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1 everal azoles but higher susceptibilities to isavuconazole.
3 1 mug/ml), posaconazole (0.5 and 1 mug/ml), isavuconazole (4 and 4 mug/ml), and amphotericin B (0.25
4 o day 42 for the ITT population was 19% with isavuconazole (48 patients) and 20% with voriconazole (5
7 ere reported in 109 (42%) patients receiving isavuconazole and 155 (60%) receiving voriconazole (p<0.
11 ality in seven (33%) of 21 primary-treatment isavuconazole cases was similar to 13 (39%) of 33 amphot
13 2013, 37 patients with mucormycosis received isavuconazole for a median of 84 days (IQR 19-179, range
14 mphotericin, he was treated effectively with isavuconazole for over 6 months despite ongoing treatmen
17 ulfate 372 mg (prodrug; equivalent to 200 mg isavuconazole; intravenously three times a day on days 1
27 acodynamic (PK/PD) analysis in patients with isavuconazole plasma concentrations was conducted to est
28 azole and voriconazole; the MIC90 values for isavuconazole, posaconazole, and voriconazole against Ca
31 f invasive mucormycosis showed efficacy with isavuconazole that was similar to that reported for amph
34 SECURE trial assessed efficacy and safety of isavuconazole versus voriconazole in patients with invas
36 ive aspergillosis found that the efficacy of isavuconazole was noninferior to that of voriconazole.
38 se studies, as well as in normal volunteers, isavuconazole was well tolerated, appeared to have few s
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