ライフサイエンスコーパス: isatin

1 the skeleton of the naturally occurring dye isatin.

2 respectively, from the 5- and 1-positions of isatin.

3 iyama aldol reaction of 2-siloxyindoles with isatins.

4 -ones was synthesized from the corresponding isatins.

5 fluoro phenoxymethyl)-pyrrolidine-1-sulfonyl)isatin ((18)F-ICMT-11), has been developed for use in PE

6 in intermolecular [4+2] cycloadditions with isatins 2a-2f to form 2-oxindole spirolactones 3a-3l.

7 n patterns, and is applicable to unprotected isatins 2b-2f bearing free NH-functionalities.

8 ased around the lead compound NSC73306 (1, 1-isatin-4-(4'-methoxyphenyl)-3-thiosemicarbazone, 4.3-fol

9 Two of these analogues, 1-isatin-4-(4'-nitrophenyl)-3-thiosemicarbazone (22, 8.3-f

10 semicarbazone (22, 8.3-fold selective) and 1-isatin-4-(4'-tert-butyl phenyl)-3-thiosemicarbazone (32,

11 Moreover, the 7-position of isatin, a potential cytochrome P450 hydroxylation site,

12 FAD, and this ligand superimposed well with isatin, a reversible inhibitor of MAO-B, when the struct

13 Isatin, a specific ANP receptor antagonist, reversed ANP

14 e have synthesized a novel series of N-alkyl isatin acylhydrazone derivatives and have identified and

15 These novel 6-methoxy-N-alkyl isatin acylhydrazone derivatives exhibited high CB2 func

16 discovered and reported a series of N-alkyl isatin acylhydrazone derivatives that are potent CB2 ago

17 three-component reactions using substituted isatins, alpha-amino acids, and cyclopropenes.

18 been established, which efficiently assembly isatins, amino-esters and 2,3-allenoate into enantioenri

19 0 ng/ml), ANP (1 pM to 1 micromol/L), and/or isatin, an ANP receptor antagonist.

20 While the isatin analogues were generally less effective at CE inh

21 Synthesis of isatin and iodoisatin from 2'-aminoacetophenone was achi

22 ith substitution at various positions of the isatin and the 2-siloxyindole being tolerated.

23 h catalytic decarbonylative coupling between isatins and alkynes, which provides a unique way to synt

24 tioselective vinylation of alpha-ketoesters, isatins, and imines to deliver a range of synthetically

25 rent classes of inhibitors: peptidomimetics, isatins, and pyrimidoindolones.

26 has been developed, employing N-substituted isatins as carbonyl substrates, and urea and alkyl aceto

27 c sequence has been demonstrated also for an isatin bearing fluorine substituents on the aromatic rin

28 Treatment with the antiviral compound isatin beta-thiosemicarbazone (IBT), a compound that was

29 ults in resistance to the anti-poxvirus drug isatin-beta-thiosemicarbazone (IBT).

30 combinatorial method, variants of the basic isatin-beta-thiosemicarbazone structure were prepared an

31 ncreased resistance to the antipoxviral drug isatin-beta-thiosemicarbazone, suggesting that these mut

32 temperature-sensitive mutant, Cts56, and an isatin-beta-thiosemicarbazone-dependent deletion mutant,

33 nd substitution around the N4-phenyl ring of isatin-beta-thiosemicarbazones (IBTs), to identify compo

34 Several isatin-beta-thiosemicarbazones from our initial study ha

35 Potent and much more selective N-aminomethyl-isatin-beta-thiosemicarbazones were discovered.

36 In contrast, the isatins bind to caspase-3 with significant heat release

37 addition, enzyme activity is abolished upon isatin binding to one active site of the homodimer resul

38 ntrast, the reversible competitive inhibitor isatin binds to all known MAO B and MAO A with similar a

39 The superior performance of isatins compared to other carbonyl based dienophiles was

40 Interestingly, the inhibitory potency of the isatin compounds was related to their hydrophobicity, su

41 harmacologically important thiazolidinedione-isatin conjugates in excellent yields and diastereoselec

42 ion of N-substituted thiazolidinediones with isatin derivatives has been developed "on water" to affo

43 pyrazoles, chromones, coumarins, xanthines, isatin derivatives, thiazolidindiones, (thiazol-2-yl)hyd

44 A series of isatin derived difluoronitromethyl substituted tertiary

45 tric 1,3-dipolar cycloadditions (1,3-DCs) of isatin-derived azomethine ylide with allenes have been e

46 n efficient asymmetric aza-Henry reaction of isatin-derived ketimines has been achieved by using a ch

47 Our data suggest that an isatin-derived spirocyclic alpha-methylene-gamma-butyrol

48 is proposed to go through C-C activation of isatins, followed by decarbonylation and alkyne insertio

49 ar iodine-promoted efficient construction of isatins from 2'-aminophenylacetylenes, 2'-aminostyrenes,

50 s, indazoles, benzotriazoles, indolones, and isatins gave analogues with weaker NR1A/2B activity than

51 ition of alpha,beta-unsaturated aldehydes to isatins has been developed.

52 Isatin hydrolase converts isatin to isatinate and belong

53 The high resolution crystal structures of isatin hydrolase from Labrenzia aggregata in the apo and

54 The functional proton wire present in isatin hydrolase isoform b represents a unique catalytic

55 The isatin hydrolase orthologues found in human gut bacteria

56 identification of orthologous genes encoding isatin hydrolases within the prokaryotic kingdom.

57 ng with commercially available 5-substituted isatins in nearly every case.

58 and the cyclic ketones 1H-indole-2,3-dione (isatin), indenoquinoxaline-11-one and acenaphthenequinon

59 Condensation of isatin (indole-2,3-dione) and 2-aminobenzamide led to th

60 assays and kinetic studies demonstrated that isatins (indole-2,3-diones), containing hydrophobic grou

61 ocatalytic method that achieves insertion of isatins into aryl difluoronitromethyl ketones under mild

62 (11) in 10 steps and 11% overall yield from isatin is reported.

63 MAO B I199F mutant protein of MAO B binds to isatin (K(i) = 3 microM) but not to the three inhibitors

64 he thiosemicarbazone and the reliance on the isatin moiety as key bioisosteric contributors.

65 es (3-fluoropropyl and 4-fluorobutyl) at the isatin nitrogen.

66 Assisted by the DG, the C-C cleavage of isatins occurs at room temperature.

67 ndmeyer reaction, followed by cyclization to isatin, reduction to indole with LiAlH4, and condensatio

68 A focused library incorporating an isatin scaffold was designed and evaluated for inhibitio

69 ion of a methoxy moiety in position 6 of the isatin scaffold.

70 A series of isatin sulfonamide analogs having a Michael acceptor wer

71 A number of isatin sulfonamide analogues were prepared and their pot

72 x between recombinant human caspase 3 and an isatin sulfonamide inhibitor has been solved to 2.8-A re

73 In this study, a series of isatin sulfonamide Michael acceptors having a high nanom

74 r new fluorinated diastereo- and enantiopure isatin sulfonamide-based potent and selective caspase-3

75 ported peptide-based caspase inhibitors, the isatin sulfonamides derive their selectivity for caspase

76 tentially enhance the metabolic stability of isatin sulfonamides.

77 has been shown to generate species (indoxyl, isatin) that couple to yield indigo and indirubin.

78 The isatin-thiazolidine conjugate undergoes a catalyst-free

79 Isatin hydrolase converts isatin to isatinate and belongs to a novel family of met

80 ns were carried out on several 5-substituted isatins to investigate the stability of sulfide adducts

81 addition of aryl acetonitrile to N-protected isatin under mild conditions has been developed.

82 The C-2 carbonyl of isatin was envisioned to react in the active site of HRV

83 (HRV-2) 3CP was solved and revealed that the isatin was situated in essentially the same conformation

84 en the structures of MAO-N proline and MAO-B-isatin were overlaid.

85 -(2(S)-(methoxymethyl)pyrrolidinyl)sulf onyl]isatin were synthesized in 140 min with 24% and 10% over

86 n-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins were developed as a new group of nonradioactive

87 A novel series of 2,3-dioxindoles (isatins) were designed that utilized a combination of pr

88 H)-ones via acylation of various substituted isatins with readily available N-Boc-protected aminoacid