ライフサイエンスコーパス: ion selectivity

1 ted energetic and solvation contributions to ion selectivity.

2 conclusions regarding the physical basis of ion selectivity.

3 NMR03 show good agreement with experimental ion selectivity.

4 18 (W568L) abolishes inactivation and alters ion selectivity.

5 the type of ligands are important factors in ion selectivity.

6 ns had normal barrier function but defective ion selectivity.

7 y with mole fraction due to the preferential ion selectivity.

8 res is explained by a theory of preferential ion selectivity.

9 additional dimension to tune the operational ion selectivity.

10 t must be placed on inferences about channel ion selectivity.

11 ow-conducting open state (O2) with differing ion selectivity.

12 A have opposite sensitivity to pH and unique ion selectivity.

13 stringency and thermodynamic origin of metal-ion selectivity.

14 r intrinsic electrostatic properties control ion selectivity.

15 ws efficient permeation without jeopardizing ion selectivity.

16 rent from Ca(2+)-induced changes, indicating ion selectivity.

17 nce of discrete channel or pore formation or ion selectivity.

18 e could contribute to altering face-specific ion selectivity.

19 y all mono- and divalent cations, showing no ion selectivity.

20 ed redesign of channelrhodopsins for altered ion selectivity.

21 ackbone mutations do not significantly alter ion selectivity.

22 r understanding the molecular basis of metal ion selectivity.

23 alphaAsp(602)) may have a role in conferring ion selectivity.

24 ng kinetics, single-channel conductance, and ion selectivity.

25 )](i) that mimic inactivation and changes in ion selectivity.

26 inding with channel gating and modulation of ion selectivity.

27 a2+ current inactivation, but did not affect ion selectivity.

28 BEST1 responsible for Ca(2+) activation and ion selectivity.

29 tiple conductance states that have identical ion selectivity.

30 versal potential near -25 mV indicating poor ion selectivity.

31 raction surface, including those involved in ion selectivity.

32 the transverse electric field and reversing ion selectivity.

33 is not a major contributor to the channel's ion selectivity.

34 er region, yet exhibit drastically different ion selectivity.

35 nd closed in the light, without altering its ion selectivity.

36 rotransmission depending on their ligand and ion selectivity.

37 mic coupling between CRAC channel gating and ion selectivity.

38 rrowest part of the open pore) control metal ion selectivity.

39 ly controls gating, but also regulates Orai1 ion selectivity.

40 as the effect of chelate ring size on metal ion selectivity.

41 ion coordination site that is essential for ion selectivity.

42 channel states, typically without changes in ion selectivity.

43 region of both proteins alter the channel's ion selectivity.

44 7 A, consistent with a barrier mechanism for ion selectivity.

45 lular function with dynamic changes in their ion selectivity.

46 identical binding sites can exhibit diverse ion selectivities.

47 on suppression, and enhancement of coeluting ions, selectivity, accuracy, precision, and stability.

48 inactivation, open probability), permeation (ion selectivity, affinity for Ca(2+) block, La(3+) sensi

49 Their ion selectivity, amantadine sensitivity, specific activi

50 The structures allow the origins of metal ion selectivity and aspects of the molecular mechanism t

51 Cation channels with unitary conductance, ion selectivity and Ca2+-dependence similar to those of

52 ning functional features of ion channels are ion selectivity and channel gating.

53 ramework for understanding the mechanisms of ion selectivity and conductance by vertebrate CaV channe

54 asis for their voltage-dependent activation, ion selectivity and drug block is unknown.

55 inetics at near-threshold potentials altered ion selectivity and facilitated the conductance of both

56 tion on KV 2.1 function leading to a loss of ion selectivity and gain of a depolarizing inward cation

57 for Orai1 puncta formation, suggesting that ion selectivity and gating are mechanistically coupled i

58 The ion selectivity and gating behavior of the two conductan

59 els possess a highly conserved structure for ion selectivity and gating mechanisms.

60 tic mechanisms can be distinguished by their ion selectivity and inhibitor sensitivity.

61 mino acid substitutions of Subdued alter the ion selectivity and kinetic properties of the CaCC chann

62 locus), a principal determinant of inorganic ion selectivity and organic cation permeation.

63 uctural insights into possible mechanisms of ion selectivity and permeation for K+ channels.

64 alpha(1S)) muscle differ from one another in ion selectivity and permeation properties, including uni

65 ch ion pair interactions dramatically alters ion selectivity and permeation.

66 The MOD-1 channel has distinctive ion selectivity and pharmacological properties.

67 ihydropyridine (I(VDDR)) displayed kinetics, ion selectivity and pharmacology that differed from dihy

68 previously unrecognized residues involved in ion selectivity and photocurrent kinetics.

69 vely charged amino acid residue reverses the ion selectivity and produces chloride-conducting ChRs (C

70 ential component required for maintenance of ion selectivity and proper gating of Kv-type K+ channels

71 n of ASICs, illuminate the basis for dynamic ion selectivity and provide the blueprints for new thera

72 n time of alpha7 nAChRs but had no effect on ion selectivity and relatively little, if any, effect on

73 nwardly rectifying K+ (GIRK) channels alters ion selectivity and reveals sensitivity to inhibition by

74 ility of a claudin to influence paracellular ion selectivity and support a role for the claudins in c

75 hich may be involved in metal sensing, metal ion selectivity and/or in regulation of the pump activit

76 onization (CDI) is currently limited by poor ion-selectivity and low salt adsorption capacity of poro

77 riable sensitivities to amiloride, different ion selectivities, and diverse unitary conductances.

78 ith their similar magnitudes of conductance, ion selectivities, and localization within eukaryotic ce

79 single-channel conductance, (4) a change in ion selectivity, and (5) a reduction in calcium pore blo

80 uch as ion concentration polarization (ICP), ion selectivity, and conductance, are significantly affe

81 ithelial Na(+) channels (ENaC) (conductance, ion selectivity, and long mean open and closed times) wa

82 been constructed that possess pH-controlled ion selectivity, and membranes have been made from gold

83 hen mutated, affects unitary conductance and ion selectivity, and modulates pore block.

84 se coupling between ORAI1 channel gating and ion selectivity, and open a new avenue to dissect the ga

85 domain influence single channel conductance, ion selectivity, and other aspects of receptor function

86 ng sites are not exclusively responsible for ion selectivity, and other steps downstream in the mecha

87 ed ideas for voltage-gated channel function, ion selectivity, and pharmacology.

88 res would display identical Ca(2+) affinity, ion selectivity, and unitary current magnitude.

89 The calculated conductance and ion selectivity are in good agreement with the experimen

90 ar requirements for gating and modulation of ion selectivity are similar, yet substantively different

91 ly, E190, a residue considered important for ion selectivity, are not close to the pore.

92 In this study, the concept of nontrivial ion selectivity arising in a highly flexible protein bin

93 Furthermore, Glu-90 is crucial to ion selectivity as also revealed by mutation of this res

94 tly to K+ and Na+ is a fundamental aspect of ion selectivity, as is the ability of multiple K+ ions t

95 (2)Si(CH(2))(3)NH(2) introduces pH-dependent ion selectivity at the pore orifice, a consequence of th

96 These results provide insights on external ion selectivity at the three binding sites.

97 The difference in ion selectivity between the wild-type and the mutants is

98 of apparent dominance not only of GluR2 for ion selectivity, but also of the flip isoform for recept

99 tics typical of a multi-ion pore and derives ion selectivity by Ca2+ binding.

100 Here, we explored the basis for ion selectivity by incorporating unnatural amino acids i

101 The origin of metal ion selectivity by members of the SmtB/ArsR family of ba

102 s rise to mechanosensitive channels in which ion selectivity can be altered by NOMPC mutation, indica

103 enetics, thus directed engineering to modify ion selectivity can be highly beneficial.

104 re, in P2X4 receptors, this ability to alter ion selectivity can be increased or decreased by alterin

105 Our results demonstrate that K+ ion selectivity can be retained even with significant re

106 ities that exceed seawater levels, and their ion selectivity can be tuned to configure them into swit

107 IL-1beta treatment led to alterations in TJ ion selectivity, combined treatment of TNF-alpha and IFN

108 RyR1-G4934A had reduced K(+) conductance and ion selectivity compared with WT.

109 nd altered apical side tight junction sodium ion selectivity, compared with wild-type mice.

110 ween the Y and D positions, which determined ion selectivity, conductance and gating.

111 that have distinct characteristics including ion selectivity, conductance, voltage dependence, and re

112 f side chains at 335 and 783 also results in ion selectivity defects, suggesting that the packing int

113 ervening hairpin segment that determines the ion selectivity (designated P).

114 ltered the conductance (E207Q and D219N) and ion selectivity (E207Q) of the channel.

115 s phylogeny we infer ancestral states of the ion selectivity filter and show that this state has been

116 our wild-type Na(V)Ab models, reshaping the ion selectivity filter at the extracellular end of the p

117 to D112 in the transmembrane VSD to form the ion selectivity filter in the channel's open conformatio

118 f, GYGD, contributes to the formation of the ion selectivity filter in voltage-gated K+ channels and

119 to animal sodium channels and has a putative ion selectivity filter intermediate between calcium and

120 pecificity can be explained by the conserved ion selectivity filter observed in the channel's crystal

121 The multi-ion selectivity filter of our CaVAb model establishes a

122 ely charged glutamate residues that form the ion selectivity filter with neutral glutamine or positiv

123 08 at the extracellular surface, T189 in the ion selectivity filter, and all phenylalanine residues.

124 e triplet of amino acids in the channel pore ion selectivity filter, and this sequence is different f

125 re, the P region, in addition to forming the ion selectivity filter, functions as the channel gate, t

126 onservation of sequence and structure of the ion selectivity filter, whereas the rates of K(+) turnov

127 The gate and ion-selectivity filter of the P2X7R could be colocalized

128 predicted extracellular loop adjacent to the ion-selectivity filter of TRPC5.

129 for other amino acids located within the CIC ion-selectivity filter.

130 t with the experimentally observed change in ion selectivity from cationic to anionic.

131 dependence of the wild type and had switched ion selectivity from cations to anions.

132 solute transporters, regulates KCNQ channel ion selectivity, gating, and pharmacology by direct phys

133 experimental single-channel conductance and ion selectivity (i.e., the reversal potential).

134 stibule does not significantly contribute to ion selectivity, implying that Ca(2+) selectivity is con

135 In this paper, disrupting the ion selectivity in another GIRK channel, chimera I1G1(M)

136 gands that control their thermodynamic metal ion selectivity in aqueous solution, and their use in se

137 lators and may be a dominant factor in metal ion selectivity in biology.

138 Ion selectivity in CLC-ck2 is similar to that in CLC-ec1

139 To reveal the structural mechanism of ion selectivity in CNG channels, particularly their Ca(2

140 the larger volume and mass, suggesting that ion selectivity in force-distance measurements are relat

141 We have investigated aspects of ion selectivity in K+ channels by functional expression

142 e barriers to ion conductance and origins of ion selectivity in models of the cationic human alpha7 n

143 into the molecular mechanisms that determine ion selectivity in OmpF porin.

144 ZnAF-2 zinc ion indicator provided high zinc ion selectivity in physiological solutions containing mi

145 Arcs provide an explanation for the observed ion selectivity in protegrin electrophysiology experimen

146 ted to clarify the molecular determinants of ion selectivity in protein binding sites.

147 rformed, and the major determinants of metal ion selectivity in proteins are not yet well understood.

148 K-1, TASK-1, and TASK-3 K(+) channels change ion selectivity in response to lowered pH(o), provide in

149 To understand the underlying principles of ion selectivity in tetrameric cation channels, we engine

150 t and hBest1, we find a sensitive control of ion selectivity in the bestrophins, including reversal o

151 he barriers to ion conduction and origins of ion selectivity in the GLIC channel by the construction

152 Gly-Met-Asn (GMN) motif, revealing clues of ion selectivity in this unique channel family.

153 mate residues (EEEE locus) are essential for ion selectivity in voltage-gated Ca(2+) channels, with i

154 Thus, metal ion selectivity in ZntA and possibly other P1-type ATPas

155 In studying ion-selectivity in biomaterials, it is common to study i

156 Moreover, analysis of ion selectivity indicated that the molecular requirement

157 annel catalytically inactive and altered the ion selectivity, indicating that the ion channel and the

158 Our results indicate that ion selectivity is accomplished by the contribution of m

159 Our findings provide new insight into how ion selectivity is achieved in the paracellular pore.

160 suggest that the channel pore is widened and ion selectivity is altered by mutations at the G98 site

161 ic forces are dominant (rigid binding site), ion selectivity is controlled by the ion-ligand interact

162 Ion selectivity is critical for the biological functions

163 Ion selectivity is generally considered an immutable pro

164 Here, we show that TWIK1 ion selectivity is modulated by extracellular pH.

165 containing major structural determinants of ion selectivity is neighbored by wide vestibules on both

166 Ion selectivity is one of the basic properties that defi

167 In this case, ion selectivity is set by the interplay between ion-liga

168 The molecular basis for this metal ion selectivity is unclear.

169 One obvious mechanism of ion selectivity is when a binding site is structurally c

170 h of approximately 8 A; we estimate that the ion selectivity lies approximately 13 A below the outer

171 The ion selectivity locus comprises four glutamate residues

172 erant Drosophila species maintained their MT ion selectivity, maintained stable extracellular ion con

173 tecture of a tetrameric cation channel whose ion selectivity mechanism appears to be distinct from th

174 mpeting ions is the essential feature in the ion selectivity mechanism of voltage-gated Ca(2+) channe

175 tion, confirm fundamental predictions of the ion selectivity model, and further elucidate electrostat

176 The alkali metal ion selectivities of the 12 hexamers were evaluated by a

177 The ion selectivity of a membrane ion conductance that is in

178 ave investigated the NMR structure and metal ion selectivity of a natural finger of lower stability d

179 n that expected and (ii) the analogous metal ion selectivity of a zinc metalloenzyme (carbonic anhydr

180 We switched the ion selectivity of an inhibitory LGC-55 anion channel to

181 e glycine receptor (GlyR), revealed that the ion selectivity of anion channels is basically determine

182 The evolutionary implications for metal ion selectivity of ArsR/SmtB metal sensor proteins are d

183 Ion selectivity of CFTR, ANO1 and GlyR is critically aff

184 Metal ion selectivity of Cpx1 expression is identical to that

185 Ion selectivity of four-domain voltage-gated Ca(2+) and

186 s during sorting could be minimized by using ion selectivity of hydrogel-infiltrated microbead membra

187 Differences in the kinetics and ion selectivity of hyperpolarization-activated currents

188 Our findings indicate that switches in ion selectivity of ligand-gated ion channels (LGICs) do

189 Few studies measuring thermodynamic metal ion selectivity of metalloproteins have been performed,

190 Here we show changes in the ion selectivity of neuronal P2X transmitter-gated cation

191 tage-independent manner without changing the ion selectivity of P2X(4) channels.

192 However, the structural basis for ion selectivity of paracellular pores is poorly understo

193 The high ion selectivity of potentiometric and optical sensors ba

194 The ion selectivity of pumps and channels is central to thei

195 Cellular stimuli can modulate the ion selectivity of some anion channels, such as CFTR, AN

196 entified a set of mutations that convert the ion selectivity of the 5-HT(3A) receptor from cationic t

197 ium transport to uptake of glutamate and the ion selectivity of the affinity for the transported amin

198 ge similar to that previously shown to alter ion selectivity of the bacterial sodium channel Na(V)Bh1

199 is unprecedented observation in terms of the ion selectivity of the binding sites in the membrane rot

200 This suggests a possible dependence of the ion selectivity of the central pore on the folding topol

201 rane charges can control the conductance and ion selectivity of the CNT porins, thereby establishing

202 the predicted pore region of TRP-4 alter the ion selectivity of the conductance.

203 point mutation of Orai1 (E106D) altered the ion selectivity of the induced Ca(2+) release-activated

204 The ion selectivity of the large conductance channel is Br(-

205 ids such as ouabain and digoxin switched the ion selectivity of the Na+ channel to this state of prom

206 current rectification phenomenon, a reversed ion selectivity of the nanopore occurs when the concentr

207 The ion selectivity of the rimantadine-sensitive current thr

208 t direction and was inversely related to the ion selectivity of the RyR pore.

209 channel is Br(-) > Cl(-) > I(-), whereas the ion selectivity of the small conductance channel is Br(-

210 ace charge potentials that contribute to the ion selectivity of this gap junction channel.

211 The difficulty of determining the ion selectivity of this minimalistic ion channel is due

212 opsins has illuminated mechanisms underlying ion selectivity of this remarkable family of light-activ

213 performed systematic characterization of the ion selectivity of TPC1 from Arabidopsis thaliana (AtTPC

214 y (ITC) studies revealed that the tailorable ion selectivity of U60 clusters is a result of the therm

215 Ca2+o-masked channels or from changes in the ion selectivity of voltage-gated Ca2+ or K+ channels.

216 1 side chain is not a primary determinant of ion selectivity or conduction in the wild-type channel,

217 binding, pH-induced conformational changes, ion selectivity or substrate specificity.

218 caused by changes in the voltage-dependence, ion selectivity, or apparent agonist affinity of the AMP

219 SMIT1 had no effect on Kv1.1 (KCNA1) gating, ion selectivity, or pharmacology.

220 We propose that the principle of ion selectivity outlined here may provide a rationale fo

221 into one that is promiscuous with respect to ion selectivity, permitting calcium ions (Ca2+) to perme

222 onductance that differed from MG channels in ion selectivity, pharmacology and sensitivity to connexi

223 ctional synapses whose properties (kinetics, ion selectivity, pharmacology, and ultrastructure) were

224 he voltage-gated potassium channels, but the ion selectivity pore domain sequence resembles that of a

225 Metal ion selectivity presumably comes from the coordination g

226 +-blockable cationic currents with different ion selectivity profiles that are carried by different c

227 Details of their underlying ion selectivity properties are still not fully understoo

228 conserved S1-S2 loop of Orai transforms the ion selectivity properties of CRAC current from being Ca

229 These changes in ion selectivity provide strong evidence that Orai1 is a

230 ) structures, key questions about gating and ion selectivity remain.

231 eceptor, it appears that the determinants of ion selectivity represent a conserved feature of the lig

232 reening length, consistent with the observed ion selectivity resulting from electrostatic interaction

233 These structures advance understanding of ion selectivity, reversed polarity gating, and cAMP regu

234 Without exception, SMIT1 altered KCNQ ion selectivity, sensitivity to extracellular K(+), and

235 -gated non-selective cation channel with the ion selectivity series lithium > sodium > N-methyl-d-glu

236 To test the effect on activity and metal ion selectivity, single alanine, histidine, and serine s

237 Metal-ion selectivity studies demonstrate that CP prefers to c

238 on concentration and species, and it altered ion selectivity, suggestive of pore constriction.

239 terminants of single channel conductance and ion selectivity that are not associated with the TM2 dom

240 ide detailed information about mechanisms of ion selectivity that is missing from mechanisms derived

241 roperties, such as electrical resistance and ion selectivity that would complement known differences

242 ssing wild-type TRPV1, indicative of loss of ion selectivity, that was completely absent in cells exp

243 ty filter mutant constructed to have altered ion selectivities, the sodium ion binding site nearest t

244 For ZntA homologues with different metal ion selectivity, the cysteines are replaced by serine, h

245 Although most ion channels exhibit stable ion selectivity, the prevailing view of purinergic P2X r

246 However, the key questions-such as, the ion selectivity, the transport pathway, and the gating m

247 common protein structure but differ in their ion selectivity, their affinity for the blocker amilorid

248 how that the D position is able to fine-tune ion selectivity through a functional interaction with th

249 , inhibited Ic by 80 % without affecting its ion selectivity, thus confirming and extending the recen

250 The mutated GIRK1 and GIRK2 retained ion selectivity to K(+) ions.

251 We determined metal-ion selectivity under fixed conditions using the voltage

252 its contributes one pore loop to the central ion selectivity unit at the interface between the subuni

253 Control of ion selectivity via ATI is proposed to be a natural, epi

254 MCC activity with the same conductance, ion selectivity, voltage dependence, and peptide sensiti

255 were unaltered in R1389H channels including ion selectivity, voltage-dependent activation or voltage

256 Ion selectivity was found to be essentially the same for

257 For both topologies, the same ion selectivity was found with a preference for K(+) fol

258 These changes in ion selectivity were confirmed by cation-dependent ATP h

259 of dominance of GluR1(R) in determination of ion selectivity, whereas expression of GluR1(R) flip wit

260 the open-state transitions and the discrete ion selectivity within these states.