ライフサイエンスコーパス: inward rectifier K channel

1 rt the intermolecular model for pH gating of inward rectifier K channels.

2 nd 3.1 are bacterial homologues of mammalian inward rectifier K channels.

3 els and heterotetrameric G-protein-regulated inward rectifier K channels.

4 RK2 to constitute a neuronal G protein-gated inward rectifier K+ channel.

5 gh-affinity ligands that directly target any inward-rectifier K+ channel.

6 itical in trafficking and conductance of the inward rectifier K+ channels.

7 age-dependent manner, characteristic of many inward rectifier K+ channels.

8 yotic pore into eukaryotic voltage-gated and inward-rectifier K+ channels.

9 very useful molecular probe for studying the inward-rectifier K+ channels.

10 , and synthesized a protein inhibitor of the inward-rectifier K+ channels.

11 all-or-none-like conductance changes of the inward-rectifier K(+) channel.

12 resembles the cytoplasmic pore structures of inward rectifier K(+) channels.

13 modulated N-type Ca(2+) and G-protein-gated inward rectifier K(+) channels.

14 and cerebral arteries through activation of inward rectifier K(+) channels.

15 We report that the IRK3 but not the IRK1 inward rectifier K+ channel activity is inhibited by m1

16 However, it is unknown whether inward-rectifier K+ channels and reentry are also import

17 Inward rectifier K(+) channels apparent lack of selectiv

18 The hypothesis that inward rectifier K(+) channels are involved in the vasod

19 Inward-rectifier K+ channels are a group of highly speci

20 lls under resting conditions is dominated by inward-rectifier K(+) channels belonging to the Kir 2 fa

21 uine's effectiveness may be explained by its inward-rectifier K+ channel blockade profile and suggest

22 (Q)), a honey bee toxin derivative, inhibits inward-rectifier K(+) channels by binding to their exter

23 Blockade of inward-rectifier K+ channels by chloroquine terminates r

24 Inward rectifier K(+) channels commonly exhibit long ope

25 Inward rectifier K+ channels control the cell's membrane

26 ROMK inward-rectifier K+ channels control renal K+ secretion.

27 Inward-rectifier K+ channels differ from voltage-activat

28 Here we report that several cloned inward rectifier K+ channels directly bind PIP2, and tha

29 A cytoplasmic pore, conserved among inward rectifier K(+) channels, extends the ion pathway

30 Kir4.1 and Kir5.1, two members of the inward rectifier K+ channel family, are expressed in sev

31 receptor (SUR1) and Kir6.2, a member of the inward rectifier K+ channel family.

32 bitory agents specific to each member of the inward-rectifier K+ channel family.

33 opmental features caused by mutations in the inward rectifier K+ channel gene KCNJ2.

34 ive sequence homology with previously cloned inward rectifier K+ channel genes.

35 a mouse liver cDNA library to identify novel inward rectifier K+ channel genes.

36 G protein-coupled inward rectifier K(+) channels (GIRK channels) are activ

37 The G-protein gated inward rectifier K+ channel (GIRK) is activated in vivo

38 ular N- and C termini of the G protein-gated inward rectifier K(+) channel GIRK1 at 1.8 A resolution.

39 sion systems showed that the G protein-gated inward rectifier K+ channel (GIRK2) bearing the weaver p

40 Inward rectifier K(+) channels govern the resting membra

41 Each of the four subunits of the inward-rectifier K+ channels has only two instead of six

42 he effect of TGF-beta(1) on the 14-pS Kir2.3 inward rectifier K(+) channel in rat primary cultured re

43 nd extracellular K(+) on the distribution of inward rectifier K(+) channels in the glial endfoot and

44 The molecular nature of the strong inward rectifier K+ channel in vascular smooth muscle wa

45 We conclude that Kir2.1 encodes for inward rectifier K+ channels in arterial smooth muscle.

46 dependent lipid kinases is known to activate inward rectifier K+ channels in cardiac membrane patches

47 Structural models of inward rectifier K+ channels incorporate four identical

48 ly, we have demonstrated that hIRK, a cloned inward rectifier K+ channel (IRK) isolated from human at

49 patches from Xenopus oocytes expressing the inward rectifier K+ channel IRK1.

50 tigated on wild-type and mutant forms of the inward rectifier K+ channel, IRK1 (Kir2.1).

51 s of metabolic inhibitors on the activity of inward rectifier K(+) channels K(ir)2.1, K(ir)2.2, and K

52 from the endothelium, and (b) activation of inward rectifier K(+) channels (K(ir)) and Na(+)-K(+) pu

53 Expression cloning of the first inward rectifier K channel (Kir) genes provided the nece

54 of the nucleus basalis (NB) by inhibiting an inward rectifier K(+) channel (Kir).

55 The ROMK subtypes of inward rectifier K+ channels (Kir 1.1, KCNJ1) mediate po

56 localize the pH-sensitive gate in the renal inward-rectifier K(+) channel Kir1.1a (ROMK1).

57 sed by mutations in KCNJ2, which encodes the inward rectifier K(+) channel Kir2.1.

58 The inward rectifier K+ channel Kir2.3 is inhibited by hyper

59 e COOH-terminal region of an ATP-insensitive inward rectifier K(+) channel (Kir2.1).

60 pore-forming H5 (or P) region of the strong inward rectifier K+ channel, Kir2.1, based initially on

61 containing the ABC transporter SUR1 and the inward-rectifier K(+) channel Kir6.2, in the presence of

62 e, these results support the hypothesis that inward rectifier K(+) channels may be involved in metabo

63 The Kir1.1 (ROMK) subtypes of inward rectifier K+ channels mediate potassium secretion

64 The ROMK subtypes of inward-rectifier K(+) channels mediate potassium secreti

65 in SUR1 (Sulfonylurea receptor 1) or KIR6.2 (Inward rectifier K(+) channel member 6.2), which encode

66 a blocker explains the signature feature of inward rectifier K+ channels, namely, that at a given co

67 ct on a cloned voltage-gated Na+ channel, an inward rectifier K+ channel, or on lymphocyte Ca2+ and C

68 ) in KCNJ2, the gene that encodes the strong inward rectifier K(+) channel protein (Kir2.1), in an 11

69 which results in the phosphorylation of the inward rectifier K+ channel protein.

70 GIRK (G protein-gated inward rectifier K(+) channel) proteins play critical fu

71 lactotrophs and the subsequent activation of inward rectifier K(+) channels provide an effective and

72 We have purified a protein inhibitor of an inward-rectifier K+ channel, ROMK1, from the venom of th

73 Inward rectifier K(+) channel subfamily 2 (Kir2) channel

74 ABSTRACT: Inward rectifier K(+) channel subfamily 2 (Kir2) channel

75 In the present study, we show that inward rectifier K(+) channel subfamily 2 isoform 1 (Kir

76 ATP-binding cassette protein family, and an inward rectifier K(+) channel subunit (Kir6.x).

77 ATP channel is a complex of two proteins: an inward-rectifier K+ channel subunit, Kir6.2, and the sul

78 G protein-gated inward rectifier K+ channel subunits 1-4 (GIRK1-4) have

79 IKAChis composed of two inward rectifier K+ channel subunits, GIRK1 and GIRK4.

80 g characteristics of two ion channels in the inward-rectifier K+ channel superfamily were compared at

81 for two representative genes, i.e. the weak inward rectifier K(+) channel (TWIK-1), and phosphate an

82 Inhibition of inward rectifier K(+) channels under ischemic conditions

83 cells were also transfected with the Kir2.3 inward rectifier K(+) channel, which allows for changing

84 Inward rectifier K+ channels, which modulate electrical

85 TPN(Q) inhibits the ROMK1 and GIRK1/4 inward-rectifier K(+) channels with affinities very simi