ライフサイエンスコーパス: irreversible

1 versible, alteration of the H126 epitope was irreversible.

2 agnose graft deterioration before it becomes irreversible.

3 he hybrid sites attL and attR is essentially irreversible.

4 hydride addition to the alkene to be largely irreversible.

5 g scenarios and the color-change reaction is irreversible.

6 Hf-bound polymers to ZnEt2 is fast and quasi-irreversible.

7 long repeated sequences would usually become irreversible.

8 Kinetic modeling was performed using an irreversible 1-plasma 2-tissue compartmental model to es

9 rmacokinetic modeling was conducted using an irreversible 1-plasma 2-tissue-compartment model to calc

10 lectrode is further applied to the system of irreversible 2-nitro-5-thiobenzoate oxidation used in th

11 ion, gave results comparable to those of the irreversible 2-tissue-compartment model with only a pare

12 An irreversible 2-tissue-compartmental model was implemente

13 istable switch that makes mitotic commitment irreversible [2-4].

14 The irreversible 3-tissue-compartment model, which included

15 to tune the relative sizes of reversible and irreversible ablation zones.

16 isability in young adults as a result of the irreversible accumulation of neurological deficits.

17 -coupled receptor that undergoes proteolytic irreversible activation by coagulant and anti-coagulant

18 ical Eley-Rideal mechanisms that involve the irreversible activation of coordinated H2O2 followed by

19 show no cytotoxicity, and in vitro nanomolar irreversible activity against herpes simplex virus (HSV)

20 ta-lactam antibacterials is the functionally irreversible acylation of the enzymes that catalyze the

21 adhesion mechanistically comparable with the irreversible adsorption of high-molecular-weight protein

22 hich exhibited lower recoveries (82%) due to irreversible adsorption to sorbent phase.

23 form solid-like gels that undergo aging into irreversible aggregates.

24 mall heat shock proteins (sHsps) prevent the irreversible aggregation of unfolding proteins by integr

25 large changes in local tau conformations and irreversible aggregation.

26 15b and 15d were more directly validated as irreversible agonists of the A1AR using membrane-based [

27 ormation, leading to rapidly progressive and irreversible allograft failure.

28 he pressure changes could be divided into an irreversible and a reversible part, where the latter is

29 , we show that low-pH inactivation of HSV is irreversible and due to a defect in virion fusion activi

30 d proteins, the assembly of the other two is irreversible and enhanced at higher temperatures, behavi

31 ion represents a critical step, which can be irreversible and establishes a hook in the channel mouth

32 d peripheral airways that results in largely irreversible and progressive airflow limitation.

33 Intestinal graft dysfunction is sometimes irreversible and requires allograft enterectomy with or

34 hierarchy of neuronal differentiation is not irreversible and that lineage commitment can be overridd

35 is consistent with the coexistence of both "irreversible" and reversible transitions in molecular ma

36 This interconversion is thermally irreversible, and cooling back to 3 K does not change th

37 Unfortunately, vision and RGC loss are irreversible, and lead to bilateral blindness in approxi

38 The transition is irreversible, and our in situ high-temperature synchrotr

39 Above 10(-4) M Ag(+), damages were irreversible, and photosynthesis and growth were definit

40 it DNA damage response, but rather induce an irreversible, anomalous state of condensed chromatin tha

41 as enhanced at a low oxygen level and became irreversible at a high NO concentration or after prolong

42 Our analysis suggests that the irreversible axon degeneration produced in the early sta

43 ine while 5,6-diethynylquinoxaline undergoes irreversible Bergman cyclization indicative of a large r

44 munocompromise, history of fulminant CDI, or irreversible bleeding disorders were excluded.

45 lar degeneration (AMD) is a leading cause of irreversible blindness among the elderly population glob

46 Early detection can reduce irreversible blindness from retinal diseases.

47 ENT Photoreceptor degeneration is a cause of irreversible blindness in a number of retinal diseases s

48 ntributing to glaucoma, the leading cause of irreversible blindness world-wide.

49 Glaucoma, the leading cause of irreversible blindness worldwide, is characterized by th

50 It is the most frequent cause of irreversible blindness worldwide.

51 Glaucoma is a major cause of irreversible blindness worldwide.

52 Glaucoma is the leading cause of irreversible blindness worldwide.

53 However, application of reverse voltages or irreversible blockage of the macroscopic conductance of

54 r a subset of infants with MoCD and prevents irreversible brain damage.

55 Irreversible breakdown of cartilage extracellular matrix

56 Acalabrutinib (ACP-196) is a more selective, irreversible BTK inhibitor that is specifically designed

57 em, which may help reduce the burden of this irreversible but preventable neurodegenerative disease.

58 stic studies imply that C-H bond cleavage is irreversible, but not the rate-determining step.

59 of DNA replication by cyclin E/Cdk2 and made irreversible by Emi1.

60 es shows that the former suffers from a huge irreversible capacity loss on cycling whereas the latter

61 suffer from capacity fading, large 1st cycle irreversible capacity or polarization.

62 -ion storage performances (i.e., 1(st) cycle irreversible capacity, specific gravimetric and volumetr

63 For both models, irreversible capture and shearing allow us to tune the d

64 DCD), that is, donors with an unexpected and irreversible cardiac arrest (Maastricht categories I and

65 and fluorescent dyes) and occurs during both irreversible (caspase cleavage-mediated) and reversible

66 nsformation, it can paradoxically promote an irreversible cell cycle arrest known as oncogene-induced

67 Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secreti

68 We identified an irreversible change in the fusion domain of gB following

69 se bands were still observed, indicating the irreversible change in the structure.

70 pronounced and largely, but not completely, irreversible changes in the optical properties.

71 etic state, prolonged suppression results in irreversible changes that compromise their developmental

72 iguat/Tween 20-preincubated sGC revealed the irreversible character of the drug.

73 of the assembly process with a reversible or irreversible chemical reaction that occurs within the co

74 esins to sample potential substrates without irreversible cleavage and inactivation.

75 phingolipid breakdown pathway, mediating the irreversible cleavage of the lipid-signaling molecule sp

76 temic immunomodulatory therapy, resulting in irreversible clinical deterioration in patients with MMP

77 model (2TC) as well as a 2TC with an extra, irreversible, compartment for endothelial binding (2TC-1

78 method (BFM) implementation of the 2-tissue-irreversible-compartment model and the Patlak method usi

79 To drive fusion, the F protein undergoes an irreversible conformational change, transitioning from a

80 ith the terpene synthase GES1 catalyzing the irreversible conversion of geranyl diphosphate (GPP) to

81 An irreversible covalent binding mechanism imparts many des

82 optimization, and unique ADME assays of our irreversible covalent drug discovery program which culmi

83 many clinical advantages over noncovalent or irreversible covalent drugs.

84 Our goal was to develop an irreversible covalent inhibitor of FGFR1-4 for use in on

85 Collagen stabilization through irreversible cross-linking is thought to promote hepatic

86 unction has traditionally been attributed to irreversible damage caused by the pathogens themselves.

87 lly suffer from large amounts of cumulative, irreversible damage to microstructure during cyclic defo

88 motherapy is associated with dose-dependent, irreversible damage to the heart.

89 promising new tool to inflict localized and irreversible damage to tumor tissue by hyperthermia, wit

90 igh temperature, but neither showed signs of irreversible damage.

91 ressive terminal airway fibrosis leads to an irreversible decline in lung function termed bronchiolit

92 f follicles within this fixed pool causes an irreversible decline in reproductive capacity, known as

93 How mitochondria escape this irreversible defect accumulation is a fundamental unsolv

94 generalization of our theory to account for irreversible deformations allows us to explain the time

95 However, irreversible degradation of chemical vapor deposition-gr

96 is an intracellular enzyme that mediates the irreversible degradation of the bioactive lipid S1P.

97 opulation structure are important in driving irreversible dependence between hosts and symbionts.

98 leads to significant deformation and mostly irreversible deposition.

99 lline phase originates from THF, DCM, or the irreversible desolvation of entrapped benzene molecules.

100 , however, exhibit limited durability due to irreversible dielectric breakdown.

101 nal aortic aneurysm (AAA) is a permanent and irreversible dilation of the lower region of the aorta.

102 Neuronal loss, a key substrate of irreversible disability in multiple sclerosis (MS), is a

103 Usher syndrome is an inherited and irreversible disease that manifests as retinitis pigment

104 drial membrane potential that resulted in an irreversible disintegration of their plasma membranes.

105 Pressure induced irreversible dissociation of the obligate ATC trimer, an

106 kin's antioxidant capacity, and reduction of irreversible DNA and protein oxidation associated with o

107 We demonstrate that complex 1 induces irreversible DNA single strand breaks following irradiat

108 es of cancer chemotherapeutics is limited by irreversible, dose-dependent, and sometimes life-threate

109 is presently known about the propensity for irreversible drug binding in these systems.

110 We demonstrate biochemically that irreversible DSBs are generated by subsequent Top1 cleav

111 tion effectively renders Bergman cyclization irreversible due to favorable aromatic stabilization ene

112 is reversible in the absence of HBpin but is irreversible during the catalytic process because reacti

113 GABAergic neurons into the circuit, produces irreversible effects on GABAergic synaptic connectivity

114 with the Au electrode experience a dramatic, irreversible efficiency loss, rendering them effectively

115 Dacomitinib is a second-generation, irreversible EGFR tyrosine kinase inhibitor.

116 itored by pulsing the cells in reversible or irreversible electropermeabilization condition at differ

117 anopore formation in bone marrow cells after irreversible electroporation (IRE) and to evaluate the a

118 Irreversible electroporation (IRE) as a non-thermal tumo

119 o (a) investigate the safety of percutaneous irreversible electroporation (IRE) for locally advanced

120 se To investigate the efficacy and safety of irreversible electroporation (IRE) in the treatment of h

121 Purpose To assess the safety and efficacy of irreversible electroporation (IRE) in the treatment of p

122 Irreversible electroporation (IRE) is a promising non-th

123 sponse for cells treated with high-frequency irreversible electroporation (IRE).

124 Irreversible electroporation is a novel, nonthermal abla

125 Irreversible electroporation seems to be a safe modality

126 chitecture remains unaffected 2 months after irreversible electroporation, purposely targeting the ad

127 prevent scarring based on nonthermal partial irreversible electroporation.

128 structural properties of enamel resulting in irreversible enamel loss.

129 Because commitment is often irreversible, entry into and progression through this ph

130 re of male mouse ES cells in 2i/L results in irreversible epigenetic and genomic changes that impair

131 e binding of EBNA3A and/or EBNA3C leading to irreversible epigenetic changes, cells become committed

132 e cell wall to undergo stress relaxation and irreversible expansion (e.g. induced by expansins), thus

133 mobilization of the bait molecule is usually irreversible; for that reason, a new chip (which is expe

134 This results in the irreversible formation of a hydrogen-bonded complex betw

135 n ambient air) with Li anode may lead to the irreversible formation of insulating Li2 CO3 , making th

136 how that flowing the suspension triggers the irreversible formation of topological entanglements of t

137 lacement of the entire membrane module after irreversible fouling, thereby hopefully reducing the ove

138 However, mallotoxin caused an irreversible functional and structural disengagement of

139 sis may lead to neuronal death, thus causing irreversible functional impairments.

140 (Tregs), was thought to imprint a unique and irreversible genetic signature within Tregs.

141 prolonged exposure to mutant IDH1 results in irreversible genomic and epigenetic alterations.

142 gnalling can contribute to the generation of irreversible genomic changes in cancer.

143 Cellular senescence, an irreversible growth arrest triggered by a variety of str

144 n of autophagy and CDK4/6 inhibitors induces irreversible growth inhibition and senescence in vitro,

145 nts at pH 5 followed by neutral pH caused an irreversible >2.5 log infectivity reduction.

146 nd that treatment with the second-generation irreversible HER-family inhibitors, particularly afatini

147 igations to ionic processes, but the risk of irreversible Hg amalgam saturation limits their operatio

148 Irreversible humin incorporation of (14)C-DNAN occurred

149 considered: (i) fully reversible, (ii) fully irreversible, (iii) partially reversible transitions, an

150 d management can have detrimental, costly or irreversible impacts on the environment and society.

151 ysfunctions of hearing and balance are often irreversible in mammals owing to the inability of cells

152 d not change after further digestion, as the irreversible inactivated myrosinase under gastric condit

153 host target membrane, this change results in irreversible inactivation of virions.IMPORTANCE HSV-1 is

154 lfinic/sulfonic acid (catalytically dead and irreversible inactivation) or a stable sulfenamide or di

155 tivating Env function, followed by rapid and irreversible inactivation.

156 es in the envelope glycoproteins, leading to irreversible inactivation; and (iii) exposure of cryptic

157 yllysine is seen to act as a time-dependent, irreversible inactivator of lysine decarboxylase from Ha

158 have indicated overestimation of the core of irreversible infarction as well as of the penumbra by th

159 tivated cyclic carbamates provided selective irreversible inhibition of a small subset of serine hydr

160 nts and organophosphorus toxicants is due to irreversible inhibition of acetylcholinesterase (AChE) i

161 Aspirin exerts antiplatelet effects through irreversible inhibition of cyclooxygenase-1, whereas its

162 Arabidopsis thaliana studied here comprises irreversible inhibition of RD21's activity by Serpin1, w

163 dues can also represent a viable approach to irreversible inhibition.

164 valent bond formation and confirmed targeted irreversible inhibition.

165 Furthermore, we developed a kinome selective irreversible inhibitor 45a with an IC50 value of 1 nM ag

166 BTKB66 is a selective, irreversible inhibitor of Btk.

167 ydroxypyrrolidin-1-yl)methanone 28, a potent irreversible inhibitor of LOXL2 that is highly selective

168 the dorsal CA1 region with thapsigargin, an irreversible inhibitor of the SERCA pump, exhibited anxi

169 eases for centuries, has been shown to be an irreversible inhibitor of the XPB subunit of the transcr

170 We used chemical proteomics with a potent irreversible inhibitor to show that the major brain TCP

171 could be overcome using a cysteine-targeted irreversible inhibitor.

172 Irreversible inhibitors developed from the nonspecific i

173 verse binding modes, and both reversible and irreversible inhibitors have been developed.

174 ly, after 20 min of preincubation with these irreversible inhibitors of BChE.

175 iazole ureas constitute a versatile class of irreversible inhibitors that target serine hydrolases in

176 ure-activity relationship (SAR) study, novel irreversible inhibitors were identified that block the t

177 precisely identify hearts that have suffered irreversible injury.

178 In cases of irreversible intestinal graft dysfunction, isolated allo

179 d temperature-dependent assembly between two irreversible isomeric 3D nanocages.

180 In summary, the unusual irreversible isomerization of prFMN is light-dependent a

181 Although this complementation is typically irreversible, it has been shown previously that light ac

182 ML) subtypes using selective, reversible and irreversible KDM1A small-molecule inhibitors.

183 ing process is at chemical equilibrium) into irreversible kinetic responses associated with proton tr

184 vercome these thermodynamic limitations with irreversible kinetics.

185 iments, the dependency of the development of irreversible lesions on the interaction of the severity

186 Arg(173)-Glu(282) network and accompanied by irreversible loss of activity.

187 mes, this differentiation is terminal due to irreversible loss of cell division ability and is associ

188 to saturation of the amalgam accompanied by irreversible loss of Hg.

189 inal ischemia-reperfusion (IR) injury causes irreversible loss of neurons and ultimately leads to per

190 predators are therefore important drivers of irreversible loss of phylogenetic diversity worldwide.

191 Hence, in order to avoid an irreversible loss of the active phase during process sta

192 In this series, MEK inhibitors did not cause irreversible loss of vision or serious eye damage.

193 neration (AMD) that leads to progressive and irreversible loss of visual function.

194 st time effort expenditure in the context of irreversible losses, with important implications for dis

195 hanges in gB, and the latter correlates with irreversible low-pH inactivation of HSV.

196 gB reported to date are reversible, despite irreversible low-pH inactivation.

197 partially inactivates HSV infectivity in an irreversible manner.

198 is of infected cells by modifying FADD in an irreversible manner.

199 sium ferricyanide illuminated an alternative irreversible mechanism-based inactivation (MBI).

200 ctrolyte membranes to ultimately control the irreversible membrane fouling in a forward osmosis (FO)

201 ting an ultimate solution to eliminating the irreversible membrane fouling in an FO process.

202 oret peak confirmed the formation of a quasi-irreversible metabolite-intermediate complex between dro

203 strain localizing mechanisms associated with irreversible microstructural damage in single-crystal, c

204 we propose that cinaciguat by virtue of its irreversible mode of action is capable of shifting this

205 as performed using a 2-tissue, 3-compartment irreversible model, and kinetic parameters were estimate

206 ing the honey at 30 degrees C results in the irreversible molecular structure changes.

207 Use of an irreversible MOR antagonist and Furchgott analysis revea

208 ging (MRI) could achieve deep, targeted, and irreversible myocardial ablation, which would be immedia

209 e T1 mapping to differentiate reversible and irreversible myocardial injury and its predictive value

210 ery T1 mapping differentiates reversible and irreversible myocardial injury, and it is a strong predi

211 olymerizations; the key difference being the irreversible nature of this polymerization.

212 is toggle switch accounts for the abrupt and irreversible nature of three specific cell-cycle checkpo

213 e ocean temperatures and consistent with the irreversible nature of watermass changes involved in the

214 cally has been hypothesized to predispose to irreversible nephron damage, thereby contributing to ini

215 These T cells drive the EAE pathogenesis to irreversible neurologic deficit.

216 hange and rituximab, but some die or acquire irreversible neurological deficits before they can respo

217 ough a series of clinical stages and lead to irreversible neurological or cardiovascular complication

218 ontrol of modifiable risk factors to prevent irreversible neurological sequelae.

219 al replication and inflammation, that causes irreversible neuronal injury and HIV associated neurocog

220 wed the selection of 11 (INF39), a nontoxic, irreversible NLRP3 inhibitor able to decrease interleuki

221 ophila model, but also rescues proteins from irreversible non-fibrillar aggregation.

222 in the f-block because these metals exhibit irreversible one- or multi-electron oxidation or reducti

223 aucoma is a chronic disease characterized by irreversible optic nerve damage and visual field loss th

224 permits the direct synthesis of practically irreversible ordered amide networks that are stable ther

225 n with glutathione may serve also to prevent irreversible oxidation of BiP by peroxide.

226 promote vascular disease through direct and irreversible oxidative damage to macromolecules, as well

227 A hallmark of tissue ageing is the irreversible oxidative modification of its proteins.

228 R-SO2(-)) and S-sulfonylation (R-SO3(-)) are irreversible oxidative post-translational modifications

229 f mesoporous silica nanoparticles occurs via irreversible packing of micelles with non-uniform size d

230 ExteNET showed that 1 year of neratinib, an irreversible pan-HER tyrosine kinase inhibitor, signific

231 -IN-8, an adenosine triphosphate-competitive irreversible pan-JNK inhibitor, significantly reduced ce

232 Additionally, the irreversible part observed in the pressure changes was a

233 e bubble domains reveal that they undergo an irreversible phase transition to cylindrical domains und

234 While irreversible phenotypic switching can be detected by stu

235 Micronutrient deficiencies result in irreversible physical and cognitive consequences.

236 romoted RG-II dimerization by B(OH)3 without irreversible polyhistidine-RG-II complexation.

237 bstrate proteins, resulting in a widespread, irreversible posttranslational modification of the prote

238 diseases-associated fibrosis was seen as an irreversible process that frequently led to intestinal o

239 ocene/ferrocenium, Fc(0/+)) via a chemically irreversible process with concomitant formation of dihyd

240 ed even though most homologous pairings form irreversible products.

241 s and instead lose pluripotency, activate an irreversible program of prospermatogonial differentiatio

242 lian proteinopathies are only detected after irreversible protein aggregates have formed.

243 of these unique postmitotic cells, in which irreversible protein degradation or damage can lead to i

244 property of bonded dentin and does not cause irreversible pulpal damage to vital teeth when the air p

245 OFs from strong bonds is challenging because irreversible rapid formation of the network produces amo

246 C/EBPbeta by helenalin acetate is not due to irreversible reaction with cysteine residues of C/EBPbet

247 ts the potential of this method for studying irreversible reactions at sub-microsecond timescales usi

248 The cyclic voltammetry of 3 shows irreversible reduction and oxidation.

249 D(+) ]/[NADH] pool to molecular oxygen, with irreversible reduction of oxygen to bound peroxide at cy

250 fusion (F) protein, which undergoes a major irreversible refolding process to merge the two membrane

251 l numerical models suggest that unstable and irreversible retreat of the grounding line-which marks t

252 itry that could help identify disease before irreversible RGC changes.

253 periods of the left ureter ligation, causes irreversible right kidney failure 3, 6 or 9 months after

254 able switch, created by CRL4(Cdt2), promotes irreversible S-phase entry by keeping p21 levels low, pr

255 rs of SBF/E2F transcription factors triggers irreversible S-phase entry in yeast and metazoans, but w

256 g that the Fe depletion stress did not cause irreversible secondary damage.

257 ppropriate treatment can prevent unfavorable irreversible sequela for the patient.

258 macular degeneration (AMD)-the main cause of irreversible severe vision loss in developed countries-g

259 lar degeneration (AMD) is a leading cause of irreversible, severe vision loss in Western countries.

260 these changes is a powerful, inevitable and irreversible shift in attitudes and norms in the directi

261 It reveals one of several irreversible shifts in the history of life.

262 ransformation of SIFSIX-1-Cu was found to be irreversible, SIFSIX-3-Ni could be regenerated by heatin

263 No irreversible sight-limiting complications were noted.

264 Ibrutinib, a potent and irreversible small-molecule inhibitor of both Bruton's t

265 In situ reaction of 25 with HCCTol gives irreversible sp C-H bond activation under kinetic contro

266 en bilateral lung transplant recipients with irreversible spirometric decline and control subjects ma

267 kade, but it progressively developed into an irreversible state.

268 ort process involves reversible steps and an irreversible step that follows release of ADP and extrac

269 ses in both rivers and volcanoes can produce irreversible structural changes that are detectable in g

270 impedance growth that stems from continuous irreversible structural transition.

271 ence that attachment of the tethered head is irreversible, suggesting a first passage model for exit

272 ffer from the precipitation of insoluble and irreversible sulfide species on the surface of carbon an

273 However, the precipitation of insoluble and irreversible sulfide species on the surface of carbon an

274 ells, allowing them to undergo reversible or irreversible switching between phenotypic states importa

275 Within the framework of linear irreversible thermodynamics, the maximum-power efficienc

276 model confirmed that adhesion to surfaces is irreversible through detachment and successive re-attach

277 With these variables, clear definitions of irreversible tissue damage and of critically hypoperfuse

278 ined values (the threshold for function) and irreversible tissue damage with blood supply further dec

279 Irreversible tissue recession in chronic inflammatory di

280 properties and in the reactivity in various irreversible transformations.

281 time-delayed electron pulse to visualize the irreversible transient states of nucleation, growth, and

282 micro-organisms could be associated with the irreversible transition to an inactivated state, as sugg

283 An irreversible transition was observed from a metastable t

284 Neratinib, an irreversible tyrosine-kinase inhibitor of HER1, HER2, an

285 k-forming chemistries such as amide that are irreversible under conventional low temperature bond-for

286 arrow reversible unfolded (intermediate) --> irreversible unfolded (denatured) state, we study the th

287 Konzo is an irreversible upper-motor neuron disorder affecting child

288 hical analysis gave metabolic rates (Ki, the irreversible uptake rate constant) comparable to compart

289 Irreversible-uptake compartmental models fitted the kine

290 osynthetic organisms, plants need to prevent irreversible UV-induced DNA lesions.

291 pproximately 190 pN) that eventually lead to irreversible viral deformation.

292 r degeneration (AMD) is the leading cause of irreversible vision impairment in older adults in the Un

293 Photoreceptor degeneration is a cause of irreversible vision loss in incurable blinding retinal d

294 -angle glaucoma (POAG) is a leading cause of irreversible vision loss worldwide, with elevated intrao

295 cular degeneration (AMD) is a major cause of irreversible vision loss.

296 a progressive retinal dystrophy that causes irreversible visual impairment and blindness.

297 -retinal in dark-adapted Rho was essentially irreversible with a half-life estimated to be 420 years,

298 s initially reversible, though becoming more irreversible within minutes after first contact with a s

299 ompletely reversible wrinkles formation; (2) irreversible wrinkles formation I: the initially formed

300 rmanently erased and never reappear; and (3) irreversible wrinkles formation II: once the wrinkles fo