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1 ction, followed by concomitant treatment, is investigational.
2 s with advanced biliary tract cancer remains investigational.
3 controversial and in general, should remain investigational.
4 e of antiangiogenic therapy in mCRPC remains investigational.
5 ic treatment of nongastric lymphomas remains investigational.
7 ple size requirements for clinical trials of investigational AD-modifying therapies, and provide stra
9 nhibitor-free protocol inclusive of a single investigational agent for use in clinical islet transpla
11 ce, selective p110alpha inhibition using the investigational agent MLN1117 (previously known as INK11
13 Within a backup program for the clinical investigational agent pretomanid (PA-824), scaffold hopp
14 to Zaire ebolavirus in West Africa received investigational agent rVSV-ZEBOV or TKM-100802 for poste
15 nsent in this placebo-controlled trial of an investigational agent was high and exceeded acceptance a
16 comes confirmed clinician reporting that the investigational agent was well tolerated and, in subgrou
20 suppression with use of better-tolerated and investigational agents for unfit patients and those with
21 of the disease have opened the door to study investigational agents that target disrupted molecular p
24 on of 304 inhibitors, including approved and investigational agents, comparing ex vivo responses of p
25 eceived uncontrolled treatment with multiple investigational agents, including convalescent plasma, w
28 low minimum inhibitory concentrations of an investigational aminoglycoside, belonged to multi-locus
30 ty preservation methods should be considered investigational and should be performed by providers wit
31 ets, is important for planning and analyzing investigational and therapeutic interventions in many bi
36 sted the hypothesis that encapsulation of an investigational anti-PAH molecule fasudil (HA-1077), a R
38 evaluating the addition of iniparib, a novel investigational anticancer agent that does not possess c
39 for estimating the maximum tolerated dose of investigational anticancer agents is based on the cytoto
45 n-spine interface have all been approved for investigational applications in similar human research,
46 at can be used for a variety of clinical and investigational applications not previously possible.
50 igm relies on randomized comparisons between investigational arms and control arms, as historical con
51 ) to arthroscopic subacromial decompression, investigational arthroscopy only, or no treatment (atten
52 hat have been used to date, and consider new investigational avenues that might accelerate clinically
54 n B-precursor ALL and can be targeted by the investigational bispecific T cell-engager antibody blina
55 Ancillary radiologic and genomic tests are investigational but may have a role in patients with dis
56 how the inclusion of children in early-phase investigational cancer drug trials might be accomplished
57 setting also facilitates the examination of investigational cancer therapies, including new immunoth
58 ed 2 vaccine doses (days 0 and 21) of either investigational CC-H5N1 vaccine (1.9 microg or 3.75 micr
59 developed resistance to vicriviroc (VCV), an investigational CCR5 antagonist, during 28 weeks of ther
61 cebo-controlled, parallel-group trial at 106 investigational centres in the Americas, Australia, Euro
62 ed combination treatment with lumacaftor, an investigational CFTR corrector that increases traffickin
64 lerosis, provide an overview of clinical and investigational characteristics of each disorder, and pr
65 tment, i.e., the gold salt auranofin and the investigational chemotherapeutic agent buthionione sulfo
66 ted to the nine clinical trials in which the investigational chemotherapeutic arm demonstrated benefi
71 text of, but not in the path of, routine and investigational clinical care for purposes of enabling d
72 ration epiretinal prosthesis approved for an investigational clinical trial by the United States Food
73 activism, clinical trial infrastructure, and investigational clinical trial designs as well as coordi
76 -CFTR cellular stability and the efficacy of investigational correctors, including 3-(6-[([1-(2,2-dif
79 t-of-care tests, efficacy of recommended and investigational CT infection treatments, and timing of t
80 ed in previous studies of one or more Gilead investigational DAAs in combination with RBV with or wit
81 rus infections with available (ribavirin) or investigational (DAS181) antiviral agents still needs to
82 aemic men (BMI 25-35 kg/m(2)) underwent four investigational days, during which SCFA mixtures (200 mm
92 ological response (SVR) after treatment with investigational direct-acting antiviral agents (DAAs) ha
94 assess the safety and immunogenicity of two investigational DNA vaccines, one (EBO vaccine) encoding
95 research on adherence to placebo-controlled investigational drug by way of drug detection in active-
96 ne-3-carboxamide (VX-770, 48, ivacaftor), an investigational drug candidate approved by the FDA for t
97 asma concentration-time results of NVP-1, an investigational drug candidate, observed in the plasma s
101 Task Force of the National Cancer Institute Investigational Drug Steering Committee convened an inte
102 atitis C immunoglobulin (HCIG) Civacir is an investigational drug that is currently being developed i
103 an hepatitis C immune globulin Civacir is an investigational drug that is currently being developed i
104 ity defect can be partially corrected by the investigational drug VX-809 (3-[6-[[[1-(2,2-difluoro-1,3
105 at several of these compounds, including the investigational drug VX-809, caused a much greater incre
109 nd some of the limitations of this important investigational drug, these findings clearly demonstrate
112 s new "breakthrough therapy" designation for investigational drugs adds to the agency's portfolio of
114 his challenge by testing 128 FDA-approved or investigational drugs as either single agents or in 768
115 atory scrutiny that affects manufacturers of investigational drugs for early-phase clinical trials en
116 r (VEGF) therapy and ionizing radiation, and investigational drugs that address different targets alo
117 ents, has led to the clinical development of investigational drugs that restore function to defective
118 leading drug candidates, several designated investigational drugs, and some medical devices, as well
119 ng to abandonment of potentially efficacious investigational drugs, and unexpected deadly adverse eve
120 F-FDG PET for guiding the selection of novel investigational drugs, choosing dose in early-phase clin
121 ating agents (HMAs), lenalidomide (LEN), and investigational drugs, may be used after ESA failure in
126 a rationale for increased basic and clinical investigational efforts to further understand Lp(a) path
127 in 4 ml (n = 73) or placebo (n = 80) via an investigational eFlow nebulizer every 12 hours for 6 mon
128 hese data establish that sebelipase alfa, an investigational enzyme replacement, in patients with CES
129 for reversing the effects of dabigatran, the investigational factor Xa decoy andexanet alfa, and the
132 nt years, there has been a shift in clinical investigational focus toward refinements in the methods
133 Chan et al. describe a novel way by which an investigational form of chemotherapy known as low-dose m
142 resistance to AC220 (quizartinib), an active investigational inhibitor of FLT3, KIT, PDGFRA, PDGFRB a
143 itor amprenavir (1) and two potent antiviral investigational inhibitors GRL-02031 (2) and GRL-0519 (3
145 A(H1N1)pdm09 (pH1N1) pandemic, peramivir, an investigational intravenous neuraminidase inhibitor, was
146 e efficacy of our approach, we evaluated the investigational JAK2 inhibitor fedratinib (FED) in 64 pa
148 xtraction, fecal specimens were processed by investigational lysis/heating (i.e., manual) and by chro
152 re, we evaluated bevacizumab and CRLX101, an investigational nanoparticle-drug conjugate containing c
153 tudy, we assessed the ability of CRLX101, an investigational nanoparticle-drug conjugate containing t
155 ations in the lymphatic system, we performed investigational near-infrared fluorescence lymphatic ima
156 are currently being studied clinically under investigational new drug (IND) applications submitted to
157 prescribers of FMT must possess an approved investigational new drug (IND) permit to administer FMT
159 s, as it promotes confidence in their use in Investigational New Drug and New Drug Application filing
161 Imaging was performed under a physician's Investigational New Drug application from the Food and D
163 the US Food and Drug Administration granted investigational new drug approval for the first phase 2A
166 eview of eligibility criteria for commercial investigational new drug clinical trial applications sub
167 ional review board, informed consent, and an Investigational New Drug Exemption, six healthy voluntee
168 and led to the selection of LFF571 (4) as an investigational new drug for treating C. difficile infec
172 e desirable.OBSERVATIONS A compassionate-use investigational new drug protocol was approved to admini
173 trol specifications were established to meet investigational new drug submission and institutional re
175 At the time of the meetings, there were no investigational new drugs (INDs) in place for the candid
177 tribution of the individual components of an investigational non-beta-antagonist fixed combination of
178 genic HPV16/18/31/33/45/52/58 targeted by an investigational nonavalent HPV vaccine ranged from 39% t
179 oral avatrombopag (2.5, 5, 10, or 20 mg), an investigational nonpeptide TPO-RA active in humans, or p
181 s of this review are to discuss standard and investigational nontransplant treatment strategies for a
182 NAi therapeutics as well as other classes of investigational oligonucleotide therapeutics to the live
184 r FDA-directed human testing and approval of investigational optical imaging devices as well as contr
185 pose To compare the diagnostic utility of an investigational optoacoustic imaging device that fuses l
193 re used to model amyloid deposition with the investigational PET imaging agent (18)F-flutemetamol.
195 six, and only the study statistician and the investigational pharmacy had the preset randomisation as
197 vel framework for physiology programs and an investigational platform for physiologists to study func
199 nically well-tolerated, orally bioavailable, investigational prodrug that delivers to the brain BCI-6
200 nteers began a thrice-daily, 7-day course of investigational product administered in sodium bicarbona
201 d patients who received at least one dose of investigational product and completed at least one post-
202 Of 168 patients randomized, 167 received investigational product and were included in the full an
203 s in the bromfenac group (3.2%) discontinued investigational product early because of a lack of effic
204 rticipants who received at least one dose of investigational product in FREEDOM or the extension were
205 ized subjects receiving one or more doses of investigational product using last-observation-carried-f
206 vents (AEs) at least possibly related to the investigational product were classified by the investiga
207 g treatment or missing more than one dose of investigational product were eligible to enrol in the op
209 nteractive response system to a double-blind investigational product, and stratified by previous expo
210 rticipants who received at least one dose of investigational product, whereas the efficacy analyses i
215 p shorter-term end points for trials testing investigational products or regimens for second-line sys
217 rols, establishing the noninferiority of the investigational pump (P<0.001; 15% noninferiority margin
223 We compared the performance of two automated investigational/research use only (IUO/RUO) NAATs for th
226 t, we discuss the development of ALN-GO1, an investigational RNA interference (RNAi) therapeutic targ
228 our results suggest that phase II obatoclax, investigational SaliPhe, and FDA/EMEA-approved gemcitabi
232 Feb 12 and July 30, 2010, 173 patients at 43 investigational sites in 12 countries were enrolled into
235 c medical disorders, were enrolled from four investigational sites in Colombia, Dominican Republic, G
245 high-risk subset who should be targeted for investigational strategies other than standard ASCT.
246 ts the causes underlying such deaths and the investigational strategies that identify surviving famil
249 sive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescen
251 management decisions and the development of investigational therapeutics are informed by an improved
253 empirical antibiotics; and 23 (85%) received investigational therapies (19 [70%] received at least tw
254 bility to determine the potential benefit of investigational therapies and the effect of patient-spec
257 l trials are needed to delineate the role of investigational therapies in the care of patients with E
258 gnaling are reviewed along with an update on investigational therapies that use this pathway to rever
260 onsultation, options for standard as well as investigational therapies were discussed, and HLA typing
261 cting patient safety, facilitating access to investigational therapies, and ensuring trial integrity.
262 e relative contributions of supportive care, investigational therapies, and patient's immune-response
263 an papillomavirus-negative HNSCC, as well as investigational therapies, such as hypoxia modification,
269 anut oral immunotherapy (OIT) is a promising investigational therapy, its potential is limited by sub
270 consent for a trial but before receiving the investigational therapy, participants answered questions
271 ted virus vectors also represent outstanding investigational tools to explore the function of individ
272 d at least one (partial or complete) dose of investigational treatment and who did not have any major
273 via a chimeric antigen receptor (CAR) is an investigational treatment capable of inducing complete t
275 ave efficacy as an off-the-shelf therapy for investigational treatment of B-lineage malignancies.
280 e include evolving treatment strategies, new investigational treatments, and earlier implementation o
281 treatment options and treatment strategies, investigational treatments, and the importance of exerci
283 uture peripheral artery disease cell therapy investigational trial design may be informed by new anat
284 ir with the MitraClip device in multicenter, investigational trials were included in this study.
285 ed, observer-blind single-centre study of an investigational trivalent GBS vaccine in healthy non-pre
286 oped tuberculosis in a phase III trial of an investigational tuberculosis vaccine, greater baseline I
288 n, we review clinical results reflecting the investigational use of CD19-targeted CAR T-cell therapeu
290 blood culture (BC-GP) nucleic acid test for investigational use only (Nanosphere, Inc., Northbrook,
291 , including 2 FDA-cleared assays, 1 test for investigational use only, and 1 laboratory-developed tes
292 intended to give an overview of the current investigational uses of OCT and its potential roles as t
293 g, 2.5 mug, or 5.0 mug of the non-adjuvanted investigational vaccine (for each serotype), or placebo.
294 were randomly assigned (2:1) to receive the investigational vaccine (two injections, 1 month apart,
295 of HSV-1- and HSV-2-seronegative women, the investigational vaccine was effective in preventing HSV-
297 nths 0, 1, and 6, some subjects received the investigational vaccine, consisting of 20 mug of glycopr
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