ライフサイエンスコーパス: irritation

1 ia and frequency but no vaginal discharge or irritation).

2 A105 and placebo groups (2 cases each of eye irritation).

3 stress, inflammation, and symptoms of ocular irritation.

4 particularly headaches, dizziness, and skin irritation.

5 ons and varied depending on the mode of skin irritation.

6 ere shoulder pain secondary to diaphragmatic irritation.

7 me (FES) presents nonspecific ocular surface irritation.

8 um and were subjected to repeated mechanical irritation.

9 approximately 100-fold without inducing skin irritation.

10 ight represent a local reaction to trauma or irritation.

11 with minimal associated discomfort and skin irritation.

12 otein expression after generalised meningeal irritation.

13 ility, pharmacological activity, and gastric irritation.

14 ient increase in skin SNA due to local nasal irritation.

15 often" or "constant" symptoms of dryness and irritation.

16 ctants producing different degrees of ocular irritation.

17 tants that caused different levels of ocular irritation.

18 entual repair processes after accidental eye irritation.

19 and signs and/or symptoms of ocular surface irritation.

20 alues, and there was no coughing or tracheal irritation.

21 d number of children who had sunburn or skin irritation.

22 in association with inflammation and chronic irritation.

23 nt growth of granulation tissue secondary to irritation.

24 the placebo group), mouth edema, and throat irritation.

25 ility during urinary bladder inflammation or irritation.

26 onditions of urinary bladder inflammation or irritation.

27 may be useful to counteract HQ-induced skin irritation.

28 sue layers of the skin without inducing skin irritation.

29 sights into the mechanism of HQ-induced skin irritation.

30 effects such as contact dermatitis and skin irritation.

31 ient required enucleation for chronic ocular irritation.

32 nt arm withdrew because of drug-related skin irritation.

33 confirmed the absence of local erythema and irritation.

34 y during saline distension but not during AA irritation.

35 e exposure to metal ions that can cause skin irritation.

36 se events in the azithromycin group were eye irritation (1.9%), conjunctival hyperemia (1.1%), and wo

37 ndard dose vs high dose: urinary obstruction/irritation (23.3 [13.7] vs 24.6 [14.0]; P = .36), urinar

38 slight increase in minor self-reported skin irritation (231 [4%] of 5429 in intervention group vs 79

39 No serious AEs were reported, and eye irritation (3.7 %; n = 7/191) was the most common treatm

40 molol patients reported ocular pain/stinging/irritation (4.4% vs 4.6%) and pruritus (2.5% vs 1.5%).

41 Pain/irritation (42%), palpable mass (27%), and fever (12%) w

42 on, 20.8 to 22.8 for urinary obstruction and irritation, 9.7 to 10.5 for urinary incontinence, and 5.

43 subjective symptoms of throat tickle and/or irritation (92.1%), cough (78.5%), shortness of breath (

44 ver, HQ treatment can evoke substantial skin irritation, a side effect that remains poorly understood

45 in has suffered from problems such as tissue irritation, abscesses, discomfort, and inconvenience.

46 oplankton cell count was associated with eye irritation [adjusted odds ratio (OR) = 1.30; 95% confide

47 Its pathogenesis involves chronic epithelial irritation, although the factors involved in the inflamm

48 Both chromic gut irritation and 10gf compression produced ipsilateral inc

49 losporine triggered mild to moderate corneal irritation and a temporary elevation in tearing.

50 velop corneal opacity and eye lesions due to irritation and constant scratching.

51 cal insertion, which often results in tissue irritation and damage.

52 with dry eye or reported significant ocular irritation and dryness were analyzed.

53 this autocoid may play a part in the airway irritation and dyspneic sensation associated with airway

54 y play a part in the manifestation of airway irritation and excessive cough under those pathophysiolo

55 de effects of ATRA treatment, including skin irritation and hair loss.

56 the parent compounds, yet free of tail vein irritation and histamine induced toxicity in vivo.

57 irming the presence of haptic-induced ocular irritation and in assisting the management of these pati

58 f distinct phenotypes, potentially linked to irritation and infections for the transient phenotypes a

59 ncers arise from sites of infection, chronic irritation and inflammation.

60 Aspirin products are known to cause irritation and injury to the gastric mucosa.

61 Eight of the 10 volunteers had tracheal irritation and intermittent coughing following exposure.

62 correlated with ocular surface staining and irritation and inversely correlated with TBUT.

63 ubcutaneous drug administration system (site irritation and local infection).

64 Both chemical irritation and mechanical compression affect radicular p

65 cient programmable devices with minimal skin irritation and no skin barrier disruption would open an

66 inary incontinence was observed, but urinary irritation and obstruction improved, particularly in pat

67 h more rapid TBUT and blink rate and greater irritation and ocular surface dye staining with 1 or bot

68 Tear EGF and the severity of irritation and ocular surface signs were correlated.

69 The most frequent AEs were throat irritation and oral pruritus.

70 ntion of dosage forms, and the potential for irritation and other adverse reactions.

71 rrhoidal symptoms (rectal bleeding, perianal irritation and prolapse), the best option for treatment

72 fferent ways, ranging from respiratory tract irritation and pulmonary edema in severe cases to constr

73 position with ocular protection but reported irritation and redness in their right eyes after the ope

74 i1(-/-) mice were small in size, with eyelid irritation and sporadic hair loss resembling the cyclica

75 e weekly was associated with minimal bladder irritation and tolerable myelosuppression.

76 ial barrier function is the cause for ocular irritation and visual morbidity in dry eye disease.

77 ial barrier function is the cause for ocular irritation and visual morbidity in dry eye disease.

78 fect on itch, potentially because of counter-irritation and/or distraction.

79 elia served by the trigeminal nerve produces irritation and/or pain by activating neuronal nicotinic

80 ned for vasovagal reactions, nerve injuries (irritations), and arterial puncture.

81 copal reactions, antecubital nerve injuries (irritations), and arterial punctures, and the medical ou

82 re fiber, (2) evidence of prolonged chemical irritation, and (3) hyper-fibrillosis about the suture w

83 isocyanates induce lacrimation, pain, airway irritation, and edema.

84 ed adverse events were oral pruritus, throat irritation, and nasopharyngitis.

85 PAP and MADs included oral or nasal dryness, irritation, and pain, among others.

86 ty, the presence or absence of pain and skin irritation, and the changes in alignment observed over t

87 Photocopying was related to nasal irritation, and video display terminal work to eye sympt

88 f dye labeled PGN exhibited Fos-IR after LUT irritation; and a larger percentage (36%) exhibited Fos-

89 The corneal irritation appeared to drive an adaptive process organiz

90 hat differences in surfactant-induced ocular irritation are directly related to area and depth of acu

91 ors involved in the potential development of irritation are: inherent irritation potential of the age

92 which elicits the same restricted pharyngeal irritation as oleocanthal, also specifically excites rod

93 trusive, uncomfortable, and often cause skin irritations as they require a metal electrode affixed to

94 greater urinary incontinence and/or urinary irritation associated with these treatments compared wit

95 with mild adverse experiences, most commonly irritation at the injection site.

96 ceived either mechanical or chemical colonic irritation between postnatal days 8 and 21 and were test

97 Analogously, following acute colonic irritation, bladder contraction frequency increased 66%,

98 y group reported having long-lasting urinary irritation, bowel and sexual symptoms, and transient pro

99 e of the neurons recorded in rats with colon irritation, but had no effect on those in control rats.

100 mportant protective response to upper airway irritation, but the central mechanisms responsible for e

101 were removed and gingival mucosa scored for irritation by a previously described method.

102 thway raised the possibility that esophageal irritation by N-BPs is mechanism-based.

103 we report that action potentials or chemical irritation can elicit transient rises in [Ca2+]i (Ca2+ t

104 itation, in sharp contrast to the overt skin irritation caused by intradermal injections.

105 The corneal irritation caused by reduced blink amplitude generated a

106 ne treatment was associated with significant irritation, causing its discontinuation in one third of

107 We have previously shown that colon irritation (CI) in neonates results in chronic visceral

108 gen group reported extreme symptoms of nasal irritation compared with seven (6%) in the room air grou

109 ollow different patterns after chemical root irritation, compression, and a combined insult.

110 All symptoms (nose, eyes, and throat irritations; cough; bronchitis; cold; wheezing; asthma a

111 There was no tracheal irritation, coughing, or changes in spirometric measures

112 Ls were also examined for cytotoxicity, skin irritation, delivery of antibiotics through the skin, an

113 ent intermittent instillation site symptoms (irritation, discomfort) primarily on the initial lifiteg

114 n vitro studies of biocompatibility, mucosal irritation, disease, and other basic oral biology phenom

115 Following acute bladder irritation, dramatic increases in abdominal wall EMG act

116 Subjects reported significantly less eye irritation during the low-humidity exposure after using

117 can be modeled in rats by transient gastric irritation during the neonatal period, a time of known n

118 Dorzolamide did not reduce irritation elicited by pentanoic acid.

119 as safe for long-term use, and did not cause irritation even at high concentrations.

120 o CRD in control rats and in rats with colon irritation following stimulation or inactivation of the

121 rrent low-grade intraocular inflammation and irritation for months after implantation of the Ophtec 3

122 There was no mucosal irritation from the empty cups.

123 epiphora and 10% required removal because of irritation from the plugs.

124 ain the test drug in situ without extraneous irritation from the retention device.

125 Before bladder irritation, graded CRDs to 40 cm H2O produced no notable

126 information on respiratory, dermal, and eye irritation health.

127 Colon irritation in neonates, but not in adults, results in ch

128 injury as a mechanistic correlate to ocular irritation in the development and validation of potentia

129 These studies demonstrate that gastric irritation in the neonatal period can result in chronic

130 It is important to note that most irritation in the oral cavity tends to reverse quickly w

131 pressing Fos immunoreactivity (IR) after LUT irritation in the rat.

132 causing ocular surface inflammation and eye irritation in typical patients suffering from tear dysfu

133 hloride which induces ocular and respiratory irritations in swimming pool workers.

134 sociated extrinsic factors (i.e., mechanical irritation) in the oral mucosa.

135 accination with BCG-MNA caused no overt skin irritation, in marked contrast to intradermal vaccinatio

136 unity without incurring any appreciable skin irritation, in sharp contrast to the overt skin irritati

137 0.5% acetic acid into the bladder to produce irritation increased bladder activity and anal sphincter

138 Mechanical irritation, inflammation and other extracellular influen

139 after neonatal perturbation or acute colonic irritation/inflammation, current models of postinflammat

140 Oral irritation is a commonly occurring phenomenon.

141 nimals (n = 14) developed signs of meningeal irritation leading to death 30 to 63 days postinjection

142 Irritation leading to oral mucosal alterations is a comm

143 R, 0.3; 95% CI, 0.1-0.9), history of vaginal irritation (LR, 0.2; 95% CI, 0.1-0.9), and vaginal disch

144 Through suppression of respiratory irritation, menthol may facilitate smoke inhalation and

145 l explants and in vivo in the rabbit vaginal irritation model.

146 y after RP, while bowel problems and urinary irritation/obstruction rose after EBRT and BT.

147 sory pathways can be upregulated by chemical irritation of afferent receptors in the urinary tract an

148 E" (as the method become known, to the great irritation of journal copyeditors and nomenclature commi

149 athophysiology of migraine involves not only irritation of meningeal perivascular pain fibers but als

150 We investigated the hypothesis that afferent irritation of one pelvic organ may adversely influence a

151 Since mechanical irritation of pulpal nociceptors is critical for evoking

152 Chemical irritation of the bladder of the rat increased the frequ

153 activation of afferent nerves after chemical irritation of the bladder.

154 e spinal cord induced by acetic acid (0.25%) irritation of the bladder.

155 Robust chemical or mechanical irritation of the colon of neonatal rats leads to chroni

156 tudy were to determine whether mild chemical irritation of the colon of neonatal rats produced persis

157 spinal cord of rats subjected to mustard oil irritation of the colon.

158 s in colon sensitivity after inflammation or irritation of the distal colon.

159 taining, increased inflammation, symptomatic irritation of the eyelid and globes, as well as decrease

160 tagonists may prevent and alleviate chemical irritation of the eyes, skin, and airways and reduce the

161 Chemical irritation of the lower urinary tract (LUT) induces c-fo

162 visceral nociception, specifically, chemical irritation of the lower urinary tract.

163 y to a supralevator perianal abscess causing irritation of the sciatic nerve, which was diagnosed on

164 e sciatic nerve, secondary to compression or irritation of the sciatic nerve.

165 hese sensations is that itch is initiated by irritation of the skin, whereas pain can be elicited fro

166 Minor irritation of the upper eyelids was noted at the 1-hour

167 noted in previous experiments after chemical irritation of the urinary bladder and urethra which acti

168 bladder pathways following acute and chronic irritation of the urinary tract of the rat.

169 olds to CRD and the effects of acute colonic irritation on micturition parameters were assessed.

170 harge, dysuria, genital pruritus, or genital irritation or odor.

171 ), rash (OR = 1.32; 95% CI: 1.05, 1.66), eye irritation (OR = 1.25; 95% CI: 0.97, 1.62), and earache

172 al cavities and being perceived as pungency, irritation, or heat.

173 children experienced vomiting, acute rectal irritation, paradoxical hyperactivity, or prolonged seda

174 creased transepidermal water loss and caused irritation, particularly in AD patients carrying FLG mut

175 Here, we show that this rare irritation pattern is a consequence of both the specific

176 gible effect on skin integrity, nominal skin irritation potential and cytotoxicity.

177 diagnostic agents, but the skin toxicity and irritation potential of QDs are unknown.

178 tial development of irritation are: inherent irritation potential of the agent, amount of exposure (c

179 nation of transient compression and chemical irritation produces sustained bilateral hypersensitivity

180 a and frequency without vaginal discharge or irritation) raise the probability of UTI to more than 90

181 tion, the effects of acetaminophen on airway irritation reflex responses to ETS were examined by plet

182 O, and IPOH would not give rise to acute eye irritation-related symptoms in office workers; similarly

183 e to marine phytoplankton and reports of eye irritation, respiratory illness, and rash.

184 ffects of menthol on the respiratory sensory irritation response in mice elicited by smoke irritants

185 Irritation response of CPEs, on the other hand, correlat

186 olated cigarettes, immediately abolished the irritation response to acrolein, an agonist of TRPA1, as

187 AP-5, inhibited the pressor, tachycardic and irritation responses elicited by intrathecal (-)-epibati

188 The potential to cause human skin irritation responses is part of the required information

189 ific to acrolein, as menthol also attenuated irritation responses to acetic acid, and cyclohexanone,

190 ne exhibited selectivity for the pressor and irritation responses.

191 in control rats, whereas, in rats with colon irritation, responses either decreased or increased; sec

192 rosis factor-alpha may result from the local irritation seen with both oxazolone and phorbol ester.

193 Irritation severity in the desiccating environment was a

194 continuously, and rated ocular sensations of irritation, stinging, burning, pricking, and cooling usi

195 Cytotoxicity and ocular irritation study demonstrated the safety of TM-implant c

196 to conduct, in dogs, a 6-hour acute mucosal irritation study of a new bioerodible treatment.

197 eatment are primarily local (ocular redness, irritation); surgical treatment carries a small risk for

198 neal staining, conjunctival staining, and an irritation symptom questionnaire (Ocular Surface Disease

199 l and conjunctival staining, blink rate, and irritation symptoms before and after each low-humidity e

200 Dryness and irritation symptoms, as opposed to a clinical diagnosis,

201 Eye irritation symptoms, blink rate, tear meniscus dimension

202 a may be involved in the pathogenesis of the irritation symptoms, recurrent epithelial erosions, vasc

203 Eye irritation symptoms, tear meniscus height, tear break-up

204 s with normal aqueous tear production and no irritation symptoms.

205 bartenders (77%) initially reported sensory irritation symptoms.

206 nts and adverse respiratory, dermal, and eye irritation symptoms.

207 rneal sensitivity is associated with greater irritation, tear instability, ocular surface disease, an

208 g to people with skin of color, such as skin irritation, tenderness, itching, or skin becoming darker

209 The skin irritation test, performed on an in vitro reconstructed

210 ed by guine pig maximization and rabbit skin irritation tests.

211 and validation of potential in vitro ocular irritation tests.

212 an entirely new in vitro alternative to skin irritation tests.

213 l abnormalities, there may be a continuum of irritation that can be termed "irritant contact stomatit

214 speculate that plasticity in rats with colon irritation that may underlie chronic pain is sustained b

215 duced visual acuity, photophobia, and ocular irritation, though these symptoms typically resolve foll

216 Symptoms range from occasional redness and irritation to corneal ulcer.

217 urs following de novo chemical or mechanical irritation to ear skin and in spontaneously arising skin

218 be unsightly, spontaneously bleed, and cause irritation to patients.

219 rats sensitized with neonatal painful colon irritation to reveal the contribution of the thalamus an

220 stem can be activated by lower urinary tract irritation to suppress visceral nociception through cent

221 peripheral sensory nerves to cause pain and irritation upon administration.

222 -sexual dysfunction, urinary obstruction and irritation, urinary incontinence, and bowel problems-eac

223 While causing little skin irritation, vaccination efficacy of BCG-MNAs was compara

224 ved such symptoms include itching, sneezing, irritation, vasodilation, and reflex secretions.

225 to produce slight, mild, moderate, or severe irritation was applied to the central cornea of one eye;

226 sponses elicited by cGAMP with no overt skin irritation was attributable to its stay in the skin, whi

227 Evidence of local irritation was found at some SC injection sites.

228 parable to a clinically useful one, no local irritation was found with SC administration in rats.

229 patients whose baseline urinary obstruction/irritation was poor, both average scale scores and most

230 nd a focal inflammatory reaction (mechanical irritation) was generated in the right flank.

231 Itch, the irritation we feel and the relief that comes from scratc

232 indicating that phagocytosis and nonspecific irritation were not responsible.

233 of vaginal discharge and history of vaginal irritation, which significantly decreased the likelihood

234 ; acute worsening of urinary obstruction and irritation with external beam radiotherapy (11.7 [95% CI

235 very time in barrier function following skin irritation, with a concomitant increase in EDC gene expr