ライフサイエンスコーパス: involution

1 erate systemic GR-effect, assessed as thymic involution.

2 enitor cells underlies the process of thymic involution.

3 erative potential of cTECs to counter thymic involution.

4 ne of cTECs is a prominent feature of thymic involution.

5 I dose, accelerating aging-associated thymic involution.

6 death during normal postpartum mammary gland involution.

7 sfunction postpartum resulting in precocious involution.

8 nflammatory drugs (NSAIDs) during postpartum involution.

9 ally declines by puberty, a result of thymic involution.

10 of mTORC1 in adult mice caused severe thymic involution.

11 ing downregulated during lactation and early involution.

12 cytokines IL-4 and IL-13 also peaked during involution.

13 central tolerance that occur owing to thymic involution.

14 sue expansion in pregnancy and regression in involution.

15 al cells during the onset of postlactational involution.

16 diversity by accelerating age-related thymic involution.

17 cell generation by inducing premature thymic involution.

18 eriods including puberty and postlactational involution.

19 aired and EZH2 overexpression caused delayed involution.

20 uption marks an early stage of mammary gland involution.

21 de, can partially reverse age-related thymic involution.

22 cteristic sequence of growth and spontaneous involution.

23 during aging contribute to the mechanism of involution.

24 ice displayed enhanced age-associated thymic involution.

25 ance of apoptotic cells during mammary gland involution.

26 environment during pregnancy, lactation, and involution.

27 e with age is largely attributable to thymic involution.

28 plantation tolerance after the age of thymic involution.

29 ting the epithelial movements of epiboly and involution.

30 well as their requirement for embryonic head involution.

31 mmary gland during pregnancy, lactation, and involution.

32 leading to the appearance of nevi and their involution.

33 s nor in recipients beyond the age of thymic involution.

34 le to protect the thymus from stress-induced involution.

35 ent inability to release milk, and premature involution.

36 cleaved form of TWEAK is upregulated during involution.

37 th mammary glands undergoing weaning-induced involution.

38 odulating Stat3 activity before the onset of involution.

39 ndent rise in p21Waf1 levels around day 3 of involution.

40 AK1 target genes that are upregulated during involution.

41 ir synergistic physiological roles in normal involution.

42 terminal endbuds and during postlactational involution.

43 ithelial cells at the onset of mammary gland involution.

44 ls accumulate within the HVS and prevent its involution.

45 ld-type) glands at days 6, 17 and 4 weeks of involution.

46 gone two cycles of pregnancy, lactation, and involution.

47 8 had normal mammary gland development until involution.

48 s decreases, roughly correlating with thymic involution.

49 mice, and, subsequently, produced a delayed involution.

50 ultiparous glands to undergo postlactational involution.

51 female mice during pregnancy, lactation and involution.

52 f the progeny and is followed by a period of involution.

53 and Zn in lysosomes and activated premature involution.

54 stologic and biochemical signs of precocious involution.

55 response to a full pregnancy, lactation and involution.

56 a, a well-characterized regulator of mammary involution.

57 gulated during weaning-induced mammary gland involution.

58 nent of the mechanism regulating age-related involution.

59 growth phases and do not undergo spontaneous involution.

60 hannels; 1 showed advanced fibrotic vascular involution.

61 volume is important in assessing growth and involution.

62 lliparous, mid gestation, lactation and post involution.

63 ptosis normally initiated by oncoprotein and involution.

64 is that it undergoes profound age-associated involution.

65 l growth and discuss their automorphisms and involutions.

66 romal wound-healing events during postpartum involution, a dynamic process characterized by widesprea

67 these individuals, who are well into thymic involution, a substantial number of clonotypes were stab

68 osis of cells in the distal region and gland involution after androgen withdrawal.

69 /503 as an important regulator of epithelial involution after pregnancy.

70 an important regulator of mammary epithelial involution after pregnancy.

71 during pregnancy, and delayed mammary gland involution after weaning.

72 Activation of MDM2 delayed mammary gland involution and accelerated tumor progression in mouse ma

73 ion between the processes of postlactational involution and breast tumorigenesis in Snai2-null mutant

74 Rapid involution and contraction of neovascular tissue adheren

75 Thus, the RB family promotes thymic involution and controls T cell production via a bone mar

76 No association was seen between involution and dense area (P trend = .56).

77 We examined the involution and density association in a large benign bre

78 to understand the mechanisms driving thymic involution and homeostatic processes across the lifespan

79 Lack of Mkl1 causes premature involution and impairs expression of Srf-dependent genes

80 KMT2D deficiency also delays germinal center involution and impedes B cell differentiation and class

81 as a critical mediator of cell death during involution and importantly, that as an initial involutio

82 ated the mechanisms underlying the choroidal involution and its long-term impact on retinal function.

83 loss of Mnt severely disrupts mammary gland involution and leads to hyperplastic ducts associated wi

84 nt > or = 380 days), and correlated with the involution and loss of Tg skin grafts.

85 ine mammary epithelium, resulting in delayed involution and lower levels of apoptosis in the STAT3 nu

86 t evidence of an inverse association between involution and mammographic density.

87 that promotes apoptosis during mammary gland involution and p53-independent apoptosis.

88 dy, there was an inverse association between involution and PD (mean PD, 22.4%, 21.6%, 17.2%, for no,

89 derm within the DMZ, which is independent of involution and prior to the formation of the dorsal blas

90 through cycles of proliferation, branching, involution and remodeling.

91 b family genes in young mice prevents thymic involution and results in an enlarged thymus competent f

92 ptotic epithelial cells during mammary gland involution and that the absence of Mfge8 leads to inflam

93 In inbred mouse strains the rate of thymic involution and the function of the hematopoietic stem ce

94 cumulation of Dab2 correlated with prominent involution and the loss of normal positioning of the int

95 ken together, these findings identify thymic involution and the persistent activation of autoreactive

96 Thymic involution and the subsequent amplified release of autor

97 thymic physiology and age-associated thymic involution and their potential use in the restoration of

98 left by infantile hemangiomas after natural involution and to identify clinical characteristics that

99 Periglacial involutions and modest geochemical differentiation of th

100 otent luminal stem cells survive consecutive involutions and retain their identity throughout adult l

101 nal movements of cells that include epiboly, involution, and convergence and extension (C&E).

102 nd proteolysis increased dramatically during involution, and denatured collagen I acted as a strong c

103 diated regeneration after castration-induced involution, and depleted smooth muscle cells are mainly

104 nderstanding of mechanisms that drive thymic involution, and develop safe and effective strategies to

105 in mammary epithelial cell proliferation and involution, and provide the first in vivo evidence of a

106 ous mechanical stresses attributable to head involution, another developmental process that occurs co

107 Mammographic density and lobular involution are both significant risk factors for breast

108 model in which thymic growth and subsequent involution are driven by cell-intrinsic changes in the p

109 namics of clonal emergence, persistence, and involution are sufficiently complex that in the individu

110 The mechanisms regulating thymic involution are unclear.

111 breast cancer that identifies mammary gland involution as a driving force of tumor progression.

112 R(+) macrophages resulted in delayed mammary involution as evidenced by loss of lysosomal-mediated an

113 the collagen fibrillogenesis associated with involution, as well as tumor growth and tumor cell infil

114 Chronic thymus involution associated with aging results in less efficie

115 hat PMCA2 is down-regulated early in mammary involution associated with changes in MEC shape.

116 in pre-established tumors caused rapid tumor involution associated with pervasive morphological chang

117 vity can be a strategy for preventing thymic involution/atrophy.

118 Following pregnancy and involution, beta Gal+ mammary epithelial cells were foun

119 ll shape change drives epithelial cell sheet involution between the oocyte and nurse cell complex whi

120 hibited apoptosis and delayed prostate tumor involution both in phosphatase and tensin homolog-defici

121 ndent mammary tumors that regress upon gland involution but progress to nonregressing, invasive adeno

122 i and regress on initiation of mammary gland involution, but eventually appear to progress in subsequ

123 grity, and sustained 5-HT7 activation drives involution by disrupting tight junctions.

124 zed, prospective data have shown that thymic involution can be pharmacologically reversed in humans,

125 h phase (anagen) to a rapid apoptosis-driven involution (catagen) and finally a relative quiescent ph

126 ated cycles of active regeneration (anagen), involution (catagen), and relative quiescence (telogen).

127 s repeatedly interrupted by apoptosis-driven involution (catagen).

128 t postpartum breast tissue remodeling during involution coincides with inflammatory lymphangiogenesis

129 in ductal branching and abnormal age-related involution compared to littermate controls.

130 r cells, and failed to undergo age-dependent involution compared with wild-type animals.

131 ophages during weaning-induced mammary gland involution, conditional systemic deletion of macrophages

132 that genetic variation in the rate of thymic involution correlates with genetic variation in the resp

133 F4/80 were examined across the pregnancy and involution cycle in rodent and human mammary tissues.

134 e hair follicles go through regeneration and involution cycles.

135 d several aging phenotypes, including thymic involution, decreased production of naive T cells, reduc

136 und this mutation to be a new allele of head involution defective (hid) and showed that hid expressio

137 geted expression of the cell death gene head involution defective (hid) in combination with cryGal80

138 can suppress the apoptotic activity of Head involution defective (Hid) in the developing eye.

139 cade that converges on reaper (rpr) and head involution defective (hid) induction, resulting in caspa

140 ed repression of the pro-apoptotic gene head involution defective (hid) is required to maintain a bal

141 s on the IAP antagonists, Reaper (Rpr), Head involution defective (Hid), and Grim.

142 the proapoptotic genes reaper (rpr) and head involution defective (hid), which are directly regulated

143 rently, the larval cells in Tr2 undergo head involution defective (hid)-dependent programmed cell dea

144 of cell death produced by a heat shock-head involution defective (hs-hid) transgene, the inhibition

145 increased apoptosis is mediated by the head involution defective (Wrinkled) gene product.

146 subsequent ecdysone-induced reaper and head involution defective death activator expression and tiss

147 opically express the pro-apoptotic gene head involution defective, activate caspase-3 and are positiv

148 duced by the proapoptotic genes reaper, head involution defective, and grim.

149 by regulating the expression of cut and head involution defective.

150 translation of caudal mRNA and exhibit head involution defects.

151 T3 and p53 therefore results in hyperdelayed involution, demonstrating their synergistic physiologica

152 expressing mammary glands exhibit a delay in involution despite induction of proapoptotic signaling e

153 Early involution, due to increased apoptosis, was observed in

154 Thymic involution during aging is a major cause of decreased pr

155 th during the first year of life followed by involution during early childhood.

156 BMDMs exposed to the postpartum mammary involution environment upregulated the M2 markers argina

157 nvade metanephric mesenchyme which undergoes involution, events replicated in organ culture.

158 identified a role for this gene during gland involution; excision of the Fog2 gene leads to the accel

159 Breast involution following pregnancy has been implicated in th

160 e because loss of Rac1 disrupts clearance in involution following the first lactation.

161 as no (0%), partial (1% to 74%), or complete involution (>or= 75%).

162 artial (odds ratio, 1.3; 95% CI, 1.0 to 1.6) involution had greater odds of high density (DY pattern)

163 erse repertoire is maintained despite thymic involution; however, peripheral fitness selection of T c

164 e hematopoietic system can accelerate thymic involution; however, the age of the stem cells appeared

165 can substantially reverse age-related thymic involution, identifying FOXN1 as a specific target for i

166 occurs during this period followed by their involution immediately following weaning.

167 E(T74A T393A) mutation delayed mammary gland involution, implicating cyclin E degradation in this ant

168 f IGFBP5 in normal mammary glands undergoing involution, implying an acceleration of the involution p

169 his study was the detection of severe thymic involution in all SHIV(SF33A)-infected infants, which is

170 d Zn transport is critical for mammary gland involution in mice.

171 eration in virgin glands, while accelerating involution in postlactation glands.

172 ing IH and appears to stop growth and hasten involution in proliferative and plateau phase IH.

173 leading to normal epithelial cell apoptosis/involution in Shp2-deficient mammary gland.

174 endent kinase inhibitor p21Waf1 at 3 days of involution in STAT3 null glands was abolished in STAT3-p

175 tosis persisted at days 6, 17 and 4 weeks of involution in STAT3-p53 doubly null mammary glands.

176 study, we have compared mouse mammary gland involution in the 129S1 and C57BL/6 inbred strains and r

177 ating that neither is sufficient to initiate involution in the absence of CSF1R(+) macrophages.

178 al and lobuloalveolar development as well as involution in the mammary gland.

179 r is an important initiator of mammary gland involution in the mouse.

180 that the critical factor triggering delayed involution in the STAT3 null gland is a p53-dependent ri

181 beta Gal) expression following pregnancy and involution in whey acidic protein promoter (WAP)-Cre/Ros

182 Long-term effects on choroidal involution included a hypoxic outer neuroretina, associa

183 eted mammary glands was sufficient to rescue involution, including apoptosis, alveolar regression and

184 ompetent mice, we discovered that postpartum involution increases mammary tumor metastasis.

185 In vivo, MMTV infection delayed involution-induced apoptosis in the mouse mammary gland.

186 We hypothesize that postpartum mammary involution induces metastasis through wound-healing prog

187 eta-catenin in thymocytes resulted in thymic involution instead of lymphomagenesis.

188 ion of TNFalpha, a potent activator of early involution, into the mammary gland fat pads of lactating

189 Although thymic involution is a primary driver of this naive T cell loss

190 Thymic involution is central to the decline in immune system fu

191 Postpartum involution is characterized by wound healing-like events

192 In the absence of C/EBPdelta, involution is delayed, the pro-apoptotic genes encoding

193 Transient thymic involution is frequently found during inflammation, yet

194 Thus, although thymic involution is largely determined by the aged environment

195 sts, which, if true, would imply that thymic involution is not an intrinsic property of thymic tissue

196 P3 and C/EBPdelta during the second phase of involution is perturbed in the absence of C/EBPdelta.

197 e dominant plasminogen activator for mammary involution is PKal, a serine protease that participates

198 Mammary gland involution is the most dramatic example of physiological

199 d growth in infancy, followed by a period of involution, leading to complete regression.

200 was slightly up-regulated shortly before/at involution, leading to normal epithelial cell apoptosis/

201 These results suggest that this defect in involution leads to an increase in the number of suscept

202 We found that thymic involution leads to T cell activation shortly after thym

203 To determine how thymic involution leads to the persistent release and activatio

204 The inability of IL-7 to prevent involution led us to the discovery of an additional age-

205 The involution macrophages exhibit an M2 phenotype as determ

206 Conversely, involution matrix failed to support ductal development i

207 ung, liver, and kidney were increased in the involution matrix group, and correlated with a twofold i

208 emixed with Matrigel, nulliparous matrix, or involution matrix, were injected into mammary fat pads o

209 During early involution, Mfge8 mutant mice had increased numbers of a

210 Cyst sclerosis with stabilization (n = 1) or involution (n = 13) was achieved following 1 (n = 10), 2

211 romal cysts is safe and effective, with cyst involution obtained in 93% (14 of 15) of patients.

212 Failure to execute involution occurred in the presence of milk stasis and S

213 We have recently demonstrated that choroidal involution occurs early in retinopathy.

214 he first reported case, to our knowledge, of involution of BRAF inhibitor-induced EMN following the c

215 to the clear fiber state and to the improper involution of cells from the anterior epithelium directl

216 f the polycystin proteins and the subsequent involution of cilia.

217 Our case report describing the involution of EMN supports data from previous clinical t

218 ease progression upon infection exhibited an involution of GCs without local IL-21 production in GCs.

219 ter, coinciding with the previously observed involution of germinal centers.

220 The mechanisms that trigger involution of hemangioma into fibro-fatty tissue remain

221 primary vitreus (PHPV), attributed to failed involution of hyaloid vessels.

222 thermography to assess the proliferation and involution of IHs compared with a visual analog scale.

223 an antagonist of IGF signaling that mediates involution of mammary gland in females after offspring a

224 In other situations, such as involution of mammary or prostate tissue, many cells dis

225 Within months, we noted clinical involution of many of her EMN.

226 To follow the kinetics of induction and involution of mitochondria, we determined the expression

227 tive ductal development, in pregnancy and in involution of mouse mammary gland.

228 ptotic stimuli and occurs in vivo during the involution of mouse mammary tissues, a morphogenic proce

229 cent (62 of 132) of respondents had observed involution of Spitz nevi.

230 ion nuclei in the bow region and also direct involution of surface lens epithelial cells (LECs) into

231 NAI2 was required for proper postlactational involution of the breast.

232 progesterone (P4) concentrations and caused involution of the CL.

233 hese compartments formed by FtsZ-independent involution of the cytoplasmic membrane (CM) rather than

234 on of the Fog2 gene leads to the accelerated involution of the gland despite diminished levels of the

235 pregnancy, which in turn leads to premature involution of the gland.

236 Bin1 loss delayed the outgrowth and involution of the glandular ductal network during pregna

237 g that mechanical forces attributable to the involution of the infarct contributed to the changes in

238 gen, consisting of a swift, apoptosis-driven involution of the lower half of the follicle.

239 ction and either failed to develop a UB with involution of the mesenchyme, or developed small kidneys

240 Finally, Bmf is expressed during involution of the mouse mammary gland, suggesting that B

241 least one other characteristic indicative of involution of the retinal pigment epithelium (i.e., shar

242 As p53 was implicated in the eventual involution of the STAT3 null gland, we examined the effe

243 Involution of the thymus is accompanied by a decline in

244 Involution of the thymus results in reduced production o

245 mune system is the structural and functional involution of the thymus, and the associated decline in

246 SERBA-1 in vivo demonstrates involution of the ventral prostate in CD-1 mice (ERbeta

247 The age-dependent involution of this organ leads to decreasing production

248 y collapse of the tumor microenvironment and involution of tumor vasculature.

249 with reduced expression, within 24 hours of involution, of the death receptor (DR) ligand TNF and it

250 ensity (DY pattern) than those with complete involution (P trend < .01).

251 Upon lactation and continuing into the involution phase, these patterns reverse with a dramatic

252 xperimental evidence indicates that improper involution plays a role in the development of this malig

253 th adverse pregnancy outcomes, such as fetal involution, prematurity, and low birth weight, and with

254 Nevertheless, involution proceeds morphologically with similar kinetic

255 involution, implying an acceleration of the involution process by inhibition of Wnt signaling.

256 e that thymus tissue is plastic and that the involution process might be therapeutically halted or re

257 As involution progressed, Mfge8 mutants developed inflammat

258 , cyclooxygenase-2 (COX-2) inhibition during involution reduced the risk of cancer metastasis and cor

259 and they suggest that onset of human thymus involution relates to decreased colonization by prothymo

260 anisms responsible for age-associated thymic involution remain unknown, a variety of theories have be

261 tical roles in mammopoiesis/lactogenesis and involution, respectively, in the mammary gland.

262 used apoptosis and accelerated mammary gland involution, respectively, with increased Bim levels.

263 during pregnancy, hormonal withdrawal during involution resulted in complete remodeling and the resto

264 NA sequencing of ST18-depleted tumors before involution revealed down-regulation of inflammatory resp

265 For instance, age-associated thymic involution seems to occur in all species that possess a

266 land microenvironment during postlactational involution shares similarities with inflammation, includ

267 The rate of involution shown by our model is compatible with indepen

268 volution and importantly, that as an initial involution signal, TNFalpha redistributes ZnT2 to lysoso

269 l between tumor regression and mammary gland involution suggests that Wnt-driven mammary tumors use t

270 In general, these proteins lack surface involutions suitable for high-affinity binding by small

271 henotype to accelerated aging-related thymic involution support the possibility that changes in Foxn1

272 mmary gland homeostasis and the lactation-to-involution switch are regulated by serotonin (5-hydroxyt

273 the first months of life and the spontaneous involution that follows throughout the course of years r

274 tic region also regulates the rate of thymic involution that is accelerated in NOD mice.

275 At 3 days post lactational involution, the mammary glands of Snai2-deficient mice e

276 Despite thymic involution, the number of naive CD4(+) T cells diminishe

277 s have been implicated in age-related thymic involution, their relative contributions are not known.

278 e as a means to reverse age-dependent thymic involution, thereby enhancing immune function and decrea

279 At the end of involution, these patterns return to that of the adult n

280 es and maintain STAT5 activation even during involution, thus preventing the apoptosis normally initi

281 motional for tumor cell dissemination during involution, thus providing a plausible mechanism to expl

282 --the formation of blood vessels followed by involution to fatty tissue.

283 that widespread cell death during postpartum involution triggers efferocytosis-induced wound-healing

284 nd provide a link between mammary epithelial involution, tumorigenesis, and the phenomenon of chemore

285 pregulated after castration-induced prostate involution-two characteristics consistent with that of a

286 birth to a peak at 1 year, followed by rapid involution until approximately 8 years, and then a more

287 Cyst involution, visual acuity, and treatment complications.

288 he average age at which hemangioma completed involution was 3.5 years.

289 This failure to induce involution was associated with reduced expression, withi

290 Thymic involution was prevented in genetically manipulated mice

291 tructural alterations associated with thymic involution were diminished in aged Foxn1 Tg.

292 The most common sequelae after involution were telangiectasias (145, 84.3%), fibrofatty

293 action, segmental groove retraction and head involution, whereas it is dispensable for other morphoge

294 ghtfold increase in macrophage number during involution, which returned to nulliparous levels with fu

295 mouse model that induces accelerated thymic involution while maintaining a young periphery.

296 clooxygenase-2 (COX-2) inhibition during the involution window decreased normal mammary gland lymphan

297 The hallmarks of skeletal involution with age, on the other hand, are decreased bo

298 in mice protects against age-related thymic involution with an increase in earliest thymocyte progen

299 = .04) and a strong positive association of involution with nondense area (P trend < .01).

300 ned loss of STAT3 and p53 severely perturbed involution, with hyperdelayed loss of epithelium and rea