ライフサイエンスコーパス: invasin

1 ggesting that this protein is an adhesin and invasin.

2 clones, suggesting that TibA also acts as an invasin.

3 ntly as a result of increased proteolysis of invasin.

4 ggesting that this protein is an adhesin and invasin.

5 ectly suggesting that Tia may also act as an invasin.

6 tegrin alpha7beta1 and the bacterial protein invasin.

7 ated by the bacterial outer membrane protein invasin.

8 ntained near wild type levels of adhesion to invasin.

9 ion from the autoagglutinin Hra1 and the Tia invasin.

10 n cells is mediated by the bacterial protein invasin.

11 ts in transcription of inv and production of invasin.

12 ), is a highly specific protease and adhesin/invasin.

13 characterized bacterial adhesins intimin and invasin.

14 e Ia strain O90R, suggesting that SCPB is an invasin.

15 ed by the presence of additional C. albicans invasins.

16 Mxi-Spa) and its cognate set of secreted Ipa invasins.

17 roteins, previously recognized as gonococcal invasins.

18 charged residues has been described in other invasins.

19 Soluble alpha 3 beta1 integrin also bound to invasin, a bacterial surface protein, that mediates entr

20 Invasin allows efficient entry into mammalian cells by Y

21 l proteinases Sap4 and Sap5 and the proposed invasin Als3.

22 Two invasins, Als3 and Ssa1, induce epithelial cell endocyto

23 ently invade Peyer's patches with the aid of invasin, an outer member protein involved in the attachm

24 A is a transcriptional activator of Yersinia invasin, an outer membrane protein involved in bacterial

25 ether, these results indicate that Tia is an invasin and adhesin that binds a specific receptor on HC

26 Tia, a close homolog of Hra1, is an invasin and adhesin that has been described in enterotox

27 the integrin-binding domain of the Yersinia invasin and C-type lectin families.

28 ins, such as the Yersinia pseudotuberculosis invasin and Escherichia coli intimin, are surface-expres

29 The integrin-binding surfaces of invasin and fibronectin include similarly located key re

30 The structures of invasin and fibronectin provide an example of convergent

31 Invasin and YadA are two of the most extensively studied

32 ion is interaction of the bacterial adhesins invasin and YadA with host cell beta1 integrin, we compa

33 r membrane localization of the C-terminus of invasin and, conversely, the N-terminal 489 amino acids

34 erculosis mutants deficient for the adhesins invasin and/or YadA were injected intravenously into BAL

35 We have isolated a complex of invasins and LPS from water-extractable antigens of viru

36 -rich repeat (LRR) motifs found in bacterial invasins and other members of the LRR protein family.

37 ype V secretion systems as well as adhesins, invasins, and hemolysins were identified.

38 shown that the C-terminal 192 amino acids of invasin are essential for binding of beta1 integrin rece

39 The mammalian receptors for invasin are five beta1 chain integrins.

40 ithelial and endothelial cells, adhesins and invasins are still unknown.

41 take, although the amount of surface-exposed invasin as well as the cell binding capacity of the reco

42 AmOmpA is both an adhesin and an invasin, as coating inert beads with it confers adhesive

43 o host cell receptors through trans-membrane invasins belonging to the thrombospondin-related anonymo

44 of attachment, which required high-affinity invasin-beta1 integrin association.

45 epiligrin, was only partially attenuated for invasin binding as well as invasin-mediated bacterial up

46 Yersinia pseudotuberculosis surface protein invasin binds to multiple beta1 integrins with high affi

47 ned that engagement of integrin receptors by invasin caused elevated levels of Rac1 self-association

48 Invasin completely displaced laminin-5 from the alpha 3

49 The Shigella invasin complex (Invaplex) is an effective mucosal vacci

50 ea pigs immunized intranasally with purified invasin complex (invaplex), without any additional adjuv

51 s not essential for Yersinia uptake, whereas invasin crucially triggers Rac1-mediated signals that en

52 An invasin-deficient mutant was significantly attenuated fo

53 d bacterial adherence to host cells, whereas invasin deletion had no effect.

54 spite the similarity of BipA to intimins and invasins, deletion of this protein from B. bronchiseptic

55 We report here invasin-dependent and invasin-independent mechanisms in

56 The invasin-dependent route is clearly discernible in mice d

57 inant-interfering effect of a non-functional invasin derivative are consistent with the presence of a

58 rminal-truncated Yersinia pseudotuberculosis invasin derivative.

59 ne were identified with gene fusions to this invasin derivative.

60 Mutants expressing defective invasin derivatives were unable to promote efficient tra

61 e internalization of latex beads coated with invasin derivatives, an additional domain of invasin was

62 er set) that amplifies a region spanning the invasin E and A genes of Salmonella enterica serovar Typ

63 ocess versus either E. coli cells expressing invasin(ent) or the invasin(pstb) derivatives deleted fo

64 Invasin(ent) was shown to be unable to promote self-inte

65 mpared to that of Y. enterocolitica invasin (invasin(ent)), which lacks the D2 self-association domai

66 gested that SCPB is one of several potential invasins essential for GBS colonization of damaged epith

67 d that both showed a significant decrease in invasin expression but are hypermotile when grown at 23

68 It was determined that E. coli sspA restored invasin expression in both the uvrC mutant and the sspA

69 Invasin expression inhibited colonization of the liver a

70 The 2.3 angstrom crystal structure of the invasin extracellular region reveals five domains that f

71 (Ilp), similar to the Gram-negative intimin/invasin family of surface proteins.

72 Ail, an outer membrane adhesin/invasin from Yersinia enterocolitica, was detected in pu

73 We have characterized invasin from Yersinia pseudotuburculosis as an output mo

74 of Salmonella enterica regulator HilA and of invasin from Yersinia spp., yet previous publications su

75 ed proteins that are similar to adhesins and invasins from prokaryotic and eukaryotic pathogens (Esch

76 Transfer of the Yersinia pseudotuberculosis invasin gene into E.coli DH10B asd(-) rendered it compet

77 nscribe shRNAs from a plasmid containing the invasin gene Inv and the listeriolysin O gene HlyA, whic

78 f hilA-homologue eilA and predicted Yersinia invasin homologue gene eaeX.

79 FadA is a unique bacterial adhesin/invasin in that it utilizes its own two forms for both s

80 ons and may serve as an important adhesin or invasin in ulcerative keratitis caused by S. aureus.

81 The unique presence of CotH invasins in all invasive Mucorales, and the correlation

82 EG7, binding affinity for both laminin-5 and invasin increased by about 10-fold, whereas the affinity

83 vealing an alternate uptake pathway that was invasin independent.

84 We report here invasin-dependent and invasin-independent mechanisms in which the enteropathog

85 and Gly-163 are not critical for adhesion to invasin, indicating that laminin-5 and invasin may use d

86 s a novel member of the virulence-associated invasin/intimin family (IIF) of Gram-negative bacteria.

87 pe III secretion apparatus (TTSA) to deliver invasins into human cells.

88 ssembly, respectively, map downstream of the invasin (inv) gene but are transcribed in the opposite (

89 and enterohaemorrhagic Escherichia coli and invasin (Inv) of Yersinia spp.

90 regulates expression of the invasion factor invasin (inv), which mediates translocation across the i

91 on receptors detecting the bacterial adhesin invasin (Inv).

92 )) was compared to that of Y. enterocolitica invasin (invasin(ent)), which lacks the D2 self-associat

93 cer region is a domain called D2 that allows invasin-invasin interaction.

94 The invasin IpaA is essential for S. flexneri pathogenesis a

95 SipB functions as an analog of the Shigella invasin IpaB.

96 ed N-terminal to the cell adhesion domain of invasin is able to self-associate.

97 Although the C. albicans Als3 invasin is critical for invasion and damage of endotheli

98 Invasin is encoded by inv, which is positively regulated

99 due superdomain of the Y. pseudotuberculosis invasin is necessary and sufficient for integrin recogni

100 Invasin is the primary invasion factor encoded by the in

101 invasion factor of Yersinia enterocolitica, invasin, is encoded by inv.

102 e DraD subunit, previously implicated as an "invasin," is not required for beta(1) integrin recruitme

103 Mg2+, alpha 3 beta 1's binding affinity for invasin (Kd = 3.1 nM) was substantially greater than its

104 There is also a significant decrease in invasin levels in bacteria recovered from mice infected

105 , a clpB null mutant, BY1v, had no effect on invasin levels or motility.

106 However, invasin levels were reduced for strains that harbored fl

107 ica mutant (JB1A8v) that shows a decrease in invasin levels yet is hypermotile when grown at 23 degre

108 ion but did not have a significant effect on invasin levels.

109 obile elements, encode predicted adhesin and invasin-like functions, and are required for full virule

110 9,042-bp chromosomal gene (YPO3944), intimin/invasin-like protein (Ilp), similar to the Gram-negative

111 Invasin may cluster integrin heterodimers extracellularl

112 on to invasin, indicating that laminin-5 and invasin may use different recognition mechanisms, and th

113 The signals linking invasin-mediated adhesion to Rac1 activation are not cle

114 but did not require YopD, pore formation or invasin-mediated adhesion.

115 RhoG significantly reduced the efficiency of invasin-mediated bacterial internalization.

116 ly attenuated for invasin binding as well as invasin-mediated bacterial uptake.

117 Invasin-mediated invasion of host cells by the pathogen

118 Invasin-mediated uptake requires high affinity binding o

119 uirement for focal adhesion kinase (FAK) for invasin-mediated uptake.

120 vasin self-interaction for the efficiency of invasin-mediated uptake.

121 le of a HAD family phosphatase and reveal an invasin of an important periodontal pathogen.

122 interaction that is also seen with the IpaA invasin of the intracellular pathogen Shigella, where bi

123 Recent studies indicate that FimH is the invasin of UPEC as its attachment to the urothelial surf

124 omain of Clostridium acetobutylicum, and the invasin of Yersinia pestis.

125 elial cells and lacks the major adhesins and invasins of its enteropathogenic relatives Yersinia ente

126 extended regions, homologous to adhesins or invasins of the immunoglobulin superfamily.

127 n epithelial cells and the inv gene product (invasin) on the surface of Yersinia pseudotuberculosis.

128 Attachment to host cells via invasin or YadA is necessary for the cell death phenotyp

129 ologous protein, Yersinia pseudotuberculosis invasin, or to maltose-binding protein.

130 an example of convergent evolution, in which invasin presents an optimized surface for integrin bindi

131 of six alanine substitutions in a region of invasin previously shown to be important for bacterial i

132 onstructed and determined to be deficient in invasin production and nonmotile when grown at 23 degree

133 plicated in cell adhesion, was competent for invasin-promoted adhesion events and appeared to encode

134 argeted Rac1 derivative restored significant invasin-promoted bacterial uptake in a PBR-dependent man

135 ge factors specificity switch mutant blocked invasin-promoted uptake as well as Cdc42-dependent uptak

136 with the proposition that Rac1(W56F) blocks invasin-promoted uptake by preventing RhoGDI from inacti

137 for interaction, is necessary for efficient invasin-promoted uptake of Yersinia pseudotuberculosis b

138 ng the involvement of a Src-family kinase in invasin-promoted uptake.

139 further examined the role of this region in invasin-promoted uptake.

140 Disruption in each case impaired invasin-promoted uptake.

141 uption of this cross-talk can interfere with invasin-promoted uptake.

142 mbrane protein A, another A. phagocytophilum invasin, pronouncedly reduced infection relative to trea

143 entry mediated by the Y. pseudotuberculosis invasin protein (invasin(pstb)) was compared to that of

144 cognition of the Yersinia pseudotuberculosis invasin protein and natural substrates requires identica

145 or escape from vacuoles and synthesizing the invasin protein from Yersinia pseudotuberculosis to enha

146 n, we have demonstrated that a region of the invasin protein located N-terminal to the cell adhesion

147 work demonstrated that AdpC is an important invasin protein of P. intermedia 17.

148 Like inv, the gene encoding the invasin protein of Y. enterocolitica, hreP is located in

149 The gene encoding the outer membrane adhesin/invasin protein OpcA was previously described in the gen

150 The Yersinia pseudotuberculosis invasin protein promotes bacterial entry by binding to h

151 The Yersinia pseudotuberculosis invasin protein promotes bacterial uptake into normally

152 is strain that expressed an uptake-defective invasin protein retaining considerable receptor binding

153 cells requires the binding of the bacterial invasin protein to beta1 integrin receptors and the acti

154 , p40, reveal similarities to the needle-tip invasin proteins SipD and IpaD of Gram-negative bacteria

155 sative agent of bacillary dysentery, injects invasin proteins through a type III secretion apparatus

156 eudotuberculosis and Yersinia enterocolitica invasin proteins to beta(1) integrin receptors allows in

157 king studies of purified and surface-exposed invasin proteins, and the dominant-interfering effect of

158 significantly less proficient than wild-type invasin(pstb) at promoting uptake, although the amount o

159 E. coli cells expressing invasin(ent) or the invasin(pstb) derivatives deleted for D2, further demons

160 assays showed that E. coli cells expressing invasin(pstb) had a significant advantage in the interna

161 rame deletion mutations that removed D2 from invasin(pstb) were significantly less proficient than wi

162 y the Y. pseudotuberculosis invasin protein (invasin(pstb)) was compared to that of Y. enterocolitica

163 olitica and upregulates the expression of an invasin (Rck) and a putative T3SS effector (SrgE).

164 t cell contact-induced secretion of a set of invasins, referred to as Ipas.

165 A 51-aa-long invasin region in the AipA passenger domain was required

166 omprises a silent chaperone gene, usher, and invasin reminiscent of Dr family fimbrial clusters.

167 hereas one strain, mutated the gene encoding invasin, replicated as well as wild-type bacteria in the

168 the presence of an undefined adhesin(s) and invasin(s).

169 D2, further demonstrating the importance of invasin self-interaction for the efficiency of invasin-m

170 domain of lambda repressor as a reporter for invasin self-interaction, we have demonstrated that a re

171 containing multiple alanine substitutions in invasin showed uptake defects that were additive, with t

172 Inv-Spa type III secretion apparatus target invasin SipB is necessary and sufficient for the inducti

173 etion system, as well as strains lacking the invasins SipB, SipC, and SipD, were impaired in iNOS ind

174 f Escherichia coli engineered to express the invasin surface receptor from Yersinia, which enables up

175 domain that is located within the region of invasin that enhances bacterial uptake.

176 Thus, A. fumigatus CalA is an invasin that interacts with integrin alpha5beta1 on host

177 ha C protein (ACP) has been identified as an invasin that plays a role in internalization and translo

178 ta indicate that CotH3 and CotH2 function as invasins that interact with host cell GRP78 to mediate p

179 anscription factors, regulates expression of invasin, the major adhesion and invasion factor in Yersi

180 mediated by a set of translocated bacterial invasins, the Ipa proteins, and its dedicated type III s

181 cation binding domains depressed adhesion to invasin to a significant extent.

182 ls is the result of high-affinity binding of invasin to beta1 chain integrins.

183 ion, D811A, resulted in depressed ability of invasin to bind purified alpha5beta1 and to promote bact

184 ted uptake requires high affinity binding of invasin to multiple beta1 chain integrin receptors on th

185 he 192-amino acid integrin binding domain of invasin was performed to identify regions, in addition t

186 invasin derivatives, an additional domain of invasin was shown to be required for efficient bacterial

187 onversely, the N-terminal 489 amino acids of invasin were sufficient to promote the localization of t

188 experiments indicated that all three of the invasins were required for induction of iNOS expression.

189 ivated in response to integrin engagement by invasin, whereas Rac1 and Arp 2/3 were found to be inten

190 inv gene encodes the primary invasion factor invasin, which has been previously shown to be critical

191 inv encodes invasin, which is the primary invasion factor of Yersini

192 Enteropathogenic Yersinia species encode invasin, which promotes uptake into host cells by bindin

193 be mediated primarily by the interaction of invasin with cell surface beta1 integrins.

194 conclude that interaction of homomultimeric invasin with multiple integrins establishes tight adhere

195 ersinia pestis strains examined, the adhesin/invasin yadA gene is a pseudogene, yet Y. pestis is inva

196 To this end, mutants defective for invasin, YadA, or pH 6 antigen were tested for movement