ライフサイエンスコーパス: invariant NKT cell

1 nd an invariant T-cell receptor-alpha chain (invariant NKT cells).

2 ionally similar to mammalian CD1d-restricted invariant NKT cells.

3 features with both the gammadelta T and the invariant NKT cells.

4 y impaired in the intrathymic development of invariant NKT cells.

5 lls have an innate-like phenotype similar to invariant NKT cells.

6 te CD8(+) T cell pool and the development of invariant NKT cells.

7 y stimulated alpha-galactosylceramide-primed invariant NKT cells.

8 FN-alpha was at least partially dependent on invariant NKT cells.

9 those of conventional NK cells, T cells, and invariant NKT cells.

10 d for presentation of autoantigens to murine invariant NKT cells.

11 s have been silenced, are unable to activate invariant NKT cells.

12 D56(+) T cells, and small numbers of classic invariant NKT cells.

13 cytokine GM-CSF in the thymic development of invariant NKT cells, a role that licenses these cells to

14 e protective later during infection than the invariant NKT cell agonist alpha-galactosylceramide.

15 wo potent variants of the highly stimulatory invariant NKT cell agonist alpha-galactosylceramide.

16 that innate T cells such as CD1d-restricted invariant NKT cells all underwent a phase of intense int

17 In contrast to invariant NKT cells and MAIT cells, this population has

18 ein (SAP) is required for the development of invariant NKT cells and mediates signals from signaling

19 genic milieu through the interplay of Tregs, invariant NKT cells, and plasmacytoid dendritic cells, w

20 Moreover, CD1d tetramer staining shows that invariant NKT cells are activated in response to oral Sa

21 Although invariant NKT cells are also innate T cells, they are se

22 In this study we show that invariant NKT cells are also recruited to CCL22-expressi

23 V alpha 24+V beta 11+ invariant NKT cells are detectable in the blood and tumo

24 cellular mechanism by which IL-4(+)IL-13(+) invariant NKT cells are necessary for IL-4Ralpha signali

25 Invariant NKT cells are present in ACD, regardless of th

26 ciprocal interactions between CD8(+) DCs and invariant NKT cells are required for tolerance induction

27 Semi-invariant NKT cells are thymus-derived innate-like lymph

28 s, effector T cells, regulatory T cells, and invariant NKT cells, as well as its impact on immune dis

29 dentified within GBM were not canonical, or "invariant," NKT cells, as they demonstrated diverse TCR

30 reveal that CCR7 controls the development of invariant NKT cells by enabling their access to IL-15 tr

31 ructing the function of the immunoregulatory invariant NKT cells can affect tumor cell survival is no

32 Invariant NKT cell (CD3(+)Valpha24(+)) proportions were

33 an anti-Valpha24-Jalpha18 Ab, human primary invariant NKT cells could be divided into Valpha24 low-

34 ory T cell development and the completion of invariant NKT cell development.

35 Invariant NKT cells differentiate into three predominant

36 gesting that both Ag-specific CD4 T cell and invariant NKT cell effector responses to Salmonella-OVA

37 Hepatic invariant NKT cells expressed distinct proinflammatory c

38 To address this issue, we examined invariant NKT cells in Itk-/- and Itk/Rlk-/- mice.

39 Valpha24-invariant NKT cells inhibit tumor growth by targeting tu

40 Type I invariant NKT cells (iNKT cells) are a subset of alphabe

41 Invariant NKT cells (iNKT cells) are a unique subset of

42 Invariant NKT cells (iNKT cells) are innate lymphocytes

43 Invariant NKT cells (iNKT cells) are innate T lymphocyte

44 Invariant NKT cells (iNKT cells) have been reported to p

45 w that regulatory T cells (T(reg) cells) and invariant NKT cells (iNKT cells) perceived stronger TCR

46 Invariant NKT cells (iNKT cells) play a pivotal role in

47 Invariant NKT cells (iNKT cells) recognize CD1d/glycolip

48 Invariant NKT cells (iNKT) are potent immunoregulatory T

49 CD1d-reactive invariant NKT cells (iNKT) play a vital role in determin

50 populations of innate-like T cells including invariant NKT cells (iNKT), CD8alphaalphaTCRalphabeta sm

51 In recipients specifically lacking host invariant NKT cells (iNKTs), RLI did not induce an antit

52 We found not only that mice deficient in invariant NKT cells (Jalpha18(-/-)) had a marked attenua

53 In contrast, the skins of UVB-irradiated invariant NKT cell-knockout (Jalpha18(-/-)) and NKT cell

54 sistant to immunopathologies associated with invariant NKT cell-mediated hepatitis and colitis.

55 ate T cells such as gammadelta TCR(+) cells, invariant NKT cells, mucosal-associated invariant T cell

56 Tumor infiltration with Valpha24-invariant NKT cells (NKTs) associates with favorable out

57 tk and Rlk, leading to a 7-fold reduction in invariant NKT cell numbers in the thymus of Itk/Rlk-/- m

58 ant in this disease but does not involve the invariant NKT cell often associated with CD1d-restricted

59 dings suggest that the activation of hepatic invariant NKT cells plays a critical role in regulating

60 Innate T cells such as invariant NKT cells provide immediate immune defense, wh

61 became clear that this cell does not express invariant NKT cell receptors characteristic of most NKT

62 Invariant NKT cells respond to IL-1beta and IL-23 provid

63 gning therapeutic glycolipids for modulating invariant NKT cell responses.

64 Upon activation by alpha-GalCer, invariant NKT cells secrete multiple cytokines and confe

65 Similar to polyclonal T-CD4 T cells and also invariant NKT cells, T3 CD4 T cell development is contro

66 itic cells are more efficient in stimulating invariant NKT cells than untreated controls.

67 18-deficient mice, which lack only type 1 or invariant NKT cells, the increase in the numbers of lung

68 d on a subset with semi-invariant TCR termed invariant NKT cells, the majority of CD1d-restricted lip

69 nd that, as has been suggested for mammalian invariant NKT cells, they may serve as immune regulators

70 The expression of PLZF, the signature invariant NKT cell transcription factor, in these innate

71 Furthermore, increased numbers of invariant NKT cells were detected in Ly9-deficient thymi

72 Invariant NKT cells were identified in all the 10 skin b

73 bers of cotransferred gammadelta T cells and invariant NKT cells, whereas either cell type alone was

74 nd activation of a unique subset of T cells, invariant NKT cells, which express limited TCR diversity

75 largely absent in mice lacking CD1d-specific invariant NKT cells, with no effect on innate itk(-/-) C