ライフサイエンスコーパス: inward

1 anually tri-folded with the endothelial side inward.

2 strate area to a continuous 2D curl of plane inward.

3 l. (2015) shed light on how these cells move inward.

4 is transmitted from the extracellular domain inward.

5 omes with the unoccupied terminal end facing inward.

6 where one points outward and the other three inward.

7 ts formed farther from the star and migrated inwards.

8 ased peer review tends to drive radiologists inward, against each other, and against practice leaders

9 by VMAT out of the vesicle lumen coupled to inward amphetamine transport.

10 cted motor, which then pulls the sliding MTs inward and clusters them at the poles.

11 D1/D5 receptors), caused inhibition of both inward and outward currents by approximately 60% and app

12 f mGluR1 and mGluR5 resulted in a mixture of inward and outward currents mediated by a nonselective c

13 e "knock-on" mechanism of permeation in both inward and outward directions, and there is no similar l

14 overning the complex temporal progression of inward and outward gas fluxes to and from the silage int

15 n silver to specific superimpositions of the inward and outward surface plasmon profiles for the two

16 parently by placing its methyl group further inward and receiving stronger water repulsion.

17 2 directed outwards, whereas A63 is directed inwards and anchored by stacking and hydrogen-bonding in

18 II)4L4 tetrahedra, one with ligands puckered inward, and the other outward.

19 embrane domains (TMDs), which switch between inward- and outward-facing (IF, OF) orientations.

20 tons and triggers alternating access between inward- and outward-facing conformations of the substrat

21 te (ABC) transporter that alternates between inward- and outward-facing conformations to capture and

22 trates across membranes by switching between inward- and outward-facing conformations.

23 s involve cycling between conformations with inward- and outward-facing substrate-binding sites in re

24 The crystal structures of MalFGK2, inward- and outward-facing, show that the transporter is

25 tching sequences or to pump liquids radially inward, as well as the complete pre-storage and release

26 light-activated proton pump recruited a slow inward ASIC current, which required molecular proximity

27 A drop in extracellular pH induces transient inward ASIC currents (IASICs) in postsynaptic MNTB neuro

28 triders rotate the curved tips of their legs inward at a relatively low descending velocity with a fo

29 s' cast by the molecular clouds as they move inward at about 300 kilometres per second towards the ac

30 energy reached approximately 60 meV and then inward at higher energies.

31 ocations in the nucleosome linkers to induce inward (AT-IN) and outward (AT-OUT) bending of the linke

32 esis that Kir2 currents non-linearly balance inward background cation currents, accounting for two le

33 at Kir2 currents non-linearly counterbalance inward background cation currents, such as K2P1 currents

34 KEY POINTS: Outward and inward background currents across the cell membrane bala

35 postulates that ILVs form individually from inward budding of the endosomal limiting membrane, plant

36 Subsequent inward budding of the endosomal membrane generates multi

37 cytosis (CME) involves nanoscale bending and inward budding of the plasma membrane, by which cells re

38 etinopathy, but specifically confined in the inward bulge of the staphyloma and secondary to excessiv

39 t on SD OCT (P < .001) were noted inside the inward bulge of the staphyloma between eyes with and wit

40 ch-clamp experiments clearly showed that the inward Ca(2+) current was absent.

41 It is concluded that D550Y/Q917H reduced inward Ca(2+) currents through a defect in the cell surf

42 at the cardiac plasma membrane, and thus the inward calcium current, through a complex pathway involv

43 ellular calcium concentrations and increased inward cation currents.

44 ls that divide by constriction of the cortex inward, cells of land plants divide by initiating a new

45 (+) ) nutrition and a robust guard cell K(+) inward channel activity is considered critical for plant

46 commonly known to function as a light-driven inward chloride pump.

47 me function as outward proton pumps, some as inward chloride pumps, whereas others function as light

48 d Cl channel (ANO2) to elicit, unusually, an inward Cl current.

49 Hence the olfactory response has inward CNG and Cl components that are in rapid successio

50 surement demonstrated lumenal narrowing from inwards collapse of hyalinized arteriolar walls unable t

51 nd the P1 active site in PDX1.3 have adopted inward conformations consistent with a catalytically pri

52 teraction sites, whereas inward-occluded and inward conformations present only a single beta-d-glucos

53 e silver element, accompanied by outward and inward counterion fluxes.

54 th AP phases 1 and 2 that was followed by an inward current (-0.42 +/- 0.03 pA pF(-1); n = 21) during

55 tion passively imports protons generating an inward current (IH), which may be exacerbated in NKA-sub

56 itive and voltage-dependent Na(+) persistent inward current (NaPIC).

57 Pinacidil failed to activate current and the inward current activated by elevated [K(+) ]o was insens

58 y terminus of the peptide, which triggers an inward current concomitant with calcium influx.

59 and had significantly larger menthol-induced inward current densities than medium-large cells, most o

60 PDM also attenuated the PM-induced inward current during co-application, providing further

61 sinhibition) combined with an increase in an inward current from excitatory synapses.

62 This inward current has two components: a canonical transient

63 Similarly, although 5-HT induced an inward current in both control and HFD gastric nodose ne

64 Alkaline pH evokes an inward current in nociceptive neurons, which is primaril

65 s activity as a SERT substrate, 4-MEC evoked inward current in SERT-expressing Xenopus oocytes, where

66 respond to the application of glutamate with inward current mediated by Ca(2+)-permeable AMPARs.

67 so poorly coupled, enabling local Ca-induced inward current of sufficient source strength to overcome

68 ry current-a nonrectangular self-terminating inward current produced in optical stimulation due to Ch

69 f firing rate corresponded with an increased inward current that was blocked by TPQ.

70 which displayed a hyperpolarization-induced inward current that was enhanced by cGMP as well as cAMP

71 on of SAN pacemaker activity by allowing net inward current to flow during the diastolic depolarizati

72 m of many itch receptors, where they mediate inward current to trigger action potentials in primary a

73 ltage clamp experiments showed activation of inward current when extracellular K(+) ([K(+) ]o ) was i

74 Spontaneous Ca release activates inward current which depolarizes membrane potential (Vm)

75 ficantly decreased firing rate and increased inward current within SCN neurons in a GIRK-dependent ma

76 duced current IMI (a nonlinear voltage-gated inward current) that effectively acted as a negative lea

77 nd that despite evoking a similar excitatory inward current, activation of NMDARs resulted in a large

78 e from caged glutamate generated a transient inward current, as expected for the electrogenic inward

79 eptor and is mediated by a voltage-dependent inward current.

80 currents increases, while the open time for inward currents (Cl(-) efflux) is constant irrespective

81 evoked rapidly activating and desensitizing inward currents (peak 18 +/- 3 pA/pF at -60 mV) in healt

82 not known although activation of persistent inward currents (PICs) might be involved.

83 repolarization represents a balance between inward currents (primarily through calcium and sodium ch

84 eration of extrasynaptic NMDAR-mediated slow inward currents (SICs) in neighboring neurons, which can

85 th single-channel conductances of 20 pS for inward currents and 80 pS for outward currents.

86 Both inward currents and 5-HT release were inhibited by Piezo

87 hermore, capsaicin-induced spontaneous pain, inward currents in DRG neurons, and synaptic currents in

88 how that activation of NMDARs evoked similar inward currents in MNCs of sham and renovascular hyperte

89 -d-aspartate receptor (NMDAR)-dependent slow inward currents in neurons.

90 BAB receptor agonist baclofen also inhibited inward currents induced by CIM0216 in DRG neurons, and n

91 Inward currents observed during exposure to NH4Cl were d

92 d for two bacterial Na(v) channels to induce inward currents of K+ ions.

93 Many chimeras have stronger light-activated inward currents than the three parents, and some have un

94 Additionally, tonic inward currents were also detected, but only in the stri

95 P2X7R-gated inward currents were suppressed in the contralateral hip

96 that activation of Piezo2 by force leads to inward currents, 5-HT release and an increase in mucosal

97 by enhancing subthreshold voltage-activated inward currents.

98 Conduction velocities were slowest at the inward curvature into the isthmus entrance (0.28+/-0.2 m

99 mical analyses show OsSWEET2b in an apparent inward (cytosolic) open state forming homomeric trimers.

100 Individuals with AN (n=28) showed localized inward deformations of the thalamus relative to healthy

101 .5), encoded by the SCN5A gene, conducts the inward depolarizing cardiac Na(+) current (INa) and is v

102 ubstrate-type releaser at DAT that evoked an inward depolarizing current and calcium influx, whereas

103 In inward destruction, species loss is almost proportional

104 th a distinct splitting margin (stage 1), an inward detached crescentic flap lying on the anterior le

105 d by the intermediate Ag20 shell, preventing inward diffusion of the surface Au atoms.

106 of palladium phosphide and consequently the inward diffusion of vacancies and their coalescence into

107 )Ab in the presence of applied forces in the inward direction, but not in the outward direction.

108 Inward displacement of TM2 might alter the sidechain env

109 Our mechanics analysis revealed that such inward expansion is enabled by the much stiffer lithiate

110 ry of SERT is thought to proceed through the inward facing conformation.

111 avity in what could be a stabilization of an inward facing conformation.

112 otide-free state, with hydrolysis driving an inward facing conformation.

113 acochaperone noribogaine, which binds to the inward facing conformation.

114 ations, unlike K(+), are unable to enter the inward facing sites in the dephosphorylated enzyme.

115 The dephosphoenzyme contains Na(+) selective inward facing sites, whereas the phosphoenzyme contains

116 avoring outside facing sites and disfavoring inward facing sites.

117 suppressor mutations, which trap SERT in the inward facing state, or (ii) by the pharmacochaperone no

118 sted to adopt different conformations in the inward facing, outward facing and amphetamine-bound stat

119 hanism, making iterative transitions between inward-facing (E1) and outward-facing (E2) conformations

120 used to resolve the backbone dynamics in the inward-facing (IF) and outward-facing (OF) states by ana

121 has an enhanced solvent accessibility in the inward-facing (relative to the outward-facing) form.

122 ads to the activation of two cytoplasmically inward-facing channels: the plasma membrane, Cch1p, and

123 ructure of the uracil transporter UraA in an inward-facing conformation allowed us to identify the an

124 the glucose EIIC superfamily, bcChbC in the inward-facing conformation and bcMalT in the outward-fac

125 gent-solubilized TmrAB in a nucleotide-free, inward-facing conformation by single-particle electron c

126 Recently, an inward-facing conformation of LeuT was solved revealing

127 In this study, an open, inward-facing conformation of Pho84 was used to study th

128 ectrogenic binding of K(+) or of H(+) to the inward-facing conformation of SERT in (i) cancelling out

129 ubstrate to LeuT, promotes an outward-closed/inward-facing conformation of the transporter and increa

130 The SUR1-ABC core is found in an unusual inward-facing conformation whereby the two nucleotide bi

131 -binding domains of the transporter adopt an inward-facing conformation with the two nucleotide-bindi

132 The structure shows UapA in an inward-facing conformation with xanthine bound to residu

133 nd ADP reveal an unprecedented closed and an inward-facing conformation, respectively.

134 nd the crystal structure of MsbA in the open inward-facing conformation.

135 ited to a series of crystal structures in an inward-facing conformation.

136 inding site when the transporter rests in an inward-facing conformation.

137 Crystal structures in the outward- and inward-facing conformations of a glutamate transporter h

138 7, suggesting that Mhp1 adopts predominantly inward-facing conformations.

139 Furthermore, simulations of inward-facing LeuT with Na(+) ions and substrate bound s

140 urrent Pho84 transport model is based on the inward-facing occluded crystal structure of the Pho84 ho

141 , indicating that the transporter lies in an inward-facing open conformation.

142 rd-facing occluded with substrate bound, and inward-facing open).

143 tal structures of outward-facing Sav1866 and inward-facing Pgp.

144 rmation until maltose triggers return to the inward-facing state for substrate and Pi release.

145 onal transition from an outward-facing to an inward-facing state of the transporter.

146 conformational change in Pho84 from an open, inward-facing state to an occluded state.

147 noribogaine (a DAT ligand selective for the inward-facing state) and/or pifithrin-mu (an HSP70 inhib

148 In our structure, TmrAB adopts an asymmetric inward-facing state, and we show that the C-terminal hel

149 +) binding by facilitating transition to the inward-facing state.

150 sporter Can1 is promoted by transition to an inward-facing state.

151 lobal (transition between outward-facing and inward-facing states) scales.

152 ng structural isomerization from outward- to inward-facing states.

153 d at residues selected to track the putative inward-facing to outward-facing transition.

154 Here we present crystal structures of the inward-facing, intermediate, and outward-facing states o

155 of the binding site to the cytoplasmic side (inward-facing, open NBD conformation).

156 en [nucleotide binding domains (NBDs) apart; inward-facing] and closed (NBDs close; outward-facing) c

157 Hyperpolarizing HCs stimulated inward feedback currents in cones that averaged 8-9 pA a

158 ectivity, where TWIK-1 displays robust Na(+) inward flux in response to subphysiological K(+) concent

159 , the overlapping tissue showed a contracted inward fold at its peripheral edge with scar tissue); 1

160 upiter and Saturn, in which Jupiter migrates inward from a > 5 astronomical units (AU) to a approxima

161 ultaneously: The frozen phase boundary moves inward from the droplet free surface toward the droplet-

162 y, is highest when habitable area disappears inward from the edge of a region, lower when it disappea

163 bly supplied these sediments, which advanced inward from the wall, infilling both the crater and an i

164 gaze and retraction of the eye on attempted inward gaze.

165 ward, outward-occluded, inward-occluded, and inward GLUT1 conformations.

166 4) The inward GLUT1 conformer presents overlapping endofacial W

167 the inner membrane, cell wall synthesis, and inward growth of the outer membrane.

168 treadmilling, which guides and regulates the inward growth of the septal wall.

169 rofile, whereas its metabolite PM induced an inward hDAT current consistent with a DAT substrate prof

170 ier model in an outward (OWF) and develop an inward (IWF) facing model employing an integrated experi

171 Both the outward and inward K(+) currents shifted Veq K(+) consistent with K(

172 membrane invagination, which grows radially inward like the shutter of a camera.

173 leosome proximity in the AT-IN arrays due to inward linker DNA bending.

174 This inward-looking threat from parochialism occurs just as t

175 This process induces cargo crowding and inward membrane buckling, followed by constriction of th

176 e from endolysosomal Ca(2+) stores activates inward membrane currents and depolarizes the beta cell t

177 Jupiter's inward migration entrained s greater, similar 10-100 km

178 There is debate whether in situ assembly or inward migration is the dominant mechanism of the format

179 This inward migration of GJ 436b could have triggered the atm

180 Inward motion of Arg664 allows it to interact with the g

181 We show that phosphorylation favors inward motion of Arg664, while simultaneously favoring o

182 ntally, and validate theoretically, that the inward motion of the phase boundary near the substrate d

183 nhibitory inputs directionally selective for inward motion opposing the excitation.

184 Inward movement is driven by the matrix-localized, Hsp70

185 rd current, as expected for the electrogenic inward movement of co-transported Na(+) In contrast, glu

186 of the open structure reflecting in part the inward movement of Glu-216 to form a hydrogen bond with

187 o GPCR deactivation that is characterized by inward movement of the TM6 intracellular end.

188 ment of K(+) induces filter opening, whereas inward movement promotes inactivation.

189 These are reflected in reduced inward Na(+) and outward K(+) currents.

190 We found that a dominance of inward Na-Ca exchanger current (I(NCX)) over Ca-dependen

191 LCR signal activating an earlier and larger inward NCX current.

192 All restored teeth initially exhibited inward (negative) cuspal flexure due to polymerization s

193 protein, as well as a mechanically-sensitive inward non-selective cation current characteristic of Pi

194 d its structure in a novel conformation, apo inward-occluded and a new nucleotide-bound state, high-e

195 ucose and maltose interaction sites, whereas inward-occluded and inward conformations present only a

196 llus halodurans, have been resolved in novel inward-occluded states, with the extracellular vestibule

197 ns, the so-called outward, outward-occluded, inward-occluded, and inward GLUT1 conformations.

198 buted to decreasing current density radially inward on the silicon surface exposed to Triton((R)) X-1

199 mediating the conformational switch between inward-open and outward-open states necessary for drug e

200 or substrate translocation by stabilizing an inward-open conformation.

201 7, and 11 form an extracellular gate in the inward-open conformation.

202 ral intermediate preceding transition to the inward-open conformation.

203 ed phosphorylation and agents that stabilize inward-open conformations (e.g., 5-HT, ibogaine) increas

204 ported here spontaneously adopt occluded and inward-open conformations.

205 nsport of 5-HT, which increases the level of inward-open SERT and may lead to unwinding of the TM5 he

206 coli BAM complex in two distinct states: an inward-open state and a lateral-open state.

207 compounds bind in the central cavity of the inward-open state of hGLUT1, and all binding sites overl

208 ith the conformational transition toward the inward-open state, a role that is likely to be shared ac

209 s relative to the Gate domains may access an inward-open state.

210 oning of the N terminus and transition to an inward-open state.

211 utward-open, outward-partially occluded, and inward-open states of the transport cycle.

212 lized in outward-open, outward-occluded, and inward-open states.

213 ions match crystal structures, including our inward-open structure.

214 Here, we present three inhibitor-bound, inward-open structures of WT-hGLUT1 crystallized with th

215 centrations that induced outward opening and inward opening, respectively, as measured by the accessi

216 modynamic coupling between Na(+) release and inward-opening, and identifies diverse, yet well-defined

217 ntial motifs regardless of whether they face inward or outward from histone octamers along the DNA he

218 ll four azaphosphatrane (+)P-H vectors point inward, or else where one points outward and the other t

219 RET to monitor intersubunit rotation and the inward/outward movement of the L1 stalk of the large rib

220 flicker) and symmetrically moving patterns (inwards, outwards, random directions) with and without p

221 etres, whose orbits do not decay appreciably inward over 4.5 billion years, contribute at most about

222 GLAST expressions and attenuated the peak of inward potassium current.

223 ASK-1, GS and GLAST expressions and enhanced inward potassium currents compared with those in the COH

224 s triggered by edge cooling and large-scale, inward propagating avalanches.

225 rectification behavior of AM2 (i.e., why the inward proton flux is allowed when the pH is low in vira

226 e creation of a light-driven, single-photon, inward proton transporter.

227 ces outward pushing forces to antagonize the inward pulling forces from kinesin-14 or dynein.

228 phasizes that measured intrinsic properties (inward rectification and external [K] dependence) and lo

229 The results demonstrate that inward rectification depends on a single amino acid (Ala

230 However, the inward rectification of GABA-induced transport currents

231 es of quasi-instantaneous activation, strong inward rectification, depended on the external [K(+)], a

232 m conductance predominantly mediated by K(+) inward rectifier (Kir)2.1, which was blocked by the NMDA

233 at depolarized membrane potentials, whereas inward rectifier channels conduct greater current at hyp

234 G protein gated inward rectifier K(+) (GIRK) channels open and thereby s

235 Although strong inward rectifier K(+) (Kir) channels have been reported

236 Inward rectifier K(+) channel subfamily 2 (Kir2) channel

237 ABSTRACT: Inward rectifier K(+) channel subfamily 2 (Kir2) channel

238 In the present study, we show that inward rectifier K(+) channel subfamily 2 isoform 1 (Kir

239 We explored the role of inward rectifier K(+) conductances in colonic ICC that m

240 In contrast, inward rectifier K(+) current and L-type Ca(2+) channels

241 onents of transient outward K(+) current and inward rectifier K(+) current, along with corresponding

242 ic and functional data showing that the K(+) inward rectifier KAT1 (K(+)Arabidopsis thaliana 1) chann

243 leads to the activation of G-protein-coupled inward rectifier potassium (GIRK) channels and hyperpola

244 G protein gated inward rectifier potassium (GIRK) channels are gated by

245 = 0.2 muM), small-molecule inhibitor of the inward rectifier potassium (Kir) channel and diuretic ta

246 Emerging evidence suggests that mosquito inward rectifier potassium (Kir) channels represent viab

247 Endothelial cells express inward rectifier potassium (Kir) channels, but their rol

248 nding partners, kainate receptor GluR6/7 and inward rectifier potassium channel Kir2.1, closely assoc

249 ed rectifier potassium current (IKr) and the inward rectifier potassium current (IK1) were also downr

250 ly non-selective members of the prokaryotic 'inward rectifier' subfamily of K(+) channels.

251 y-which activates capillary endothelial cell inward-rectifier K(+) (KIR2.1) channels to produce a rap

252 containing the ABC transporter SUR1 and the inward-rectifier K(+) channel Kir6.2, in the presence of

253 The defining structural feature of inward-rectifier potassium (Kir) channels is the unique

254 rent at physiological conditions is strongly inward rectifying and predominantly carried by chloride.

255 Inward rectifying currents (IKir) had the canonical feat

256 ells of SUR1 null islets have an upregulated inward rectifying K+ current that helps to compensate fo

257 Inward rectifying potassium (Kir) channels play a centra

258 ncodes the GABAB R-coupled G protein-coupled inward rectifying potassium channel subunit 2 (GIRK2) ch

259 with that wave leads to the activation of an inward rectifying potassium conductance in microglia.

260 The inward-rectifying K(+) channel AKT1 constitutes an impor

261 tant, indicating that ZxAKT1 functions as an inward-rectifying K(+) channel.

262 ract with and suppress the activities of the inward-rectifying K(+) channels KAT1 and KC1.

263 selective inactivation of current carried by inward-rectifying K(+) channels of tobacco (Nicotiana ta

264 d signaling pathway that selectively targets inward-rectifying K(+) channels.

265 sal CA1 neurons and that a G-protein-coupled inward-rectifying potassium channel mediated regulation

266 xpression of specific BacNav orthologues, an inward-rectifying potassium channel, and connexin-43 in

267 potassium channel TRESK (2-pore-domain weak inward-rectifying potassium channel-related spinal cord

268 wer, acts via 5HT2A receptors to suppress an inward-rectifying potassium conductance in FSIs.

269 DMEK tissue, trifolded with the endothelium inward, reduces surgical trauma to donor cells and facil

270 hanism that couples the transport-associated inward release of the Na(+) ion from the Na2 site to int

271 d, but over a range of transmural pressures, inward remodelling occurred after T3-SCI with a 40% redu

272 dy demonstrates profibrosis and hypertrophic inward remodelling within the largest cerebral artery af

273 ctivation loop first opens up followed by an inward rotation of the alphaC-helix, takes place via a d

274 ormation, protecting nucleosomal DNA with an inward rotational setting, even though such DNA is, on a

275 To reinvestigate this phenomenon, we studied inward short-circuit currents (Isc) in tracheal mucosa f

276 hat are slow near the cortex and fast on the inward side of the subcortical microtubule layer.

277 s, and the asymmetric freezing dynamics with inward solidification causing not fully frozen mass to b

278 pneumatically-driven bending into multi-turn inward spiraling.

279 had started from the outside, then proceeded inward, suggesting that the size of the newly formed bon

280 ng the peak of the population discharge, the inward synaptic current was essentially mediated by glut

281 lular Cl(-) with gluconate(-) diminishes the inward tail current (Cl(-) efflux) at a membrane potenti

282 hat Zn(2+) dissociated more rapidly from the inward- than from the outward-facing state of DAT.

283 rd flow produces a relatively constant force inward, the peak of local contractile forces by CUs scal

284 If projected inward, the reaction is slow and not selective.

285 ar surface when CGS21680 is bound, due to an inward tilt of TM2 in that region.

286 narratives than when attention was directed inward to a mental arithmetic task during stimulus prese

287 binding domains, with loop L1 switching from inward to outward conformations with respect to the DNA

288 l gates as the protein transitioned from the inward to outward facing state.

289 as the mutant proteins were driven from the inward to the outward open Na(+)-bound conformation.

290 l that the Core domains of Bor1 have rotated inwards to achieve an occluded state.

291 nsporter facilitates a reorientation from an inward- to outward-facing state.

292 ly, with 5 degrees and 10 degrees LWIs, toes inward ('Toe in'), and toes outward ('Toe out wide').

293 ma toward the dendritic tips than for motion inwards toward the soma.

294 b activates the TRPM4 channel and results in inward transient cation currents that depolarize smooth

295 recruitment of repair proteins; for example, inward translocation of the DNA-end-binding protein Ku w

296 oligopeptide transporters (POTs) couple the inward transport of di- or tripeptides with an inwardly

297 d to Ala, was hyperactive, causing increased inward transport of phosphatidylethanolamine.

298 itro studies have shown that IMDs can induce inward tubulation of liposomes.

299 bit the cancellation between the outward and inward waves.

300 The third uridine is turned outwards or inward, wedging between the other uridines, thus filling

301 localizes to the CUs and subsequently moves inward with the actin flow.