ライフサイエンスコーパス: iron-regulatory protein

1 ranslation or stability; all IREs bind IRPs (iron regulatory proteins).

2 ated by iron-regulated RNA-binding proteins (iron regulatory proteins).

3 ystem, mediated through effects on the Aft1p iron-regulatory protein.

4 uster, to its apo-form which functions as an iron-regulatory protein.

5 r the physiological actions of this critical iron-regulatory protein.

6 xpression, intracellular oxidant levels, and iron regulatory proteins.

7 een proposed to make direct contact with the iron regulatory proteins.

8 wo homologous cytosolic regulatory proteins, iron regulatory protein 1 (also known as IRP1 and Aco1)

9 ranscriptional control through the action of iron regulatory protein 1 (IRP1) and IRP2 coordinate the

10 -sulfur cluster-dependent interconversion of iron regulatory protein 1 (IRP1) between its RNA binding

11 Iron regulatory protein 1 (IRP1) binds iron-responsive e

12 Iron regulatory protein 1 (IRP1) is a bi-functional prot

13 Iron regulatory protein 1 (IRP1) is regulated through th

14 Iron regulatory protein 1 (IRP1) modulates iron metaboli

15 In contrast to yeast, vertebrates use iron regulatory protein 1 (IRP1) to sense intracellular

16 As examples, we use the binding of the iron regulatory protein 1 (IRP1) to the iron response el

17 ve element-binding (IRE-binding) activity of iron regulatory protein 1 (IRP1) was activated, and incr

18 Interconversion of iron regulatory protein 1 (IRP1) with cytosolic aconitas

19 Knockdown of ISCU enhanced the binding of iron regulatory protein 1 (IRP1), a cytosolic Fe-S prote

20 plicated in Fe/S cluster repair of cytosolic iron regulatory protein 1 (IRP1), a key regulator of cel

21 ble of repairing oxidatively damaged Fe-S of iron regulatory protein 1 (IRP1), a master regulator of

22 the mammalian cytosolic aconitase, known as iron regulatory protein 1 (IRP1), led to the characteriz

23 by the binding of two cytoplasmic proteins, iron regulatory protein 1 and 2 (IRP1 and IRP2) to stem

24 o the bifunctional eukaryotic protein IRP-1 (iron regulatory protein 1).

25 In this situation, control of iron regulatory protein 1, a key cytosolic modulator of

26 omolog, cytoplasmic aconitase, also known as iron regulatory protein 1, a well-recognized RNA-binding

27 osolic aconitase is known to be converted to iron regulatory protein 1, and consistent with this, we

28 a domain not present in the closely related iron regulatory protein 1, and we found that this domain

29 When incubated with iron regulatory protein 1, cysteine, and iron, the cytos

30 iron-responsive element-binding activity of iron regulatory protein 1, increased protein levels of i

31 anslational regulation of its expression via iron regulatory proteins 1 and 2 (IRP1 and IRP2, respect

32 (IRE) sequence, and ferritin IRE repressors (iron regulatory proteins 1 and 2).

33 Iron-regulatory protein 1 (IRP1) belongs to a family of

34 The generally accepted role of iron-regulatory protein 1 (IRP1) in orchestrating the fa

35 Iron-regulatory protein 1 (IRP1) is a dual-function prot

36 ependent manner, by enhancing the binding of Iron-Regulatory Protein 1 (IRP1) to a recently reported

37 everal cytosolic Fe/S proteins, for example, iron-regulatory protein 1, a major component of posttran

38 Iron-regulatory proteins 1 and 2 (IRP1 and IRP2) are RNA

39 as well as subsequent reoxygenation, on the iron-regulatory proteins 1 and 2 (IRP1 and IRP2) in a ra

40 Iron regulatory protein-1 (IRP-1) is a cytosolic RNA-bin

41 , while heavy chain ferritin mRNA levels and iron regulatory protein-1 (IRP-1) RNA binding activity w

42 o provide in vitro and in vivo evidence that iron regulatory protein-1 (IRP1) inhibits protoporphyrin

43 We show that Drosophila iron regulatory protein-1 (IRP1) registers cytosolic iro

44 dependent manner by promoting the binding of iron regulatory protein-1 (IRP1) to a noncanonical iron

45 aconitase was responsible for activation of iron regulatory protein-1 and increased expression of Tf

46 g involvement of reactive oxygen species and iron regulatory protein-1 in this mechanism.

47 ked by the antioxidant N-acetyl cysteine and iron regulatory protein-1 siRNA, suggesting involvement

48 n converting cytosolic aconitase (ACO1) into iron regulatory protein-1 to bind iron-responsive elemen

49 ugh disruption of the iron-sulfur complex of iron regulatory protein-1, a translational regulator.

50 lular iron ((55)Fe) uptake and activation of iron regulatory protein-1.

51 effect of NO on the RNA binding activity of iron regulatory protein-1.

52 se of repressor interaction of APP mRNA with iron-regulatory protein-1 (IRP1) whereas IRP2 controls t

53 protein 1 (also known as IRP1 and Aco1) and iron regulatory protein 2 (also known as IRP2 and Ireb2)

54 Three SNPs in the iron regulatory protein 2 (IREB2) gene met this stringen

55 Genetic ablation of iron regulatory protein 2 (IRP-2), a protein responsible

56 eficient cells revealed increased binding of iron regulatory protein 2 (IRP2) and decreased binding o

57 pletion, as indicated by increased levels of iron regulatory protein 2 (IRP2) and/or increased IRE-bi

58 Iron regulatory protein 2 (IRP2) controls the synthesis

59 The degradation of iron regulatory protein 2 (IRP2) in iron-replete cells i

60 Iron regulatory protein 2 (IRP2) is a central regulator

61 Iron regulatory protein 2 (IRP2) is a key iron sensor th

62 Iron regulatory protein 2 (IRP2) is an RNA-binding prote

63 Here, we demonstrate that iron regulatory protein 2 (IRP2) plays a key role in iro

64 The first is that overexpression of iron regulatory protein 2 (IRP2) recapitulates many aspe

65 lated tightly in mammalian cells, in part by iron regulatory protein 2 (IRP2), a protein that is degr

66 ate covalently modifies cysteine residues on iron regulatory protein 2 (IRP2), rendering it unable to

67 ter regulators of iron metabolism, including iron regulatory protein 2 (IRP2).

68 ional regulation of iron metabolism genes by iron regulatory protein 2 (IRP2).

69 /6 mice and mice with a targeted deletion of iron regulatory protein 2 (IRP2-/-) that have been repor

70 the expression of transferrin receptor 1 and iron regulatory protein 2 consistent with decreased iron

71 Iron regulatory protein 2 contains a domain not present

72 Iron regulatory protein 2 coordinates cellular regulatio

73 Iron regulatory protein 2 coordinates the cellular regul

74 eceptor-interacting protein 1, Hemo-oxidized iron regulatory protein 2 ligase 1 (HOIL-1), HOIL-1-inte

75 he catalytic core component is heme-oxidized iron regulatory protein 2 ubiquitin ligase-1-interacting

76 igase complex that mediates the stability of iron regulatory protein 2, an important posttranscriptio

77 atory protein 1, increased protein levels of iron regulatory protein 2, and resulted in abnormal punc

78 cient erythropoietic tissues of mice lacking iron regulatory protein 2, in iron-deficient murine eryt

79 lated neurodegeneration has been reported in iron regulatory protein 2-deficient (IRP2 -/-) mice coin

80 nism by which heme can regulate the level of iron regulatory protein 2.

81 iron, and to stimulate the expression of the iron regulatory protein-2 (IRP2), which increases the in

82 es and controls iron homeostasis through the iron regulatory protein-2 in human cell lines.

83 We propose that iron regulatory protein activation could serve as a mark

84 The consistent finding of loss of iron regulatory protein activity in restless legs syndro

85 with relatively higher labile iron pool and iron regulatory protein activity than WT or H63D HFE.

86 ynthesis at the translational level and that iron regulatory proteins appear to differentially affect

87 RE RNA and in possible interactions with the iron regulatory protein are discussed.

88 onal mRNAs whose expression is controlled by iron regulatory proteins, as well as provide insight int

89 Iron regulatory protein bandshift and calcein fluorescen

90 ays revealed that induction of p53 decreased iron regulatory protein binding.

91 RNA using a poly(G) stretch or the mammalian iron regulatory protein bound to the iron responsive ele

92 in an oxidative process with disturbance of iron regulatory protein capacity.

93 expression of genes encoding Epo, EpoR, and iron regulatory proteins contributes to defective erythr

94 d cytosolic aconitase of the capacity of the iron regulatory protein controlling the translation of s

95 t excess H-ferritin generated as a result of iron-regulatory protein deactivation sequesters toxic ir

96 te immune protein, has emerged as a critical iron regulatory protein during physiological and inflamm

97 The iron-regulatory protein Fur has been implicated in the A

98 reased intracellular iron levels measured by iron regulatory protein gel-shift assays and ferritin le

99 A putative iron-regulatory protein has also been identified in cyto

100 reased tissue iron, in analogy to mRNA (IRE)/iron regulatory protein in animals.

101 s was examined by the level of activation of iron regulatory protein in band shift assays.

102 is analysis revealed that the basal level of iron regulatory protein in growth-arrested cells was 6-f

103 determined iron levels and the expression of iron regulatory proteins in the liver and gut of nonobes

104 [2Fe-2S]-coordinating complexes in vitro and iron-regulatory proteins in fungi, but it is not clear h

105 tin-H, and increased iron-responsive element-iron regulatory protein interaction are also observed in

106 pendent iron signaling via activation of the iron-regulatory protein/iron-responsive element interact

107 IRP1 [iron regulatory protein (IRP) 1] is a bifunctional prote

108 nganese (Mn) exposure alters the function of iron regulatory protein (IRP) and increases iron (Fe) co

109 t enhancing ferritin expression by targeting iron regulatory protein (IRP) binding activity reduces c

110 ithelial antigen of the prostate (STEAP) and iron regulatory protein (IRP) families in cancer have pr

111 The cytoplasmic iron regulatory protein (IRP) modulates iron homeostasis

112 Iron regulatory proteins (IRP) are sequence-specific RNA

113 eimer brain might result from alterations in iron regulatory proteins (IRP) such as IRP-1 and IRP-2,

114 ), to which a transacting protein called the iron-regulatory protein (IRP) is bound.

115 ed its identity to the previously identified iron-regulatory protein (IRP)-like cDNA from Plasmodium

116 ng the IRE, bind specifically to recombinant iron-regulatory proteins (IRP) and to IRP from neuroblas

117 IRE-RNA riboregulators bind specifically to iron-regulatory proteins (IRP) proteins, inhibiting ribo

118 lls is orchestrated posttranscriptionally by iron-regulatory proteins (IRP)-1 and -2.

119 translational control through regulation of iron-regulatory proteins (IRP).

120 muscle was associated with a decrease in the iron regulatory protein IRP1 and intracellular iron over

121 The RNA-binding iron regulatory proteins IRP1 and IRP2 are inactivated b

122 The two iron regulatory proteins IRP1 and IRP2 bind to transcrip

123 use, and storage through the actions of the iron regulatory proteins IRP1 and IRP2.

124 In low-iron conditions, the cytosolic iron-regulatory protein IRP1 binds to iron-responsive el

125 Iron regulatory proteins (IRP1 and IRP2) are master regu

126 Iron regulatory proteins (IRP1 and IRP2) are RNA-binding

127 Equal modulated interaction of the iron regulatory proteins (IRP1 and IRP2) with canonical

128 th transferrin receptor (TfR) expression and iron-regulatory protein (IRP1 and IRP2) activity.

129 Iron-regulatory proteins (IRP1 and IRP2) are RNA-binding

130 uctures (iron-responsive elements, IREs) and iron-regulatory proteins (IRP1 and IRP2), controlling ei

131 Iron is stringently regulated by the iron regulatory proteins, IRP1 and IRP2, which regulate

132 llular iron homeostasis is controlled by the iron regulatory proteins (IRPs) 1 and 2 that bind cis-re

133 Iron regulatory proteins (IRPs) are cytoplasmic RNA bind

134 Iron regulatory proteins (IRPs) are RNA-binding proteins

135 When cells are iron-depleted, iron regulatory proteins (IRPs) bind to IREs in the tran

136 tural group of mRNA-specific sequences, bind iron regulatory proteins (IRPs) differentially and fold

137 lar iron concentrations are modulated by the iron regulatory proteins (IRPs) IRP1 and IRP2.

138 Iron regulatory proteins (IRPs) regulate iron metabolism

139 h iron regulation by altering the binding of iron regulatory proteins (IRPs) to their response elemen

140 metabolism is mediated by the interaction of iron regulatory proteins (IRPs) with RNA stem-loop seque

141 IREs serve as binding sites for iron regulatory proteins (IRPs), iron-sensing proteins t

142 of cellular iron homeostasis is regulated by iron regulatory proteins (IRPs), which control the expre

143 teractions of iron-sensing proteins known as iron regulatory proteins (IRPs), with transcripts that c

144 metabolism largely through the action of the iron regulatory proteins (IRPs).

145 binding a family of mRNA-specific proteins, iron regulatory proteins (IRPs).

146 m in the cell via their interaction with the iron regulatory proteins (IRPs).

147 expression post-transcriptionally by binding iron regulatory proteins (IRPs).

148 Iron-regulatory proteins (IRPs) 1 and 2 are cytosolic RN

149 Iron-regulatory proteins (IRPs) 1 and 2 posttranscriptio

150 involving hypoxia-inducible factor (HIF) and iron-regulatory proteins (IRPs) are responsive to both t

151 The iron-regulatory proteins (IRPs) posttranscriptionally re

152 Iron-regulatory proteins (IRPs) recognize and bind to sp

153 Iron regulatory proteins play a principal role in mainta

154 erritin mRNA model that is recognized by the iron-regulatory protein repressor, were identified by us

155 Hemojuvelin is a recently identified iron-regulatory protein that plays an important role in

156 by NO into an mRNA binding protein (IRP, or iron-regulatory protein) that regulates iron homeostasis

157 The roles of proteins such as iron regulatory proteins, the hereditary hemochromatosis

158 tal muscle cells by promoting the binding of iron regulatory proteins to iron-responsive elements pre

159 The presence of an iron regulatory protein was demonstrated in the brain mi

160 ation principally through the interaction of iron regulatory proteins with mRNAs that contain an iron