ライフサイエンスコーパス: irritant

1 This did not generalize to the control irritant.

2 6%, is a possible carcinogen and respiratory irritant.

3 ally to cutaneously applied phenol, an acute irritant.

4 ween protons and piperine, another vanilloid irritant.

5 ha,beta unsaturated aldehyde and respiratory irritant.

6 n an assay with a cockroach, proved potently irritant.

7 ied in the vapor, and acrolein is a powerful irritant.

8 airway defense against inhaled pathogens and irritants.

9 y airway exposures to allergens and chemical irritants.

10 ell as environmental and endogenous chemical irritants.

11 pungent natural compounds and environmental irritants.

12 y for behavioral responses to these chemical irritants.

13 nd mediates behavioral responses to chemical irritants.

14 pungent natural compounds, and environmental irritants.

15 ion of nociceptors by endogenous and natural irritants.

16 mach less susceptible to damage from luminal irritants.

17 lvents, welding fumes, and other respiratory irritants.

18 hich respond to numerous odorants as well as irritants.

19 xposure to allergens, pathogens, or chemical irritants.

20 tinocytes treated with certain allergens and irritants.

21 es to protect the host against pathogens and irritants.

22 rs chronically exposed to moderate levels of irritants.

23 after chronic exposure to moderate levels of irritants.

24 ons or exposure to allergic and non-allergic irritants.

25 hagous fluids, environmental xenobiotics and irritants.

26 ent of TRPA1, a key sensor for environmental irritants.

27 in increased penetrability to allergens and irritants.

28 matory responses to cutaneous and peritoneal irritants.

29 oxyethylene) ammonium chloride (ITDOP); mild irritants: 5% 3-decyloxypropyl-bis(polyoxyethylene) amin

30 Test materials included slight irritants: 5% sodium lauryl sulfate (SLS), polyoxyethyle

31 alkylbenzene sulfonate (LAS); and a moderate irritant: a proprietary detergent (DTRGT).

32 o enhance permeability and susceptibility to irritants; accordingly, increased attention should be gi

33 rritation response in mice elicited by smoke irritants (acrolein, acetic acid, and cyclohexanone).

34 Treatment was associated with local irritant adverse effects.

35 ral, bacterial, and nonmicrobial (toxins and irritants) agents, resulting in production of many diffe

36 though the intestine is routinely exposed to irritant alimentary compounds and inflammatory mediators

37 rosols with increasing doses of the chemical irritants allyl isothiocyanate (AITC; also known as must

38 is opposite of that associated with another irritant, ammonia fumes, which elicited an increase in t

39 The lung irritant, ammonia, obtained as vapor over a 30% solution

40 Despite the irritant and allergenic properties of fungi, early-life

41 mediated, anti-inflammatory activity in both irritant and allergic contact dermatitis animal models.

42 tivated receptor-alpha agonists in models of irritant and allergic contact dermatitis produced in mou

43 R, GW3965, were examined utilizing models of irritant and allergic contact dermatitis.

44 onest forms of occupational skin disease are irritant and allergic contact dermatitis.

45 ay potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requ

46 IV hypersensitivity, in part due to the dual irritant and antigenic properties of sensitizing chemica

47 he importance of the interaction between the irritant and antigenic properties of sensitizing chemica

48 er show that PAP-1 is not a sensitizer or an irritant and exhibits no toxicity in a 28-day toxicity s

49 jury measured at day 1, regardless of ocular irritant and the stromal response measured by the area u

50 nded chemical data set, comprising five skin irritants and 11 contact allergens.

51 s can affect airway inflammatory response to irritants and allergens, but the importance of stress in

52 r challenges, including allergens, exercise, irritants and aspirin.

53 uction machinery through which environmental irritants and endogenous proalgesic agents depolarize no

54 ormal breathing by a myriad of environmental irritants and infectious insults.

55 cautions should be taken against respiratory irritants and molds and to prevent children from becomin

56 acts as a sensory receptor for environmental irritants and oxidants.

57 tion following long-term exposure to harmful irritants and pollutants, particularly in the airways.

58 el is the molecular target for environmental irritants and pungent chemicals, such as cinnamaldehyde

59 hat they can be activated by various inhaled irritants and/or cold air.

60 pecific allergen sodium lauryl sulfate as an irritant, and appropriate controls.

61 Expression is also activated by a chemical irritant, and is suppressed by topical administration of

62 condary ozonides (SOZ), which are known skin irritants, and a modest change in particle size.

63 PCR analyses of multiple chemical allergens, irritants, and non-sensitizers have identified 10 genes

64 multiple symptomatic high-level exposures to irritants; and (iii) possible IIA, that is asthma occurr

65 Receptors for trigeminal irritants are generally assumed to be located exclusivel

66 ctivated by noxious heat, acid, and alkaloid irritants as well as several endogenous ligands and is s

67 nses in an oxidative stress-induced model of irritant asthma.

68 ons to aeroallergens, contact allergens, and irritants at days 2, 3, and 4.

69 side' world from potentially harmful toxins, irritants, bacteria and other pathogens that also exist

70 gions in the mouth are uniquely sensitive to irritants because they can penetrate through the tissue

71 s sensory detection of pathogens, toxins and irritants; breakdown of the epithelial barrier is associ

72 ubstances, toxins, venoms, and environmental irritants but that also trigger exuberant allergic react

73 Detection of such irritants by the trigeminal nerve evokes protective refl

74 ow a strong potentiation of responses to the irritant capsaicin in an acidic environment.

75 s thermal stimuli, protons, and the alkaloid irritant capsaicin open the channel.

76 by noxious heat, acidic pH and the alkaloid irritant capsaicin.

77 Airway irritants cause a variety of lung pathologies.

78 rs after treatment, mild and moderate ocular irritants caused a significant increase in corneal thick

79 he epithelium, whereas the mild and moderate irritants caused complete epithelial cell loss with incr

80 On day 1, mild, moderate, and severe irritants caused complete loss of epithelium and disappe

81 nvestigate the kinetics of both allergic and irritant CD (ACD and ICD) in vivo.

82 nsitive to mechanical stimuli and a range of irritant chemicals (bradykinin, capsaicin, low pH, plate

83 Here we show that noxious heat and irritant chemicals elicit robust escape behaviors in the

84 the tested compounds, i.e., strong and weak irritant chemicals selected from the literature, induced

85 s of the reactive hapten urushiol and by the irritant chemicals sodium lauryl sulfate and PMA.

86 Irritant chemicals triggered rapid ATP and ADP release f

87 ated by a range of noxious stimuli including irritant chemicals, acids and heat.

88 rnatants treated with either urushiol or the irritant chemicals.

89 narily conserved detector of temperature and irritant chemicals.

90 nflammation via hapten-specific T cells) and irritants (chemicals that are toxic to epidermal cells).

91 The environmental irritant chloroform, a naturally occurring small volatil

92 tinocytes treated with certain allergens and irritants, compared with untreated keratinocytes.

93 apsaicin is unique among naturally occurring irritant compounds because the initial neuronal excitati

94 opic dermatitis (AD) as well as allergic and irritant contact dermatitis (ACD, ICD) are characterized

95 Atopic dermatitis (AD), as well as irritant contact dermatitis (ICD) and allergic contact d

96 In AD patients, there is often a coexisting irritant contact dermatitis (ICD) or allergic contact de

97 rs responsible for the signs and symptoms of irritant contact dermatitis (ICD).

98 flammation and condition immune responses in irritant contact dermatitis and atopic dermatitis.

99 phorbol 12-myristate-13-acetate, a model of irritant contact dermatitis and oxazolone, a model of al

100 We report 7 cases of erosive irritant contact dermatitis due to chlorhexidine glucona

101 Furthermore, allergic and irritant contact dermatitis reactions were exaggerated i

102 cterized by either inflammation alone (acute irritant contact dermatitis, acute allergic contact derm

103 eratinocytes, especially during allergic and irritant contact dermatitis, however, is less well under

104 morphine had no effect on croton oil-induced irritant contact dermatitis, indicating that morphine's

105 he amelioration of the phorbol ester-induced irritant contact dermatitis.

106 m dodecyl sulfate is a well-known inducer of irritant contact dermatitis.

107 iolet-B-induced skin cancers or allergic and irritant contact dermatitis.

108 C motif ligand 1 (CXCL1) in a mouse model of irritant contact dermatitis.

109 sponses in BALB/c mice to oxazolone, but not irritant contact hypersensitivity responses to croton oi

110 elements in the pathogenesis of allergic and irritant contact hypersensitivity.

111 acute stress has no effect on the course of irritant contact sensitivity, an immune reaction that do

112 continuum of irritation that can be termed "irritant contact stomatitis." This may be due to the fac

113 d having a significantly greater effect than irritant control (p < 0.001); however, neither applicati

114 ans retinoic acid, 5% sodium lauryl sulfate (irritant control), or vehicle were applied under occlusi

115 and bulb may provide an avenue whereby nasal irritants could affect processing of coincident olfactor

116 nstrated that both spontaneous and augmented irritant dermatitis in FVB.delta(-/-) mice were down-reg

117 During irritant dermatitis induced by topical application of cr

118 Irritant dermatitis is the most common cause of diaper d

119 Irritant dermatitis represents innate inflammatory respo

120 Irritant dermatitis was induced by applying phorbol 12-m

121 Neither spontaneous nor augmented irritant dermatitis was observed in FVB.beta(-/-) delta(

122 ses (e.g., psoriasis, atopic dermatitis, and irritant dermatitis) triggered by abnormal barrier funct

123 hogenic role for keratinocyte-derived ATP in irritant dermatitis, they also form the basis for a form

124 ocytes may serve as a causative mediator for irritant dermatitis.

125 mouse models of atopic dermatitis and acute irritant dermatitis.

126 emoresponsive capabilities of the trigeminal irritant-detection system.

127 ymethane and subsequently exposed to colonic irritant dextran sodium sulfate (DSS).

128 clinician be aware of cutaneous mimickers of irritant diaper dermatitis as well as their treatments.

129 nasal epithelium, requiring that trigeminal irritants diffuse through the junctional barrier at the

130 ave been identified, including environmental irritants (e.g., acrolein) and ingredients of pungent na

131 (e.g., allyl isothiocyanate), environmental irritants (e.g., acrolein), and endogenous ligands (4-hy

132 nerve endings can detect certain lipophilic irritants (e.g., mints, ammonia), the epithelium also ho

133 gic contact dermatitis, and suggest that the irritant effect of chemicals may be mediated through the

134 h PBS or OVA-peptide, indicating a potential irritant effect of drop application.

135 tionally attributed to immunosuppressive and irritant effects of CS on human cells.

136 The nAChR subtype transduces the irritant effects of nicotine in tobacco smoke and, in ce

137 patients, who may be more susceptible to the irritant effects of these dressings.

138 e (CYP) which is metabolized to acrolein, an irritant eliminated in the urine.

139 various clinical forms of asthma related to irritant exposure at work.

140 The causal relationship between irritant exposure(s) and the development of asthma can b

141 matory conditions provoked or exacerbated by irritant exposure.

142 d by subcutaneous injections of the chemical irritant formalin substantially increased the release of

143 n excitatory ion channel targeted by pungent irritants from mustard and garlic.

144 with accidental exposures to high levels of irritant gases depended on cumulative levels of pulp mil

145 s, microbial products and sterile endogenous irritants governs whether the outcome will be with suppr

146 Plant-derived irritants have predominated in this regard, but animal v

147 vironmental and occupational sensitizers and irritants in its pathogenesis and the interaction with b

148 exposed to a range of physical and chemical irritants in the environment that are known to trigger a

149 eurons and are activated by several chemical irritants in vitro.

150 igeminally mediated reflex reactions to some irritants including acyl-homoserine lactone bacterial qu

151 where it acts as a sensor for environmental irritants, including acrolein, and some pungent plant in

152 mediators and to a diverse array of volatile irritants, including those found in tear gas and garlic.

153 The term irritant-induced (occupational) asthma (IIA) has been us

154 ier against water loss and pathogen/allergen/irritant invasion.

155 Control of environmental allergens and irritants is essential.

156 injury, information on possible etiology of irritants is very important.

157 a known human carcinogen and mucous membrane irritant, is emitted from a variety of building material

158 ature of bronchial asthma, and inhalation of irritants may facilitate development of nonallergic AHR.

159 These data suggest that allergens and irritants may, in part, break peripheral tolerance by th

160 , but not prevented, by elimination of local irritants, meticulous oral hygiene, and regular periodon

161 ave examined in vivo and in vitro effects of irritants, most focused on events developing hours to da

162 Intramuscular injection of an inflammatory irritant, mustard oil (MO), induces significant edema fo

163 by the same injury [application of a C-fiber irritant, mustard oil (MO), to the hindpaw].

164 e-activity relationships in analogues of the irritant natural product capsaicin have previously been

165 th exposures to fungal taxa considered to be irritant or allergenic in sensitive subjects, yeasts in

166 osures are assumed to provoke wheeze through irritant or allergenic mechanisms, little is known about

167 ve types of cutaneous inflammation caused by irritant or allergic chemicals.

168 Irritant or allergic contact dermatitis usually presents

169 n and mycalamide, psymberin does not display irritant or blistering activity.

170 oduction of mineralization in response to an irritant or parasite threat to the mantle organ.

171 cancer, PICCs were rated as appropriate for irritant or vesicant infusion, regardless of duration.

172 itial management includes avoiding causative irritants or allergens (e.g., by wearing impermeable glo

173 s) may increase the risk of LRI by acting as irritants or through increasing susceptibility to infect

174 unds attenuate pain behavior in a trigeminal irritant pain model that is known to rely on TRPV4 and T

175 ion-specifically dead cells and a variety of irritant particles, including crystals, minerals, and pr

176 ls but not to microbial molecules or sterile irritant particles.

177 and clears the airways and lungs of inhaled irritants, particulates, pathogens, and accumulated secr

178 anate (AITC; aka, mustard oil) is a powerful irritant produced by Brassica plants as a defensive trai

179 e trees' because their anesthetic or counter-irritant properties render them useful in the treatment

180 For the skin, Doxil is classified as an irritant rather than a vesicant.

181 Irritant reactions can closely resemble allergic ones, a

182 care products have been documented to cause irritant reactions in susceptible individuals, particula

183 sorders varying from straightforward topical irritant reactions, such as those to synthetic pyrethroi

184 tial channel vanilloid subtype 1 (TRPV1), an irritant receptor for capsaicin, the pungent ingredient

185 te that HQ is an activator of the peripheral irritant receptor transient receptor potential (TRP) cat

186 acidosis activates and sensitizes the human irritant receptor TRPA1 (hTRPA1).

187 be distinguished within the wide spectrum of irritant-related asthma: (i) definite IIA, that is acute

188 Effects of acetaminophen on oxidant and irritant respiratory tract responses to environmental to

189 An irritant response induced by chronic exposure of mouse s

190 , acetaminophen greatly increased the reflex irritant response to ETS.

191 own to be integral to a CHS but not an acute irritant response, whereas CD44 does not significantly c

192 and/or potentiates the oxidative stress and irritant responses to an inhaled oxidant: environmental

193 eloped an in vitro assay for potential human irritant responses via the skin, employing human passage

194 oscopy showed that application of the slight irritant resulted in decreased epithelial thickness at 3

195 at are presumably involved in signaling oral irritant sensations.

196 ent receptor potential ankyrin 1 (TRPA1), an irritant-sensing channel.

197 TRPA1 is an irritant-sensing ion channel expressed in airway chemose

198 sophila melanogaster orthologue of the human irritant sensor, acts in gustatory chemosensors to inhib

199 On day 1, mild and moderate irritants showed increasing stromal cell death from 9.8+

200 o function as chemical sensor of noxious and irritant signaling.

201 Pretreatment with a mild irritant significantly decreased intracellular calcium i

202 lls with low concentrations of ethanol (mild irritant) significantly attenuated injury induced by hig

203 y examined whether repetitive exposure to an irritant stimulant leads to desensitization and whether

204 or the local environment for the presence of irritant stimuli and, when activated, provide input to t

205 ter a single exposure to very high levels of irritant substances; (ii) probable IIA, that is asthma t

206 ess C5aRs and that exposure to environmental irritants such as cigarette smoke modulates the expressi

207 Various irritants such as foods, chemicals, friction, thermal/me

208 Oxidative stresses from irritants such as hydrogen peroxide and ozone (O(3)) can

209 s and responds to a wide variety of chemical irritants, such as acrolein in smoke or isothiocyanates

210 TRPA1 is also targeted by environmental irritants, such as acrolein, that account for toxic and

211 This contrasts with most other common oral irritants, such as cinnamaldehyde, capsaicin, and alcoho

212 rodentium but not to that caused by chemical irritants, such as dextran sodium sulfate.

213 Inhalation of irritants, such as toluene diisocyanate (TDI), stimulate

214 activity as measured by the mouse abdominal irritant test (MAIT) when dosed at 100 mg/kg, sc, but di

215 inociceptive activity in the mouse abdominal irritant test (MAIT).

216 nd 21e were very active in the rat abdominal irritant test (RAIT) with ED(50) doses of 0.38 and 0.31

217 TNBS, an intestinal irritant that induces the development of inflammatory bo

218 stimulation on the muscle and to a chemical irritant that is known to produce pain in humans provide

219 cle beginning on page 2574), have identified irritants that activate transient receptor potential cat

220 In response to infections and irritants, the respiratory epithelium releases the alarm

221 With the slight ocular irritants there was little or no change in corneal thick

222 can be activated by exogenous electrophilic irritants through direct covalent modification, we reaso

223 ized epithelial chemosensors that respond to irritants through the canonical taste transduction casca

224 vivo CM revealed corneal injury with slight irritants to be restricted to the epithelium, whereas th

225 Thus, in CF, the reduced ability of mucosal irritants to stimulate airway gland secretion via SubP m

226 y dependent on both the concentration of the irritant used and the duration of exposure and was abrog

227 ociceptors and is sensitive to noxious heat, irritant vanilloids, and protons.

228 In summary, repetitive exposure to an irritant vapor results in a specific desensitization to

229 show opposing outcomes of CD39 deficiency in irritant versus allergic contact dermatitis, reflecting

230 , that is activated by a variety of reactive irritants via the covalent modification of cysteine resi

231 ndin inhibitor (indomethacin) or if the mild irritant was administered in calcium-free media.

232 The protection conferred by the mild irritant was directly dependent on both the concentratio

233 ed with sodium lauryl sulfate (SLS), a model irritant, were used to examine early molecular events of

234 hannels are activated by chemically reactive irritants, whereas snake and Drosophila TRPA1 orthologs

235 single or multiple high-level exposure(s) to irritants, whereas this relationship can only be inferre

236 ntration of a damaging agent, termed a "mild irritant," which by itself is not injurious, can attenua