ライフサイエンスコーパス: inwardly rectifying K channel

1 that these functions are likely served by an inwardly rectifying K+ channel.

2 ulphonylurea sensitivity on several types of inwardly-rectifying K-channels.

3 s a blocker of Na+/K+ ATPase and Ba2+ blocks inwardly rectifying K+ channels.

4 urine colonic muscles express genes encoding inwardly rectifying K(+) channels.

5 man resistance arteries is also regulated by inwardly rectifying K(+) channels.

6 nductance KCa1.1, Kv1.2/1.3, Kv7.4, hERG, or inwardly rectifying K(+) channels.

7 neal endothelial cells express IRK1 (Kir2.1) inwardly rectifying K(+) channels.

8 hate (PIP(2)) is critical for opening of the inwardly rectifying K(+) channels.

9 t investigations in this unexplored class of inwardly rectifying K(+) channels.

10 ree A9-elevated molecules [G-protein coupled inwardly rectifying K channel 2 (GIRK2), adenine nucleot

11 A mutation in the G-protein-linked inwardly rectifying K+ channel 2 gene (Girk2) is the cau

12 The immunoreactivities of the inwardly rectifying K(+) channel 6.2 (Kir6.2) and the su

13 BaCl(2), a blocker of inwardly rectifying K(+) channels, also inhibited AITC-i

14 This study provides direct evidence that an inwardly rectifying K+ channel and an ATP-binding casset

15 ROMK1, also known as Kir 1.1, is an inwardly rectifying K+ channel and is the prototypical m

16 insight into the assembly and regulation of inwardly rectifying K+ channels and the domains which de

17 sensors formed by association of Kir6.2, an inwardly rectifying K+ channel, and the sulfonylurea rec

18 Members of the Kir3.0 family of inwardly rectifying K(+) channels are expressed in neuro

19 most circumstances, outward currents through inwardly rectifying K(+) channels are reduced at more de

20 Inwardly rectifying K+ channels are highly selective for

21 in the level of cellular cholesterol affect inwardly rectifying K+ channels belonging to a family of

22 Inwardly rectifying K+ channels bind intracellular magne

23 hannels are present in the lumen or when the inwardly rectifying K(+) channel blocker BaCl(2) is pres

24 Ethanol activates G protein-gated inwardly rectifying K(+) channels, but the molecular mec

25 We studied ion permeation and gating of an inwardly rectifying K+ channel by individually changing

26 teromultimers composed of Kir6.2 subunit, an inwardly rectifying K(+) channel core, and SUR2A, a regu

27 perpolarization, increased G-protein-coupled inwardly rectifying K(+) channel current, and attenuated

28 e frequency, increased GIRK (G-protein-gated inwardly rectifying K+ channel) current, and attenuated

29 calcium currents, increasing G-protein-gated inwardly rectifying K+ channel currents, and presynaptic

30 reduction in GABABR-dependent activation of inwardly rectifying K+ channel currents.

31 We investigated whether these inwardly rectifying K(+) channels displayed distinct spe

32 e that this inhibition requires one of three inwardly rectifying K(+) channels encoded by the C. eleg

33 complexes containing four subunits from the inwardly rectifying K+ channel family (Kir6.2) and four

34 We have cloned an inwardly rectifying K+ channel from the hamster insulino

35 serine in the H5 region of a G protein-gated inwardly rectifying K+ channel gene (GIRK2).

36 alling (RGS) proteins to G protein modulated inwardly rectifying K(+) channel (GIRK) activation/deact

37 on the regulation of G(betagamma)-regulated inwardly rectifying K(+) channel (GIRK) current (I(ACh))

38 ctivation of the heteromeric G protein-gated inwardly rectifying K(+) channel (GIRK) GIRK1 and GIRK4

39 The activity of G protein-activated inwardly rectifying K(+) channels (GIRK or Kir3) is impo

40 ions of four subunits termed G protein-gated inwardly rectifying K(+) channels (GIRK).

41 acaine selectively inhibited G protein-gated inwardly rectifying K(+) channels (GIRK:Kir3) but not ot

42 e expression levels of the G-protein-coupled inwardly rectifying K+ channel (GIRK) subunits using sol

43 G protein-gated, inwardly rectifying K+ channels (GIRK) are effectors of

44 ls of the N-, P/Q-, and R-type and G protein inwardly rectifying K+ channels (GIRK) are modulated via

45 G protein-activated inwardly rectifying K+ channels (GIRK) generate slow inh

46 y transfected along with G protein-regulated inwardly rectifying K+ channels (GIRK) into HEK 293 cell

47 (GABAB) receptors, activates G protein-gated inwardly rectifying K+ channels (GIRK) which, in turn, i

48 YFP-beta 1/CFP-gamma 2 with G-protein-gated inwardly rectifying K(+) channels (GIRK1 and GIRK4) resu

49 The G protein-coupled inwardly rectifying K+ channel, GIRK1/GIRK4, can be acti

50 A mutation in the G-protein-linked, inwardly rectifying K+ channel GIRK2 leads to the loss o

51 stitution at residue 156 in the H5 region of inwardly rectifying K(+) channel, GIRK2.

52 naptic inhibition in the brain by activating inwardly rectifying K(+) channels (GIRKs) and inhibiting

53 e been shown to activate G protein-activated inwardly rectifying K(+) channels (GIRKs) via pertussis

54 amus through activation of G-protein-coupled inwardly rectifying K(+) channels (GIRKs).

55 In one example, an inwardly rectifying K+ channel, gpIRK1, provides a potas

56 t DNA sequencing of KCNJ10, which encodes an inwardly rectifying K(+) channel, identifies previously

57 Cardiac muscarinic receptors activate an inwardly rectifying K+ channel, IK+Ach, via pertussis to

58 n currents through the Gbeta gamma-regulated inwardly rectifying K+ channels, IK(ACh), in the absence

59 lial cell Ca(2+)-activated K(+) channels and inwardly rectifying K(+) channels in arterial myocytes.

60 ABA(B)) receptors from their G-protein-gated inwardly rectifying K(+) channels in hypothalamic neuron

61 The aim of this study was to characterize inwardly rectifying K+ channels in cultured and freshly

62 nist baclofen to activate G-protein-coupled, inwardly rectifying K+ channels in hypothalamic neurons.

63 Therefore, GABAB receptors are coupled to inwardly rectifying K+ channels in SON and PVN magnocell

64 Inwardly rectifying K+ channels (IRKs) maintain resting

65 uR6, Galpha(o1), and a GIRK (G-protein-gated inwardly rectifying K+) channel, it accelerated the deac

66 Activation of several inwardly rectifying K(+) channels (Kir) requires the pre

67 excised apical membrane patches, we found an inwardly rectifying K+ channel (Kir).

68 Here, we report that two inwardly rectifying K+ channels, Kir 2.1 and 2.3, bind t

69 to map the extracellular topology of a weak inwardly rectifying K+ channel, Kir1.1 or ROMK1, and fou

70 rant localization, and enhanced block of the inwardly rectifying K(+) channel Kir2.1, compared with t

71 18, which encodes a skeletal muscle-specific inwardly rectifying K(+) channel Kir2.6, were reported i

72 double mutations in the M1-M2 segment of an inwardly rectifying K(+) channel, Kir2.1, using the cell

73 t excitatory effects of AA on a cloned human inwardly rectifying K(+) channel, Kir2.3, which is highl

74 and Phe(147) in the H5 sequence of a strong inwardly rectifying K+ channel, Kir2.1.

75 (100-200 nM) irreversibly blocked the strong inwardly rectifying K+ channel, Kir2.1.

76 expressing rat CB1 with the G-protein-gated, inwardly rectifying K+ channels Kir3.1 and Kir3.4.

77 etic neuralgia through downregulation of the inwardly rectifying K(+) channel Kir4.1 in satellite gli

78 ia development through downregulation of the inwardly rectifying K(+) channel Kir4.1 in satellite gli

79 Knockdown of the KCNJ15 gene (encoding inwardly rectifying K(+) channel Kir4.2) specifically ab

80 at the CaR interacts with and inactivates an inwardly rectifying K(+) channel, Kir4.1, which is expre

81 EK293 cells transfected transiently with the inwardly rectifying K+ channel Kir6.1 (uKATP1) or cotran

82 (ABC) protein (SUR1, SUR2A or SUR2B) and an inwardly rectifying K(+) channel (Kir6.1 or Kir6.2).

83 K+ (K(ATP)) channels are hetero-octamers of inwardly rectifying K+ channel (Kir6.2) and sulphonylure

84 y can be reconstituted by coexpression of an inwardly rectifying K+ channel, Kir6.2, with an ATP-bind

85 periments on two-dimensional crystals of the inwardly rectifying K+ channel KirBac3.1 from Magentospi

86 Inwardly rectifying K+ channels or Kirs are a large gene

87 d putative transmembrane segment of the IRK1 inwardly rectifying K+ channel, previously implicated in

88 This gene codes for a G-protein-activated, inwardly rectifying K+ channel protein (8).

89 coupling of GABA(B)R1/GABA(B)R2 receptors to inwardly rectifying K(+) channels rapidly desensitizes.

90 age-gated potassium channel (Kv), as well as inwardly rectifying K(+) channel remodeling, were invest

91 pus oocytes injected with GIRK1 mRNA express inwardly rectifying K+ channels resembling IKACh.

92 annels (GIRK:Kir3) but not other families of inwardly rectifying K(+) channels (ROMK:Kir1 and IRK:Kir

93 xternal potassium (K) and cesium (Cs) on the inwardly rectifying K channel ROMK2 (K(ir)1.1b) was stud

94 Several inwardly rectifying K+ channels show an ATP-dependent ru

95 died mice with a null mutation in the weakly inwardly rectifying K(+) channel subunit Kir4.1.

96 sulphonylurea receptor subunit (SUR) and an inwardly rectifying K+ channel subunit (Kir).

97 We detected GIRK1 (G-protein-gated inwardly rectifying K+ channel subunit 1) and GIRK2 subu

98 R, the sulfonylurea-binding protein, and the inwardly rectifying K+ channel subunit, KIR6.2.

99 in oocytes coexpressing the G protein-gated inwardly rectifying K+ channel subunits GIRK1 and GIRK4,

100 Inwardly rectifying K+ channel subunits may form homomer

101 In many tissues, inwardly rectifying K channels such as the renal outer m

102 Comparison of high-resolution structures of inwardly rectifying K(+) channels suggests a model for a

103 uple to the activation of the GIRK family of inwardly rectifying K+ channels; thus, these decreases r

104 In contrast, inhibition of inwardly rectifying K+ channels using Ba2+ (3-10 microM)

105 The inwardly rectifying K+ channels were constitutively acti

106 Activities of these inwardly rectifying K+ channels were inhibited by Ba2+ (

107 operties (e.g., density of Ca2+ channels and inwardly rectifying K+ channels), will generate sharp tu

108 ppocampal CA1 pyramidal neurons, we recorded inwardly rectifying K+ channels with a single-channel co