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1 s highly expressed in the BCM (mainly in the islets of Langerhans).
2 sulin-producing beta cells in the pancreatic islets of Langerhans.
3 rough the analysis of insulin secretion from islets of Langerhans.
4 lls, the largest cellular constituent of the islets of Langerhans.
5 n of the insulin-producing beta cells in the islets of Langerhans.
6 ulin-secreting beta-cell found in pancreatic islets of Langerhans.
7 w blood-borne factors dynamically access the islets of Langerhans.
8 , eIF2-GTP.Met-tRNAi, in both MIN6 cells and islets of Langerhans.
9 resence of cytotoxic amyloid deposits in the islets of Langerhans.
10 cells, endocrine progenitor cells and adult islets of Langerhans.
11 factor (TNF)-alpha in the beta-cells of the islets of Langerhans.
12 one marrow-derived cells populate pancreatic islets of Langerhans.
13 gates, which subsequently differentiate into islets of Langerhans.
14 that STAT3 is deleted from beta cells in the islets of Langerhans.
15 tion following localized inflammation in the islets of Langerhans.
16 derstanding the developmental biology of the islets of Langerhans.
17 secretion from beta-cells in the pancreatic islets of Langerhans.
18 ion process by beta -cells in the pancreatic islets of Langerhans.
19 uced and secreted by specialized structures, islets of Langerhans.
20 maintaining the identity and function of the islets of Langerhans.
21 s contain stem cells that differentiate into islets of Langerhans.
22 lective destruction of the beta cells of the islets of Langerhans.
23 ping and mature beta-cells in the pancreatic islets of Langerhans.
24 ells, while weaker ones were detected in the islets of Langerhans.
25 m apoptotic destruction of beta cells in the islets of Langerhans.
26 mulated insulin release from perifused human islets of Langerhans.
27 mes restricted to the endocrine cells of the islets of Langerhans.
28 nitrite production, and insulin secretion by islets of Langerhans.
29 e genesis of the inflammatory lesions of the islets of Langerhans.
30 sult of a T cell-mediated destruction of the islets of Langerhans.
31 n of insulin by beta cells in the pancreatic islets of Langerhans.
32 well as low Km hexokinase I in isolated rat islets of Langerhans.
33 sulin-producing beta-cells in the pancreatic islets of Langerhans.
34 persed in multiple micro-organs known as the islets of Langerhans.
35 on of the costimulatory molecule B7.1 in the islets of Langerhans.
36 ction of insulin-producing beta cells in the islets of Langerhans.
37 bundance of the transporter localized in the islets of Langerhans.
38 ne cell clusters of the type found in normal islets of Langerhans.
39 sponse and insulin secretion dynamics of the islets of Langerhans.
40 insulin-secreting cells and isolated rodent islets of Langerhans.
41 ly expressed in pancreatic insulin-producing islets of Langerhans.
42 d by a subpopulation of nonbeta cells in the islets of Langerhans.
43 ng endocrine cell activity in the pancreatic islets of Langerhans.
44 uitment of autoaggressive lymphocytes to the islets of Langerhans.
45 ion of the pancreas and complete loss of the islets of Langerhans.
46 widely expressed in adult tissues, including islets of Langerhans.
47 ggregating in the extracellular space of the islets of Langerhans.
48 umber of insulin-secreting beta-cells in the islets of Langerhans.
49 eleted in the thymus but is activated in the islets of Langerhans.
50 epithelial lining of the ducts and form the islets of Langerhans.
51 in oscillations of intracellular [Ca(2+)] in islets of Langerhans.
52 by leukocyte infiltration of the pancreatic islets of Langerhans.
53 lucose waves that were needed to entrain the islets of Langerhans.
54 ere applied in this work to stimulate single islets of Langerhans.
55 s and in insulin-producing beta cells of the islets of Langerhans.
56 e secreted with insulin by beta-cells in the islets of Langerhans.
57 insulin by the beta cells of the pancreatic islets of Langerhans.
59 ulates protein synthesis in freshly isolated islets of Langerhans, across a range of glucose concentr
63 a(2+)](i)) in isolated mouse, rat, and human islets of Langerhans and in the MIN6 insulin-secreting m
64 truction of the beta cells of the pancreatic islets of Langerhans and is recapitulated in the nonobes
65 1R) is mainly expressed on beta-cells in the islets of Langerhans and is therefore an attractive targ
66 and ultrastructural changes were observed in islets of Langerhans and livers of mutant animals, as we
67 PC1/3 are expressed in the beta cells of the islets of Langerhans and participate in the processing o
68 tion, the virtual absence of CPE activity in islets of Langerhans and pituitary was associated with a
70 Herein, we focus on the resident APC of the islets of Langerhans and their role in autoimmune diabet
71 d islet-specific T cells from reentering the islets of Langerhans and thereby blocked the autodestruc
72 ed to measure glucagon secretion from single islets of Langerhans and to differentiate cross-reactive
73 s from the rat pituitary, the rat pancreatic islets of Langerhans, and from the Aplysia californica n
75 rown on nontransparent nanoneedle arrays, of islets of Langerhans, and of hippocampal neurons under u
76 phospholipase C- (PLC-) is expressed in the islets of Langerhans, and that the knockout (KO) of PLC-
77 The availability of paracrine factors in the islets of Langerhans, and the constitution of the beta c
84 protein deposits (amyloid) in the pancreatic islets of Langerhans are thought to be involved in death
85 ecreting beta-cells, found in the pancreatic islets of Langerhans, are destroyed by infiltrating T ce
89 ity extends beyond the pancreatic lymph node-islets of Langerhans axis and indicates that circulating
91 en, Peyer's patches, lymph nodes, pancreatic islets of Langerhans, bone marrow, and salivary glands o
92 APCs in close contact with beta cells in the islets of Langerhans bore vesicles with the antigenic in
93 r the determination of insulin secreted from islets of Langerhans by a capillary electrophoresis comp
94 and release of interleukin 1 (IL-1) in human islets of Langerhans by resident macrophages results in
95 Insulin secretion from beta cells in the islets of Langerhans can be stimulated by a number of me
96 s is organized into clusters of cells called islets of Langerhans comprising four well-defined cell t
101 nsulin from the beta-cells of the pancreatic islets of Langerhans controls energy homeostasis in vert
102 secretion from beta cells of the pancreatic islets of Langerhans controls metabolic homeostasis and
104 o the endocrine cells forming the pancreatic islets of Langerhans depends on a cascade of gene activa
106 s caused by dysfunction to beta-cells in the islets of Langerhans, disrupting insulin secretion and g
107 y the alpha-cells of the endocrine pancreas (islets of Langerhans) during fasting and is essential fo
108 tion and hypertrophy are key determinants of islets of Langerhans "dysfunctional remodeling" and hype
112 mulation, nephropathy, atrophy of pancreatic islets of Langerhans, fatty streaks in the aorta, and hy
114 are the major barriers to transplantation of islets of Langerhans for the cure of type 1 diabetes in
115 (MALDI MS) peptide and protein profiling of Islets of Langerhans, for future type 2 diabetes (T2D) s
117 pression of CD44 isoforms in highly purified islets of Langerhans from 4- and 10-week-old NOD mice.
120 together with intraportal transplantation of islets of Langerhans, GVHR might damage the implanted is
121 te of success in clinical transplantation of islets of Langerhans has dramatically improved with pers
122 c innervation of the endocrine pancreas, the islets of Langerhans, has been shown to provide choliner
123 lls in adult pancreatic ducts or in isolated islets of Langerhans have been induced to grow in cultur
124 not seem to adversely influence function of islets of Langerhans implanted intrahepatically in this
125 tion by glucose-stimulated beta-cells of the islets of Langerhans in a dose- and time-dependent manne
126 secretory dynamics of multiple peptides from islets of Langerhans in a highly automated fashion is ex
127 anded human Treg to prevent the rejection of islets of Langerhans in a humanized mouse model and exam
128 tense radioactive spots colocalized with the islets of Langerhans in clorgyline-treated animals.
131 d insulin secretion (GSIS) from live, murine islets of Langerhans in microfluidic devices by the down
134 ol of diabetes, suggesting that the inflamed islets of Langerhans in prediabetic NOD mice are under p
141 mbohedral of Zn-insulin hexamers form in the islets of Langerhans in the pancreases of many mammals.
144 f the alginate-based capsules that sequester Islets of Langerhans include fabrication and implantatio
146 riggers a cascade of stressful events in the islets of Langerhans involving activation of apoptosis a
147 cal activity of insulin-secreting pancreatic islets of Langerhans is characterized by bursts of actio
149 mulate insulin secretion from the pancreatic islets of Langerhans is enhanced by the intestinal hormo
151 ification of insulin release from pancreatic islets of Langerhans is of interest for diabetes researc
152 esis in the endocrine pancreas, of which the islets of Langerhans is the major constituent, has been
153 icted manner in the mature beta cells in the islets of Langerhans, is essential both for organ format
154 coupling mechanisms in beta-cells and intact islets of Langerhans isolated from three patients with a
157 ne mediated destruction of beta cells of the islets of Langerhans leads to insulin-dependent diabetes
161 l profiles of macrophages that reside in the islets of Langerhans of 3-wk-old non-obese diabetic (NOD
162 rogenitor cells isolated from the pancreatic islets of Langerhans of adult human donor pancreata.
163 constituent of amyloid deposits found in the islets of Langerhans of patients with type II diabetes.
164 have identified a CD4high population in the islets of Langerhans of prediabetic nonobese diabetic (N
167 nd smoothened are expressed in the endocrine islets of Langerhans of the fully developed rat pancreas
168 d the antigen presenting cells (APCs) in the islets of Langerhans of the non-obese diabetic (NOD) mou
170 secretion from pancreatic beta-cells within islets of Langerhans plays a critical role in maintainin
172 es similar, but not identical, to pancreatic islets of Langerhans, produced insulin at levels far gre
173 le the endocrine compartment, organized into islets of Langerhans, produces hormones that regulate bl
174 ly and functionally normal at birth, but the islets of Langerhans progressively degenerate, resulting
177 with metabolic parameters and its effect on islets of Langerhans remodeling and relative endocrine-c
179 ocalization of diabetogenic CD4 T cells into islets of Langerhans resulting in diabetes were examined
180 ocytes to the endothelial venules inside the islets of Langerhans seems to initiate the infiltration
181 ded that the intercellular communications in islets of Langerhans should contribute to the effective
182 tro upon external glucose application to the islets of Langerhans, such as usual bursting oscillation
183 line MIN6 (mouse insulinoma cell line 6) and islets of Langerhans that agents which stimulate increas
184 on of the resident macrophages of pancreatic islets of Langerhans that lasted for several weeks.
185 er a few seconds or a few minutes, in intact islets of Langerhans they are intermediate (10-60 s).
186 cium dynamics and islet mass of transplanted islets of Langerhans throughout diet-induced progression
188 e expressing CXCL10 in the beta cells of the islets of Langerhans to evaluate how bystander inflammat
189 hown that prolonged exposure of isolated rat islets of Langerhans to excessive fatty acid levels impa
190 e hindered the successful transplantation of islets of Langerhans to human patients in efforts to cur
191 d clinical sections of an IND for allogeneic islets of Langerhans to treat type 1 diabetes mellitus a
192 (IND) applications for the use of allogeneic islets of Langerhans to treat type 1 diabetes mellitus.
194 Transplantation of an excessive number of islets of Langerhans (two to four pancreata per recipien
196 mmatory mediators that are secreted by human islets of Langerhans upon CVB infection and may shed lig
198 in and islet amyloid polypeptide (IAPP) from islets of Langerhans using a microfluidic system with tw
199 has shown that homing of these cells to the islets of Langerhans was affected by the lack of IFN-gam
200 e immunoassay, the insulin content of single islets of Langerhans was determined by flow injection an
202 ther accumulation of pathogenic Th1 cells to islets of Langerhans, we conclude that CD40L-CD40 costim
203 d beta-cells purified from rodent pancreatic islets of Langerhans, we studied the expression and role
204 The T cells were directly recruited into islets of Langerhans, where they established contact wit
205 Glucose homeostasis is controlled by the islets of Langerhans which are equipped with alpha-cells
206 The remnant Hlxb9-/- pancreas has small islets of Langerhans with reduced numbers of insulin-pro
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