ライフサイエンスコーパス: irreparable

1 caused by immune pathology in the CNS can be irreparable.

2 n the continuous strand, the heteroduplex is irreparable.

3 This behavioral defect is not irreparable.

4 synthesis is observed on both reparable and irreparable 3' and 5' heteroduplexes as judged by [32P]d

5 al a profound toxicity of strand breaks with irreparable 3' blocking lesions, and extend the function

6 Processing of the irreparable 3' heteroduplex is also associated with inci

7 hallenge the traditional view of the static (irreparable) adult brain.

8 These lesions are irreparable and persistent in the short term, but their

9 The accumulation of irreparable cellular damage restricts healthspan after a

10 s during near-infrared irradiation can cause irreparable cellular damage to the prostate cancer cells

11 G explains the transient resistance, whereas irreparable chromosomal fragmentation explains subsequen

12 these proteinases are released and can cause irreparable damage by degrading host connective tissue p

13 It is associated with severe, irreparable damage in the GI tract and extremely low sur

14 irs cognitive function and ultimately causes irreparable damage to brain tissue.

15 xternalities." Specifically, the potentially irreparable damage to fisheries because of mangrove loss

16 Concerned about the possibly irreparable damage to the environment and to native comm

17 ias, which may be immediately fatal or cause irreparable damage to the heart sustained over long peri

18 lated event that would be expected to reduce irreparable damage to the mitochondria.

19 eservoir develops, the immune system suffers irreparable damage, and the infected (often unsuspecting

20 ow for either DNA repair or, in the event of irreparable damage, commitment to apoptosis.

21 led to prevent it from spreading and causing irreparable damage.

22 g late gestation and early infancy can cause irreparable deafness in both humans and rodents.

23 llowing enzymatic dissociation comes from an irreparable disruption of E-cadherin signaling, which th

24 ves indicate that a single event, such as an irreparable DNA break, may be sufficient to induce arres

25 responses to replication stress, accumulated irreparable DNA damage, and permanently exited the cell

26 by minimizing propagation of cells that have irreparable DNA damage.

27 ggered by neurotrophic factor deprivation or irreparable DNA damage.

28 ulating S. pombe cells induced misrepair and irreparable DNA double strand breaks causing chromosome

29 ave suggested that ionizing radiation causes irreparable DNA double-strand breaks in mice and cell li

30 on of damaged templates and, in the event of irreparable DNA lesions, induction of apoptosis.

31 enhance EcoRI inactivation of foreign DNA by irreparable double-strand cuts, in preference to readily

32 epairable double-strand breaks and then into irreparable double-strand gaps may be behind lethality o

33 nce of Slx4 or Rtt107, Rad9 binding near the irreparable DSB is increased, leading to robust checkpoi

34 x4 is recruited within a few kilobases of an irreparable DSB, through the interaction with Rtt107 and

35 y or Sae2 are required for Mec1 signaling at irreparable DSBs.

36 ted as large-budded cells when faced with an irreparable dsDNA break in a nonessential chromosome.

37 Cells with irreparable genomic damage pose a problem for developmen

38 nucleolytic activity, which otherwise causes irreparable genomic damage.

39 ctosidase (SA beta-gal) activity, apparently irreparable genomic DNA breaks, and elevation of p21(Cip

40 GE axis may provide a novel means to prevent irreparable glomerular injury in diabetes and other scle

41 s when exploiting natural resources leads to irreparable harm to the environment.

42 DSBs, a majority of complex DNA lesions were irreparable in organotypic 3D culture.

43 uent excision and chromosomal fragmentation, irreparable in the absence of RecBCD-catalyzed repair an

44 es harmful immune responses that can lead to irreparable injury to innocent bystander cells that are

45 prompting avoidance of further damage to the irreparable inner ear.

46 ay lead to prompt treatment and avoidance of irreparable late sequelae.

47 replication over any remaining unrepaired or irreparable lesions in the DNA.

48 al DNA polymerase, pol gamma, interacts with irreparable lesions such as T-T.

49 in translesion synthesis over unrepaired or irreparable lesions.

50 verity of kidney injury at day 1, suggesting irreparable microvascular damage.

51 Cells exposed to severe and irreparable mitochondrial damage agents such as valinomy

52 vin and light (Mirasol PRT treatment) causes irreparable modification of nucleic acids.

53 s demonstrated that newly synthesized DNA on irreparable molecules is subject to re-excision in a rea

54 search supports the view that degradation of irreparable O(6)-mG-T mispair-containing DNA by the MMR

55 -free extracts, CAF-1-dependent packaging of irreparable O(6)-mG-T mispair-containing DNA into nucleo

56 uggest that CAF-1-dependent incorporation of irreparable O(6)-mG-T mispair-containing DNA into nucleo

57 vity of the MMR system causes degradation of irreparable O(6)-mG-T mispair-containing DNA, triggering

58 appears diverse, a final common pathway for irreparable optic nerve injury may exist.

59 osure (1 kJ/m(2) three times weekly) induced irreparable skin damage in high PKCepsilon-overexpressin

60 butes by allowing these DSBs to transit into irreparable states.

61 ng in a pathway that allows the tolerance of irreparable UV lesions.

62 for kidneys that have minuscule function of irreparable vascular anomalies.