ライフサイエンスコーパス: ion channel

1 of rASIC3 did not produce a proton-sensitive ion channel.

2 rfaces between AMPA receptor subunits in the ion channel.

3 C) transporter that uniquely functions as an ion channel.

4 and a spliced transcript that encodes the M2 ion channel.

5 induce an acidosis and activate acid sensing ion channels.

6 a range of proteins, including transmembrane ion channels.

7 ors, which are Cl(-)-permeable, ligand-gated ion channels.

8 et differ from them in their ability to form ion channels.

9 ode-shift or hysteresis has been reported in ion channels.

10 ssion of genetically encoded photo-excitable ion channels.

11 nism could also occur in the gating of other ion channels.

12 the structural basis for gating in potassium ion channels.

13 n cytoplasmic Ca(2+), which is controlled by ion channels.

14 ly hypothesized temperature mechanism in TRP ion channels.

15 niscent of an omega current in voltage-gated ion channels.

16 creening for G-protein-coupled receptors and ion channels.

17 A2), whose metabolites are known to modulate ion channels.

18 hannel gating in all pentameric ligand-gated ion channels.

19 ions form voltage-independent, non-selective ion channels.

20 activity, suggesting no involvement of other ion channels.

21 analyzing the behavior of transmitter-gated ion channels.

22 of a variety of membrane proteins including ion channels.

23 to lipid bilayers and forms IAA-94-sensitive ion channels.

24 ed DNA and the synthesis of mechanosensitive ion channels.

25 ifying, and adaptive functions of biological ion channels.

26 ABAA receptors are brain inhibitory chloride ion channels.

27 transmission by functioning as ligand-gated ion channels.

28 ena, notably the gating of stretch activated ion channels.

29 nvolved in this process are mechanosensitive ion channels.

30 sient receptor potential (TRPM) subfamily of ion channels.

31 nd is extendable to other toxin peptides and ion channels.

32 low sequence similarity to CFTR and are not ion channels.

33 different combinations of voltage-dependent ion channels.

34 s, represent different subtypes of glutamate ion channels.

35 eria in the form of SspA, forming functional ion channels.

36 Acid-sensing ion channel 1a (ASIC1a) is the primary acid sensor in ma

37 se express functional homomeric Acid-sensing ion channel-1a (ASIC-1as) that can be activated by proto

38 ncluding the SNAREs [3], SM proteins [4, 5], ion channels [6, 7], and receptors (e.g., [8]).

39 rsion of ion current among numerous fragment ion channels (a,b,c,x,y,z ions).

40 annels (ASICs) are trimeric cation-selective ion channels activated by protons in the physiological r

41 s (NMDARs) are Ca(2+)-permeant, ligand-gated ion channels activated by the excitatory neurotransmitte

42 NMDA receptors (NMDARs) are ion channels activated by the excitatory neurotransmitte

43 e coupling, are at work in voltage-dependent ion channel activation.

44 has made it possible to investigate directly ion channel activities and characteristics in isolated e

45 activating mutations, and Rac1 induces TRPC5 ion channel activity and cytoskeletal remodeling in podo

46 that NHERF proteins are direct regulators of ion channel activity and that DAG sensitivity is a disti

47 The modulation of ion channel activity by lipids is increasingly recognize

48 lar signaling, gene expression, and membrane ion channel activity.

49 that a synthetic peptide of the NSP4 VPD has ion channel activity.

50 is that is mediated by neurotransmitters and ion channel activity.Functions of the embryonic brain pr

51 tion-activated cyclic nucleotide-gated (HCN) ion channels, alters both the cell surface expression an

52 as to demonstrate that the NSP4 VPD forms an ion channel and determine whether the channel can conduc

53 eases expression of the heat-sensitive TRPV1 ion channel and reduces expression of the mechanically-s

54 ransitions during opening and closing of the ion channel and represents a novel allosteric binding si

55 alpha2betagammadelta nAChRs, binding in the ion channel and to a gamma(+)-alpha(-) subunit interface

56 Studying how the membrane modulates ion channel and transporter activity is challenging beca

57 ighted by redocking of peptide toxins to two ion channels and a binding protein in which the peptide

58 ential switching is achieved by establishing ion channels and an oxygen-functional-group gradient in

59 each other, adhesion molecules interact with ion channels and cytokine and neurotransmitter receptors

60 s integrate the action of several classes of ion channels and exchangers, they could act as functiona

61 Blockage of some ion channels and in particular, the hERG (human Ether-a'

62 iffusive receptors is a common feature among ion channels and is crucial to modulate signaling transd

63 of a conserved protein family that comprises ion channels and lipid scramblases.

64 ong to the family of pentameric ligand-gated ion channels and mediate fast excitatory transmission in

65 f thalamocortical cells, such as dynamics of ion channels and membrane potentials, is useful and esse

66 tic proteins including many GPCRs, receptors/ion channels and peripheral membrane proteins.

67 We also explore the role of membrane ion channels and pumps in setting up the spatially varyi

68 Piezo proteins are distinct from other ion channels and their structure remains poorly defined,

69 proteomics analyses, more than 70 different ion channels and transporters are harbored in membranes

70 lling molecule which affects the activity of ion channels and transporters in epithelial cells.

71 defining the contributions of the individual ion channels and transporters were estimated by least-sq

72 GluR2/3 receptors and Nav, Cav voltage-gated ion channels) and demonstrated the ability of our model

73 r, hindered by a limited variety of suitable ion channels, and by low spatial and temporal resolution

74 retion was inhibited by the mechanosensitive ion channel antagonists gadolinium, ruthenium red and D-

75 acteristics of tetrameric glutamate receptor ion channels are determined by their subunit composition

76 nals arising from measurement using multiple ion channels are more complicated to interpret.

77 It has been proposed that mechanically gated ion channels are of functional importance in chondrocyte

78 Allosteric modulators of ligand-gated ion channels are of particular interest as therapeutic a

79 steric modulators of pentameric ligand-gated ion channels are thought to act on elements of the pathw

80 KEY POINTS: Ion channels are transmembrane proteins that are synthes

81 synaptic inputs and the roles of particular ion channels are unclear.

82 ction and PD pathogenesis and highlight this ion channel as a potential therapeutic target for treati

83 lution and it demonstrates the usefulness of ion channels as highly sensitive reporters of membrane p

84 low extracellular pH, leads to acid-sensing ion channel (ASIC) activation and reflexively increases

85 peptide that targets the nociceptor-specific ion channel ASIC3.

86 Acid-sensing ion channels (ASICs) are neuronal receptors for extracel

87 Acid-sensing ion channels (ASICs) are proton-activated Na(+) channels

88 Acid-sensing ion channels (ASICs) are proton-gated Na(+) channels tha

89 Acid-sensing ion channels (ASICs) are trimeric cation-selective ion c

90 Acid-sensing ion channels (ASICs) form both homotrimeric and heterotr

91 Acid-sensing ion channels (ASICs) regulate synaptic activities and pl

92 drug (NSAID) pharmacology with acid-sensing ion channels (ASICs), a small family of excitatory neuro

93 Acid-sensing ion channels (ASICs), expressed in thin muscle afferents

94 to excitatory sodium influx by acid-sensing ion channels (ASICs).

95 tate receptors (NMDARs) are heterotetrameric ion channels assembled as diheteromeric or triheteromeri

96 activated transient receptor potential (TRP) ion channel at S936 is a fast, graded, light-dependent,

97 als via the gating of mechanically activated ion channels at sensory endings in the skin.

98 romycin caused effects consistent with multi-ion channel block, with significant sinus slowing and in

99 ugs that are determined not to cause cardiac ion channel blockage are more likely to pass successfull

100 er blue/green, and could be inhibited by the ion channel blocker, capsazepine.

101 ) dependence as R-mTFD-MPAB within the nAChR ion channel, but it does not bind to the intersubunit bi

102 nkyrin repeat 1 (TRPA1), a major nociceptive ion channel, but the underlying mechanisms and site of a

103 iples governing the operation of light-gated ion channels, but also enabled the creation of new prote

104 neuronal excitability by acting directly on ion channels, but such mechanisms are poorly understood.

105 g via the transient receptor potential (TRP) ion channel C6 plays a pivotal role in hereditary and sp

106 layers expressing a depolarizing light-gated ion channel (Ca(2+)-translocating channelrhodopsin) were

107 Several transient receptor potential (TRP) ion channels can be directly activated by hot or cold te

108 3D structural information on the unique ABC ion channel, CFTR, hinders elucidation of its functional

109 neural cells expressing the light-sensitive ion channel, channelrhodopsin, were isolated from the fe

110 flexibility to neurons and to participate in ion channel clustering at axon initial segments (AIS) an

111 ed 2378 models of voltage- and calcium-gated ion channels coded in NEURON to 211 clusters.

112 (PC1) and polycystin-2 (PC2), which form an ion channel complex that may mediate ciliary sensory pro

113 tin-2 (PC2), form a plasma membrane receptor-ion channel complex.

114 encode novel subunits of a 9-subunit CatSper ion channel complex.

115 These channels colocalize and form ion channel complexes with voltage-dependent Ca(2+) (CaV

116 By implementing known differences in ion channel composition and morphology, our model reprod

117 Neuronal physiology depends on a neuron's ion channel composition and unique morphology.

118 ates the expression of a mechanotransductive ion channel comprising MEC-4 and MEC-10 in touch-recepto

119 Ion channel conductance results suggested that Abeta(1-4

120 Pentameric ligand-gated ion channels control synaptic neurotransmission by conve

121 Mechanosensitive ion channels convert external mechanical stimuli into el

122 the fundamental role that membrane-mediated ion-channel cooperativity can play in sensory physiology

123 ABSTRACT: The normal function of ion channels depends critically on the precise subcellul

124 Episodic ataxia is an autosomal dominant ion channel disorder characterized by episodes of imbala

125 he overexpression or activation of the TRPC5 ion channel does not cause kidney barrier injury or aggr

126 De novo KCNB1 missense variants in the ion channel domain and loss-of-function variants in this

127 , 20 (77%) carried a missense variant in the ion channel domain of KCNB1, with a concentration of var

128 ng out a role for the lipid bilayer in their ion channel effects.

129 store-operated Ca(2+) entry (SOCE) and other ion channels either as an endoplasmic reticulum Ca(2+)-s

130 fer light-sensitivity on endogenous neuronal ion channels, enabling photocontrol of neuronal activity

131 trotrapezoid nucleus (RTN), but the specific ion channels essential to these activities remain to be

132 measurement of the single-channel current of ion channels even when it is too small to be resolved di

133 ctional "reporters" for the constellation of ion channels/exchangers expressed in each sensory neuron

134 Ion channels expressed by peripheral sensory neurons lar

135 eceptors (GlyRs) are inhibitory ligand-gated ion channels expressed in nerves of the spinal dorsal ho

136 drome through a HEY2-dependent alteration of ion channel expression across the cardiac ventricular wa

137 rojections, neurochemistry, and receptor and ion channel expression in this cell population vary wide

138 (2+) currents after downregulation of Cav2.3 ion channel expression, in a process involving ERbeta.

139 al-to-animal variability and compensation in ion channel expression.

140 d Western blotting to investigate changes in ion channel expression.

141 We conclude that the ion channel extracellular collar plays a distinct role i

142 esis and patch-clamp recordings to probe the ion channel extracellular collar, the binding region for

143 mains M1, M3 and M4, which contribute to the ion channel extracellular collar, undergo significant re

144 ing the driving force and permeation through ion channels facing the synaptic cleft.

145 Genes involved in sleep control code for ion channels, factors influencing neurotransmission and

146 Ion channel families are broadly classified into three t

147 ion of Cre-recombinase and a light-activated ion channel for optical stimulation of the transduced fi

148 for fast ICWs or opening of mechanosensitive ion channels for slow ICWs, which then propagated in the

149 nsertion and channel formation, now aligning ion channel formation with the differential neurotoxic e

150 eceptor potential (TRP) channels, a group of ion channels from the transient receptor potential famil

151 tions, indicating that anesthetic effects on ion channel function are not bilayer-mediated but rather

152 esting that the isoboles for drug actions on ion channel function are not linear.

153 ufficiently to produce meaningful changes in ion channel function at clinically relevant concentratio

154 ORF3's ion channel function is further evidenced by its ability

155 Loss of embryonic ion channel function leads to morphological defects, but

156 proposes that anesthetic-induced changes in ion channel function result from changes in bilayer late

157 The precise control of an ion channel gate by environmental stimuli is crucial for

158 highly conserved transmembrane domain of the ion channel gate, immediately adjacent to the analogous

159 Other medicinally important ion channels, gated by glutamate, gamma-aminobutyric aci

160 Ion channel gating is essential for cellular homeostasis

161 nment, and highlight the power of describing ion channel gating through the lens of allosteric coupli

162 r Notch reactivation may stably alter atrial ion channel gene expression and arrhythmia inducibility.

163 ansient Notch activation persistently alters ion channel gene expression and atrial electrophysiology

164 signaling regulates transcription factor and ion channel gene expression within adult atrial myocardi

165 in of the Gloeobacter violaceus ligand-gated ion channel (GLIC) channel, characterize the putative bi

166 ment with fully atomistic simulations of the ion channel gramicidin embedded in a POPC membrane.

167 transport studies was tested using the model ion channel, gramicidin, and voltage-clamp fluorometry m

168 tial vanilloid 4 (TRPV4), a mechanosensitive ion channel, has been implicated in cardiac and pulmonar

169 Modulators of transmitter-gated ion channels have a wide range of maximal effects as wel

170 major principles of function for light-gated ion channels have been elucidated by creating channelrho

171 Tetrameric ion channels have either swapped or non-swapped arrangem

172 A variety of mechanosensitive ion channels have evolved to facilitate these responses,

173 codes the cardiac human ether-a-go-go (hERG) ion channel, have been associated with sudden cardiac de

174 on-activated and cyclic nucleotide-modulated ion channel (HCN) drives the pacemaker activity in the h

175 RATIONALE: Downregulation of the pacemaking ion channel, HCN4 (hyperpolarization-activated cyclic nu

176 vitro using mice, cardiomyocytes, and human ion channels heterologously expressed in human embryonic

177 hallenges of docking large toxin peptides to ion channel homology models, as exemplified by the alpha

178 ssumed to be neuronal membrane receptors and ion channels, however new evidence points to critical ef

179 The binding of a target analyte to an ion channel (IC), which is readily detected electrochemi

180 pedo model; the only pentameric ligand-gated ion channel imaged in a native lipid membrane.

181 on of the adult brain.SIGNIFICANCE STATEMENT Ion channels implicated in oligodendrocyte differentiati

182 We used a mouse expressing a light-sensitive ion channel in beta-cells to understand how alpha-cell a

183 h the scaffolding protein Yotiao and the IKs ion channel in heart.

184 tial vanilloid 1 (TRPV1), a Ca(2+)-permeable ion channel in nociceptors.

185 that enabled the analysis of availability of ion channels in multiple states during spiking.

186 However, the activation of MS ion channels in planar supported lipid bilayers, such as

187 le of mechanosensitive (MS) Ca(2+)-permeable ion channels in platelets is unclear, despite the import

188 pharmacological inhibition of overexpressed ion channels in specific cancer subtypes as a potential

189 Rather, it is mediated by voltage-gated ion channels in the cone membrane and acts by changing t

190 evaluating drug effects on multiple cardiac ion channels in vitro and using these data in a predicti

191 tion of the cardiac lineages in neonates and ion-channels in adults.

192 ivity by modulating the function of membrane ion channels, in particular, by enhancing activity of GA

193 The KCNQ1 ion channel inhibitor chromanol 293B caused membrane dep

194 Membrane proteins, such as ion channels, interact dynamically with their lipid envi

195 TRPA1 is a Ca(2+)-permeable ion channel involved in many sensory disorders such as p

196 p7 viroporin, an oligomeric membrane protein ion channel involved in the assembly and release of the

197 We conclude that the KCNQ1 ion channel is a target gene and regulator of the Wnt/be

198 One ion channel is activated by sound and is responsible for

199 We show here that the second ion channel is expressed at the apical surface of hair c

200 Gating of ion channels is based on structural transitions between

201 The sensitivity of Piezo mechanically gated ion channels is controlled by stomatin-like protein-3 (S

202 wever, measuring the dynamical properties of ion channels is extremely challenging experimentally and

203 siological characterization of intracellular ion channels is lacking, mainly because standard methods

204 The functional repertoire of surface ion channels is sustained by dynamic processes of traffi

205 show that the binding of cGMP to pacemaking ion channels is weakened by a slower internal conformati

206 ive comparisons of simulated and/or measured ion channel kinetics, and facilitates field-wide standar

207 ed by stator units, ion motive force-powered ion channels known to assemble and disassemble dynamical

208 can directly alter the properties of native ion-channel Kv4.3 and accelerate the pacemaker activity

209 racellular channels (CLIC) are non-classical ion channels lacking a signal sequence for membrane targ

210 d relationships with the activities of other ion channels lead to exquisite control of intracellular

211 The S672R mutation in heart cell ion channels leads to low heart rates and arrhythmia by

212 structure within this class of ligand-gated ion channels (LGICs).

213 , and indicates how local-global coupling of ion channels may affect cell behavior.

214 mechanisms that eukaryotic mechanosensitive ion channels may use to detect and fine-tune their respo

215 icrofluidic approach, we find that potassium ion channel-mediated electrical signaling generated by a

216 Ion channel models are the building blocks of computatio

217 k of standardization, make the comparison of ion channel models with one another and with experimenta

218 the automated large-scale classification of ion channel models.

219 ermidine, a large natural cation involved in ion channel modulation, revealing a previously unrecogni

220 gene expression of K(+)-channel subunits and ion channel modulators, relevant in human AF.

221 lay at least two types of mechanically gated ion channel: normal mechanotransducer (MT) channels at t

222 Fluoride ion channels of the Fluc family combat toxicity arising

223 us be utilized for drug development aimed at ion channel opener- or inhibitor-function.

224 ator of conformational rearrangements during ion channel opening and closing.

225 r along the complete reaction coordinate for ion channel opening have never been observed.

226 tes and determine the iris-like mechanism of ion channel opening.

227 tion process connecting glutamate binding to ion-channel opening, which is central to NMDAR physiolog

228 functional characterization of transporters, ion channels, or G-protein-coupled receptors in cotransl

229 in the endoplasmic reticulum, and the Ca(2+) ion channel Orai in the plasma membrane.

230 proteins (NF200, Ankyrin G, and Myelin) and ion channels (Pan-Nav , Nav 1.6, and Kv 3.1b).

231 mic drug-hERG channel interactions and multi-ion channel pharmacology improves the prediction of tors

232 cific ablation of the mechanically activated ion channel Piezo2 causes respiratory distress and death

233 sent study suggest that the mechanosensitive ion channel Piezo2 is specifically expressed by the EC c

234 or the first time, that the mechanosensitive ion channel Piezo2 is specifically expressed by the huma

235 ium selectively express the mechanosensitive ion channel Piezo2, and also that activation of Piezo2 b

236 Together, our data indicate that DEG/ENaC ion channels play a fundamental role in the postsynaptic

237 -activated cyclic nucleotide-regulated (HCN) ion channels play crucial physiological roles in phototr

238 Desensitization in pentameric ligand-gated ion channels plays an important role in regulating neuro

239 Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical signaling th

240 barbiturate binding site within the central ion channel pore in a closed conformation.

241 ch Abeta exerts toxicity is the formation of ion channel pores that disrupt intracellular Ca(2+) home

242 ate (PIP2) can directly or indirectly modify ion-channel properties.

243 Viroporins are small virus-encoded ion channel proteins.

244 aled TGF-beta1-dependent changes in 29 of 63 ion channel/pump/connexin transcripts, indicating a plei

245 trical cell signaling requires adjustment of ion channel, receptor, or transporter function in respon

246 larization-activated cyclic nucleotide-gated ion channel rescues the muscle phenotype and the neural

247 sought to understand why a defect in an RPE ion-channel result in abnormal electrophysiology at the

248 The ryanodine receptor ion channel RyR1 is present in skeletal muscle and has a

249 The ion channel selectivity filter is formed by the extended

250 Ca(2+)-activated, non-selective (CAN) ion channels sense increases of the intracellular Ca(2+)

251 molecules, transmitter-modulator receptors, ion channels, signaling proteins, neuropeptides and vesi

252 r the investigation of mechanosensitive (MS) ion channels, since they are highly sensitive to their l

253 define a cryptic binding pocket unlike other ion channel small-molecule binding sites and, together w

254 KCNQ-SMIT complex formation facilitates ion channel-solute transporter cross talk.

255 TARPs encircle the receptor ion channel, stabilizing M2 helices and pore loops, illu

256 cal model of a dopamine neuron incorporating ion channel stochasticity that enabled the analysis of a

257 nstrate how discrete evolutionary changes in ion channel structure facilitate sensory adaptation.

258 of understanding of the structural basis for ion channel subconductance states further highlight chal

259 ping and raise the possibility that a single ion channel subtype can fold into either arrangement in

260 remodeling events, reduced expression of the ion channel subunit KChIP2 is consistently observed in n

261 standard methods to analyze plasma membrane ion channels, such as the patch-clamp technique, are not

262 They belong to the voltage-gated ion channel superfamily but their activities are control

263 ) are members of the pentameric ligand-gated ion channel superfamily.

264 Stochastic events in a single ion channel system can be measured using current-time tr

265 Moreover, this novel ion channel-targeted peptide rapidly crosses the BBB aft

266 ptor Potential A 1 (TRPA1) is a ligand-gated ion channel that contributes to inflammatory mechanical

267 alcium uniporter (MCU) is a highly selective ion channel that transports Ca(2+) into the mitochondria

268 s) form both homotrimeric and heterotrimeric ion channels that are activated by extracellular protons

269 Data sets describing the main types of ion channels that are expressed in human synovial fibrob

270 Insulin exocytosis is regulated by ion channels that control excitability and Ca(2+) influx

271 odopsins (ChR1 and ChR2) are light-activated ion channels that enable photomobility of microalgae fro

272 are members of the ENaC/degenerin family of ion channels that evolved to respond to extracellular fa

273 The ion channels that mediate electrogenic ion transport are

274 Piezo1 and Piezo2 are mechanically activated ion channels that mediate touch perception, propriocepti

275 dies have focused on pentameric ligand-gated ion channels, the details of anesthetic binding and chan

276 ly target specific neuronal proteins, mainly ion channels, the targets of conopeptides are less well

277 Similar to other ligand-gated ion channels, their gating cycle begins with transitions

278 gh ligand concentrations and high numbers of ion channels to demonstrate that there is an upper limit

279 ubule) membrane microfolds, which facilitate ion channel trafficking and modulate local ionic concent

280 Sensitization of the heat-activated ion channel transient receptor potential vanilloid 1 (TR

281 showed that activation of a thermoregulatory ion channel, transient receptor potential vanilloid 1 (T

282 ation of various membrane proteins including ion channels, transporters and membrane-integrated enzym

283 Recent evidence suggests that the ion channel TRPA1 is implicated in lung adenocarcinoma (

284 chmidtea mediterranea and that the conserved ion channel TRPA1 is required for these responses.

285 t G2A activation sensitizes the ligand-gated ion channel TRPV1 in sensory neurons via activation of P

286 These dimeric voltage-gated ion channel (VGIC) superfamily members have a unique top

287 In voltage-activated ion channels, voltage sensor (VSD) activation induces po

288 sient receptor potential vanilloid 1 (TRPV1) ion channel was expressed in hADSC, and the TRPV1 ligand

289 ns of this structural family on ligand-gated ion channels, we employed HEK cells transfected with cDN

290 onin, acetylcholine and opioids-and numerous ion channels were associated with SCZ.

291 assessing drug effects on expressed cardiac ion channels were integrated into the O'Hara-Rudy myocyt

292 2+) uniporter complex (MCUC) is a multimeric ion channel which, by tuning Ca(2+) influx into the mito

293 study provides an example of a ligand-gated ion channel whose deactivation is sensitive to agonist c

294 hannel is a Ca(2+)-permeable thermosensitive ion channel widely expressed in keratinocytes, where tog

295 Channelrhodopsins (ChRs) are light-activated ion channels widely employed for photostimulation of exc

296 Channelrhodopsins (ChRs) are light-gated ion channels widely used for activating selected cells i

297 atin 7 (TRPM7) is a protein that combines an ion channel with an intrinsic kinase domain, enabling it

298 a 35-residue protein that binds to the Kv1.3 ion channel with high affinity.

299 ress specific calcium permeable plasmalemmal ion channels with available selective pharmacological ac

300 that hERG1b preferentially forms heteromeric ion channels with hERG1a at the plasma membrane.