ライフサイエンスコーパス: irreversibly

1 nd consumes neither the walker nor the track irreversibly.

2 an indeed bind to MntC reversibly as well as irreversibly.

3 Ni anode damages the SOFC significantly and irreversibly.

4 from RNA/CP complexes and nucleocapsids form irreversibly.

5 alogue 39 inhibited proteasome CT-L activity irreversibly.

6 fate of the pore, which may reseal or dilate irreversibly.

7 atural environment could damage an ecosystem irreversibly.

8 atly perturb the formation of amyloid fibres irreversibly.

9 al, to be visualized immediately and ablated irreversibly.

10 osed repeatedly before dilating or resealing irreversibly.

11 organisms results in homologous chromosomes irreversibly accumulating mutations and thus evolving in

12 icities of yeast and human proteasomes using irreversibly acting alpha',beta'epoxyketone (ep) inhibit

13 ccupancy of an anesthetic binding site would irreversibly activate TASK-3.

14 tact tumor epithelial cells (TEC) can become irreversibly activated as cancer-associated-fibroblasts

15 G-protein-coupled receptors (GPCRs) that are irreversibly activated by proteolytic cleavage of the N

16 NEM irreversibly activated M159C TASK-3, with minimal effect

17 Thrombin irreversibly activates PAR1 by cleaving the amino-termin

18 and determine whether the cell reversibly or irreversibly adhered to the surface.

19 cid sites have a high tendency to convert to irreversibly adsorbed carbonaceous deposits and are resp

20 dsorbed electron-acceptor molecule and as an irreversibly adsorbed molecule that heals natural oxygen

21 eter thicknesses that were relatively rigid, irreversibly adsorbed, and collapsed upon air drying, as

22 , hence they are usually thought of as being irreversibly adsorbed.

23 muscle homeostatic conditions, and that this irreversibly affects their intrinsic regenerative and se

24 ncy steadily diminished until rhythm stopped irreversibly after 85+/-20 (mean +/- SEM) cellular ablat

25 .2 +/- 0.1 S, together with minor amounts of irreversibly aggregated material.

26 These drugs irreversibly alkylate parasite DNA, blocking their abili

27 The state of a given scratchpad can be irreversibly altered by CRISPR/Cas9-based targeted mutag

28 n showed the capsid expands similarly to the irreversibly altered cell entry intermediate (135S) part

29 modifies beta2M286C side-chain sulfhydryls, irreversibly altering GABA-induced currents.

30 c film on a triolein/water interface and was irreversibly anchored to the lipid surface, which is con

31 eals how only orbiting mode cells can attach irreversibly and form microcolonies.

32 t remain stable for some time before opening irreversibly and fully depolymerizing.

33 olecular hydrogen in a helium carrier gas by irreversibly and quantitatively scavenging all reactive

34 Replication forks can stall irreversibly, and if two converging forks stall with no

35 ein which can be converted from green to red irreversibly, and thus allows spatiotemporal labeling of

36 spheric oxygen may have varied before rising irreversibly approximately 2.4 billion years ago, during

37 temperature, a majority of synMuv B mutants irreversibly arrest at the L1 stage.

38 Centrosome loss irreversibly arrested normal cells in a senescence-like

39 These compounds irreversibly arrested parasite growth at all stages of t

40 Sod2 loss induced cellular senescence, which irreversibly arrested proliferation in a fraction of ker

41 Cellular senescence is a state of irreversibly arrested proliferation, often induced by ge

42 rature-sensitive growth mutant, FV-P6, which irreversibly arrests before the middle of the G1 stage o

43 Cellular senescence irreversibly arrests proliferation in response to potent

44 port here that tideglusib inhibits GSK-3beta irreversibly, as demonstrated by the lack of recovery in

45 production of female offspring, leaving them irreversibly asexual, further linking host and symbiont.

46 We hypothesized Wolbachia strains infecting irreversibly asexual, resistant to horizontal transfer T

47 ing of up to approximately eight loosely but irreversibly assembled monomeric subunits.

48 DNA to a protected state in which it is not irreversibly associated with the protoplast, and presuma

49 required by Pseudomonas fluorescens Pf0-1 to irreversibly attach to a surface and form a biofilm.

50 ity to sand in freshwater and appeared to be irreversibly attached in primary energy minima at elevat

51 asma membrane with a polybasic domain and an irreversibly attached lipid instead of palmitate rendere

52 re terbium-labeled fluorescent reporters are irreversibly attached to receptors by metabolic glycan e

53 a chemical reporter (CR) group, where the AB irreversibly attaches the ligand to the receptor upon bi

54 the development of virus variants, which are irreversibly attenuated in terms of production of infect

55 ion of other alphaviruses with a programmed, irreversibly attenuated phenotype.

56 of ATP have been previously shown to inhibit irreversibly bacterial infection through ligation of P2X

57 Second, GUVs shrink irreversibly because the membrane/glass adhesion creatin

58 um-mediated structural plasticity, switching irreversibly between an amorphous aggregate state and th

59 ostics, or therapeutics that selectively and irreversibly bind a target protein in vitro or in living

60 een shown to disable ibrutinib's capacity to irreversibly bind this primary target, the detailed mech

61 port the development of small molecules that irreversibly bind to a common oncogenic mutant, K-Ras(G1

62 the use of a set of research tools that can irreversibly bind to and affect the function of recombin

63 ive inhibitors of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of this

64 roxysuccinimidyl (NHS) ester of oleate (SSO) irreversibly binds CD36 and has been widely used to inhi

65 ble, biotinylated pan-caspase inhibitor that irreversibly binds to and traps the active caspase, we i

66 lamp experiments, phosphine-stabilized AuNPs irreversibly blocked hERG channels, whereas thiol-stabil

67 rine-containing photoaffinity probe (RX-055) irreversibly blocked membrane transport of both endocann

68 d gastrosophageal reflux disease and acts by irreversibly blocking ATP4A, a P-type H+/K+ ATPase in ga

69 ified a small molecule that specifically and irreversibly blocks parasite attachment and subsequent i

70 The composition of the irreversibly bound lignin component differed markedly be

71 at suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin remain

72 that DNAN biotransformation products can be irreversibly bound to humin in soils as a remediation st

73 ally trapped by colloidal particles that are irreversibly bound to the oil-water interface.

74 rticle, they are predicted to be essentially irreversibly bound to the viral DNA.

75 In the above examples the dye is reduced irreversibly, but when the photocatalyst in an ink is us

76 le to cause swimming worms to stick together irreversibly by their tails, leading to the rapid format

77 P-Xyl from UDP-glucuronic acid (UDP-GlcA) is irreversibly catalyzed by UDP-glucuronic acid decarboxyl

78 strategies and methods of organic synthesis irreversibly changed for the modern chemist, both in aca

79 Because proteases irreversibly cleave peptide bonds of protein substrates,

80 Sphingosine 1-phosphate lyase (S1P lyase) irreversibly cleaves sphingosine 1-phosphate (S1P) in th

81 e the point at which stem cells (SCs) become irreversibly committed along a differentiation lineage.

82 ts and unveil the intriguing concept that an irreversibly committed cell in an SC lineage can become

83 ising degradation because substrates must be irreversibly committed to degradation before Rpn11 acts.

84 monstrated that differentiated cells are not irreversibly committed to their fate.

85 It has been hypothesized that, before irreversibly committing, ESCs pass through at least one

86 e of Mecp2 during brain development does not irreversibly compromise brain function.

87 llowed by pericyte death in rigor, which may irreversibly constrict capillaries and damage the blood-

88 to stimuli and developing probes that do not irreversibly consume H2S.

89 iation capacity steadily decreases, Li(+) is irreversibly consumed at a steady rate, and pronounced S

90 ion and contraction; the rate of Li(+) being irreversibly consumed declines, and the Si SEI thickness

91 and epithelial cell dysfunction and does not irreversibly contribute to the pathogenic cascade in NPC

92 Choline can be irreversibly converted to betaine, a major source of met

93 a result, the nanoparticles are rapidly and irreversibly converted to macroscopic aggregates.

94 clic hemiaminal cross-links (7-10) that were irreversibly converted under conditions of reductive ami

95 infection, the virus usually wins the race, irreversibly crippling the immune system before an effec

96 Gel nanoparticles (GNPs) were synthesized by irreversibly cross-linking 8 Arm PEG thiol with 1,6-hexa

97 Since incomplete remyelination will irreversibly damage axonal connections, treatments effec

98 uring enzymatic catalysis, could rapidly and irreversibly damage polypeptides were protective mechani

99 Formaldehyde is one such compound that can irreversibly damage proteins and DNA through alkylation

100 Distinguishing between irreversibly damaged and surviving tissue could have con

101 the cognitive ability of offspring might be irreversibly damaged as a result of their mother's mild

102 ; however, a small fraction of proteins were irreversibly damaged by each oxidation cycle, and so rep

103 It has been proposed that when HCs are irreversibly damaged by noise or ototoxic drugs, surroun

104 SirT3 acts to sort moderately stressed from irreversibly damaged organelles.

105 proposed threshold of 1400 ms, the volume of irreversibly damaged tissue was in good agreement with t

106 reduce dinitrogen (N2) to ammonia (NH3), is irreversibly damaged upon exposure to molecular oxygen (

107 o-11,12-didehydrodibenzo[a,e][8]annulene and irreversibly deactivate the diamagnetic molybdenum metal

108 e activity of AMP deaminase, the enzyme that irreversibly deaminates AMP to form IMP.

109 unmet medical needs for life threatening or irreversibly debilitating conditions.

110 r Unmet Medical Need for Life Threatening or Irreversibly Debilitating Diseases or Conditions documen

111 Here we establish a platform for irreversibly decorating VLPs simply by mixing with prote

112 d in various physiological processes, can be irreversibly degraded by the membrane-bound S1P lyase (S

113 and, it is found that overstressed LEDs show irreversibly degraded device performance, possibly becau

114 Sphingosine-1-phosphate (S1P) lyase (SPL) irreversibly degrades the bioactive sphingolipid S1P and

115 In contrast, surface water of gammaS-G18V irreversibly dehydrates with moderate concentration incr

116 ived enzyme, without its prosegment (PS), is irreversibly denatured and folds to a thermodynamically

117 Low pH irreversibly denatures and precipitates many bacterial p

118 After rings open irreversibly, depolymerization of the remaining filament

119 n, degradation of host tissue, and bone that irreversibly destroys the supporting apparatus of teeth.

120 the identity of differentiated cells is not irreversibly determined but can be changed back to a plu

121 Exhaustion was not irreversibly determined by initial activation, but was m

122 icating that the autopod positional value is irreversibly determined.

123 post-mitotic cells are generally considered irreversibly developmentally locked, i.e. incapable of b

124 s, including those able to terminally (i.e., irreversibly) differentiate in form and function.

125 d through a transient ('kiss and run') or an irreversibly dilating pore (full fusion).

126 and alkyne substituents, these radicals can irreversibly dimerize, exist as monomers in solution but

127 Protein kinase C (PKC) activation irreversibly diminished Ih and HCN1 surface expression,

128 tems might suffer sharp population drops and irreversibly disintegrate into a system collapse, via a

129 d of chromatin-remodeling agents and without irreversibly disrupting the host nucleosome.

130 Gestational exposure to SS irreversibly disrupts lung development leading to a BPD-

131 x straightening is reversible, but phosphate irreversibly dissociates from the postpower stroke state

132 d values and the fraction of DNA duplex that irreversibly dissociates in the gas phase.

133 Moreover, a significant proportion of the irreversibly downregulated genes featured upstream bindi

134 n be specifically targeted by antibodies and irreversibly downregulated in circulating platelets in v

135 In contrast, KAR activity was irreversibly downregulated in response to induction of l

136 se studies demonstrate that Hsp90 inhibition irreversibly downregulates cell surface expression of cr

137 , while the equilibria can be reversibly and irreversibly driven toward the MOLP products by addition

138 ind that circulating ILCs are lost early and irreversibly during HIV infection.

139 ith Tat protein for 10 to 30 min suffices to irreversibly engage the activation of the TLR4 pathway,

140 which persisted after pathogen clearance and irreversibly escalated in severity with repeated infecti

141 ays, the PFP-instigated infection process is irreversibly established within 15 minutes of initial ex

142 C pecan shell biochars occurred rapidly and irreversibly even at neutral pH where retention was less

143 rrhotic livers suggest that hepatocytes from irreversibly failing livers show signs of replicative se

144 ctly activating tbx16, which in turn acts to irreversibly flip a bistable switch, leading to maintena

145 is observed (by stopped-flow) to rapidly and irreversibly form in this reaction (k1(-10 degrees C) =

146 cterial biofilms, the amyloid protein curli, irreversibly formed fibers with bacterial DNA during bio

147 wild-type A and a mutant allele A' produced irreversibly from A at small uniform rate v.

148 photoconvertible protein whose color changes irreversibly from a green to a red fluorescent form upon

149 ical systems are known to shift abruptly and irreversibly from one state to another when they are for

150 tions reveal that the defective RBCs respond irreversibly, i.e., they lose their ability to recover t

151 On top of these films, neutravidin was irreversibly immobilized by complexing the biotin moieti

152 dentified at which SFR2 was induced prior to irreversibly impacting plant growth, suggesting that SFR

153 sexually dimorphic expression of CYP2C11 is irreversibly imprinted shortly after birth by a hormone

154 r biological building blocks efficiently and irreversibly in diverse architectures.

155 ological activity and was formed rapidly and irreversibly in response to increases in auxin levels.

156 bilized from IOCS, which bound both bacteria irreversibly in the absence of NOM.

157 the case of Zn(II)) or as a chemodosimeter (irreversibly in the case of Cu(II)); however, the imine

158 tastability built into virus the envelope to irreversibly inactivate HIV-1 and provide a conceptual p

159 Both did not irreversibly inactivate the enzyme but efficiently trapp

160 the MS data identified sulfinic acid as the irreversibly inactivated enzyme species.

161 nizable group with a pK(a) of 7.0 and can be irreversibly inactivated through covalent modification b

162 -hydrogenase isoforms, HydA1 and HydA2, both irreversibly inactivated upon a few seconds exposure to

163 ll-free extracts, (iii) both activities were irreversibly inactivated upon exposure to O2, and (iv) b

164 temperature-rescued DeltaF508-CFTR channels irreversibly inactivated with a time constant of 5-6 min

165 ts phosphate backbone led to a molecule that irreversibly inactivates DNA polymerase beta in solution

166 We found that TmtA irreversibly inactivates ETP by S-alkylation and that th

167 generate new pathway behaviours: OspF, which irreversibly inactivates mitogen-activated protein kinas

168 hrombin (AT) is an anticoagulant serpin that irreversibly inactivates the clotting proteinases factor

169 acellular pathogens can inhibit autophagy by irreversibly inactivating Atg8 proteins during infection

170 Interestingly, the irreversibly inactive variant of the StI mutant StI W111

171 SOICR, whereas high levels of RyR2 oxidation irreversibly increase the threshold for SOICR leading to

172 ozymes are also increased in immune cells in irreversibly inflamed human dental pulp, and extracts of

173 synthesized and screened for the ability to irreversibly inhibit DNA polymerase beta.

174 s of nuclear export (SINEs) bind to CRM-1 to irreversibly inhibit its ability to export proteins; we

175 cription and provides a rational approach to irreversibly inhibit other kinases in vivo.

176 proach offers a novel catalytic mechanism to irreversibly inhibit protein function by targeting prote

177 ble through total synthesis and are found to irreversibly inhibit sodium ion conductance in recombina

178 ese quasi-spherical Zn(2+)-Abeta40 oligomers irreversibly inhibit spontaneous neuronal activity and c

179 g anticoagulant with active metabolites that irreversibly inhibit the platelet surface GPCR P2Y12 and

180 of bacterial natural product inhibitors that irreversibly inhibit the proteasome of eukaryotes by a n

181 of of the conjugation and new chemicals that irreversibly inhibited African malaria mosquito AChE wit

182 WIN 18,446 strongly and irreversibly inhibited ALDH1A2 in vitro.

183 recapitulates wild type activity and can be irreversibly inhibited both in vitro and in cells.

184 nd inducible NOS but not endothelial NOS are irreversibly inhibited by H2S/NO at modest concentration

185 inesterases (AChEs) could be selectively and irreversibly inhibited by methanethiosulfonates presumab

186 The catalytic activity of BChE could be irreversibly inhibited by organophosphorus pesticides (O

187 oncentrated within human ABC-DLBCL cells and irreversibly inhibited cleavage of MALT1 substrates.

188 In comparison, the insecticide paraoxon irreversibly inhibited mosquito and human AChEs with k(i

189 The aromatic aldehyde o-vanillin also irreversibly inhibited the deoxygenation-induced conduct

190 es between active, reversibly inhibited, and irreversibly inhibited thrombin.

191 However, when Ca2+ -ATPase activity was irreversibly inhibited with thapsigargin, the S170F and

192 the inhibitor, is dragged 75 A apart, and is irreversibly inhibited.

193 more, granule products directly degrade LLO, irreversibly inhibiting its activity.

194 , it was reported that estrone-3-O-sulfamate irreversibly inhibits a new potential hormone-dependent

195 However, ibrutinib also irreversibly inhibits alternative kinase targets, which

196 ylglutaryl-coenzyme A (HMG-CoA) synthase and irreversibly inhibits HMG-CoA synthase in a dose-depende

197 ine (K731) in a time-dependent reaction that irreversibly inhibits LOXL2 and converts the trihydrophe

198 It irreversibly inhibits nicotinic acetylcholine receptors

199 Prolonged NO exposure irreversibly inhibits respiration by covalent modificati

200 erogeneous breast cancer cell population and irreversibly inhibits the formation of free-floating mam

201 small molecule, FiVe1, which selectively and irreversibly inhibits the growth of mesenchymally transf

202 ete the virulence factor syringolin A, which irreversibly inhibits the proteasome by a novel mechanis

203 smatodendrosis, a morphological attribute of irreversibly injured astrocytes.

204 que to exclude patients with a large area of irreversibly injured brain tissue.

205 (CT) perfusion, can estimate the size of the irreversibly injured ischemic core and the volume of cri

206 dentin-pulp interface in direct contact with irreversibly injured pulp tissue.

207 patients with large baseline ischemic cores (irreversibly injured tissue).

208 Like all retroviruses, HIV-1 irreversibly inserts a viral DNA (vDNA) copy of its RNA

209 how that Ag16Al16Si24O8.16H2O (Ag-natrolite) irreversibly inserts xenon into its micropores at 1.7 GP

210 0 exhibit a 3D layered array that transforms irreversibly into columnar periodicities during heating

211 ounts of Co(Sal(tBu,tBu))Cl and organosilane irreversibly isomerize terminal alkenes by one position.

212 ular cells are fixed progenitors, cells were irreversibly labeled before ischemia reperfusion injury

213 hat operates via an aromatization mechanism, irreversibly labeling the PLP cofactor.

214 iety and a fluorescein isothiocyanate group, irreversibly labels sigma-2 receptors in rat liver; the

215 I-edge x-ray absorption near-edge spectra of irreversibly laser excited Molybdenum using an average o

216 ch under reaction conditions leaves probably irreversibly, leading to faster decomposition and deacti

217 as if they were overdamped because energy is irreversibly leaked into diverging nonaffine fluctuation

218 acyl-Ser and LPETGG-isoacyl-Hse) that can be irreversibly ligated to N-terminal Gly-containing moieti

219 We demonstrate that Mcm proteins are irreversibly loaded onto chromatin cumulatively througho

220 on nanotubes (SWNTs) passively transport and irreversibly localize within the lipid envelope of extra

221 Proliferating descendents further en route irreversibly lose their stemness, although they retain m

222 When hair cells are irreversibly lost from the mammalian cochlea, supporting

223 from apoptosis upon p14(ARF) induction, but irreversibly lost their ability to proliferate and initi

224 inue to allow the resource to be essentially irreversibly lost through dilution in surface waters.

225 romote regeneration of hard and soft tissues irreversibly lost to periodontitis in the Hanford miniat

226 nnels bearing Cys at position 79 or 416 were irreversibly modified by thiol-reactive reagents in a st

227 and drugs that produce biological effects by irreversibly modifying proteins.

228 -cell dependency on Kv1.3 or KCa3.1 might be irreversibly modulated by antigen exposure.

229 otent mechanism-based inhibitor and inhibits irreversibly MPO at nanomolar concentration.

230 layer on the anode robs Li from the cathode irreversibly on an initial charge, further lowering the

231 ant mass yield in the gas phase and condense irreversibly onto aerosol surfaces to produce secondary

232 Aldehyde dehydrogenase enzymes irreversibly oxidize aldehydes generated from metabolism

233 -dimethyl-1-pyrroline-N-oxide, we found more irreversibly oxidized betaCys-93in HbS than in HbA.

234 Irreversibly oxidized GAPDH accumulated in stored erythr

235 vels, including the repair or degradation of irreversibly oxidized proteins (IOPs).

236 Removal of irreversibly oxidized, functionally compromised GAPDH id

237 th a large Stokes shift, fluorescent timers, irreversibly photoactivatable and reversibly photoswitch

238 le fluorescent protein tdEosFP, which can be irreversibly photoswitched from a green to red fluoresce

239 Yet, because neurons are irreversibly post-mitotic and not readily available from

240 pled protease-activated receptor 1 (PAR1) is irreversibly proteolytically activated by thrombin.

241 ishingly small extent and the Rh-precatalyst irreversibly reacts with dissolved K2CO3 to form the act

242 ose a structural model for p.Q207D-c.a. that irreversibly relocates the GS domain into an activating

243 cellular matrix (ECM), are significantly and irreversibly remodeled by cellular traction forces, as w

244 extracellular matrix, are significantly and irreversibly remodelled by cellular traction forces and

245 ins through a novel catalytic mechanism that irreversibly removes the phosphate group from a phosphor

246 ents demonstrate that training the electrode irreversibly reorders the surface.

247 shortly after birth ssTnI is completely and irreversibly replaced by the adult cardiac TnI (cTnI) is

248 to investigate whether these materials could irreversibly retain a model nanoparticle, ZnO, and if so

249 and U were reversibly sorbed, Se and Cr were irreversibly sequestered via reductive precipitation.

250 ed with a competing allene dimerization that irreversibly sequesters rhodium.

251 equired strongly electrophilic reagents that irreversibly sever bonds between native organic ligands

252 oligosaccharides can be used, with TSG-6, to irreversibly shuffle HCs from pathological, HMW HC-HA to

253 ells from a patient's own blood, identifying irreversibly sickled cells in a sickle cell patient, and

254 pressed in double-positive and CD4 cells but irreversibly silenced in CD8 cells.

255 fruitful, as many tumor suppressor genes are irreversibly silenced through somatic mutation or entire

256 tions between active, reversibly silent, and irreversibly silent states.

257 trates, which in turn remodel the matrix and irreversibly simplify the alveoli.

258 Our research suggested that Hg was irreversibly sorbed via complexation with phenolic hydro

259 eveal that the surface structure of MGITC is irreversibly stabilized or "locked" in its pi-conjugated

260 ke cystic fibrosis and Liddle's syndrome are irreversibly stimulated by membrane-anchored proteases (

261 ps, are also found to block channel function irreversibly; such compounds have potential as reagents

262 omain-containing transcriptional regulators, irreversibly suppressed development of type-1 diabetes i

263 that these inert precursors specifically and irreversibly tag any HaloTag-fused protein of interest (

264 onal transgenic mice, in which podocytes are irreversibly tagged upon tamoxifen treatment (NPHS2.iCre

265 hibitors are disclosed that additionally and irreversibly target a cysteine (Cys269) found in the enz

266 Ryanodine (Ryd) irreversibly targets ryanodine receptors (RyRs), a famil

267 nditions of high local concentration through irreversibly tethering the two G domains together at the

268 ed drug discovery approach is reported which irreversibly tethers drug-like fragments to catalytic cy

269 ivation wavelength, the oxazine ring cleaves irreversibly to bring the adjacent BODIPY fragment in co

270 analysis suggested that MSNB inhibitors bind irreversibly to Cys-298 within the AF-2 cleft of TRbeta

271 compounds and a taxane that otherwise bound irreversibly to dialysis membranes and which exhibited d

272 xplains how a small molecule binds virtually irreversibly to inhibit receptor activation by the tethe

273 a selective proteasome inhibitor that binds irreversibly to its target.

274 s an indication that some chemicals may sorb irreversibly to muscle proteins, which needs further res

275 protein when newly synthesized, which shifts irreversibly to red fluorescence when oxidized.

276 omprising four species, that bacteria adhere irreversibly to surfaces through multiple, reversibly-bi

277 n of first covalent ligands designed to bind irreversibly to the CB1R allosteric site.

278 alidation of BQCA analogues designed to bind irreversibly to the M1 mAChR.

279 inactive version of the Csy4 nuclease binds irreversibly to transcripts engineered with a 16-nt hair

280 64)Cu-L19K-FDNB), which binds covalently and irreversibly to vascular endothelial growth factor (VEGF

281 g detergents, a step that can lead, possibly irreversibly, to protein denaturation.

282 al calculations suggest that 1T phase can be irreversibly transformed into a more active 1T' phase as

283 In addition, the less stable Au38T can be irreversibly transformed to the more stable Au38Q at 50

284 at uncontrolled PI3K activity within oocytes irreversibly transforms granulosa cells (GC), causing GC

285 th high concentrations of plasma capture and irreversibly trap abundant proteins.

286 t neither the tracer nor its metabolites are irreversibly trapped in the prehepatic splanchnic area w

287 During the elution step, irreversibly trapped proteins remain captured while low

288 it proved to be a reactive Michael acceptor, irreversibly trapping thiol nucleophiles, which prevente

289 s 1 can react with N2 reversibly and with CO irreversibly under photochemical conditions.

290 metry analysis revealed that polymorph alpha irreversibly undergoes endothermic transition to polymor

291 ect and acidification, pH 6.4, activated TRP irreversibly, unlike the endogenous activator.

292 Interestingly, genes irreversibly upregulated by suppression of AREG overlapp

293 Photoconvertible FPs, which can be activated irreversibly via a photo-induced chemical reaction that

294 can resist small stresses without deforming irreversibly, whereas unjammed systems flow under any ap

295 includes ions, to show that fluid can react irreversibly with eclogite at 900 degrees C and 5.0 GPa,

296 ethylmaleimide (NEM), a chemical that reacts irreversibly with free cysteines to block disulfide form

297 enabling the design of analogues that react irreversibly with model thiols, as well as the model pro

298 suggests that HIV influences immune function irreversibly, with several pathways that are persistentl

299 s a medium-sized ring that forms rapidly and irreversibly without any catalyst at low muM concentrati

300 glet oxygen via a pi2 + pi4 cycloaddition to irreversibly yield a highly fluorescent endoperoxide.