ライフサイエンスコーパス: isocyanate

1 onium reagents to generate the corresponding isocyanate.

2 No exchange was observed with the terminal isocyanate.

3 ladium isocyanate complex to produce an aryl isocyanate.

4 the hindered amine via a stable and isolable isocyanate.

5 -MS using stable isotope tagging with phenyl isocyanate.

6 ocyanurate by reaction with chloro(carbonyl) isocyanate.

7 rearrangement to generate the corresponding isocyanate.

8 and sulfur nucleophiles to N-chlorosulfonyl isocyanate.

9 yields without the formation of intermediary isocyanates.

10 lts were obtained using highly electrophilic isocyanates.

11 methyl)pyridine and amino acid ester derived isocyanates.

12 )4 (3a), which was successfully trapped with isocyanates.

13 ivatives with different carboxylic acids and isocyanates.

14 of arachidonyl alcohol with the appropriate isocyanates.

15 esized from 2-cyanoaziridine and appropriate isocyanates.

16 as been accomplished with aryl and aliphatic isocyanates.

17 etones in the presence of primary amines and isocyanates.

18 n of C-chiral allylic sulfilimines with aryl isocyanates.

19 iochemical yield from [(11)C-carbonyl]methyl isocyanate (10) (decay corrected).

20 -carboxamide (7) with [(11)C-carbonyl]methyl isocyanate (10) gave [4-(11)C-carbonyl]temozolomide (11)

21 Thermolysis of benzannulated enyne-isocyanates 13 and enyne-isocyanates 36 and 37 promoted

22 benzannulated enyne-isocyanates 13 and enyne-isocyanates 36 and 37 promoted the cycloaromatization re

23 f carbon, oxygen, and sulfur nucleophiles to isocyanate 41 to obtain salicylihalamide A and congeners

24 ld stereocontrolled elaboration to E-alkenyl isocyanate 41, and (3) addition of carbon, oxygen, and s

25 Treatment of 2-(1-alkynyl)phenyl isocyanates 6 with the iminophosphorane 14 produced in s

26 ized by treatment of the benzannulated enyne-isocyanates 8 with the iminophosphoranes 9 and 13, respe

27 adiochemical yield from [(11)C-methyl]methyl isocyanate (8) (decay corrected).

28 he novel labeling agent [(11)C-methyl]methyl isocyanate (8) gave [3-N-(11)C-methyl]temozolomide (9) i

29 r-bearing species, and four compounds-methyl isocyanate, acetone, propionaldehyde, and acetamide-that

30 ence of acid and engender both electrophilic isocyanate activation and nucleophilic alcohol activatio

31 work, can diffuse out and be reacted with an isocyanate, allowing us to quantify the enantioselectivi

32 addition of primary amines to alpha-tertiary isocyanates (alpha-(t)NCO).

33 tion energies of the transient dimethylamino isocyanate and 1,1-dimethyldiazene have been computed us

34 achieved through the polymerization of hexyl isocyanate and 4-phenylbutyl isocyanate, initiated by an

35 Reaction of racemic 2 with p-chlorophenyl isocyanate and a catalytic quantity of triethylamine in

36 f a readily available molecule containing an isocyanate and a thiolactone.

37 of some Fc fragments and were identified as isocyanate and alpha-ketoacyl derivatives generated by r

38 of ureas and isoureas; however, with excess isocyanate and heat, thermodynamic equilibration is poss

39 roups, that is, acyl isothiocyanate-thioacyl isocyanate and imidoyl isothiocyanate-thioacyl carbodiim

40 soelectronic heteroallene functions, such as isocyanate and isothiocyanate.

41 reactions to the carbonyl groups of an alkyl isocyanate and of carbon dioxide to form the respective

42 tween phenyl isocyanate or pentafluorophenyl isocyanate and polyfluorinated alcohols and diols is des

43 lly unstable engaging the terminal hafnocene isocyanate and promoting deoxygenation and additional N-

44 s with mesityl azide and CO2 to form mesityl isocyanate and the dinuclear bis(mu-oxo)-bridged U(V)/U(

45 the [2 + 2 + 2] cyclotrimerization of phenyl isocyanate and the polymerization of DL-lactide.

46 ients exposed to (i) protein allergens, (ii) isocyanates and (iii) welding fumes the day after releva

47 hafnocene complex with terminal and bridging isocyanates and a terminal carbonyl.

48 ic acids), urethanes, or ureas (derived from isocyanates and allylic alcohols and amines) as substrat

49 s governing the reactions of amines, amides, isocyanates and carbamates with OH radicals.

50 After demethylation, reaction with isocyanates and catalytic debenzylation over hydrogen, t

51 ersibly binds unsaturated substrates such as isocyanates and isocyanides, suggesting the intermediacy

52 tes and thiocyanates RX-YCN and the isomeric isocyanates and isothiocyanates of the type RX-NCY (X =

53 II)-catalyzed denitrogenative reactions with isocyanates and isothiocyanates, respectively.

54 Reaction of racemic 2 with aromatic isocyanates and potassium carbonate afforded C-acylation

55 FLP tBu(2)PCH(2)BPh(2) with H(2), CO(2), and isocyanates and supported computationally.

56 We conclude that isocyanates and tear gas agents target the same neuronal

57 requent exposures, the biological targets of isocyanates and tear gases in vivo have not been identif

58 d to explain the different behaviors of both isocyanates and the mechanisms of the processes.

59 ysiology to show that the noxious effects of isocyanates and those of all major tear gas agents are c

60 nnulation of 2-(2,2-dibromovinyl)aniline, an isocyanate, and a terminal alkyne in a three-component t

61 primary alcohols, carboxylic acids, amides, isocyanates, and carbamates, as well as tetrahydrofuran

62 s of 1,3-oxazinane-2,4-diones from epoxides, isocyanates, and CO.

63 ndol-2-yl)methanone 11 with diverse ketones, isocyanates, and isothiocyanates in the presence of base

64 cal inhibition of TRPA1 dramatically reduces isocyanate- and tear gas-induced nocifensive behavior af

65 Organic isocyanates are versatile intermediates that provide acc

66 Nitrogen-substituted isocyanates (N-isocyanates) are rare amphoteric reagents with high, but

67 hanes and diurethanes, derived from aromatic isocyanates, are produced in good yields in a photoreact

68 N bond construction event was possible using isocyanate as urea precursor and Ag(I) catalyst as alkyn

69 Employing vinyl isocyanates as 1,4-dipoles, the cycloannulation occurs u

70 ion of an amide with a large excess of ethyl isocyanate at elevated temperatures.

71 esis of a polymerization mediator bearing an isocyanate at the R group and with the handling of such

72 iolates and other sulfur-based nucleophiles, isocyanate, azide, nitrite, and cyanide.

73 of anionically synthesized model poly(hexyl isocyanate-b-styrene) rod-coil diblock copolymers examin

74 The synthesis of rigid-rod, helical isocyanate-based macromonomers was achieved through the

75 lysis of CF3 S(O)NCO at ca. 1200 K, sulfinyl isocyanate, bearing resonance structures of O=C-N=S=O an

76 Since isocyanates bind to both amines (forming a urea linkage)

77 found to attack at the oxo moiety to produce isocyanate by oxygen atom transfer.

78 phase alkali metal reduction of [8]annulenyl isocyanate (C8H7NCO) yields an EPR spectrum, which revea

79 As demonstrated, the resultant allyl isocyanates can be directly trapped with various nucleop

80 Both aliphatic and aromatic isocyanates can be used to produce fused 2-pyridones, al

81 ddition of alpha,beta-unsaturated imines and isocyanates catalyzed by a phosphoramidite-rhodium compl

82 s similarly with carbonyl sulfide and phenyl isocyanate, causing sulfur-atom and nitrene-group transf

83 ed polymers in a one-pot RAFT polymerization/isocyanate "click" procedure.

84 ers in a one-pot simultaneous polymerization/isocyanate "click" reaction.

85 hesis and structural characterization of the isocyanate complex (OCN)V(N[t-Bu]Ar)(3) (1-V(NCO)) to co

86 ions, respectively, to produce the nitrosyl, isocyanate complex Cp*Mo[N((i)Pr)C(Me)N((i)Pr)](kappa-N-

87 reductive elimination from an arylpalladium isocyanate complex to produce an aryl isocyanate.

88 with CO(2), but the product obtained is the isocyanate complex, [kappa(4)-Tptm]ZnNCO.

89 itope specificity for self protein (albumin)-isocyanate conjugates.

90 tudy the biotransformation of p-chlorophenyl isocyanate (CPIC) to CPA in rats administered intraperit

91 Chlorosulfonyl isocyanate (CSI) is reported to react with hydrocarbon a

92 s performed with the reactive chlorosulfonyl isocyanate (CSI) reagent.

93 ies with monomers (e.g. bis-aldehydes, multi-isocyanates, cyclic esters, epoxides, N-carboxyanhydride

94 With substituted isocyanates, cycloaddition to the dihafnocene mu-nitrido

95 hat is caused by the nonenzymatic binding of isocyanate derived from urea dissociation or myeloperoxi

96 carboxamido NH initiates elimination and the isocyanate-derived products form; the resulting platinum

97 ma patients exposed to protein allergens and isocyanates elicit similar nasal proteome responses and

98 conjugated rhodamine-lactam and fluorescein isocyanate (FITC) leads to efficient metabolic incorpora

99 tivation of [(32)P]orthophosphate with ethyl isocyanate followed by aminolysis with ammonium hydroxid

100 of substituted anilines to nitro-substituted isocyanates followed by reduction generates new aniline-

101 Using p-toluenesulfonyl isocyanate for derivatization and a stable isotope label

102 Insight into the mechanism of aryl isocyanate formation was gleaned through studies of the

103 A mild and metal-free synthesis of aryl isocyanates from arylamines under an atmosphere of CO2 w

104 talyzed carbonylative generation of sulfonyl isocyanates from sulfonyl azides, followed by a [2 + 2]

105 a new class of stable molecules, alpha-boryl isocyanates, from alpha-borylcarboxylic acid precursors.

106 es as adhesives arises in part because their isocyanate functionality is available for reaction indep

107 The isocyanate functions as a "pseudo-catalyst" for this sys

108 The first method trapped the intermediate isocyanate generated via a modified Curtius rearrangemen

109 ed as coproducts, and carbamoyl chlorides or isocyanates generated as yield-diminishing byproducts.

110 d through the coupling of the norarachidonyl isocyanate (generated from arachidonic acid using diphen

111 Reactions of dianion 10 with isocyanates give 15a,b, which contain the 4,5,6,7-tetrah

112 Aromatic isocyanates give better results when they bear electron-

113 Subsequent reaction with isocyanates gives 3-amino-1,2,4-benzothiadiazine 1,1-dio

114 hat the electron is not localized within the isocyanate group (as in the alkyl analogues) but is dist

115 able from valinomycin hydroxylation) and the isocyanate group of pentafluorophenyl N-carbonyl glycina

116 C-terminal fragment containing an N-terminal isocyanate group which undergoes hydrolysis to a free am

117 Isocyanate groups are well suited to serving as a glass

118 was performed by covalent attachment to free isocyanate groups from PUU microparticles, or by physica

119 olymerizable vinyl double bonds and reactive isocyanate groups.

120 ng of 2-phenylimidazo heterocycles with aryl isocyanates has been achieved via a chelation-assisted c

121 dation of anilide and enamide C-H bonds with isocyanates has been developed.

122 cycloaddition of terminal alkynes and dienyl isocyanates has been developed.

123 of cycloaddition reactions of nitrones with isocyanates has been studied using density functional th

124 ion radicals of p-tolyl- and p-methoxyphenyl isocyanate have also been generated.

125 s for amines to days for amides to years for isocyanates, highlighting unique functional group reacti

126 involved a novel approach that required the isocyanate II (B = NCO) with a hydroxyl-protected scaffo

127 The release of methyl isocyanate in Bhopal, India, caused the worst industrial

128 go one-step carboxamidation by reaction with isocyanates in CF3SO3H solution.

129 Mo(CO)6, were assembled to generate sulfonyl isocyanates in situ, and alcohols and aryl amines were e

130 cycloadditions with nitriles, cyanamides, or isocyanates in the presence of CpCo(CO)2 (Cp = cyclopent

131 e synthesized from a variety of epoxides and isocyanates, including some epoxides that do not undergo

132 chemistry (reaction of a bulky amine with an isocyanate), incorporation of the catalyst-free dynamic

133 Exposures to industrial isocyanates induce lacrimation, pain, airway irritation,

134 zation of hexyl isocyanate and 4-phenylbutyl isocyanate, initiated by an exo-norbornene functionalize

135 by attacking the central carbon atom of the isocyanate (interacting with the pi-system of the C hori

136 vealed that the reaction pathway through the isocyanate intermediate (E1cB) is energetically favored.

137 The isocyanate intermediate can be trapped by several nucleo

138 minocarbonylation pathway involving an imino-isocyanate intermediate is proposed and supported by DFT

139 dral intermediate, and stepwise involving an isocyanate intermediate.

140 unprecedented catalytic double insertion of isocyanates into the P-H bond of diphenylphosphine to yi

141 s pairs (FLPs) by the hydroboration of bulky isocyanates (iPr2) ArNCO ((iPr2) Ar=2,6-iPr2 C6 H3 ) and

142 nsequence of this delocalization is that the isocyanate is expected to remain linear upon reduction o

143 and that N-C bond formation in the bridging isocyanate is reversible.

144 p-Maleimidophenyl isocyanate is used as a heterobifunctional cross-linker

145 pyridin-2(1H)-ones 7 are prepared when tosyl isocyanate is used.

146 C(sp(2))-O and C(sp(3))-O electrophiles with isocyanates is described.

147 sition metal catalyzed hydrophosphination of isocyanates is presented.

148 clotrimerizations of alpha,omega-diynes with isocyanates, isothiocyanates, and carbon disulfide.

149 za-norbornene 1 and isoquinuclidene 2 add to isocyanates, isothiocyanates, and in situ-generated carb

150 imental rate coefficients of amines, amides, isocyanates, isothiocyanates, carbamates and thiocarbama

151 e moiety with different electrophiles (i.e., isocyanates, isothiocyanates, cyclic anhydrides, and acy

152 Fluorescein isocyanate-labelled dextran (FITC dextran; molecular mas

153 ycloaddition of terminal alkynes and alkenyl isocyanates leading to the formation of indolizidine and

154 nd formation with a typically inert terminal isocyanate ligand.

155 tion of a mu-oxo hafnocene with two terminal isocyanate ligands.

156 volving rate-determining C-C coupling of the isocyanate ligands.

157 deoxygenation and N-C bond formation to form isocyanate ligands.

158 ith I(2) yielded the monomeric iodohafnocene isocyanate, Me(2)Si(eta(5)-C(5)Me(4))(eta(5)-C(5)H(3)-3-

159 Sequential formation of dimethylamino isocyanate (Me2N-NCO), 1,1-dimethyldiazene (Me2N horizon

160 , and the gamma-lactam 7g via chlorosulfonyl isocyanate-mediated cycloaddition.

161 A vapor-catalyzed, isocyanate-mediated surface immobilization scheme is use

162 Furthermore, the sulfilimine/isocyanate metathesis reaction with 4,4'-methylene diphe

163 ater-stable compound that reacts as a methyl isocyanate (MIC) substitute.

164 rials (e.g., polyisocyanates) made from this isocyanate might exhibit unique properties.

165 olymerization yielding well-controlled alpha-isocyanate modified polymers.

166 and demonstrated its ability to transfer the isocyanate moiety to alkyl radicals.

167 ssen rearrangement and regeneration of a new isocyanate molecule.

168 The isocyanate monomers were copolymerized at seven comonome

169 ng mechanical properties, avoidance of toxic isocyanate monomers, and catalyst-free repair processes.

170 Nitrogen-substituted isocyanates (N-isocyanates) are rare amphoteric reagents

171 er isocyanates such as (iPr2) ArNCO leads to isocyanate-N/B FLP adducts, hydroboration of the bulkier

172 iazoimidazole-4-carbonitrile (28) and methyl isocyanate or by diazotization of 5-amino-1-(N-methylcar

173 idazole-4-carboxamide (13) and either methyl isocyanate or N-methylcarbamoyl chloride.

174 ntally friendly photoreaction between phenyl isocyanate or pentafluorophenyl isocyanate and polyfluor

175 ous (pseudo)halides (trimethylsilyl azide or isocyanate or potassium azide, cyanate, and bromide) to

176 the isolation of the initially formed labile isocyanates or their subsequent conversion to stable car

177 h efficiencies with modules having a ketone, isocyanate, or active ester and alkyne function, respect

178 temperature sodium metal reduction of phenyl isocyanate (PhNCO) in hexamethylphosphoramide yields the

179 The attachment chemistry is a protected isocyanate (PI) group.

180 reagent pair, (12)C(6)- and (13)C(6)-phenyl isocyanate (PIC), that offers significant advantages ove

181 The release of the isocyanate precursor in model hydrolysis experiments was

182 is of a small set of beta-lactams containing isocyanate precursors is described.

183 on of N-isocyanates using blocked (masked) N-isocyanate precursors: the effect of the masking group a

184 addition reaction of 2 with the appropriate isocyanate produced an initial series of compounds (3-6)

185 tal terminal oxo complex with release of the isocyanate product.

186 Moreover, the isocyanate products can be readily converted to substitu

187 conversions with ferrocene carboxylic acids, isocyanates provide imides in good yields.

188 Reaction of compounds 5 and 6 with different isocyanates provided two series novel carbamates (7-12)

189 to ca. 40 kcal/mol for rearrangement to the isocyanates RCO-NCO.

190 enzymatic kinetic resolution and cyanate-to-isocyanate rearrangement as key steps.

191 key step is stereospecific allyl cyanate-to-isocyanate rearrangement, which proceeds with chirality

192 The key step is allyl cyanate-to-isocyanate rearrangement.

193 ustering revealed that protein allergen- and isocyanate-related asthma had similar profiles, whereas

194 = CH3, X = OC6H4NO2-p), which cannot form an isocyanate, releases nitrophenol almost as rapidly (kobs

195 utylisocyanate and 3,4,5-tridodecyloxyphenyl isocyanate, respectively.

196 ally, reaction of an amine with the produced isocyanate resulted in urea.

197 Using an isocyanate scavenging resin, the photodecay product coul

198 allylamines via stereocontrolled cyanate-to-isocyanate sigmatropic rearrangement reactions of the co

199 In both cases, a new isocyanate species ClF(2)CNCO was produced and character

200 While hydroboration of smaller isocyanates such as (iPr2) ArNCO leads to isocyanate-N/B

201 alkyl carbamoylimidazoles and serve as alkyl isocyanate surrogates.

202 cyanate and subsequent derivatization of the isocyanate-terminated polymeric intermediate with methyl

203 Isocyanates that bear an electron-withdrawing group reac

204 an reversibly dissociate to bulky amines and isocyanates, the latter of which can be further hydrolyz

205 mply mixing multifunctional bulky amines and isocyanates, the versatility of the structures, and the

206 rimethylol-tris-3-mercaptopropionate, at 1:2 isocyanate:thiol.

207 cle has been developed for the production of isocyanates through the molecular fixation of N2 , CO2 a

208 ion of an allylic silane with chlorosulfonyl isocyanate to assemble the bicyclic core of the alkaloid

209 itional N-C bond formation with the terminal isocyanate to form bridging ureate-type ligands.

210 trated by their reaction with n-octadecane-1-isocyanate to form PMMA surfaces terminated with well-or

211 inserts CO(2) and eliminates trimethylsilyl isocyanate to give [(BDI-2)Zn(mu-OSiMe(3))](2).

212 e uniparticulate electrophile chlorosulfonyl isocyanate to the nitrogen atom of N-(alkoxycarbonyl)-2-

213 A regioselective addition of isocyanates to fluoroalkylated alpha,beta-unsaturated im

214 the cyclotrimerization of a wide variety of isocyanates to isocyanurates under mild conditions with

215 ted and Sambucus nigra tetramethyl rhodamine isocyanate (TRITC)-conjugated lectins.

216 oride upon thermolysis, or (N-ethoxycarbonyl)isocyanate upon treatment with tertiary amines.

217 rmed by the reaction of beta-amino azide and isocyanate) upon treatment with Bu3P or polymer-supporte

218 A catalytic hydroamidation of alkynes with isocyanates using alkyl bromides as hydride sources has

219 dazolones by Friedel-Crafts cyclization of N-isocyanates using blocked (masked) N-isocyanate precurso

220 rst synthetic method for preparing aliphatic isocyanates via direct C-H activation.

221 tius rearrangement and the resulting furanyl isocyanate was trapped with various organometallic reage

222 Isocyanates were also effective reactants, as exemplifie

223 roduce fused 2-pyridones, although aliphatic isocyanates were more reactive.

224 l anhydride for the in situ generation of an isocyanate, which reacts with an amine.

225 ion of an array of chiral nonracemic allylic isocyanates, which are versatile intermediates for the c

226 cific [2+2] cycloaddition of trichloroacetyl isocyanate with a d-glycal possessing a 3-benzyloxy grou

227 nes 4 are obtained by the reaction of phenyl isocyanate with fluorinated imines 1, while fluorinated

228 volved the condensation of p-maleimidophenyl isocyanate with mPEG has been optimized to generate a pr

229 s was successfully achieved by quenching the isocyanate with the lithium salts of the corresponding a

230 d by this observation, a one-pot reaction of isocyanates with amines 1, 2, and 3b followed by BF3.OEt

231 eports the first method for coupling of aryl isocyanates with the imidazo[1,2-a]pyridine system via a

232 By contrast, reaction with an isocyanate yielded a 1,4,2-diazaarsolidine-3,5-dionide a