ライフサイエンスコーパス: iron metabolism

1 n cancer exhibits a targetable alteration in iron metabolism.

2 mone, has emerged as the master regulator of iron metabolism.

3 iron transport protein that may function in iron metabolism.

4 ional regulator of several genes involved in iron metabolism.

5 ant regulatory link between inflammation and iron metabolism.

6 being developed to investigate mitochondrial iron metabolism.

7 ression of hepcidin, the master regulator of iron metabolism.

8 luable contributions to our understanding of iron metabolism.

9 witching between white and opaque cells, and iron metabolism.

10 ffects on both inflammation and dysregulated iron metabolism.

11 n synthesis is involved in the regulation of iron metabolism.

12 levated cellular nickel levels) that disrupt iron metabolism.

13 mojuvelin (HJV) is an important regulator of iron metabolism.

14 ntifying a potentially new role for ZIP14 in iron metabolism.

15 gene symbol: Hfe2) plays a critical role in iron metabolism.

16 pression in diseases associated with altered iron metabolism.

17 into the cytosol and is involved in cellular iron metabolism.

18 sed sensitivity to oxidants, and a change in iron metabolism.

19 BMP signals regulate hepcidin expression and iron metabolism.

20 nd class II di-iron proteins not involved in iron metabolism.

21 n patients with CHF and evidence of abnormal iron metabolism.

22 aling that regulates hepcidin expression and iron metabolism.

23 eracting transcript, and studied its role in iron metabolism.

24 the IRE/IRP interaction could greatly affect iron metabolism.

25 -gallium (DFO-Ga) that targets P. aeruginosa iron metabolism.

26 RNA-binding proteins that modulate metazoan iron metabolism.

27 at functions as a key regulator of mammalian iron metabolism.

28 loss-of-function phenotypes associated with iron metabolism.

29 own Fur-repressed genes that are involved in iron metabolism.

30 tosolic protein binding to mRNAs to regulate iron metabolism.

31 and mammals and that this function regulates iron metabolism.

32 cidin is considered the central regulator of iron metabolism.

33 and IRP2) are master regulators of cellular iron metabolism.

34 interrogate the genetic circuitry regulating iron metabolism.

35 nthesized in the liver, is a key mediator of iron metabolism.

36 iology, six Minireviews deal with aspects of iron metabolism.

37 ntributed to the dysregulation of hepatocyte iron metabolism.

38 ary hemochromatosis is a genetic disorder of iron metabolism.

39 ion changes are often indicative of abnormal iron metabolism.

40 f new therapeutic approaches to disorders of iron metabolism.

41 mitochondrial protein implicated in cellular iron metabolism.

42 ink between A. phagocytophilum infection and iron metabolism.

43 acquisition is integrated with mitochondrial iron metabolism.

44 of copper-containing proteins in eukaryotic iron metabolism.

45 lobe of hTF, thereby interfering with normal iron metabolism.

46 deletions to identify genes that function in iron metabolism.

47 ested, in keeping with their central role in iron metabolism.

48 were not previously known to play a role in iron metabolism.

49 thanol is mediated by its effects on hepatic iron metabolism.

50 ntified and shown to play a critical role in iron metabolism.

51 oaciduria, cholestasis, and abnormalities in iron metabolism.

52 igmentation, neurotransmitter synthesis, and iron metabolism.

53 ditary hemochromatosis patients have altered iron metabolism.

54 fish as a genetic system to study vertebrate iron metabolism.

55 but essential and is putatively involved in iron metabolism.

56 ts for the treatment of diseases of abnormal iron metabolism.

57 s that may encode other proteins involved in iron metabolism.

58 repair of Fe/S clusters and/or mitochondrial iron metabolism.

59 and probably plays roles in inflammation and iron metabolism.

60 hyperosmotic stress and SchA was involved in iron metabolism.

61 stress genes, including several involved in iron metabolism.

62 plants indicate that AtHSCB plays a role in iron metabolism.

63 hepcidin gene, HAMP, is the master switch of iron metabolism.

64 epcidin is the central regulator of systemic iron metabolism.

65 ferritin and hepcidin, two major proteins of iron metabolism.

66 ducible factor-1alpha signaling pathways and iron metabolism.

67 suppressor, in part, by modulating cellular iron metabolism.

68 olA-like protein family has been involved in iron metabolism.

69 ferrireductase activity and modulates kidney iron metabolism.

70 chanism involving interference with cellular iron metabolism.

71 al peptide that is also the key regulator of iron metabolism.

72 nged our understanding of human disorders of iron metabolism.

73 d many cancer cells exhibit dysregulation in iron metabolism.

74 chanistic insight into how copper influences iron metabolism.

75 nal regulators, but they also participate in iron metabolism.

76 meostasis and was required for FDXR-mediated iron metabolism.

77 homeostasis by altering mitochondrial matrix iron metabolism.

78 tion of hepatic hepcidin gene expression and iron metabolism.

79 ffect of bdh2 deletion on erythropoiesis and iron metabolism.

80 mone hepcidin is a key regulator of systemic iron metabolism.

81 physiologically relevant whole-body model of iron metabolism.

82 al role in the transcriptional regulation of iron metabolism.

83 hesion, immune cell regulation, and systemic iron metabolism.

84 abnormalities in erythropoiesis and systemic iron metabolism.

85 s not affected by overt genetic disorders of iron metabolism, a genome-wide association study was con

86 ferritin inclusion bodies, misregulation of iron metabolism, accumulation of ubiquitinated proteins,

87 be the consequence of a disruption of normal iron metabolism and an increased availability of catalyt

88 rt to better understand the linkages between iron metabolism and breast cancer, a predictive mathemat

89 enes, IRP2-/- mice significantly misregulate iron metabolism and develop neurodegeneration, whereas I

90 bility of transferrin injections to modulate iron metabolism and erythropoiesis in Hbb(th1/th1) mice,

91 s will provide a deeper understanding of how iron metabolism and erythropoiesis intersect in MDSs and

92 ith hamp1 more involved in the regulation of iron metabolism and hamp2 mostly performing an antimicro

93 d proteins involved in systemic and cellular iron metabolism and heme syntheses.

94 of mutations affecting conserved pathways in iron metabolism and heme synthesis.

95 crocytic anemias due to genetic disorders of iron metabolism and heme synthesis.

96 tial importance of iron deficiency, abnormal iron metabolism and hemodilution.

97 been found to play an important role in the iron metabolism and hemogenesis.

98 We studied iron metabolism and hepcidin expression in mice constitu

99 ealing important links between the V-ATPase, iron metabolism and HIFs.

100 e that the mTORC1 pathway serves to modulate iron metabolism and homeostasis, and we speculate that i

101 a reveal the centrality of PI3K signaling in iron metabolism and host colonization.

102 The distinct roles of iron metabolism and inflammation triggered by interleuki

103 Regulation of iron metabolism and innate immunity are tightly interlin

104 It also depends on a strict control of iron metabolism and intracellular iron levels to prevent

105 Ferritin plays a central role in iron metabolism and is made of 24 subunits of 2 types: h

106 ances that have changed our understanding of iron metabolism and its regulation.

107 system, little is known about intracellular iron metabolism and its relation to oxidative stress in

108 rthologues, MRS3 and MRS4, causes defects in iron metabolism and mitochondrial Fe-S cluster biogenesi

109 conserved mitochondrial protein involved in iron metabolism and neurodegenerative disease.

110 res and has provided new insights into human iron metabolism and nutrition.

111 The Fur protein is a global regulator of iron metabolism and other processes in many bacterial sp

112 L5 and CIA acts through both IRPs to control iron metabolism and promote optimal cell growth.

113 These findings provide insights into the iron metabolism and the etiology of anemia in parasitic

114 These cells, which are involved in iron metabolism and the phagocytosis of erythrocytes and

115 Iron metabolism and transport are severely deranged in A

116 uded those for lipopolysaccharide synthesis, iron metabolism and type III secretion.

117 we review the impact of macrophages on heme-iron metabolism and, reciprocally, how heme-iron modulat

118 ry, (3) immunohistochemistry for proteins of iron metabolism, and (4) quantitative analysis by digita

119 gradation, immune signaling, cell signaling, iron metabolism, and apoptosis.

120 volved in detoxifying aldehydes, controlling iron metabolism, and degrading toxic lipoproteins.

121 altered expression of redox-active proteins, iron metabolism, and DNA repair, as well as via biofilm

122 fect of these changes on ferritin synthesis, iron metabolism, and downstream effects on iron-responsi

123 recently defined pathways in RBC production, iron metabolism, and fetal globin-family gene expression

124 complex contribute to normal hematopoiesis, iron metabolism, and growth.

125 The peptide hormone hepcidin regulates iron metabolism, and insufficient hepcidin synthesis is

126 monoxide (NO) markedly affects intracellular iron metabolism, and recent studies have shown that mole

127 s the synthesis of many proteins involved in iron metabolism, and the level of IRP2 itself is regulat

128 As a consequence of disturbed iron metabolism, archazolid caused S-phase arrest, doubl

129 Disturbances in brain iron metabolism are linked with synucleinopathies.

130 tein expression suggested defective zinc and iron metabolism arising from altered ZnT protein express

131 ggest modulation of FHC or, more broadly, of iron metabolism as a potential approach for anti-inflamm

132 s and underscores the importance of haem and iron metabolism as rational targets for anti-tick interv

133 ve to the dysregulation of the intracellular iron metabolism as suggested by reports on loss of iron

134 eins involved in amino acid biosynthesis and iron metabolism, as well as two so-called sulfur-induced

135 Furthermore, by mimicking the altered iron metabolism associated with Hfe deficiency, we found

136 f inflammatory, metabolic, liver injury, and iron metabolism biomarkers on the association between co

137 protein 2 coordinates cellular regulation of iron metabolism by binding to iron responsive elements i

138 ein 2 coordinates the cellular regulation of iron metabolism by binding to iron-responsive elements i

139 Hepcidin regulates iron metabolism by down-regulating ferroportin-1 (Fpn1).

140 ted into the circulation, hepcidin regulates iron metabolism by inhibiting iron release from cells, i

141 that mitochondrial SIRT3 regulates cellular iron metabolism by modulating IRP1 activity.

142 ction as a facilitator of heme synthesis and iron metabolism by reducing ROS production.

143 levels of hepcidin, a peptide that regulates iron metabolism by triggering degradation of ferroportin

144 ditary hemochromatosis (HH) is a disorder of iron metabolism caused by common mutations in the gene H

145 nown function, followed by genes involved in iron metabolism, cell communication, and intermediary me

146 chromatosis (HH) is a common inborn error of iron metabolism characterized by excess dietary iron abs

147 This change in iron metabolism contributes to the development of the an

148 The discovery of hepcidin and its role in iron metabolism could lead to new therapies for hemochro

149 Despite having dysregulated iron metabolism, critically ill patients may receive exo

150 of suppressing the abnormalities of cellular iron metabolism demonstrated by Deltaatm1 cells.

151 on TBSV replication in yeast, while altered iron metabolism did not reduce TBSV replication.

152 Despite the fact that the mechanisms of iron metabolism differ drastically in fungi and higher e

153 de hormone hepcidin, a systemic regulator of iron metabolism, dramatically decreased FPN1 protein lev

154 report we investigate changes in proteins of iron metabolism during p53-mediated replicative arrest.

155 erstand stress erythropoiesis and changes in iron metabolism during pregnancy and development, especi

156 s) in mRNAs that encode proteins involved in iron metabolism (e.g. ferritin and transferrin receptor

157 re transcription factors controlling energy, iron metabolism, erythropoiesis, and development.

158 h normal iron absorption and the disorder of iron metabolism found in patients with HH.

159 ophages to saturated fatty acids also alters iron metabolism gene expression.

160 Conservation of iron metabolism genes across Wolbachia suggests iron hom

161 requires post-transcriptional regulation of iron metabolism genes by iron regulatory protein 2 (IRP2

162 This study shows that FixK regulates key iron metabolism genes in an alpha-proteobacterium, point

163 s to the differential expression of specific iron metabolism genes in Brucella strains are unclear.

164 Renal iron levels and the expression of iron metabolism genes were examined.

165 on levels and posttranscriptionally regulate iron metabolism genes, including transferrin receptor 1

166 Hepatic and/or duodenal response patterns of iron metabolism genes, such as Trfr, cybrd1, and Slc11a2

167 rived Hif-2 is involved in the regulation of iron metabolism genes, supporting a role for HIF-2 in th

168 egulate mRNA stability or the translation of iron metabolism genes.

169 The transcription and translation of iron-metabolism genes (light polypeptide ferritin chain,

170 s that involve mutations in newly-identified iron-metabolism genes, such as TFR2--a transferrin recep

171 n (FXN), which is critical for mitochondrial iron metabolism, global cellular iron homeostasis, and a

172 s of genes that participate in angiogenesis, iron metabolism, glucose metabolism, and cell proliferat

173 rent degrees of severity of anemia, abnormal iron metabolism, growth retardation and shortened lifesp

174 The study of iron metabolism has advanced greatly with the identifica

175 Understanding iron metabolism has been enhanced by identification of g

176 The spectrum of known disorders of iron metabolism has expanded dramatically over the past

177 side, hepcidin, a key regulator of mammalian iron metabolism, has emerged as an important mediator of

178 icate that physiologic changes in macrophage iron metabolism have an important effect on HIF hydroxyl

179 New insights into cellular iron metabolism have been provided by the recognition th

180 Perturbations in iron metabolism have been shown to dramatically impact h

181 Recent advances in the study of iron metabolism have led to a better understanding of th

182 strategies designed to interfere with tumor iron metabolism have targeted TFRC1.

183 lude the discovery of a new gene involved in iron metabolism, hemojuvelin, and new data on the role o

184 As a central regulator of iron metabolism, hepcidin inhibits dietary iron absorpti

185 ythropoietin production and abnormalities in iron metabolism identical to what is commonly referred t

186 Iron metabolism impacts mitochondrial function and oxida

187 n many diseases, and as our understanding of iron metabolism improves, the list of iron-related disor

188 the other hand, while the autoregulation of iron metabolism in Baker's yeast is well-understood, lit

189 The regulation of iron metabolism in biological systems centers on providi

190 2 is an early nodal point underlying altered iron metabolism in breast cancer and may contribute to p

191 e model successfully captures key aspects of iron metabolism in breast cancer cells and provides a fr

192 Dysregulation of iron metabolism in cancer is well documented and it has

193 sis in roots, also play a role in regulating iron metabolism in developing leaves.

194 how the newer understanding of hepcidin and iron metabolism in general can lead to very practical im

195 ells and that it may play a role in zinc and iron metabolism in hepatocytes, where this transporter i

196 The mechanisms of iron metabolism in insects are still poorly understood,

197 ry is an important step toward understanding iron metabolism in insects.

198 central nervous system, evidence of abnormal iron metabolism in IRP2-/- mice precedes the development

199 Iron metabolism in mammalian cells is orchestrated postt

200 Iron regulatory proteins (IRPs) regulate iron metabolism in mammalian cells.

201 tic peptide hepcidin is the key regulator of iron metabolism in mammals.

202 dominates post-transcriptional regulation of iron metabolism in mammals.

203 any fundamental cellular processes linked to iron metabolism in order to coordinate the overall respo

204 the molecular mechanisms regulating cellular iron metabolism in osteoclasts remain largely unknown.

205 l measures of iron status accurately reflect iron metabolism in physically active, nonanemic women.

206 The peptide hormone hepcidin regulates iron metabolism in response to erythropoietic demand, ir

207 Regulation of iron metabolism in Saccharomyces cerevisiae is achieved

208 We have investigated in vitro erythroblast iron metabolism in the anemia of rheumatoid arthritis (R

209 IREs serve as the main control mechanism for iron metabolism in the cell via their interaction with t

210 fluid indices reflect a disruption of normal iron metabolism in the lungs of acute respiratory distre

211 These results point to a critical role for iron metabolism in the regulation of intra-graft alloimm

212 In this review, we discuss regulation of iron metabolism in the setting of infection and delineat

213 obably due to a greater effect of ethanol on iron metabolism in the susceptible strain.

214 dies further demonstrate the conservation of iron metabolism in vertebrates and suggest the existence

215 The ability to manipulate iron metabolism in vivo may also allow investigation of

216 ogenous regulator of hepcidin expression and iron metabolism in vivo.

217 n is due to the combined effects of abnormal iron metabolism, inappropriately low erythropoietin prod

218 nflammation cause many changes in total body iron metabolism including the sequestration of iron in p

219 r expression of several master regulators of iron metabolism, including iron regulatory protein 2 (IR

220 te-dehydrogenase, and ascorbate peroxidase), iron metabolism (iron deficiency-specific proteins IDS3a

221 ing the crosstalk between erythropoiesis and iron metabolism is an area of active investigation in wh

222 regulation by miR-210 perturbing trophoblast iron metabolism is associated with defective placentatio

223 The essential role of hepcidin in iron metabolism is being elucidated through mouse and hu

224 Iron metabolism is controlled by hepcidin, a 25-amino ac

225 Iron metabolism is controlled by hepcidin, a 25-amino-ac

226 neral regulatory mechanism for mitochondrial iron metabolism is described that defines frataxin invol

227 Iron metabolism is disturbed, and administration of iron

228 Iron metabolism is essential for many cellular processes

229 am signaling events affect genes involved in iron metabolism is incompletely understood.

230 vestigate how expression of genes related to iron metabolism is linked to breast cancer prognosis.

231 m by which hepatitis C virus (HCV) regulates iron metabolism is poorly understood.

232 In bacteria, iron metabolism is regulated by controlling transcriptio

233 atus and are increased in disorders in which iron metabolism is secondarily disregulated, such as the

234 nlikely that a gross defect in mitochondrial iron metabolism is the cause of the decreased enzyme act

235 or process of iron homeostasis in whole-body iron metabolism is the release of iron from the macropha

236 These biological properties demand that iron metabolism is tightly regulated such that iron is a

237 Polymorphisms of genes linked to iron metabolism may account for individual variability i

238 Because aberrant iron metabolism may cause neural and retinal degeneratio

239 der-related disparities in the regulation of iron metabolism may contribute to the differences exhibi

240 Finally, Irr-mediated control of iron metabolism may reflect a cellular strategy that acc

241 tions in Alzheimer's disease (AD), including iron metabolism, mitochondrial complex IV, heme oxygenas

242 Iron metabolism, monooxygenases, and secondary metabolis

243 a critical role in two important aspects of iron metabolism, namely, maintenance of whole-plant iron

244 show an additional role for AhpC in cellular iron metabolism of E. coli.

245 ansporter FeoB is an important factor in the iron metabolism of many bacteria.

246 We characterized the genetics and iron metabolism of the severe anemia mutant hea (heredit

247 in were used to investigate the influence of iron metabolism on the release of nitric oxide (NO) in r

248 IRP1-/- mice misregulate iron metabolism only in the kidney and brown fat, two ti

249 posttranscriptional regulator of animal-cell iron metabolism or as the cytosolic isoform of the iron-

250 ons and eight ORFs with unknown functions in iron metabolism or iron transport-related functions.

251 NAs from genes encoding proteins involved in iron metabolism or protection against oxidative damage a

252 es with repeated measurements of glucose and iron metabolism parameters are needed to establish the r

253 urcumin has the potential to affect systemic iron metabolism, particularly in a setting of subclinica

254 Our findings demonstrate that parameters of iron metabolism, particularly transferrin saturation, th

255 -)) animals do not significantly misregulate iron metabolism, partly because IRP1 is an iron-sulfur p

256 othiol multidomain glutaredoxins in cellular iron metabolism pathways, including the biogenesis of Fe

257 s that dysregulation of proteins involved in iron metabolism plays a critical role in cancer.

258 f and HFE, HIV-1 directly regulates cellular iron metabolism, possibly benefiting viral growth.

259 Moreover, ferritin, a key protein in iron metabolism, prevents excessive ALIS formation.

260 AtHSCB play a key role in iron metabolism, probably taking part in the control of

261 due to frataxin deficiency which may impair iron metabolism, promote oxidative damage and lead to pr

262 tion of putative virulence genes involved in iron metabolism, protein secretion, and glycosylation, w

263 er target genes to control the expression of iron metabolism proteins at the post-transcriptional lev

264 iptional regulation of expression of several iron metabolism proteins, predisposes IRP-2 -/- mice to

265 t alteration in expression of genes encoding iron metabolism proteins.

266 nsferrin receptor (TfR), ferritin, and other iron metabolism proteins.

267 of transferrin receptor, ferritin, and other iron metabolism proteins.

268 ngle hepcidin gene, with a dual role in both iron metabolism regulation and antimicrobial response, m

269 Many aspects of plant iron metabolism remain obscure.

270 n horse delivery system that interferes with iron metabolism shows promise as a treatment for P. aeru

271 thway are associated with human disorders of iron metabolism, such as hereditary hemochromatosis and

272 -surface and secreted molecules unrelated to iron metabolism, suggesting that it has a fundamental ro

273 The information on iron metabolism that has become available in recent year

274 in Ex12 mutant mice is favored by changes in iron metabolism that optimize iron availability to allow

275 he current series deal with redox cycling in iron metabolism, the biogenesis and assembly of iron-sul

276 th the proposed role of the sufBCDS genes in iron metabolism, the growth rate of the null mutant was

277 ed in regulation of the master controller of iron metabolism, the hormone hepcidin, in malaria infect

278 contrast to previous mathematical models of iron metabolism, the liver is included as a key site of

279 oteins involved in coenzyme biosynthesis and iron metabolism, the pyruvate dehydrogenase kinase, and

280 H2O2 are capable of disrupting intracellular iron metabolism, thereby selectively sensitizing non-sma

281 ta uncover a novel role of SIRT3 in cellular iron metabolism through IRP1 regulation and suggest that

282 emojuvelin regulates hepcidin expression and iron metabolism through the BMP pathway, the role of the

283 Here, we report that p53 regulates iron metabolism through the transcriptional regulation o

284 loops in messenger RNAs encoding proteins of iron metabolism to control their rate of translation.

285 on during infection and inflammation couples iron metabolism to host defense and decreases iron avail

286 Connecting iron metabolism to innate immunity, hepcidin is a key me

287 technology for studying the contributions of iron metabolism to physiology and pathology.

288 ceptor (TfR) binds two proteins critical for iron metabolism: transferrin (Tf) and HFE, the protein m

289 , a model of the human inherited disorder of iron metabolism type I hemochromatosis.

290 gain insight into FPN1's role in macrophage iron metabolism, we examined the effect of iron status a

291 The mRNAs of proteins involved in iron metabolism were measured in isolated hepatocytes, K

292 ession was not generally apparent, genes for iron metabolism were strongly induced specifically on sw

293 We found that IRP2-/- cells misregulated iron metabolism when cultured in 3 to 6% oxygen, which i

294 embers in Saccharomyces cerevisiae influence iron metabolism, whereas the single protein expressed in

295 chanistic computational model of human liver iron metabolism, which includes the core regulatory comp

296 tory protein 1, a key cytosolic modulator of iron metabolism, which is responsive to the availability

297 is emerging as a novel mechanism to promote iron metabolism while also providing anti-oxidant protec

298 at MYC upregulates ADHFE1 through changes in iron metabolism while coexpression of both ADHFE1 and MY

299 his review we summarize current knowledge of iron metabolism with an emphasis on the sources and pote

300 ndings reveal an essential role for HSPB1 in iron metabolism with important effects on ferroptosis-me