ライフサイエンスコーパス: ion permeation

1 ations, reduced K(+) affinity, and increased ion permeation.

2 and points to a role of the internal pore in ion permeation.

3 ergetics and electrostatics control membrane ion permeation.

4 of ligand-gating, allosteric modulation and ion permeation.

5 whether a mutation alters the energetics of ion permeation.

6 e charge and solvent philicity could enhance ion permeation.

7 ossibly be a temporary reservoir involved in ion permeation.

8 in channel gating in addition to its role in ion permeation.

9 states, consistent with its explicit role in ion permeation.

10 also be generated in more detailed models of ion permeation.

11 e central hydrated cavity, a crucial step in ion permeation.

12 e molecular mechanisms of channel gating and ion permeation.

13 the microscopic details of the mechanism of ion permeation.

14 uggesting that these residues have a role in ion permeation.

15 imer assembly, in addition to any effects on ion permeation.

16 pore loop are crucial for pore structure and ion permeation.

17 and pose intriguing mechanistic questions of ion permeation.

18 egatively charged residues in the process of ion permeation.

19 osolic G loop) may serve as gates to control ion permeation.

20 isms of channel gating, desensitization, and ion permeation.

21 esize that membrane interactions also affect ion permeation.

22 onductance; thus, the TARP C-tail influences ion permeation.

23 -helices is a key determinant of the rate of ion permeation.

24 a single gate into a position that occludes ion permeation.

25 y filter are critical for pain behaviour and ion permeation.

26 inhibited CRAC channel activity by blocking ion permeation.

27 ty to modulate RyR1 gating without affecting ion permeation.

28 es) into a position that physically occludes ion permeation.

29 an important role in channel activation and ion permeation.

30 h stabilizes a hydrated K(+) and facilitates ion permeation.

31 id interface and allosterically modulate the ion permeation.

32 hydrophobic gating mechanism for control of ion permeation.

33 nnels vary significantly among their rate of ion permeation.

34 ntribution of individual charged residues to ion permeation.

35 arallels to membranes deformed by unassisted ion permeation.

36 scanning to map the paracellular pathway of ion permeation across claudin-2-transfected Madin-Darby

37 c acid, significantly decreased paracellular ion permeation across I66C-transfected cells by a mechan

38 Understanding the mechanism of ion permeation across lipid bilayers is key to controlli

39 However, the relationship between ion permeation and animals' nocifensive behaviour is unk

40 rchitecture explains the crucial features of ion permeation and blockade, and gives some strong hints

41 ring models of the channel in the context of ion permeation and blocking agents.

42 sidue determines single-channel conductance, ion permeation and channel block in the NMDA receptor, t

43 These domains determine ion permeation and channel block processes and are exten

44 ses), revealing intriguing interplay between ion permeation and channel gating.

45 -wide oscillation caused by coupling between ion permeation and channel gating.

46 ning ligand recognition, heteromer assembly, ion permeation and desensitization in this prototypical

47 membrane channels both for basic studies of ion permeation and for applications in biotechnology.

48 e fundamental implications for understanding ion permeation and gating in P2X receptor channels, as w

49 We studied ion permeation and gating of an inwardly rectifying K+ c

50 ntributed profoundly to our understanding of ion permeation and gating, it remains unclear how much t

51 may stem from the closed interaction between ion permeation and gating.

52 uch a wide inner pore may greatly facilitate ion permeation and high-affinity binding of multiple por

53 The structural basis for ion permeation and ion channel block also remain areas o

54 these results and describe the energetics of ion permeation and ionic fluxes, continuum approaches (P

55 arge distribution of the channel that govern ion permeation and selectivity in OmpF.

56 ies that have increased our understanding of ion permeation and selectivity mechanisms.

57 We explored the contribution to ion permeation and selectivity of residues in the TM2 se

58 The ion permeation and selectivity properties of these nanop

59 nal DE motif that has a critical role in RyR ion permeation and selectivity.

60 asparagine and glutamine profoundly affected ion permeation and selectivity.

61 els that underlie ligand binding, gating, or ion permeation, and have thus served as invaluable tools

62 ior (gating kinetics, modal transitions, and ion permeation) are interrelated and are modulated by th

63 that quantitatively relates the spontaneous ion permeation at equilibrium to the stationary ionic fl

64 racts lipid molecules, which probably causes ion permeation, but no molecular leakage.

65 Light-gated ion permeation by channelrhodopsin-2 (ChR2) relies on th

66 ing medium is incorporated into the model of ion permeation by including the free energy of inserting

67 with creation of an electrostatic barrier to ion permeation by lidocaine's charge.

68 + channel subunits mediate rapid blockade of ion permeation by physical occlusion of the ion-conducti

69 Q747A) predicted to increase the size of its ion permeation cavity enhanced the sensor response and a

70 87 A resolution as a basis for understanding ion permeation, channel activation, the location of volt

71 (+) dynamics reveals a knock-on mechanism of ion permeation characterized by alternating occupancy of

72 segments are drawn tightly together to block ion permeation completely.

73 icated that the mutation selectively impacts ion permeation coupled to 5HT occupancy.

74 eration and migration through both canonical ion permeation-dependent and noncanonical ion permeation

75 rporating intra- and extracellular geometry, ion permeation, diffusion, extrusion, and buffering sugg

76 (1) Presently, we consider ion permeation energetics in the gramicidin A channel us

77 te makes it feasible to simulate entire K(+) ion permeation events driven by a voltage bias and, ther

78 ry between S2 and S3 in the context of multi-ion permeation events.

79 t the GYG motif is a critical determinant of ion permeation for HCN channels, and that HCN1 and HCN2

80 the potential of mean force (PMF) governing ion permeation from molecular dynamics simulations (MD)

81 ate dependence, suggesting the absence of an ion permeation gate at the cytosolic side of BK channel.

82 cal conditions, although their mechanisms of ion permeation gating are not well understood.

83 cal conditions, although their mechanisms of ion permeation gating are not well understood.

84 ew framework for understanding mechanisms of ion permeation, gating and channelopathy of cyclic-nucle

85 RPV6 channels open and close their pores for ion permeation has remained unclear.

86 new insight into the mechanism of selective ion permeation in bacterial Na(v) channels.

87 Understanding the mechanisms of gating and ion permeation in biological channels and receptors has

88 Here, we show that ion permeation in CNG channels is tightly regulated at t

89 ism to lower the free energy barrier for the ion permeation in disagreement with predictions from the

90 arge-ring amino acids affects gating but not ion permeation in HCN2 and CNG channels.

91 y simulation studies on the understanding of ion permeation in selective and nonselective ion channel

92 lations capture the essential nature of K(+) ion permeation in the KcsA channel and provide a proof-o

93 and CRAC the general property of monovalent ion permeation in the nominal absence of extracellular d

94 o study and compare monovalent (Na(+), K(+)) ion permeation in the open-activated TRP vanniloid-1 (TR

95 ide a framework for understanding gating and ion permeation in this superfamily.

96 rts of the subunits involved in ATP binding, ion permeation (including calcium permeability), and mem

97 al ion permeation-dependent and noncanonical ion permeation-independent functions.

98 Ion permeation involving TRPC5 is crucial because S1P-ev

99 eory indicated that the major barrier to Cl- ion permeation is at the intracellular side of the membr

100 Modulation of ion permeation is crucial for the physiological function

101 In this regime, ion permeation is found to be thermally activated with e

102 Ion permeation is influenced by the orientation of the s

103 As in standard PNP, ion permeation is modeled as a continuum drift-diffusion

104 nt implications for our understanding of how ion permeation may be controlled in similar ion channels

105 The ion permeation mechanism in the transient receptor poten

106 g in fluid anisotropic media and details the ion permeation mechanism on atomic level.

107 barriers associated with the different multi-ion permeation mechanisms.

108 work, we employed a simulation strategy for ion permeation (molecular-dynamics simulations with bias

109 d the location of two binding sites for K(+) ion permeation near the channel entrance--i.e., an inner

110 important implications for understanding how ion permeation occurs, and further how it may be control

111 opening of Slo2.1 or Slo2.2, suggesting that ion permeation of Slo2 channels is not predominantly gat

112 Here we explore ion permeation on multimicrosecond timescales using the

113 To understand ion permeation, one must assign correct ionization state

114 )-ATPases (CopA) and deliver copper into the ion permeation path.

115 late about their mechanistic consequences on ion permeation, pathological mutations, as well as funct

116 nner pore-forming domain, which contains the ion permeation pathway and elements of its gates, togeth

117 The PD contains the ion permeation pathway and the activation gate located o

118 l is thought to decay nonlinearly across the ion permeation pathway because of the irregular three-di

119 ivation particle, which is stabilized in the ion permeation pathway by the N(153)VHNL(157) residues.

120 s (VSDs), one from each subunit, control one ion permeation pathway formed by four pore domains.

121 ve recently been shown to define part of the ion permeation pathway in several closely related member

122 ng inner helix, creating an hourglass-shaped ion permeation pathway in the channel tetramer.

123 ure of the C1C2 chimera demonstrate that the ion permeation pathway includes residues on one face of

124 The PKD2 ion permeation pathway is constricted at the selectivity

125 cation of these mutations indicates that the ion permeation pathway lies between the core and gate ri

126 The ion permeation pathway of ASIC1a is defined by residues

127 microscopy structure of chicken Slo2.2, the ion permeation pathway of the channel is closed by a con

128 that ouabain is trapped within the external ion permeation pathway of the pump.

129 oscopy structure of Slo2.2 suggests that the ion permeation pathway of these channels is closed by a

130 t 1 (TM1) is involved in forming part of the ion permeation pathway, and a missense mutation S427L in

131 potassium channels, a main component of the ion permeation pathway, configures a stack of binding si

132 ng an amino-acid residue thought to line the ion permeation pathway, identifying a region that govern

133 Analysis of the ion permeation pathway, in the case of a highly conducti

134 Along the ion permeation pathway, three relatively narrow regions

135 her spermine occludes the channel within the ion permeation pathway.

136 e domains of each subunit contributes to the ion permeation pathway.

137 ransporter is intimately associated with the ion permeation pathway.

138 of the transmembrane helix S6 region of the ion permeation pathway.

139 s with the transmembrane helices to form the ion permeation pathway.

140 al N-terminal structure (ball) occluding the ion permeation pathway.

141 cGMP, and the tetrameric central pore is the ion permeation pathway.

142 s a homodimer, and each protomer contains an ion permeation pathway.

143 to form the entrance into the substrate and ion permeation pathway.

144 TTX occludes the ion-permeation pathway at the outer vestibule of the cha

145 rdly rectifying K (Kir) channels control the ion-permeation pathway through diverse interactions with

146 permeant ions via their binding sites in the ion-permeation pathway.

147 its outward configuration with two potential ion permeation pathways exposed to the extracellular env

148 n the absence of PIP(2) show the cytoplasmic ion-permeation pathways occluded by four cytoplasmic loo

149 c-nucleotide binding site on these channels, ion permeation, pharmacological blockers, channel gating

150 These structures reveal the ion permeation pore and represent different functional s

151 suggesting that all 3 TRPs contribute to the ion permeation pore of the channels.

152 e mechanisms of receptor desensitization and ion permeation, principles of antagonism, and complete s

153 ctric (continuum lipid), we found reasonable ion permeation profiles; cations bind and permeate, wher

154 h impedes detailed study of their gating and ion permeation properties.

155 eras between mPiezo1 and dPiezo to show that ion-permeation properties are conferred by C-terminal re

156 res as the dominant mechanism of uncatalyzed ion permeation, providing new understanding for the acti

157 of ion channels, including the mechanisms of ion permeation, selectivity, and gating.

158 actors give rise to energetic constraints on ion permeation that have important functional consequenc

159 To begin to understand ion permeation, the potential of mean force (PMF) was ca

160 A recent model of ion permeation through a single, open RyR channel is use

161 lter and supports a 'knock-off' mechanism of ion permeation through a stepwise-binding process.

162 ading to the opening of a gate that controls ion permeation through an integral transmembrane pore.

163 channels achieve highly selective and rapid ion permeation through an open pore, by restricting the

164 he context of electrostatics calculations of ion permeation through channels, and the effect of the l

165 ite and that alphaSer-583 may have a role in ion permeation through ENaC.

166 arizes the postsynaptic afferent by altering ion permeation through hyperpolarization-activated cycli

167 olarized the postsynaptic neuron by altering ion permeation through hyperpolarization-activated cycli

168 Our understanding of ion permeation through K(+) channels, and by extension t

169 tions are perhaps most obvious in studies of ion permeation through membrane channels.

170 racterized scorpion toxin Agitoxin2 inhibits ion permeation through Shaker K+ channels by binding to

171 and compared to refine our understanding of ion permeation through the channel formed by OmpF porin

172 However, the structural determinants of Cl- ion permeation through the channel pore are not known.

173 sed to compute current-voltage relations for ion permeation through the gramicidin A ion channel embe

174 Ion permeation through the gramicidin channel is studied

175 aluminal loop contribute to determination of ion permeation through the intracellular Ca(2+) release

176 dius of about 3-4 A is sufficient to prevent ion permeation through the pore.

177 lished and molecular dynamics simulations of ion permeation through these channels are consistent wit

178 perhaps also ring size and are important for ion permeation through these channels.

179 M2 "pore", Brownian dynamics simulations of ion permeation through this putative conducting open sta

180 Ion permeation through voltage-gated sodium channels is

181 powerful and general approaches to study of ion permeation through wide molecular pores.

182 els in the absence of ATP, or 2) coupling of ion permeation to gating, for which there is currently n

183 lored the mechanisms of uncatalyzed membrane ion permeation using atomistic simulations and electroph

184 th negatively charged amino acids facing the ion permeation vestibule of the channel in question.

185 For these mutants, ion permeation was not a function of the diameter of the

186 the pore-lining helix in channel gating and ion permeation was probed by replacing them with amino a

187 olding, hydrogen bonding, ion solvation, and ion permeation, we replaced the peptide bond between Val

188 the peptide backbone and Trp side chains for ion permeation, we undertook an investigation of the two