ライフサイエンスコーパス: iron uptake

1 presence of additional pathways involved in iron uptake.

2 iently use iron, despite unimpaired cellular iron uptake.

3 um colony was designed to model whole colony iron uptake.

4 ght cell proteins loaded with iron following iron uptake.

5 gonist FPL 64176 was administered to promote iron uptake.

6 ereas FupA facilitates high affinity ferrous iron uptake.

7 s a co-repressor and inappropriately repress iron uptake.

8 ctive under high-iron conditions, repressing iron uptake.

9 ation of ferritin, leading to an increase in iron uptake.

10 e iron assimilation and siderophore-mediated iron uptake.

11 elative to hemophores and the Isd system, in iron uptake.

12 nickel ion homeostasis, acid adaptation, and iron uptake.

13 lipoprotein that increases the efficiency of iron uptake.

14 te both recycling-dependent and -independent iron uptake.

15 ple mutants showed a significant decrease in iron uptake.

16 in system incapable of obstructing bacterial iron uptake.

17 represses transcription of genes involved in iron uptake.

18 as a negative regulator of genes involved in iron uptake.

19 ) is produced by enteric bacteria to mediate iron uptake.

20 nes required for ergosterol biosynthesis and iron uptake.

21 and show enhanced compensatory high affinity iron uptake.

22 d to function in siderophore biosynthesis or iron uptake.

23 ion arrest owing to defects in mitochondrial iron uptake.

24 , via PAP7 and DMT1, physiologically induces iron uptake.

25 many species of enteric bacteria to mediate iron uptake.

26 egulator of transferrin-independent, nonheme iron uptake.

27 ormation via its ability to augment cellular iron uptake.

28 transporter known to be involved in cellular iron uptake.

29 This in turn decreases erythroid iron uptake.

30 e Tf cycle endosome and facilitates Tf-bound iron uptake.

31 treatment to chelation, reducing myocardial iron uptake.

32 P(C) to a detergent-insoluble form, limiting iron uptake.

33 egress from cells and thus limits intestinal iron uptake.

34 y repressing iron consumption and activating iron uptake.

35 ses such as oxidative stress, heat shock and iron uptake.

36 agreement with the need to prevent excessive iron uptake.

37 th other genes encoding proteins involved in iron uptake.

38 ndent repression of FET3, a gene involved in iron-uptake.

39 oblasts (vs CV1 fibroblasts) showed enhanced iron uptake (1.8 mmol +/- 0.5 x 10(-8) vs 0.9 mmol +/- 0

40 3p turnover of Fe(II) supports high affinity iron uptake across the yeast plasma membrane, whereas it

41 on release and Mfrn2-dependent mitochondrial iron uptake act synergistically to induce PDT-mediated a

42 A feoA(E40K) mutant contained partial iron uptake activity in culture that supported normal gr

43 The feoA(E40K) strain had partial iron uptake activity in situ within nodules and in isola

44 t influence several central processes, e.g., iron uptake, adsorption/desorption of contaminants and n

45 led with group 3 and 5 media had the highest iron uptake after cells labeled with group 1 medium.

46 ng iron-scavenging siderophores that promote iron uptake and alleviate iron-regulated host immune res

47 These changes may increase dietary iron uptake and allow release of stored iron to ensure a

48 s allow a distinction to be made between its iron uptake and any putative cell signaling roles.

49 embrane-associated glycoprotein critical for iron uptake and cell proliferation, are controlled by SI

50 The iron chelator desferoxamine reduced both iron uptake and colony formation.

51 ession of AtHSCB induced an increase in root iron uptake and content along with iron deficiency in sh

52 Thus, iron uptake and distribution in plants are controlled by

53 e components of transporters associated with iron uptake and DNA repair.

54 ted that HGA-melanin is able to both promote iron uptake and enhance growth under iron-limiting condi

55 unexpected role of ARHGEF3 in regulation of iron uptake and erythroid cell maturation.

56 the induction of genes that are required for iron uptake and for the maintenance of cellular iron hom

57 equires iron for survival, and the genes for iron uptake and homeostasis are regulated by the Fur pro

58 anism, potentially including facilitation of iron uptake and induction of toxicity to other organisms

59 e to polystyrene nanoparticles can influence iron uptake and iron transport in an in vitro model of t

60 major missing piece in our understanding of iron uptake and mammalian nutrition.

61 Iron uptake and metabolism are tightly regulated in both

62 ndicated high level up-regulation of several iron uptake and metabolism genes that are part of the Af

63 regulon increases the cellular capacity for iron uptake and mobilizes an iron-sparing response media

64 iron excess, induction of hepcidin restricts iron uptake and movement within the body.

65 ust be strictly regulated to ensure adequate iron uptake and prevent toxic iron accumulation.

66 ays a central role in the diel regulation of iron uptake and recycling and that this regulation of ir

67 separated by a phospholipid bilayer, such as iron uptake and redox signaling.

68 sport system, resulted in a severe defect in iron uptake and reduced ability to use the C. diphtheria

69 hus plants have evolved a complex network of iron uptake and regulation mechanisms.

70 esses hepcidin, thereby enhancing intestinal iron uptake and release from internal stores.

71 acid binding sites whose occupancy modulates iron uptake and release.

72 ccharomyces pombe was known to use reductive iron uptake and siderophore-bound iron transport to scav

73 The transcription of iron uptake and storage genes in Saccharomyces cerevisia

74 ta herein provide evidence for regulation of iron uptake and storage within brain microvessels that c

75 They caused significant changes in iron uptake and storage, the rate of ferritin synthesis

76 We found that the regulation of iron uptake and TfR1 expression contribute to the tumor-

77 or TfR1, a housekeeping protein required for iron uptake and the cell surface receptor for at least t

78 The mechanisms of root iron uptake and the transcriptional networks that contro

79 Continued HU stress activates iron uptake and toxins MazF and RelE, whose activity cau

80 Chromatin in the promoter regions of iron uptake and utilization genes showed repressed and a

81 In the Deltairr DeltarirA mutant, iron uptake and utilization genes were derepressed, roug

82 hat Steap4 is a critical enzyme for cellular iron uptake and utilization in osteoclasts and, thus, in

83 , as these enzymes are crucial for bacterial iron uptake and virulence and have been identified as an

84 veloped and provide further insight into the iron uptake and/or release and mineralization mechanism

85 myces cerevisiae by activating expression of iron-uptake and -transport genes when intracellular iron

86 ulticopper oxidase involved in high-affinity iron uptake), and Aft1p (iron regulator) were also compa

87 xhibited a defect in siderophore production, iron uptake, and growth in low-iron medium.

88 This receptor is crucial for placental iron uptake, and its decrease was accompanied by decreas

89 rol and cell wall biosynthesis, cell growth, iron uptake, and known fungal virulence factors compared

90 include urease enzyme production, motility, iron uptake, and stress response.

91 ly low levels of hepcidin, increased dietary iron uptake, and systemic iron accumulation, has been as

92 ine biosynthesis, methyl transfer reactions, iron uptake, and utilization of carbon.

93 demonstrated, but the molecules involved in iron uptake are currently unknown.

94 ow that microbial genes involved in cellular iron uptake are highly expressed in the Guaymas Basin de

95 those involved in siderophore synthesis and iron uptake - are strongly induced during biofilm format

96 pounds synthesized by microbes to facilitate iron uptake, are a dynamic component of the marine ligan

97 cludes the known components of high-affinity iron uptake as well as candidates for distributive iron

98 iron demand from shoots to roots to regulate iron uptake as well as the transport systems mediating i

99 nstitutively high capacity for high affinity iron uptake associated with loss of the chromosomal copy

100 Deletion of hapX does not affect iron uptake but causes derepression of genes involved in

101 gen receptor signaling or increased cellular iron uptake, but was impaired by mutation of either BMP

102 e of attenuated sunlight increased bacterial iron uptake by 70% and algal uptake by >20-fold.

103 n BeWo cells, a placental cell line, reduced iron uptake by approximately 40%, suggesting that ZIP8 p

104 enic strains, we have been able to show that iron uptake by C. albicans from transferrin was mediated

105 ken sulfated GAG polysaccharides can enhance iron uptake by Caco-2 cells.

106 ations in mineral contents of sorghum on the iron uptake by Caco-2 cells.

107 e of iron from endosomes and lysosomes after iron uptake by endocytosis of Fe(3+)-bound transferrin r

108 thropoiesis, and impairing transferrin-bound iron uptake by erythroid cells.

109 sulting in inefficient transferrin-dependent iron uptake by erythroid precursors.

110 null mutant is due to elevated repression of iron uptake by Fur, exacerbated by heme sequestration by

111 Iron uptake by HEK and Sf9 cells expressing Zip14 was in

112 addition, HFE potentially modulates cellular iron uptake by interacting with transferrin receptor, a

113 Iron uptake by osteoclast precursors via the transferrin

114 atocytes, plays a central role in regulating iron uptake by promoting internalization and degradation

115 Tf) cycle, which is the dominant pathway for iron uptake by red blood cell precursors.

116 Transferrin-mediated iron uptake by regenerating myofibers occurs independent

117 main transporter responsible for apoplastic iron uptake by rhizobia-infected cells in zone II.

118 ic iron may not be the rate-limiting step in iron uptake by strategy I plants such as Arabidopsis.

119 ssible mechanism explaining how GAGs promote iron uptake by the Caco-2 cells.

120 tal-ion transporter-1 (DMT1) is required for iron uptake by the intestine and developing erythroid ce

121 ium uniporter, consistent with mitochondrial iron uptake by the uniporter.

122 Iron uptake by the Yiu system in Y. pestis was demonstra

123 By measuring radiolabelled iron uptake, by monitoring the levels of cytosolic and i

124 -NOX(Vf) and modulates the expression of its iron uptake capacity during the early stages of the ligh

125 loss of transferrin receptor 1, involved in iron uptake, caused neuronal iron deficiency, age-progre

126 correspond to metal-binding sites within an iron-uptake channel and a ferroxidase site, common featu

127 corresponded to the 3 recognized siderophore iron uptake clusters, reflecting the iron-restrictive en

128 acquisition, given that mutants deficient in iron uptake colonize the intestine but do not reduce S.

129 The high affinity iron uptake complex in the yeast plasma membrane (PM) co

130 uggesting that Fe(III) dissociation from the iron uptake complex, if it occurs, is kinetically slow r

131 Iron uptake decreased with increasing the affinity const

132 Direct interrogation of iron uptake demonstrated that CSCs potently extract iron

133 l ligands show they can facilitate or impede iron uptake depending on their identity.

134 mice, further supporting a critical role for iron uptake during leukemogenesis.

135 culature appears to mediate the compensatory iron uptake during postnatal development and iron conten

136 up-regulation of transcripts related to heme/iron uptake (e.g., isdA, isdB, and isdCDEFsrtBisdG), and

137 ion of sreA in the DeltaacuM mutant restored iron uptake, extracellular siderophore production and vi

138 ties of the mutant confirm the importance of iron uptake for cellular function, e.g. for the Krebs cy

139 rom the phenylpropanoid pathway, compromised iron uptake from an iron source of low bioavailability.

140 rous iron chelator, inhibited Zip14-mediated iron uptake from ferric citrate, suggesting that iron is

141 in the fur-fhu and hupDGC regions diminished iron uptake from ferric hydroxamates and haemin/haemoglo

142 at mobilizing cellular (59)Fe and inhibiting iron uptake from human transferrin depending on the cell

143 es, both of which are critical for efficient iron uptake from human transferrin.

144 phytate, and calcium, had limited effect on iron uptake from intact ferritin by Caco-2 cells, which

145 n expression is reduced to promote increased iron uptake from the diet and release from cells, wherea

146 matosis (HH) because of inappropriately high iron uptake from the diet resulting from decreased hepat

147 The peptide hormone hepcidin (Hepc) limits iron uptake from the intestine by triggering degradation

148 factors in B. anthracis are responsible for iron uptake from the most abundant iron source for mamma

149 gh affinity iron transporter responsible for iron uptake from the soil in Arabidopsis (Arabidopsis th

150 em of Neisseria gonorrhoeae is necessary for iron uptake from transferrin in the human host and requi

151 erizes a new B. bronchiseptica mechanism for iron uptake from transferrin that uses host stress hormo

152 decrease in transferrin receptor levels and iron uptake from transferrin.

153 ssion of genes encoding proteins involved in iron uptake (Frp1, Fip1, Fio1, Str3, Str1, Sib1), withou

154 xide production, together with the increased iron uptake, fuels the formation of hydroxyl radicals th

155 Our results indicate that, albeit its iron uptake function, TfR1 is a signaling molecule and t

156 ng through a role that is independent of its iron-uptake function.

157 virus entry while simultaneously preserving iron-uptake functionalities, both in rodent and human Tf

158 this mutant leads to increased expression of iron uptake genes accompanied by elevated levels of mito

159 and molecular bases are unclear, as very few iron uptake genes have been functionally characterized f

160 RNA sequencing results identified changes in iron uptake genes in Hst 5-treated C. albicans cells.

161 utant demonstrated up-regulation of multiple iron uptake genes under control of Aft1p (the iron regul

162 Iron uptake genes were derepressed in the DeltarirA muta

163 fur mutant confirmed previous findings that iron uptake genes were highly de-repressed in the mutant

164 or strains can be isolated with mutations in iron uptake genes.

165 n limitation and regulates the expression of iron uptake genes.

166 was directly involved in SRE1 regulation of iron-uptake genes.

167 We also demonstrate that enhancing root iron uptake has an impact on the expression of genes tha

168 the iron acquisition machinery or to repress iron uptake has deleterious effects for M. tuberculosis.

169 D and bfrE genes, the role of these genes in iron uptake has not been demonstrated.

170 tworks that control root-level regulation of iron uptake have been well studied, but the mechanisms b

171 tris genome predicts a membrane-bound nickel-iron uptake hydrogenase and several regulatory proteins

172 P6 content of wholemeal bread, its impact on iron uptake in Caco-2 cells and the predicted bioavailab

173 Finally, structural analysis of iron uptake in crystallo suggests a possible pathway for

174 eductase required for efficient Tf-dependent iron uptake in erythroid cells.

175 In this study, we investigated regulation of iron uptake in GAS and the role of a putative transcript

176 gulates TfR-dependent, recycling-independent iron uptake in hBMVECs by fine-tuning the endosomal pH i

177 Hepcidin plays a key role in modulating iron uptake in iron-overload disorders and new studies e

178 rrin receptor 1 (TFRC1), a major mediator of iron uptake in mammalian cells, is a common feature of h

179 fluctuations in atmospheric CO2, may perturb iron uptake in many marine heterotrophic bacteria due to

180 r IdeR is a key transcriptional regulator of iron uptake in Mycobacterium tuberculosis.

181 ontribute substantially to the efficiency of iron uptake in natural conditions.

182 howed that JTR-009 did not indirectly change iron uptake in neuronal cells suggesting a direct intera

183 Recent studies revealed a novel role for iron uptake in orchestrating the differentiation of amas

184 indicate that the shoot-directed control of iron uptake in roots functions properly in these lines,

185 tion in shoots despite the reduced levels of iron uptake in roots.

186 ased iron accumulation in shoots and reduced iron uptake in roots.

187 ofilm development and mediates intracellular iron uptake in the absence of TonB.

188 cquisition systems that facilitate essential iron uptake in the human host.

189 died homeostatic mechanism is the control of iron uptake in the roots by shoots.

190 In high-affinity iron uptake in the yeast Saccharomyces cerevisiae, Fe(II

191 sor cells possess an efficient mechanism for iron uptake in which iron loaded transferrin (Tf) binds

192 of autoptic MS tissue, an in vitro model of iron-uptake in human cultured macrophages and ultra-high

193 Increments in mitochondrial iron uptake induced stepwise assembly of Yfh1 species ra

194 Iron uptake into cells and incorporation into ferritin w

195 is the cell-surface receptor that regulates iron uptake into cells, a process that is fundamental to

196 Although iron uptake into the cytoplasm in the form of heme has b

197 Our findings indicate that cellular iron uptake is a major process in plume microbial commun

198 Here we show that iron uptake is a major trigger for the differentiation o

199 t a plasma membrane-associated mechanism for iron uptake is essential for the establishment of infect

200 One mechanism of iron uptake is mediated by the cell surface transferrin

201 Because iron uptake is vital for almost all bacteria, expression

202 ve stress-induced vicious cycle of increased iron uptake leading to further oxidative stress was intr

203 we describe the E. ictaluri Fur protein, the iron uptake machinery controlled by Fur, and the effects

204 tivities due to their ability to exploit the iron uptake machinery of Gram-negative bacteria.

205 nd, thus, for modulating the activity of the iron uptake machinery.

206 res early signaling components with the root iron-uptake machinery.

207 s (C282Y and H63D) associated with increased iron uptake may modify the effect of metal-rich particle

208 Therefore, at least one step of the iron uptake mechanism involves a thermodynamically contr

209 significant role in the siderophore-mediated iron uptake mechanism of LVS whereas fslE appears to pla

210 ls must have an alternative, as-yet-unknown, iron uptake mechanism.

211 We investigated iron uptake mechanisms in five marine microalgae from di

212 Iron uptake mechanisms probably involve very different c

213 M. tuberculosis has two iron uptake mechanisms, one that utilizes non-heme iron

214 pJ homolog, and genes encoding at least five iron uptake mechanisms, two potential type IV secretion

215 pecies production via enhanced intracellular iron uptake, mitochondrial damage, and sources of vascul

216 The use of bacterial ferric iron uptake mutants further showed that both the Fe(II)

217 thought to meet the increased requirement of iron uptake necessary for cell growth.

218 siderophore analogs, supplanting the natural iron uptake of most bacteria.

219 nd with the start of PS release a "window of iron uptake" opens.

220 nfers on cells the ability to undergo either iron uptake or apoptosis, dependent upon the iron conten

221 We show that many mRNAs encoding iron uptake or iron mobilization proteins are expressed

222 responds to dynamic changes in mitochondrial iron uptake or stress exposure in a highly controlled fa

223 infection, but it is unclear whether ferric iron uptake or the ferric iron binding siderophores ente

224 with siderophore transport, had no effect on iron uptake or the utilization of the C. diphtheriae sid

225 rs a more comprehensive picture of microbial iron uptake pathways in the ocean.

226 tion of norA-lacZ, suggesting that bacterial iron uptake plays an important role in regulating norA t

227 a surface-exposed lipoprotein that makes the iron uptake process more efficient.

228 Second, deregulation of root iron uptake processes in opt3-2 roots resulted in the ac

229 cally characterized, for the first time, the iron uptake processes of this facultative intracellular

230 gulation of the expression of mRNAs encoding iron uptake proteins is essential to control iron homeos

231 fully functional in regulated genes encoding iron uptake proteins.

232 n the feoAB operon encoding ferrous (Fe(2+)) iron uptake proteins.

233 infection model and its role in transferrin iron uptake raise the possibility that transferrin is a

234 pression of schT and iutA2 as well as of the iron uptake rate to the degree of starvation, a model fo

235 The iron uptake rates, however, were higher in the mutant st

236 , we found that HCV alters expression of the iron uptake receptor transferrin receptor 1 (TfR1).

237 Iron uptake-related TBDTs and siderophore biosynthesis g

238 iptional regulation of genes responsible for iron uptake, release, use, and storage through the actio

239 iron exit pore were found to be important in iron uptake/release kinetics.

240 Kinetics of iron uptake/release of the wild type and mutants were co

241 , heme biosynthesis enzymes (hemAXCDBL), the iron uptake repressor (fur), and perR itself.

242 and exhibits constitutive expression of its iron uptake responses.

243 ckdown of ISIP2a in P. tricornutum decreases iron uptake, resulting in impaired growth and chlorosis

244 This effect was most prominent in the iron uptake results.

245 ical cultures, the NMDA-NO-Dexras1-PAP7-DMT1-iron uptake signaling cascade also appears to mediate NM

246 results, at least in part, from insufficient iron uptake, since it can be corrected by iron supplemen

247 Furthermore, iron uptake studies in hem6 reticulocytes demonstrate de

248 hematopoietic stem cell transplantation and iron uptake studies in nm1054 reticulocytes, we provide

249 xpression of AtHSCB led to activation of the iron uptake system and iron accumulation in roots withou

250 The gonococcal transferrin-iron uptake system is composed of two transferrin bindin

251 The iron uptake system of Edwardsiella ictaluri, a host-rest

252 monstrate that ywbLMN, encoding an elemental iron uptake system orthologous to the copper oxidase-dep

253 ence traits in B. anthracis, the PB-mediated iron uptake system presents a potential target for antim

254 demonstrate that another putative Y. pestis iron uptake system, Yiu, which potentially encodes an ou

255 independent and thermodynamically controlled iron uptake system.

256 enhancing our understanding of this critical iron uptake system.

257 a mutant that also lacked the high-affinity iron uptake system.

258 nal activator of multiple ferrous and ferric iron uptake systems in addition to a haem uptake system.

259 nfection, bacterial pathogens have developed iron uptake systems that are upregulated in the absence

260 icularly when cells expressing high affinity iron uptake systems transition to iron rich environments

261 Expression of genes that encode iron uptake systems was decreased in the Deltairr mutant

262 istant Proteus-like (MR/P) fimbriae, urease, iron uptake systems, amino acid and peptide transporters

263 disulfide oxidoreductases likely involved in iron uptake systems.

264 DNA binding protein that represses bacterial iron uptake systems.

265 wed a significantly higher degree of cardiac iron uptake than wild-type littermates following iron de

266 e of receptor that participates in a form of iron uptake that is mechanistically distinct from the ex

267 Consistent with deregulation of iron uptake, the mtsR mutant is hypersensitive to strept

268 s cerevisiae express very similar systems of iron uptake, these species differ in their capacity to u

269 porter-1 (DMT-1), indicating PrP(C)-mediated iron uptake through DMT-1.

270 The enhanced iron uptake through enzymatic GAG depolymerisation could

271 h the wild type, presumably due to the lower iron uptake through IRT1.

272 Here, we investigated whether mitochondrial iron uptake through mitoferrin-2 (Mfrn2) enhanced PDT-in

273 errin receptor 1 (Tfr1) facilitates cellular iron uptake through receptor-mediated endocytosis of iro

274 on is completely abolished when the vacuolar iron uptake transporter VIT1 is disrupted.

275 ptionally regulating factors responsible for iron uptake, utilization, and storage.

276 ta indicate that VciB functions by promoting iron uptake via a ferrous, but not ferric, iron transpor

277 from impaired function of PrP(C) in neuronal iron uptake via its ferrireductase activity.

278 erythropoiesis depends on transferrin-bound iron uptake via the transferrin receptor.

279 Careful regulation of iron uptake, via the ferric uptake regulator Fur, is ess

280 mo943; 0.97 Mb) decreased growth and altered iron uptake: Vmax of [59Fe]-corynebactin transport tripl

281 he expression of genes involved in hemin and iron uptake was determined in parent and luxS mutant str

282 Iron uptake was evaluated with 3,3'-diaminobenzidine-Pru

283 ected in unstressed cells when mitochondrial iron uptake was maintained at a steady, low nanomolar le

284 Iron uptake was minimal in myelin-laden macrophages and

285 Enhanced iron uptake was not observed with a ferrous iron transpo

286 an with others but no difference in cellular iron uptake was observed.

287 ron import, confirming that dysregulation of iron uptake was the root problem.

288 d explain the increase in heme synthesis and iron uptake we observe in human neuroblastoma cells.

289 hypothesis that DMT1 is required for hepatic iron uptake, we examined mice with the Dmt1 gene selecti

290 s the transferrin receptor to increase their iron uptake, we hypothesized that iron-dependent, antima

291 on factors of unknown function and genes for iron uptake were differentially expressed in response to

292 ke protein 14, which may also participate in iron uptake, were unaffected in Dmt1(liv/liv) mice.

293 s able to directly bind Fe(III) and increase iron uptake when heterologously expressed, whereas knock

294 E is involved in siderophore-mediated ferric iron uptake, whereas FupA facilitates high affinity ferr

295 is expressed in erythroid cells and impairs iron uptake, whereas its absence exclusively from the he

296 fecBCDE and an upstream regulator likely for iron uptake, whereas the other phylotype consistently ca

297 salicylate formation, and hence of bacterial iron uptake, which is directly related to the virulence

298 ase chimera and demonstrate that it supports iron uptake with a kinetic pattern consistent with a cha

299 n aerobic environments, and the mechanism of iron uptake within symbiotic soybean root nodules is unk

300 blem, as in iron-rich environments excessive iron uptake would endanger H(2)O(2)-stressed cells by ac