ライフサイエンスコーパス: iodothyronine

1 thyronine and elevated levels of reverse Tri-iodothyronine.

2 DLK1-DIO3 (delta-like 1 homolog-deiodinase, iodothyronine 3) cluster on human chromosome 14.

3 due in part to decreased activity of type I iodothyronine 5'-deiodinase (5' D-I), the hepatic enzyme

4 xine dynamically regulates levels of type II iodothyronine 5'-deiodinase (5'D-II) by modulating enzym

5 f genes: (A). clone MGC: 19375; (B). Type II iodothyronine 5'-deiodinase (D2); (C). reduced expressio

6 abeling of p29 in astrocytes lacking type II iodothyronine 5'-deiodinase activity and examined the ef

7 ow that cAMP-dependent activation of type II iodothyronine 5'-deiodinase activity results from the sy

8 encodes an essential subunit of rat type II iodothyronine 5'-deiodinase and 2) identify the first no

9 Type II iodothyronine 5'-deiodinase catalyzes the bioactivation

10 n sequence elements from the GPX1 and type I iodothyronine 5'-deiodinase genes in RNA electrophoretic

11 Type II iodothyronine 5'-deiodinase is an approximately 200-kDa

12 In astrocytes, thyroxine modulates type II iodothyronine 5'-deiodinase levels by initiating the bin

13 ired to express catalytically active type II iodothyronine 5'-deiodinase.

14 aracterized by low levels of circulating tri-iodothyronine and elevated levels of reverse Tri-iodothy

15 relative concentrations of three circulating iodothyronines, as well as neurological abnormalities, i

16 y displacing an autoinhibitory loop from the iodothyronine binding site.

17 ormone or free tri-iodothyronine, free tetra-iodothyronine decreased by 19% (23 to 16) in the 50 mug

18 ry, there is a persistent increase in type 2 iodothyronine deiodinase (D2) activity in the mediobasal

19 the tadpole catalyzed by the enzyme type II iodothyronine deiodinase (D2) and the local effect (cell

20 The enzyme type II iodothyronine deiodinase (D2) converts thyroxine (T4) to

21 Although a putative human type 2 iodothyronine deiodinase (D2) gene (hDio2) encoding a si

22 Type 2 iodothyronine deiodinase (D2) is a recently cloned selen

23 Type 2 iodothyronine deiodinase (D2) is a selenoenzyme, the pro

24 The type 2 iodothyronine deiodinase (D2) is an integral membrane ER

25 The type 2 iodothyronine deiodinase (D2) is critical for the intrac

26 The cAMP-responsive gene for type 2 iodothyronine deiodinase (D2), an intracellular enzyme t

27 limiting steps in the inactivation of type 2 iodothyronine deiodinase (D2).

28 inactivating (TH-inactivating) enzyme type 3 iodothyronine deiodinase (D3) is an oncofetal protein th

29 Type 3 iodothyronine deiodinase (D3), the thyroid hormone-inact

30 xpresses extremely high levels of the type 3 iodothyronine deiodinase (D3), which inactivates thyroxi

31 H was caused by reduced expression of type 2 iodothyronine deiodinase (Dio2), a gene that is required

32 we found that the activity and expression of iodothyronine deiodinase 2 (DIO2), an enzyme that activa

33 lenium, which is at the active center of the iodothyronine deiodinase enzymes that catalyze the conve

34 by the action of activating and inactivating iodothyronine deiodinase enzymes.

35 e delta-like homolog 1 gene and the type III iodothyronine deiodinase gene (Dlk1-Dio3) is located on

36 Type I iodothyronine deiodinase is a approximately 50-kDa, inte

37 thyroid hormone (TH) receptor or a type-III iodothyronine deiodinase transgene in the nervous system

38 Type 2 iodothyronine deiodinase, an enzyme involved in the conv

39 s the actin-based endocytosis of the type II iodothyronine deiodinase.

40 hat antithyroid drug treatment and targeting iodothyronine deiodinases (DIOs) to suppress cellular tr

41 Iodothyronine deiodinases (IDs) are mammalian selenoenzy

42 ly (GPX1, GPX2, GPX3, and GPX4), one or more iodothyronine deiodinases and two thioredixin reductases

43 The iodothyronine deiodinases are a family of oxidoreductase

44 Types 1 and 3 iodothyronine deiodinases are known to be selenocysteine

45 ins containing redox-active cysteines or the iodothyronine deiodinases containing an active site sele

46 Targeting iodothyronine deiodinases locally in the retina is a the

47 d selenoprotein genes encoding type I and II iodothyronine deiodinases, respectively.

48 oral dependency, we investigated the role of iodothyronine deiodinases, which in target tissues conve

49 Cl(-) uptake was inhibited differentially by iodothyronine derivatives.

50 r TH level is mainly regulated by deiodinase iodothyronine (DIO)-2 and -3.

51 and experimental evidence for the use of tri-iodothyronine during cardiac surgery are reviewed.

52 s of thyroid-stimulating hormone or free tri-iodothyronine, free tetra-iodothyronine decreased by 19%

53 A new study shows that iodothyronines induce metamorphosis in the cephalochorda

54 Iodothyronine-induced metamorphosis may be an ancestral

55 with decreased concentrations of plasma tri-iodothyronine, low thyroxine, and normal range or slight

56 lled in a randomized controlled trial of tri-iodothyronine+/-methylprednisolone [MP] therapy) undergo

57 eceptors, rapid (5 s) actions of a series of iodothyronines on muscimol-stimulated uptake of (36)Cl(-

58 at Tyr130 is an important donor of the outer iodothyronine ring.

59 The type 3 iodothyronine selenodeiodinase (D3) is an integral membr

60 This low tri-iodothyronine state may have significant hemodynamic con

61 Clinically, tri-iodothyronine supplementation after cardiac surgery impr

62 evidence has accumulated suggesting that tri-iodothyronine supplementation to the ischemically injure

63 Thyroid hormone thyroxine (T(4)) and tri-iodothyronine (T(3)) production is regulated by feedback

64 lls treated (24 h) with a combination of tri-iodothyronine (T(3), 10 nM) and dexamethasone (200 nM).

65 Thyroid hormone 3,5,3'-tri-iodothyronine (T3) binds and activates thyroid hormone r

66 hyperthyroidism, we administered 200 mug tri-iodothyronine (T3) in 7- and 27-mo-old rats for 14 d.

67 accomplished by injecting suspensions of tri-iodothyronine (T3) in coconut oil into the midbrain vent

68 Both glucose-insulin-potassium (GIK) and tri-iodothyronine (T3) may improve cardiovascular performanc

69 deiodinases (DIOs) to suppress cellular tri-iodothyronine (T3) production or increase T3 degradation

70 Here we show that tri-iodothyronine (T3) treatment in mice acutely and specifi

71 fter stimulation, in vivo, for 24 h with tri-iodothyronine (T3).

72 (subnormal ratio of free thyroxine:free tri-iodothyronine [T3], low concentration of total reverse T

73 Thyroid hormones are iodothyronines that control growth and development, as w

74 ing the reductive elimination of iodide from iodothyronines through a poorly understood mechanism.

75 insulin, cortisol, parathyroid hormone, tri-iodothyronine uptake (T3 uptake), and free thyroxine ind

76 Molecular modeling of the active iodothyronines using the Gaussian03 series of programs i