1 ds the more lipophilic chelators have better iron-clearing efficiency.

2 P(app) value of the compound, the better the iron-clearing efficiency.

3                                          The iron-clearing efficiency and ferrokinetics were evaluate

4 ts of stereochemistry at C-4 on the ligands' iron clearing efficiency are reviewed and assessed using

5 ,9-trioxadecyloxy group, ligand 4, increased iron clearing efficiency (ICE) and ameliorated the renal

6  log P(app), is determined, along with their iron-clearing efficiency (ICE) in both non-iron-overload

7 assessed for their lipophilicity (log Papp), iron-clearing efficiency (ICE) in rodents and iron-loade

8                                          The iron-clearing efficiency (ICE) in rodents and primates i

9                                  A series of iron-clearing efficiencies (ICEs), ferrokinetics, and to

10 lipophilicity can both substantially augment iron clearing efficiency in Cebus apella primates as wel

11 his methyl ether was a ligand with excellent iron-clearing efficiency in both rodents and primates; h

12 nce the lipophilicity/toxicity problem while iron-clearing efficiency is maintained.

13  a dose of 150 micromol/kg, both ligands had iron clearing efficiencies of >13%, which is much greate

14 is shown to have a substantial effect on the iron clearing efficiency of desferrithiocin analogues, a

15 s further underscored by a comparison of the iron-clearing efficiency of (S)-2-(2,3-dihydroxyphenyl)-

16                                 Finally, the iron-clearing efficiency of the (S)-4'-(HO)-DADFT conjug

17 ctor had a profound effect on increasing the iron-clearing efficiency of this chelator relative to it