbored lesions in elements of the RAS-RAF-M

147 The resulting tumours invariably harbour the Eml4-Alk inversion, express the E

148 Patients almost invariably have prominent extrapyramidal movement abnorm

149 The targets whose vulnerabilities are invariably high might be more universally acceptable tar

150 iological complexes, temperature effects are invariably important, and a similarly successful frictio

151 whereas combustion produces respirable smoke invariably in As(III) form and ash invariably as As(V).

152 Although consensus criteria will invariably include certain arbitrary features, an organi

153 to a clinically heterogeneous phenotype that invariably includes neurological dysfunction and early d

154 udy suggests that rising temperatures do not invariably increase CO2 emissions from aquatic ecosystem

155 We now know that IgE levels are invariably increased in patients affected by atopic cond

156 and helminth infection in particular almost invariably induces an allergic phenotype, rendering this

157 The results show that translation invariably initiates off the thylakoid membrane and that

158 singlet oxygen in solution-phase systems is invariably invoked when explaining the biological antiox

159 with symmetrical reactants, the trajectories invariably involve unequal bond formation in the transit

160 bserved following caecum implantation, which invariably involves peritoneal carcinomatosis.

161 n microscopy (TEM) can resolve nanowires but invariably lacks the facility for direct observation of

162 ver, largely relies on manual efforts, which invariably lag behind the increasingly automated generat

163 (i.e. hemispherectomies or hemispherotomies) invariably lead to contralateral hemiparesis.

164 Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional programs

165 DSB formation did not invariably lead to nucleosome dissolution, and in some c

166 Chemical inducers of ER stress invariably lead to pain behavior that is reversed by a c

167 ardiac electrophysiological alterations that invariably lead to premature aging and death.

168 regulation of cell cycle progression in HSCs invariably lead to the development of hematologic malign

169 ision clearly deviates from this rule, which invariably leads to asymmetric cell division.

170 can sometimes attenuate size variations, it invariably leads to higher-order moments growing unbound

171 nd positive changes in population size, this invariably leads to questions about whether favorable cl

172 o invade into normal brain parenchyma, which invariably leads to tumor recurrence and patient death.

173 ting duct cells, enhanced apical Na(+) entry invariably led to increased basolateral Na,K-ATPase expr

174 sential to successfully treating this almost invariably lethal disease.

175 fibrosis (IPF) is a common, progressive, and invariably lethal interstitial lung disease with no effe

176 entifying a clinical distinction between the invariably lethal prion disease Creutzfeldt-Jakob diseas

177 jor neurological symptoms, compared with the invariably lethal wild-type virus.

178 and other nonspecific therapies, and almost invariably lethal.

179 tients whose tumours harbour such alleles is invariably limited by innate or acquired drug resistance

180 rugs can produce dramatic responses that are invariably limited by the emergence of drug-resistant ce

181 Drug resistance invariably limits the clinical efficacy of targeted ther

182 trol of infection, and Sb's efficacy are not invariably linked expressions of the same T cell-depende

183 tional behaviour, and that such coherence is invariably linked to the development of ensemble represe

184 ng that PSEN1 FAD causing mutations generate invariably long Abeta and seed amyloid.

185 eneficial endosymbiotic lifestyle, it almost invariably loses a large fraction of its genome [1, 2].

186 a- and IFN-gamma-receptor-deficient mice had invariably lost antigen expression, suggesting that poor

187 of origin Sonic hedgehog (Shh) expression is invariably lost during progression to invasive urothelia

188 Post-extinction survival faunas are invariably low diversity, especially benthic communities

189 that heterogeneity in PI3K protein levels is invariably maintained in cell populations through a degr

190 In multiple sclerosis tissue, iron presence invariably matched with an increase in R(2)*.

191 Analysis of invariably methylated transposons and genes across this

192 ntreated tumors confirmed that C2 cells were invariably more abundant than C3 cells.

193 However, the natural cellular membrane is invariably more complex than the proteoliposomes most of

194 Invariably, mouse models of genetically manipulated circ

195 linical human cytomegalovirus (HCMV) strains invariably mutate when propagatedin vitro Mutations in g

196 s that prioritize investment across a region invariably navigate trade-offs among multiple objectives

197 ossible adverse effects, and adjustments are invariably needed along the way.

198 lasms, including 79 HCL-like disorders, were invariably negative for BRAF-V600E.

199 sh the viral genome hypermethylation that is invariably observed in asymptomatic, recovered tissues.

200 a member of the beta-herpesvirus family that invariably occupies hosts for life despite a consistent

201 that (i) accounts for intrinsic changes that invariably occur in the optical baseline of the EA-IOW d

202 ry FLT3-ITD(+) AML, but leukemia progression invariably occurs.

203 therapy in this setting; however, resistance invariably occurs.

204 erpreting clinical datasets in which signals invariably originate from hundreds to thousands of cells

205 It is shown that the likelihood estimator invariably outperforms the other estimators and metrics

206 Prostate tumors invariably overexpress prostate surface membrane antigen

207 We observed that dicentric chromosomes invariably persisted through mitosis and developed into

208 on malignant primary brain tumor, carries an invariably poor prognosis.

209 Sensitivity analyses show that results are invariably positive but sensitive to assumptions about t

210 Real networks invariably possess topological imperfections that negati

211 iviral therapy, the finding that IFN-lambda3 invariably possesses the highest activity among type III

212 Factor binding invariably potentiates chromatin accessibility.

213 matic colonization of the nasopharynx almost invariably precedes disease, the critical determinants e

214 )(4)-specific T cells, but graft destruction invariably predated their recruitment.

215 Whereas NBO analysis at the B3LYP DFT level invariably predicts a propargylic electronic structure,

216 SUB1C is invariably present and acts downstream of the enhancemen

217 regions are always affected, and lesions are invariably present in >/=3 areas.

218 These nephropathies invariably present with microscopic hematuria and freque

219 tations, +12, and subset 8 BCR configuration invariably primes CLL transformation into Richter syndro

220 ional GABs, filament elongation on a surface invariably proceeded with the same rate as with the VASP

221 r concentration of 0.1%, all the emulsifiers invariably produced stable nanodispersions with small pa

222 Unlike the invariably progressive deterioration of the disease, 8 m

223 Thus, the MD does not invariably project out into solution as in one structura

224 this effect, as A + T-rich sequence settings invariably provoke de novo DNA methylation leading to lo

225 resistant variants, which would explain the invariably rapid emergence of stem-like resistant cells.

226 mors with full penetrance and the tumors are invariably Rb1(-/-), modeling tumorigenesis by two-hit l

227 several potent proteins and lipids that are invariably recognized as foreign by immune system cells.

228 nce-specific interactions, these experiments invariably record a contribution due to proximity FRET,

229 hways, attachment of cargo molecules to CPPs invariably reduces their cellular uptake.

230 nomes, the top enriched function for each is invariably reflective of their very different medical hi

231 infection by EBV is often subclinical; this invariably reflects the necessity of the virus to preser

232 y unable to decode male courtship and almost invariably reject males.

233 Recurrent glioblastomas (rGBM) invariably relapse after initial response to anti-VEGF t

234 d treatment for metastatic PCa, but patients invariably relapse despite castrate androgen levels (cas

235 Mice invariably relapsed after treatment with drug-resistant

236 ntensive, twice-daily dasatinib therapy, but invariably relapsed with disseminated and/or central ner

237 Undisturbed sites invariably released modern DOC and POC (<20 years old),

238 hat the ceramic aragonite platelets in nacre invariably remain shielded from the propagating crack.

239 to human cells on an SV40-based episome were invariably repaired, this process induced mutations in f

240 r database, a decision that published papers invariably report but do not discuss.

241 While calpains are invariably reported to be exclusively intracellular (exc

242 tive cases, we demonstrate that relapsed AML invariably represents re-emergence or evolution of a fou

243 Previously developed methodologies invariably require activated, electronically engineered

244 These processes invariably require that reactivity be relayed from inter

245 king is more complex because patients almost invariably require valve replacement.

246 This activity invariably requires HBx binding to the cellular UV-damag

247 vation of PI3K mediated by p110beta does not invariably restore AKT phosphorylation, demonstrating th

248 icate this feat in artificial systems almost invariably result in bubble formation, except under high

249 This will invariably result in higher melt rates.

250 ever, alleviating growth inhibition does not invariably result in increased production.

251 enital disorders of ganglioside biosynthesis invariably result in intellectual disability and are oft

252 ted with autosomal recessive (AR) conditions invariably result in loss-of-function.

253 induced a change in membrane potential that invariably resulted in cellular senescence.

254 t a high concentration (10 microM), baclofen invariably resulted in hyperpolarization, at low concent

255 ions within the zinc finger region of ZBTB7A invariably resulted in loss of function.

256 inherent to the system being studied, which invariably results from the non-linear nature of biologi

257 subunit contacts by amino-acid substitutions invariably results in accelerated catalysis, slowed-down

258 Such rejection invariably results in allosensitization and accelerated

259 dministered, and therapy interruption almost invariably results in robust viral rebound.

260 mmation by any one of several methods almost invariably results in the prevention or delay of obesity

261 Unfortunately, interruption of ART almost invariably results in viral rebound, attributed to a poo

262 ies of the normally episomal HPV genome that invariably retain intact forms of the two HPV oncogenes

263 nsiently suppresses virus replication, which invariably returns to pre-treatment levels and results i

264 PRRT-induced myelosuppression is almost invariably reversible and rarely requires clinical measu

265 with decompensated cirrhosis, who are almost invariably sarcopenic.

266 circuit that may cause the AD-like pathology invariably seen in DS that could help to identify mechan

267 ts in the form of lung hypoplasia are almost invariably seen in patients with CDH and frequently in a

268 sRNAPs are highly conserved in evolution and invariably share a approximately 400 kDa five-subunit ca

269 efficacy in melanoma patients, response is, invariably, short lived.

270 a-modulated cells in ventral striatum almost invariably showed firing phase precession relative to th

271 ant:sensitive) ratio and the tolerant plants invariably showed normal grain filling.

272 ChR2-EYFP-expressing neurons almost invariably stained for tyrosine hydroxylase, identifying

273 olar fuel) through photocatalytic processes, invariably starts with photoinduced generation of energy

274 res, these viruses, once established, almost invariably stay one step ahead of the host's immune syst

275 We define how Hsp104(DeltaN) invariably stimulates Sup35 prionogenesis by fragmenting

276 with pancreatic ductal adenocarcinoma (PDAC) invariably succumb to metastatic disease, but the underl

277 op metastatic castration-resistant PC (CRPC) invariably succumb to the disease.

278 castration-resistant prostate cancer (CRPC) invariably succumb to the disease.

279 trast, single-molecule FRET (smFRET) studies invariably suggest that protein unfolded states contract

280 idence/models that support one theory almost invariably supports other theories as well.

281 s, hierarchical ordering and properties that invariably surpass those of their synthetic counterparts

282 r thyroid pole, the first nodal basin is not invariably the central compartment (as for primaries ari

283 Invariably, the rates of benzoic acid oxidation with dif

284 Invariably, this has required enzymatic incubation at 37

285 ription factors that reprogram cell fate are invariably those that are crucial for the initial cell p

286 the transcription start site and to produce invariably tight repression of all of the strong viral/m

287 t-onset neurodegenerative disease that leads invariably to fatal paralysis associated with motor neur

288 al connections, but their ultimate effect is invariably to minimize arterial PCO2 fluctuations.

289 New spacers are added invariably to the 5' end of the array; therefore, the fi

290 Colonies arising with STEMCCA-loxP were invariably TRA-1-60(+), yielding 5.3 +/- 2.8 iPSC coloni

291 erance of pathogenic autoreactive T cells is invariably triggered by recognition of the peptide-MHC c

292 enotype, whereas heat stress at 41 degrees C invariably triggers fulminant MH in Hom, but not Het, mi

293 ng resistance to MET oncogene-targeted drugs invariably underwent NRP2 loss, a step required for EGFR

294 ns of f-block chemistry, however, arenes are invariably used as solvents rather than ligands.

295 FITs are invariably used in a dichotomous manner using pre-specif

296 In addition, the term "lone AF" is not invariably useful in making treatment decisions, and oth

297 ulation sizes at the time of measurement are invariably very large and mutation rates are low.

298 e, and first thoracoabdominal metastases are invariably visible on abdominal images.

299 IgE sensitization started almost invariably with group A molecules and expanded sequentia

300 of different colloidal crystals, but almost invariably with the restriction that the particles must