ライフサイエンスコーパス: isocitrate lyase

1 or assimilation of acetate in the absence of isocitrate lyase.

2 se with only an NAD-dependent IDH never have isocitrate lyase.

3 t this enzyme is regulated differentially to isocitrate lyase.

4 inhibited import of the peroxisomal protein isocitrate lyase.

5 as imported more efficiently than oligomeric isocitrate lyase.

6 eA) which exhibits a low similarity to other isocitrate lyases.

7 ose-1,6-bisphosphatase 1) and ICL1 (encoding isocitrate lyase 1) are under control of the Mig1 repres

8 sis thaliana to identify the segments of the isocitrate lyase 5' flanking region that influence promo

9 Isocitrate lyase, a glyoxysomal protein, and the leaf-ty

10 Activity of isocitrate lyase AceA, an S-allylmercapto-modified candi

11 Genes encoding isocitrate lyase (aceA) and malate synthase (aceB), both

12 An isocitrate lyase (aceA) mutant was virulent, so the inab

13 Isocitrate lyase (AceA) was induced by oxygen across the

14 A putative isocitrate lyase (aceA; blr2455) was among the most stro

15 eling is mediated by the bifunctional enzyme isocitrate lyase acting in a noncanonical role distinct

16 l-coenzyme A synthetase; Acs) expression and isocitrate lyase activity without affecting key TCA cycl

17 as AceA proteins, and show that both exhibit isocitrate lyase activity.

18 cleotide sequence of the structural gene for isocitrate lyase (acu-7) is presented and features of it

19 d comparison with the closed conformation of isocitrate lyase and 2-methylisocitrate lyase revealed t

20 ssion of the latent infection genes encoding isocitrate lyase and alpha-crystallin, respectively.

21 st serine cycle methylotrophic bacteria lack isocitrate lyase and convert acetyl coenzyme A (acetyl-C

22 ass of the tricarboxylic acid cycle in which isocitrate lyase and malate synthase (GlcB) catalyze the

23 In addition, isocitrate lyase and malate synthase activities were six

24 Enzyme assays validated the increase in isocitrate lyase and malate synthase activities.

25 In this study the genes encoding isocitrate lyase and malate synthase from Chlorogloeopsi

26 showed strong homology to gene sequences for isocitrate lyase and malate synthase from plants and oth

27 Transcript abundances for isocitrate lyase and malate synthase increased, and C. f

28 When the genes encoding isocitrate lyase and malate synthase were expressed in S

29 ve expression of the glyoxylate shunt genes (isocitrate lyase and malate synthase) was >300-fold high

30 n for the two glyoxylate cycle (GC) enzymes, isocitrate lyase and malate synthase, are expressed in a

31 Previous studies reported the activities of isocitrate lyase and malate synthase, the key enzymes of

32 In order to specifically address the role of isocitrate lyase and nitrogenase in chemoautotrophic gro

33 w that two additional gluconeogenic enzymes, isocitrate lyase and phosphoenolpyruvate carboxykinase,

34 ed for two other enzyme superfamily members, isocitrate lyase and phosphoenolpyruvate mutase.

35 sphosphatase (FBPase), malate dehydrogenase, isocitrate lyase, and phosphoenolpyruvate carboxykinase

36 tress-related alkyl hydroperoxide reductase, isocitrate lyase, and the cell surface protein A.

37 mRNA for the glyoxylate cycle enzyme isocitrate lyase declined at similar rates in patients r

38 An isocitrate lyase-deficient mutant of Mtb (Deltaicl1) exh

39 nt in glyoxylate shunt enzymes, specifically isocitrate lyase (DeltaaceA) and malate synthase (Deltaa

40 Isocitrate lyase-dependent production of succinate affor

41 ne the chemical function a new member of the isocitrate lyase enzyme family derived from the flowerin

42 osely related phosphoenolpyruvate mutase and isocitrate lyase enzymes.

43 on of elements is involved in regulating the isocitrate lyase gene and that distinct DNA sequences pl

44 with PR genes and highest expression of the isocitrate lyase gene coinciding with highest solar irra

45 sequences that regulate the expression of an isocitrate lyase gene from Brassica napus L. during late

46 We showed previously that isocitrate lyase (ICL) activity is constitutively upregu

47 CoA (HS-CoA) and, on the other hand, between isocitrate lyase (ICL) and isocitrate dehydrogenase (ICD

48 sition in which the glyoxylate cycle enzymes isocitrate lyase (ICL) and malate synthase (MLS) are rep

49 cised and incubated without a carbon source, isocitrate lyase (ICL) and malate synthase (MS) mRNAs in

50 like isoforms of the glyoxylate cycle enzyme isocitrate lyase (ICL) are jointly required for fatty ac

51 uch information is, however, lacking for the isocitrate lyase (Icl) gene which is coordinately regula

52 A cDNA with sequence similarity to isocitrate lyase (ICL) genes was isolated from the unice

53 The role of isocitrate lyase (ICL) in the glyoxylate cycle and its n

54 Isocitrate lyase (ICL) is a peroxisomal glyoxylate cycle

55 The activity of the glyoxylate cycle enzyme isocitrate lyase (ICL) was surveyed in eight barley cult

56 of M. tuberculosis in mice is facilitated by isocitrate lyase (ICL), an enzyme essential for the meta

57 at the first enzyme of the glyoxylate shunt, isocitrate lyase (ICL), may mediate survival of Mtb duri

58 nd C2 compounds in an unknown pathway in the isocitrate lyase (ICL)-negative Methylobacterium.

59 glyoxysomal/peroxisomal targeting signal of isocitrate lyase (ICL).

60 pseudotuberculosis, constitutively produces isocitrate lyase (ICL).

61 Isocitrate lyase (ICL, types 1 and 2) is the first enzym

62 e principal enzymes of the glyoxylate cycle, isocitrate lyase (ICL1) and malate synthase (MLS1).

63 this profiling, a single gene for the enzyme isocitrate lyase (ICL1) was found to be up regulated at

64 A]], homodomain transcription factor [StlA], isocitrate lyase [Icl1], polyaromatic amino acid biosynt

65 Although MCLs share limited homology with isocitrate lyases (ICLs) of the glyoxylate cycle, these

66 all three drugs trigger activation of Mtb's isocitrate lyases (ICLs), metabolic enzymes commonly ass

67 s (Mtb) more profoundly than deletion of its isocitrate lyases (ICLs).

68 Isocitrate lyase (IL) is an essential enzyme in the glyo

69 Isocitrate lyase is a key enzyme in the glyoxylate cycle

70 s in fungi, in conjunction with reports that isocitrate lyase is both upregulated and required for th

71 erculosis the production and activity of the isocitrate lyase is enhanced under minimal growth condit

72 Although isocitrate lyase is essential for Salmonella persistence

73 Isocitrate lyase is required for fatty acid utilization

74 Isocitrate lyase is stabilized in pex4 pex22, indicating

75 In contrast, ABA repressed the expression of isocitrate lyase (ll9) mRNA.

76 s in central carbon metabolism, specifically isocitrate lyase, malate synthase, transaldolase, fructo

77 Isocitrate lyase mRNA correlated highly with CFU in sput

78 Data suggest that isocitrate lyase mRNA is a reliable marker of M. tubercu

79 Isocitrate lyase mRNA was detectable in sputum of cultur

80 abase (Sanger) with similarity to the enzyme isocitrate lyase of both Corynebacterium glutamicum and

81 three enzymes are: trace levels of OGDH, the isocitrate lyase of the glyoxylate shunt and an unantici

82 ame shows significant sequence similarity to isocitrate lyases of bacteria (70%), molds (48%), yeasts

83 ngus Magnaporthe grisea, a gene that encodes isocitrate lyase, one of the principal enzymes of the gl

84 n feed into either the glyoxylate shunt (via isocitrate lyase) or the TCA cycle (via isocitrate dehyd

85 ranscriptional regulators and genes encoding isocitrate lyase, oxidative stress responses, the synthe

86 , Shewanella oneidensis MR-1 uses the serine-isocitrate lyase pathway common to many methylotrophic a

87 To examine its use of the serine-isocitrate lyase pathway under anaerobic conditions, we

88 rel fold of PDP is the same as that of other isocitrate lyase/PEP mutase superfamily members, includi

89 mber of the phosphoenolpyruvate (PEP) mutase/isocitrate lyase (PEPM/ICL) superfamily, hydrolyzes P-py

90 markers common to the C-C bond lyases of the isocitrate lyase/phosphoenolpyruvate mutase superfamily,

91 and sigH (alternative sigma factors), aceA (isocitrate lyase), ponA (class I penicillin-binding prot

92 he proposed mechanism of the closely related isocitrate lyases, PrpB residue C123 is proposed to serv

93 ns, although glyoxylate synthesized from the isocitrate lyase reaction can be converted to glycine, a

94 d inhibits the growth of bacteria expressing isocitrate lyase, such as Salmonella enterica and Mycoba

95 at they lack the key glyoxylate cycle enzyme isocitrate lyase, suggesting that alternative pathway(s)

96 functionally novel member of the PEP mutase/isocitrate lyase superfamily and therefore targeted for

97 As with other PEP mutase/isocitrate lyase superfamily members, the protein assemb

98 ase branch of the phosphoenolpyruvate mutase/isocitrate lyase superfamily to provide insight into the

99 , a member of the phosphoenolpyruvate mutase/isocitrate lyase superfamily, catalyzes the hydrolysis o

100 at belongs to the phosphoenolpyruvate mutase/isocitrate lyase superfamily.

101 Methylobacterium extorquens AM1, which lacks isocitrate lyase, the key enzyme in the glyoxylate cycle

102 ic acid is an organic compound that inhibits isocitrate lyase, the key enzyme of the glyoxylate shunt

103 tumefaciens BlcR is a member of the emerging isocitrate lyase transcription regulators that negativel

104 structure of the targeted protein; monomeric isocitrate lyase was imported more efficiently than olig

105 Mutants of the glyoxylate shunt gene for isocitrate lyase were able to grow in the presence of oi

106 Various known inhibitors for isocitrate lyase were effective.

107 nomes reveals that those genomes that encode isocitrate lyase, which is essential for growth on aceta