ライフサイエンスコーパス: ionic current

1 on with 400-520 nm light to generate a large ionic current.

2 luoresces a calcium ion wave at a controlled ionic current.

3 te, reduce the proton current along with the ionic current.

4 ndocytosis and consequent attenuation of its ionic current.

5 cale pore leading to detectable blockades of ionic current.

6 ing particle may either block or enhance the ionic current.

7 and the Poisson-Nernst-Planck formalism for ionic current.

8 phosphorylation-dependent suppression of its ionic current.

9 l molecules by measuring the electrochemical ionic current.

10 itions of the probe and channel activity via ionic current.

11 nd is responsible for a mechanically induced ionic current.

12 is and hypertrophy and by modulating cardiac ionic currents.

13 to identify the genes that encode different ionic currents.

14 that are defined by different complements of ionic currents.

15 nation among the four tags based on nanopore ionic currents.

16 mechanism of AMPK action is modification of ionic currents.

17 th serotonin transport and serotonin-induced ionic currents.

18 fraction of the tubes pass anomalously high ionic currents.

19 cemaking dynamics with a small complement of ionic currents.

20 on via LOX-1-mediated alteration sarcolemmal ionic currents.

21 tterns via coordinate regulation of a set of ionic currents.

22 KChIP2 is a multimodal regulator of cardiac ionic currents.

23 inks variations in temperature to changes in ionic currents.

24 duced large changes in the levels of several ionic currents.

25 V(m) alternans through Ca-sensitive membrane ionic currents.

26 hey can also occur in vivo through intrinsic ionic currents.

27 abetes minimally affected the P2X(7)-induced ionic currents.

28 feedback mode as well as measuring localized ionic currents.

29 Blocking inhibitory ionic currents abolishes small object sensitivity and fa

30 By monitoring the ionic current across a single protein nanopore, differen

31 The ionic current across each micropore channel was continuo

32 hesis that transient pores open by measuring ionic currents across phospholipid bilayers and cell mem

33 an electrostatic potential gradient, induce ionic currents across planar phospholipid bilayers, as w

34 ltaneously detect conformational changes and ionic currents across the membrane.

35 gated potassium channel that shows very slow ionic current activation kinetics, and an unusual underl

36 tials (A735V) or at later times (G752R) than ionic current activation, indicating that the DII-VSD al

37 poles, I study how certain voltage-dependent ionic currents affect firing thresholds and contribute t

38 spiratory synaptic inputs, and expression of ionic currents, albeit all neurons presented persistent

39 analysis was used to predict how changes in ionic currents alter action potential duration, and thes

40 Analysis of the ionic current amplitude and noise, as the protein unfold

41 te on the millisecond time scale between two ionic current amplitude states when captured atop the al

42 d from KF-DNA-dNTP complexes on the basis of ionic current amplitude.

43 by Piezo1 dependence of shear-stress-evoked ionic current and calcium influx in endothelial cells an

44 solution reservoir is capable of rectifying ionic current and enrichment of ionic species.

45 e, which filters the microtubules but allows ionic current and flow to pass through it.

46 al role of endolymph in the delivery of both ionic current and fluid pressure, coupled with the cupul

47 e ability to simultaneously monitor both the ionic current and fluorescence from membrane channels an

48 stitution at position 666 (TM), affects both ionic current and gating current associated with channel

49 ias are examined for their influences on the ionic current and rectification factor, and the mechanis

50 ral pore induced inward rectification of the ionic current and shifted reversal potential by approxim

51 the overall regulatory effect of miRs on the ionic currents and action potentials.

52 cause inhibition or augmentation of various ionic currents and alter functioning of neurons and myoc

53 s of celecoxib, rofecoxib, and diclofenac on ionic currents and calcium signaling in vascular smooth

54 ace topography and is suitable for measuring ionic currents and conductance of biological ion channel

55 and consequent modification of the relevant ionic currents and discharge patterns, of STN neurons.

56 ted for residues 105-125 exhibit spontaneous ionic currents and hypersensitivity to certain classes o

57 current, shorten action potential, and alter ionic currents and intracellular Ca(2+) signals.

58 Pathological remodeling of ionic currents and network properties of the heart criti

59 pronounced implications for the dynamics of ionic currents and the signaling pathways that they regu

60 channel alpha-subunit expression with native ionic currents and their pharmacological sensitivity in

61 t underlie the modulation of the macroscopic ionic currents and V(z) by different AChR activation are

62 re missing], ribbon synapse numbers, outward ionic currents, and efferent innervation.

63 rication, ease of scaling up to support high ionic currents, and flexibility.

64 amp to measure action potential duration and ionic currents, and quantitative polymerase chain reacti

65 the translocation time and extent of blocked ionic current are presented.

66 In nanopore sensing, changes in ionic current are used to analyse single molecules in so

67 duced nociception, neuropeptide release, and ionic currents are suppressed by cold, it is not known i

68 The nucleic acid molecule transiently blocks ionic current as it is translocated through the pore, an

69 re determined by the detection of changes in ionic current as the proteins interact with the nanopipe

70 These novel probes measure ionic currents as small as picoampere while providing na

71 s we compared macroscopic and single-channel ionic currents as well as gating currents in tsA201 cell

72 ute simultaneously polymer conformations and ionic current, as single polymer molecules undergo trans

73 onal framework to investigate how individual ionic currents, as well as cellular and tissue level fac

74 he N-terminal domain abolish the spontaneous ionic currents associated with neurotoxic mutants of PrP

75 e complex showed strong rectification of the ionic current at positive voltages, an effect similar to

76 in recording very small ( approximately pA) ionic currents at a bandwidth consistent with fast trans

77 gested roles in cell adhesion, regulation of ionic currents at the cell membrane and neuroprotection.

78 These data show that a set of ionic currents at the preBotC imparts the network with r

79 Measurements of surface-charge governed ionic currents between BN nanosheets in a variety of sal

80 Ionic current blockade signal processing, for use in nan

81 This produces a unique ionic current blockade signature due to the tag's distin

82 g is based upon what has come to be known as ionic-current blockade sensing, there is a vast, growing

83 es and biophysical model systems because the ionic current blockades they produce contain information

84 display characteristic macromolecule-induced ionic current blockades.

85 By microperfusing ionic current blockers into the preBotC of adult rats, w

86 eport that RhoA elicits suppression of Kv1.2 ionic current by modulating channel endocytosis.

87 cal pacemaking can be achieved by modulating ionic currents by gene transfer or by delivering enginee

88 ructures elicited well-defined transmembrane ionic currents by inducing pore formation in the underly

89 This feedback mechanism explains how net ionic current can be constrained to <1-2 pA but reliably

90 Moreover, the ionic currents can also be used to image structures.

91 A number of voltage-gated ionic currents can contribute to the generation or ampli

92 ABSTRACT: Imbalances of ionic currents can destabilize the cardiac action potent

93 Imbalances of ionic currents can destabilize the cardiac action potent

94 o predicts that circadian control of certain ionic currents can induce hyperexcited states.

95 We tested the hypothesis that an ionic current carried by chloride ions contributes to br

96 plets allow the measurement of transmembrane ionic currents carried by individual channels and pores.

97 signal in such experiments is the change in ionic current caused by the nanoparticle translocation t

98 g specific parameter values corresponding to ionic current conductances and kinetics.

99 Here, we explore how individual ionic currents contribute to these hyperexcited states,

100 es with the capability to generate a tunable ionic current could pave the way towards precise ion-sys

101 us APs, implying wild-type function of other ionic currents critical for AP generation.

102 critical for understanding how flow-induced ionic currents, deformations of transmembrane proteins,

103 without electrode damage, and the impact of ionic current density gradients on velocity profiles ove

104 The ionic current density, j, was generated in 0.095 M K3Fe(

105 The ionic currents described here are distinct from those pr

106 median durations of approximately 28 ms and ionic current differences of up to 40 pA.

107 acutely dissociated neurons to quantify the ionic currents driving the spontaneous firing of substan

108 their target proteins caused a change in the ionic current due to a partial blockade or an altered su

109 The ionic currents during a mouse ventricular AP showed a fa

110 These include genetic suppression of an ionic current, embryonic as well as adult stem cell ther

111 coeruleus produced a rapid inhibition of the ionic currents evoked by multiple agonists of the mu-opi

112 cking to the cell surface, leading to little ionic current expression (loss-of-function).

113 anism could be the coordinated regulation of ionic current expression.

114 twork have a novel role in the regulation of ionic current expression.

115 While a great deal is known about the ionic currents, far less is known about the specific cha

116 otein pore can be monitored by observing the ionic current flow through the pore, which acts as a nan

117 onitored by observing the time-dependence of ionic current flow through the pore, which responds to b

118 probe microscopy technique that utilizes the ionic current flowing between an electrode inserted insi

119 During spontaneous firing, net ionic current flowing between spikes was calculated from

120 ctions on the nanopipette tip surface affect ionic current flowing through a 50-nm pore.

121 olecules is observed as the modulation of an ionic current flowing through a single engineered protei

122 h, individual analyte molecules modulate the ionic current flowing through a single nanopore.

123 tial difference, and measuring the resulting ionic current flowing through the nanopore.

124 through a nanopore will uniquely modulate an ionic current flowing through the pore, allowing the rec

125 We find that the distribution of ionic currents for each of the 20 proteinogenic amino ac

126 Despite the slowed kinetics of ionic currents, FPL had no discernible effect on the fun

127 ear-infrared pulses to modulate light-evoked ionic current from Channelrhodopsin-2 (ChR2) in brain ti

128 s silicon chips tailored to monitor cellular ionic currents from cultured cells stably expressing a p

129 Further analysis of ionic currents from mutants uncovers SERCA-dependent mec

130 Here, by recording ionic currents from spermatozoa of an infertile CatSper-

131 te the mechanism(s) that may account for the ionic current gating signatures.

132 Coexpression of ionic currents has been observed in an increasing number

133 the transport of NH3 and the lack of coupled ionic currents has been provided for many Rh proteins.

134 athematical modeling to determine whether an ionic current having the biophysical characteristics of

135 rotein kinase A (PKA) pathway enhances Kv1.2 ionic current; however, the mechanisms for this are not

136 ked action potentials, and induced an inward ionic current (I(BK)) with two distinctive membrane cond

137 ximately 140 muA/cm(2)), and the peak inward ionic current (I(ion)) during depolarization was approxi

138 tide gated channel 4), and the corresponding ionic current, If, underlies exercise training-induced s

139 downregulation of HCN4 and the corresponding ionic current, If.

140 Additionally, the same ionic current (IMI) can play different roles under these

141 in NaV1.5, N1764A and N1764C, produce little ionic current in transfected mammalian cells, they both

142 The species recognized by SPR generate ionic currents in artificial lipid bilayers and inhibit

143 We hypothesized that regional differences of ionic currents in cells of the EBZ form these lines of b

144 ular free Ca(2)(+) concentration signals and ionic currents in freshly isolated DRG neurons.

145 on the characterization of voltage-activated ionic currents in GnRH-containing TN cells in zebrafish.

146 ysis allows the measurement of transmembrane ionic currents in intact hearts.

147 Ionic currents in liquid crystals that have been traditi

148 n an orchestrated interplay of transmembrane ionic currents in myocardial cells.

149 We find that DeltaCR PrP induces abnormal ionic currents in neurons in culture and in cerebellar s

150 ficantly reduced NMDAR-mediated synaptic and ionic currents in PFC pyramidal neurons, which was media

151 neutral pH (7.3) but exhibited robust mixed ionic currents in response to voltage stimuli at pH 5.3.

152 brain synaptosomes and transporter-mediated ionic currents in SERT-expressing Xenopus oocytes.

153 ique allowed the dissection of transmembrane ionic currents in the intact heart.

154 n the magnetic field and naturally occurring ionic currents in the labyrinthine endolymph fluid.

155 The Hodgkin-Huxley model for the ionic currents in the membrane of the squid giant axon h

156 m-black tip (10-30 microm), which can detect ionic currents in the microA cm(-2) range in physiologic

157 led mathematical model for Ca2+ handling and ionic currents in the rabbit ventricular myocyte.

158 tructed in NEURON, includes all of the known ionic currents in these cells and receives synaptic inpu

159 the morphology and functional expression of ionic currents in trans-differentiated hair cells resemb

160 Here, we used specific computer-simulated ionic currents in vitro to selectively replicate or supp

161 Moreover, SecA-liposomes elicit ionic currents in Xenopus oocytes.

162 molecule under the same conditions causes an ionic current increase.

163 wo-thirds (K(D) approximately 40 microm) and ionic currents increased 5-fold (K(D) approximately 0.5

164 correlation of the kinetics of S4 motion and ionic current indicated that slowing of sensor movement

165 Comparison of gating and ionic currents indicates only 2% of the surface channels

166 The frequency and character of ionic current instabilities are regulated by the potenti

167 Cell viability, ionic currents, intracellular calcium, and pericyte cont

168 Among the panoply of sarcolemmal ionic currents investigated (I(Na)(+)/I(CaL)(+)/I(Kr)(+)

169 of the chain, and the permanent blockade of ionic current is due to the threading of the tether thro

170 We frequently observe substates where the ionic current is reduced by approximately 50%.

171 that accompanying KCNQ1 channel opening, the ionic current is suppressed by a rapid process called in

172 beta-adrenergic signaling and modulation of ionic currents is blunted in heart failure.

173 Homeostatic regulation of ionic currents is of paramount importance during periods

174 erred frequency results from the dynamics of ionic currents, it can be assumed to depend on parameter

175 tal and theoretical approach, we explain how ionic currents lead to the unusual electrophysiological

176 Collectively, this plasticity of ionic currents leads to increased action potential firin

177 etic algorithm, which allowed us to estimate ionic current levels in each of the cells studied.

178 A, we observe well-resolved and reproducible ionic current levels with median durations of approximat

179 by the loss of the coordinated regulation of ionic current levels.

180 acellular calcium (Ca2+) cycling or membrane ionic currents, manifested by a steep slope of cellular

181 he nominal model showed that coregulation of ionic currents may preserve the key characteristics of m

182 ric mutant G85R SOD1YFP had no effect on net ionic currents measured under voltage clamp.

183 nductances, reversal potentials, kinetics of ionic currents, measurement and intrinsic noise, based o

184 current nanopore sequencing methods rely on ionic current measurements from individually addressed p

185 Ionic current measurements through electrolyte-filled na

186 NavBeta1 subunits has been explored through ionic current measurements, but the molecular mechanism

187 have been demonstrated with nanopores using ionic current measurements, direct sequencing has not be

188 Two critical ionic current mechanisms are the inwardly rectifying pot

189 Here, we present an ionic current model that reproduces the basic electrophy

190 al atrial structure incorporating a detailed ionic-current model of an atrial myocyte.

191 n potential propagation begins with detailed ionic current models for a patch of membrane within a di

192 of single DNA molecules through detection of ionic current modulations as DNA passes through a pore's

193 The ionic currents necessary for spike production have been

194 hosphorylation-mediated suppression of Kv1.2 ionic current occurs by endocytosis of the channel prote

195 Moreover, the fast OPN4-activated ionic current of Drosophila photoreceptors relative to t

196 gh a synthetic nanochannel and measuring the ionic current of each amino acid through an intersecting

197 The origin of strong fluctuations in the ionic current of the channel is found to arise from the

198 he perforated-patch technique to monitor the ionic currents of pericytes located on microvessels fres

199 ocyte voltage-clamp recordings of gating and ionic currents of the Shaker Kv channel expressed in Xen

200 Size and ionic currents of unexcitable cells electrically coupled

201 The analysis identified a variety of FRD ionic current perturbations and generated specific predi

202 We propose that a set of ionic currents plays a key role in generating respirator

203 of VSDs II and III were compatible with the ionic current properties, suggesting that these voltage

204 ess EADs due to the complex effects of Ca on ionic current properties; 2) spontaneous Ca waves also e

205 ailed characterization of folded proteins by ionic current recordings.

206 The behavior of ionic current rectification (ICR) in a conical nanopore

207 Ionic current rectification behaviors are observed using

208 The method takes advantage of ionic current rectification effect discovered in nanoflu

209 tration polarization dynamics in addition to ionic current rectification inside conical nanopores and

210 We study ionic current rectification observed in a nanofluidic de

211 and nanochannels have been reported to yield ionic current rectification, with the aim to control the

212 ced nanofluidic device designs for tailoring ionic current rectification.

213 to the pore, and further modulations of the ionic current reflect enzyme function at the single-mole

214 The ionic currents regulated by shear stress remain poorly u

215 In experiments and simulations, the ionic current relative to that in the absence of DNA can

216 The unique combination of PZ ionic current remodeling and different degrees of Mfb in

217 Ionic current remodeling in PZ was also included.

218 ensity; the latter arises predominantly from ionic current remodeling in PZ.

219 overcoming the arrhythmogenic effects of PZ ionic current remodeling.

220 lectrostatic fields produced a transmembrane ionic current; repeating simulations at several voltage

221 e NRVMs to a dynamic clamp model of HEK cell ionic current reproduced the cardiac maximal diastolic p

222 The ionic current resistance profile of conductance states p

223 The dynamics of different ionic currents shape the bursting activity of neurons an

224 tween Na(v)1.5 and Kir2.1 and the respective ionic currents should be important in the ability of the

225 We measure the ionic current signal of translocating DNA carriers as a

226 ogies MinION using this nanopore sequencer's ionic current signal.

227 ocation and demonstrate how structure within ionic current signals can give new insights into the tra

228 Ionic current signals during electrophoretically driven

229 DNA hairpins produce ionic current signatures when captured by the alpha-hemo

230 Protein bound to the aptamer produces unique ionic current signatures which facilitates accurate targ

231 nnel resolution, imaging their structure and ionic currents simultaneously is difficult.

232 le structures and can be modified to measure ionic currents simultaneously.

233 dentification was based on three consecutive ionic current states that correspond to passage of modif

234 cision boundaries based on three consecutive ionic current states were implemented to call mC, hmC, c

235 equences by analyzing the sequence-dependent ionic current steps produced as biomolecules pass throug

236 This can be achieved with specific ionic currents, such as A-type potassium currents, which

237 negative shift of the reversal potential for ionic currents suggesting that inactivation alters chann

238 quantitative understanding of modulations in ionic current that arise from the rotational dynamics of

239 These observations identify Ih as an ionic current that is regulated in a cyclical manner by

240 present study found no evidence of a resting ionic current that is unique to warm-sensitive neurones.

241 Notably, S1P evoked a small excitatory ionic current that resulted in nociceptor depolarization

242 lemmal Ca2+ currents) and, therefore, by all ionic currents that affect membrane voltage.

243 robust Ca(2+)-dependent PLS coinciding with ionic currents that are explained by ionic leak during p

244 Voltage-gated ion channels generate dynamic ionic currents that are vital to the physiological funct

245 n cultured cells, DeltaCR PrP induces large, ionic currents that can be detected by patch-clamping te

246 ts (Delta105-125) induces large, spontaneous ionic currents that can be detected by patch-clamping te

247 However, little is known about ionic currents that control the duration and probability

248 However, the ionic currents that determine the electrical activity of

249 We analyzed the ionic currents that drive pacemaking in dopaminergic VTA

250 llular action potential, and fluctuations in ionic currents that may lead to ventricular arrhythmias.

251 er sarcoplasmic reticulum Ca(2+) content and ionic currents that reduce excitation threshold and prom

252 We analyzed ionic currents that regulate pacemaking in dopaminergic

253 dinated expression of multiple voltage-gated ionic currents that they do not acutely modulate.

254 its accurate assessment of metabolic cost of ionic currents that underlie AP conduction along the axo

255 , modulates I-SK and I-TRPC channel-mediated ionic currents that we have shown previously to regulate

256 In the presence of an ionic current, the probe detects a voltage difference be

257 echanical forces results in a characteristic ionic current, the release of serotonin and stimulation

258 nd I(KCa) are positively correlated, yet the ionic currents themselves are negatively correlated, acr

259 The concentration field, the ionic current though the pore, and the particle's veloci

260 During a resistive pulse experiment, the ionic current through a conducting channel is monitored

261 ent ionic solution results in an oscillating ionic current through a conical nanopore.

262 red through observation of the modulation of ionic current through a single nanopore.

263 within the pore, substantially affecting the ionic current through it.

264 We demonstrate that the ionic current through the engineered Mycobacterium smegm

265 een two electrolytes, and monitoring how the ionic current through the nanopore changes as single mol

266 In this demonstration of the phenomenon, the ionic current through the nanopore decreases when the ds

267 Changes in the flow of ionic current through the pore reflect the individual st

268 s a cation-stabilized quadruplex, alters the ionic current through the pore.

269 anoprecipitates, which temporarily block the ionic current through the pore.

270 solutions on either side to pass a constant ionic current through the pores.

271 This technique monitors the ionic current through the small opening of an electrolyt

272 by electrophysiology, where fluctuations in ionic current through these pores inserted in model memb

273 Ionic currents through AMPA receptor channels can be all

274 ixyl acetate as blockers of Ca(2+) entry and ionic currents through diacylglycerol- or receptor-activ

275 and submillisecond temporal resolution from ionic current time traces recorded when individual DNAP

276 The ionic current to generate the action potential is conduc

277 ectrodes embedded within the droplets allows ionic currents to be driven across the interface and mea

278 the respiratory network, the contribution of ionic currents to respiratory rhythm is unclear.

279 ge of this fact, we linked the peak phase of ionic currents to their amplitude, in order to provide a

280 of human Orai1 and comparing in detail their ionic currents to those of native CRAC channels and chan

281 ctate crucially the unique signatures of the ionic current trace of the channel and provide design ru

282 , we used a patch clamp amplifier to acquire ionic current traces caused by phi29 DNA polymerase-cont

283 state and the post-translocation state from ionic current traces of captured phi29 DNAP-DNA binary c

284 ranslocation fluctuations can be observed in ionic current traces when individual complexes are captu

285 ith single-nucleotide precision in real-time ionic current traces when individual complexes are captu

286 -translocation states can be quantified from ionic current traces, when individual Phi29 DNAP-DNA com

287 Channel activity was assayed as ionic currents under patch clamp and as optical signals

288 Simulations of stable propagation using the ionic current versus transmembrane potential relationshi

289 This ionic current was preserved in "cation-free" solution an

290 well as AMPAR-mediated synaptic response and ionic current was selectively decreased in APP transgeni

291 phasic time dependence for the activation of ionic currents was observed at low [Ca(2+)], which appea

292 ed the range of voltages where TRPM8-induced ionic currents were measured and made careful measuremen

293 trast to the wild type AtAMT1;2 transporter, ionic currents were not associated with the substrate tr

294 id residues display neither Ca(2+) entry nor ionic currents when expressed alone.

295 further evidenced by its ability to mediate ionic currents when expressed in Xenopus laevis oocytes.

296 ge moved approximately threefold faster than ionic current, which suggests the presence of additional

297 to opposite sides of the NCM did not rectify ionic current; while a NCM connected between fluid baths

298 at the end of the nanopipette, generates an ionic current with a greatly reduced electric field stre

299 ded at 0 mV voltage bias and 0 pA background ionic current with high signal-to-noise ratio as the par

300 These properties derive from ionic current within the MOF and the deposition of nanom