ライフサイエンスコーパス: ischemic preconditioning

1 followed by 15 min of reflow before harvest (ischemic preconditioning).

2 r, could suffice to mediate local and remote ischemic preconditioning.

3 tion and showed no protection in response to ischemic preconditioning.

4 PKMzeta levels were elevated 3 days after ischemic preconditioning.

5 cate key roles of PKMzeta and Na/K ATPase in ischemic preconditioning.

6 compounds blocked neuroprotection following ischemic preconditioning.

7 tion comparable to wild-type mice exposed to ischemic preconditioning.

8 lation of Src and Cav-1 after isoflurane and ischemic preconditioning.

9 idative injury and abolish the late phase of ischemic preconditioning.

10 infarction by a mechanism similar to that of ischemic preconditioning.

11 e hypothesis that cardiac nerves may mediate ischemic preconditioning.

12 onged ischemic insult, a phenomenon known as ischemic preconditioning.

13 arct size observed in WT after a protocol of ischemic preconditioning.

14 protective effect that normally occurs after ischemic preconditioning.

15 by very short periods of ischemia, so-called ischemic preconditioning.

16 7 is upregulated in the retina after retinal ischemic preconditioning.

17 to learning and memory, drug tolerance, and ischemic preconditioning.

18 ntributes to the early protective effects of ischemic preconditioning.

19 rdiac myocytes during ischemia is delayed by ischemic preconditioning.

20 teatosis were also particularly protected by ischemic preconditioning.

21 lethal ischemic insult, in a process termed ischemic preconditioning.

22 factors affecting the protective effects of ischemic preconditioning.

23 spase cleavage of PARP-1 could contribute to ischemic preconditioning.

24 the kidney protection afforded by 30 min of ischemic preconditioning.

25 ion injury, and epsilon-PKC activator mimics ischemic preconditioning.

26 naling pathway may play an important role in ischemic preconditioning.

27 ficantly reduced in mice treated with remote ischemic preconditioning.

28 role in protecting the heart from injury in ischemic preconditioning.

29 se channels as key players in the process of ischemic preconditioning.

30 as triggers and end effectors in myocardial ischemic preconditioning.

31 sinusoidal endothelial cell protection after ischemic preconditioning.

32 receptor blockade did not prevent protective ischemic preconditioning.

33 may be the final mediator of protection for ischemic preconditioning.

34 No adverse events were reported with remote ischemic preconditioning.

35 y component of signaling cascades leading to ischemic preconditioning.

36 nd reperfusion, a phenomenon known as remote ischemic preconditioning.

37 -reperfusion injury, and cardioprotection by ischemic preconditioning.

38 ene transcription and is required for remote ischemic preconditioning.

39 rts where the expected loss was prevented by ischemic preconditioning.

40 nd loss of the cardioprotection conferred by ischemic preconditioning.

41 major adverse events were related to remote ischemic preconditioning.

42 f metalloproteinases 2 after surgery (remote ischemic preconditioning, 0.36 vs control, 0.97 ng/mL2/1

43 nts [27.7%], respectively; hazard ratio with ischemic preconditioning, 0.95; 95% confidence interval,

44 Ischemic preconditioning 24 hours before ischemia-reperf

45 tion comparable to that of the late phase of ischemic preconditioning (29+/-3%, P<0.01 group II versu

46 Patients received either remote ischemic preconditioning (3 cycles of 5-minute ischemia

47 injury was significantly reduced with remote ischemic preconditioning (45 of 120 patients [37.5%]) co

48 R-21 in the infarcted areas was inhibited by ischemic preconditioning, a known cardiac protective met

49 channels in the heart is believed to mediate ischemic preconditioning, a phenomenon whereby brief per

50 In ischemic preconditioning, a sublethal ischemic insult pr

51 These findings indicate that ischemic preconditioning acts at step(s) upstream from s

52 whether the cardioprotective intervention of ischemic preconditioning affected mitochondrial protein

53 Ischemic preconditioning affords robust protection of CA

54 A brief period of ischemia, i.e., ischemic preconditioning, affords robust protection of C

55 MCC-134 also attenuated the effect of ischemic preconditioning against myocardial infarction i

56 Thus, although ischemic preconditioning allowed hepatocytes to better w

57 Ischemic preconditioning also induces autophagy, but the

58 erved for comparisons involving xanthine and ischemic preconditioning, although the impact of NAC and

59 jury (IRI) and may signal the development of ischemic preconditioning, an adaptive state that is prot

60 ilon gene blocked cardioprotection caused by ischemic preconditioning and alpha(1)-adrenergic recepto

61 out the role of bone marrow-derived cells in ischemic preconditioning and also reveal that distinct m

62 tivate signaling pathways that contribute to ischemic preconditioning and cardioprotection, high leve

63 e to hypoxic stress with involvement in both ischemic preconditioning and delayed neuroprotection.

64 Ischemic preconditioning and GluR2 antisense knockdown a

65 adaptive mechanisms such as those related to ischemic preconditioning and hibernation.

66 s have been reported to mediate both cardiac ischemic preconditioning and ischemia/reperfusion injury

67 erase-5 inhibitors and beneficial actions of ischemic preconditioning and ischemic postconditioning b

68 heart against ischemia-reperfusion injury by ischemic preconditioning and K(ATP) channel openers is k

69 Brain is also protected by ischemic preconditioning and K(ATP) channel openers, and

70 over, ethanol abolished protection from both ischemic preconditioning and mitochondrial KATP channel

71 an effector of the cell-survival program of ischemic preconditioning and the Mediterranean diet.

72 l ischemia of internal organs induces local (ischemic preconditioning) and systemic (RIPC) resistance

73 es in the regulation of cardiac contraction, ischemic preconditioning, and hypertrophy/failure.

74 ts of ischemic preconditioning (IPC), remote ischemic preconditioning, and ischemic postconditioning

75 Adenosine can initiate ischemic preconditioning, and mitochondrial ATP-sensitiv

76 Although xanthine, NAC, NaHCO3, NAC+NaHCO3, ischemic preconditioning, and natriuretic peptide may ha

77 id, xanthine, dopaminergic agent, peripheral ischemic preconditioning, and natriuretic peptide.

78 n of the cGMP-degrading phosphodiesterase-5, ischemic preconditioning, and postconditioning regimens.

79 c mitoK(ATP) channels play a pivotal role in ischemic preconditioning, and thus represent interesting

80 Ischemic preconditioning appears to sustain the benefici

81 to evaluate the clinical evidence for remote ischemic preconditioning as a potential strategy to prot

82 This study establishes ischemic preconditioning as a protective strategy agains

83 Remote ischemic preconditioning before contrast medium use prev

84 Little data exist regarding the use of ischemic preconditioning before sustained hepatic cold s

85 that is at least as powerful as traditional ischemic preconditioning but is mediated through radical

86 Tolerance was observed at 24 hours after ischemic preconditioning, but not at 72 hours.

87 an important role in cardiac development and ischemic preconditioning, but the mechanism underlying t

88 an obligatory mediator of the late phase of ischemic preconditioning, but the mechanisms of its card

89 reconcile the controversy over the basis of ischemic preconditioning by demonstrating that SDH is a

90 ain how mitoK(ATP) channel activation mimics ischemic preconditioning by protecting mitochondria as t

91 However, ischemic preconditioning cannot be used to reduce infarc

92 otection is unknown, NO is a mediator of the ischemic preconditioning cell-survival program.

93 patients undergoing cardiac surgery, remote ischemic preconditioning compared with no ischemic preco

94 Ischemic preconditioning confers powerful protection aga

95 fter induction of anesthesia) or sham remote ischemic preconditioning (control), both via blood press

96 mote ischemic preconditioning or sham remote ischemic preconditioning (control).

97 to the temporally distinct acute and delayed ischemic preconditioning cytoprotective phenotypes, we r

98 Remote ischemic preconditioning did not improve clinical outcom

99 e hypothesized that RIC before shock (remote ischemic preconditioning), during shock (remote ischemic

100 ic transgenic activation of PKCepsilon or by ischemic preconditioning enhances the formation of PKCep

101 e propose that, at 48 h of reperfusion after ischemic preconditioning, epsilonPKC is poised at synapt

102 cted to sublethal transient global ischemia (ischemic preconditioning) exhibit neuroprotection agains

103 Despite the potential of ischemic preconditioning for organ protection, long-term

104 n, patients were randomly assigned to remote ischemic preconditioning (four 5-minute inflations and d

105 rate at 6 years remained lower in the remote ischemic preconditioning group (hazard ratio, 0.58; 95%

106 the control group and 6 (12%) in the remote ischemic preconditioning group (odds ratio, 0.21; 95% co

107 12 months between the patients in the remote ischemic preconditioning group and those in the control

108 is early benefit in MACCE rate in the remote ischemic preconditioning group was sustained long-term.

109 parable in the intermittent clamping and the ischemic preconditioning group, whereas intermittent cla

110 nts (811 in the control group and 801 in the ischemic-preconditioning group) at 30 cardiac surgery ce

111 Ischemic preconditioning has been demonstrated in animal

112 synthase kinase (GSK) inhibition produced by ischemic preconditioning has been previously shown to be

113 Ischemic preconditioning has been successfully applied t

114 This phenomenon, called ischemic preconditioning, has been observed in virtually

115 The Cardiac Remote Ischemic Preconditioning in Coronary Stenting (CRISP Ste

116 Remote ischemic preconditioning in humans has two phases of pro

117 e randomized study to evaluate the impact of ischemic preconditioning in liver surgery.

118 c postconditioning and all studies on remote ischemic preconditioning in patients with AMI reported r

119 We determined consequences of hepatic ischemic preconditioning in rats, including cell transpl

120 l uncoupling proteins 2 and 3 during delayed ischemic preconditioning in the rat.

121 p27 is a gene-specific event associated with ischemic preconditioning in the retina.

122 ent of the neuroprotective events induced by ischemic preconditioning in the retina.

123 ve shown tissue-protective effects of remote ischemic preconditioning in various target organs, inclu

124 ethanol exposure has been reported to mimic ischemic preconditioning in vitro, but it failed to prot

125 Ischemic preconditioning in vivo increased the formation

126 e of the species-related differences seen in ischemic preconditioning in which one redundant pathway

127 ATP content in liver tissue was preserved by ischemic preconditioning in young but not older patients

128 te analysis revealed an increased benefit of ischemic preconditioning in younger patients, in patient

129 In this study, we demonstrate that remote ischemic preconditioning increases plasma IL-10 levels a

130 Here we report that ischemic preconditioning induced a small, transient down

131 -10) levels play an important role in remote ischemic preconditioning induced by clamping the femoral

132 ippocampal neurons, the protective effect of ischemic preconditioning induced by oxygen-glucose depri

133 genomic profile of cardioprotection between ischemic preconditioning induced by RCS and that induced

134 ar mechanisms differ markedly when mediating ischemic preconditioning induced by repetitive episodes

135 Ischemic preconditioning induced persistent alterations;

136 Mitigation of ischemic preconditioning-induced DNA damage and deleteri

137 The mechanism of ischemic preconditioning involves both triggers and medi

138 hort- and long-term clinical consequences of ischemic preconditioning (IP) during percutaneous corona

139 Ischemic preconditioning (IP) has been shown in animal m

140 The discovery of ischemic preconditioning (IP) has raised hopes that natu

141 recovery in CA donors, and that CA triggers ischemic preconditioning (IP) in liver grafts.

142 Ischemic preconditioning (IP) is a well-established phen

143 h little information regarding their role in ischemic preconditioning (IP) of stem cells.

144 Ischemic preconditioning (IP) renders tissues more toler

145 ib) abolishes the cardioprotective effect of ischemic preconditioning (IP), presumably by inhibiting

146 ethal ischemic insult, a phenomenon known as ischemic preconditioning (IP).

147 /L) abolished the protection associated with ischemic preconditioning (IPC) (20.2+/-3.6% versus 45.9+

148 Ischemic preconditioning (IPC) activates cell signaling

149 Ischemic preconditioning (IPC) and pharmacological preco

150 silon activation is necessary for myocardial ischemic preconditioning (IPC) and PKC activators increa

151 ecently, it was demonstrated that both renal ischemic preconditioning (IPC) and systemic adenosine pr

152 vascular bundle was compared against direct ischemic preconditioning (IPC) and the standard of care

153 disease, this study compares the effects of ischemic preconditioning (IPC) and therapies targeting v

154 In the brain, ischemic preconditioning (IPC) diminishes mitochondrial

155 In the rodent, ischemic preconditioning (IPC) has been shown to improve

156 Ischemic preconditioning (IPC) has been shown to involve

157 Ischemic preconditioning (IPC) has been studied predomin

158 ing factors in the induction of tolerance by ischemic preconditioning (IPC) in the brain.

159 2-LO) has been shown to be a factor in acute ischemic preconditioning (IPC) in the isolated rat heart

160 Ischemic preconditioning (IPC) is a robust neuroprotecti

161 Their role in ischemic preconditioning (IPC) is currently unknown.

162 PURPOSE OF REVIEW: Ischemic preconditioning (IPC) is gaining attention as a

163 Ischemic preconditioning (IPC) may increase the hepatic

164 Ischemic preconditioning (IPC) may prevent dysregulation

165 It is unclear whether ischemic preconditioning (IPC) of solid organs induces r

166 ma-based AAR (% of left ventricle) following ischemic preconditioning (IPC) or cyclosporin-A (CsA) tr

167 We investigated whether ischemic preconditioning (IPC) prevents cardiac RAS acti

168 Ischemic preconditioning (IPC) protects the rat retina a

169 Acute as well as delayed ischemic preconditioning (IPC) provides protection again

170 ction against cerebral ischemia conferred by ischemic preconditioning (IPC) requires translocation of

171 ive mechanism similar to what is observed in ischemic preconditioning (IPC) response.

172 This study assessed the ability of remote ischemic preconditioning (IPC) to attenuate cardiac trop

173 up of isolated rabbit hearts were exposed to ischemic preconditioning (IPC) via 2 episodes of flow in

174 g; IP) on retinal neuroprotection induced by ischemic preconditioning (IPC) were evaluated.

175 Ischemic preconditioning (IPC), a brief period of ischem

176 27 is specifically upregulated after retinal ischemic preconditioning (IPC), and this upregulation ac

177 K(ATP)) is implicated in cardioprotection by ischemic preconditioning (IPC), but the molecular identi

178 This process, called ischemic preconditioning (IPC), can be induced in adult

179 schemic injury in a natural process known as ischemic preconditioning (IPC), induced a rapid release

180 l infarct size and the protective effects of ischemic preconditioning (IPC), remote ischemic precondi

181 obal ischemia and the tolerance conferred by ischemic preconditioning (IPC), would reveal new neuropr

182 nged ischemic episode, a phenomenon known as ischemic preconditioning (IPC).

183 wn to be an important signaling messenger in ischemic preconditioning (IPC).

184 generation of cytoprotective NO during liver ischemic preconditioning (IPC).

185 ts that chloride channels may be involved in ischemic preconditioning (IPC).

186 a-reperfusion injury (IRI) and is reduced by ischemic preconditioning (IPC).

187 sue injury during IR can be reduced by prior ischemic preconditioning (IPC).

188 nomenon whereby a sublethal ischemic insult [ischemic preconditioning (IPC)] provides robust protecti

189 5+/-4.1% (P<0.01), an effect comparable with ischemic preconditioning (IPC; 27.5+/-2.3%; P<0.01).

190 e short episodes of forearm ischemia (remote ischemic preconditioning [IPC]) reduce exercise-induced

191 Ischemic preconditioning is a natural adaptive process w

192 Ischemic preconditioning is a phenomenon in which low-le

193 Ischemic preconditioning is an effective protective stra

194 Neuronal ischemic preconditioning is an endogenous mechanism that

195 Neuronal ischemic preconditioning is an endogenous neuroprotectiv

196 Understanding the mechanisms responsible for ischemic preconditioning is important for formulating th

197 sp70.3 gene in the myocardium in response to ischemic preconditioning is NF-kappaB-dependent and nece

198 Ischemic preconditioning is the phenomenon whereby brief

199 Ischemic preconditioning is used to describe the protect

200 This phenomenon, known as ischemic preconditioning, is mediated by signaling pathw

201 t, which abrogates the protective effects of ischemic preconditioning, is not associated with ischemi

202 is area, the appropriate intensity of remote ischemic preconditioning, its mechanisms of action, and

203 infarct-sparing effect of the late phase of ischemic preconditioning (late PC) lasts for 72 hours.

204 Remote ischemic preconditioning may offer a novel, noninvasive,

205 Remote ischemic preconditioning may result in reduction in infa

206 schemia/reperfusion-induced brain injury and ischemic preconditioning-mediated neuroprotection.

207 In mice subjected to ischemic preconditioning, myocardial SDF-1alpha mRNA was

208 atio to standard care with (n=50) or without ischemic preconditioning (n=50; intermittent arm ischemi

209 ice was similar to wild-type mice undergoing ischemic preconditioning; no increased protection was ob

210 In mouse hearts subjected to in vivo ischemic preconditioning, O-GlcNAc levels were significa

211 ium (mitoK(ATP)) channels play a key role in ischemic preconditioning of the heart.

212 First, we show that cardiac ischemic preconditioning of the in vivo mouse heart resu

213 e secondary to recruitment of collaterals or ischemic preconditioning of the myocardium, and they app

214 e-dependent kinase-1 (PDK1) is essential for ischemic preconditioning of the myocardium.

215 rger trial to establish the effect of remote ischemic preconditioning on clinical outcomes.

216 led trial was to assess the impact of remote ischemic preconditioning on contrast medium-induced acut

217 There was no significant effect of remote ischemic preconditioning on myocardial infarction, strok

218 It has been recently demonstrated that ischemic preconditioning or adenosine receptor modulatio

219 Brief periods of ischemia (ischemic preconditioning or IPC) can reduce neuronal dea

220 This phenomenon has been termed ischemic preconditioning or ischemic tolerance.

221 We randomized them to receive remote ischemic preconditioning or sham remote ischemic precond

222 Cerebral ischemic preconditioning or tolerance is a powerful neur

223 of coronary occlusion/reperfusion preceding (ischemic preconditioning) or following (ischemic postcon

224 short period of ischemia before transection (ischemic preconditioning), or pharmacological preconditi

225 Nonetheless, ischemic preconditioning partially protected from toxic

226 ic acid (aspirin) (ASA) on the late phase of ischemic preconditioning (PC) against myocardial stunnin

227 endothelial nitric oxide synthase (eNOS) in ischemic preconditioning (PC) and cardioprotection is po

228 ecent studies suggest that the late phase of ischemic preconditioning (PC) can be mimicked by pretrea

229 ardioprotective effects of the late phase of ischemic preconditioning (PC) can be mimicked pharmacolo

230 Although the late phase of ischemic preconditioning (PC) is known to confer cardiop

231 ed the hypothesis that cardioprotection with ischemic preconditioning (PC) is lost in the aging, or s

232 To investigate its role in the late phase of ischemic preconditioning (PC), conscious rabbits underwe

233 rigger and the mediator of the late phase of ischemic preconditioning (PC), it is unknown whether NO

234 S)-mediated signaling is implicated in early ischemic preconditioning (PC).

235 eptors (GPCRs) in the protection afforded by ischemic preconditioning (PC).

236 nositol-3-kinase (PI3-kinase) is involved in ischemic preconditioning (PC).

237 cription (STAT) pathway in the late phase of ischemic preconditioning (PC).

238 ardioprotective effects of the late phase of ischemic preconditioning (PC); however, the signaling pa

239 neurons overexpressing NCX1 and subjected to ischemic preconditioning (PC+OGD/RX), the neurotoxic eff

240 Remote ischemic preconditioning prevents IR-induced endothelial

241 In brief, ischemic preconditioning promoted significant increases

242 Delayed ischemic preconditioning promotes cardioprotection via g

243 We hypothesized that ischemic preconditioning protects hepatic grafts via a t

244 The data indicate that ischemic preconditioning protects the liver from sustain

245 surgery to either receive or not receive an ischemic preconditioning protocol (10 minutes of ischemi

246 Fewer patients receiving remote ischemic preconditioning received renal replacement ther

247 ; 95% CI, 2.25%-17.75%; P = .01), and remote ischemic preconditioning reduced intensive care unit sta

248 (CRISP Stent) study demonstrated that remote ischemic preconditioning reduced procedural symptoms, EC

249 Ischemic preconditioning reduces local tissue injury cau

250 Remote ischemic preconditioning reduces the incidence of postpr

251 In mice subjected to S/R, remote ischemic preconditioning, remote ischemic "PER"condition

252 Ischemic preconditioning renders the mouse kidney resist

253 This biological phenomenon, termed ischemic preconditioning, results in improved clinical o

254 Remote ischemic preconditioning (RIPC) by brief arm ischemia/re

255 Remote ischemic preconditioning (RIPC) by repeated brief cycles

256 Remote ischemic preconditioning (RIPC) by repeated brief cycles

257 We assessed whether remote ischemic preconditioning (RIPC) improves myocardial, ren

258 y assess the renoprotective effect of remote ischemic preconditioning (RIPC) in patients undergoing a

259 Remote ischemic preconditioning (RIPC) is a phenomenon whereby

260 Remote ischemic preconditioning (RIPC) is reported to reduce bi

261 Additionally, remote ischemic preconditioning (RIPC) may have higher translat

262 time course and neuronal mechanism of remote ischemic preconditioning (RIPC) of the vasculature in hu

263 Remote ischemic preconditioning (RIPC) protects against liver i

264 f this study was to determine whether remote ischemic preconditioning (RIPC) protects aged liver agai

265 Remote ischemic preconditioning (rIPC) with short episodes of i

266 Remote ischemic preconditioning (rIPC), defined as transient br

267 In remote ischemic preconditioning (RIPC), ischemia to one organ p

268 duction of myocardial infarct size by remote ischemic preconditioning (RIPC), that is, cycles of isch

269 Remote ischemic preconditioning (RIPC), the repetitive transien

270 nst ischemia-reperfusion (IR) injury (remote ischemic preconditioning [RIPC]).

271 Remote ischemic preconditioning significantly attenuated the re

272 Ischemic preconditioning significantly improved hepatic

273 Ischemic preconditioning significantly improved postisch

274 r results between centers and confirmed that ischemic preconditioning significantly reduced infarct s

275 te ischemic preconditioning compared with no ischemic preconditioning significantly reduced the rate

276 ked the protection afforded by both NMDA and ischemic preconditioning significantly, suggesting a sig

277 Following ischemic preconditioning, SNO occupancy increased to an

278 ium channel function plays a central role in ischemic preconditioning, stunned myocardium, and in ane

279 ) or a traditional protocol of second-window ischemic preconditioning (SWIPC).

280 on angina may act as a clinical surrogate of ischemic preconditioning that may reduce infarct size an

281 on was markedly reduced in a model of kidney ischemic preconditioning that was established in the mou

282 This model identified two regulators of ischemic preconditioning: the atypical protein kinase M

283 enation-dependent Nrf-2 activity facilitates ischemic preconditioning through the induction of antiox

284 Here, we used ischemic preconditioning to induce a stress-tolerant sta

285 To validate CAESAR, we tested the ability of ischemic preconditioning to reduce infarct size in 3 spe

286 Whether remote ischemic preconditioning (transient ischemia and reperfu

287 Remote ischemic preconditioning, triggered by brief episodes of

288 Remote ischemic preconditioning, using cycles of upper limb isc

289 Ischemic preconditioning was blocked in rat hearts perfu

290 Ischemic preconditioning was elicited in 80% of patients

291 The protective effect of ischemic preconditioning was reversed after VEGF-A inhib

292 een caspase activation, PARP-1 cleavage, and ischemic preconditioning was supported by studies using

293 naling molecules and have been implicated in ischemic preconditioning, we examined diazoxide-induced

294 Intermittent inflow occlusion and ischemic preconditioning were both protective against is

295 ion of Hsp in the rat retina associated with ischemic preconditioning were evaluated.

296 tors of JNK and p38, was markedly reduced by ischemic preconditioning, whereas the post-ischemic phos

297 Fifteen minutes of prior ischemic preconditioning, which does not result in the d

298 long term protection afforded the kidney by ischemic preconditioning, which results in persistent re

299 Nicorandil can mimic ischemic preconditioning, while mitochondrial K(ATP) (mi

300 sham laparotomy (n = 10, 2) I/R (n = 25), 3) ischemic preconditioning with 5 min of ischemia and 10 m