ライフサイエンスコーパス: isocyanide

1 l iodide, dimethyl disulfide, and tert-butyl isocyanide.

2 f the oxo ligands, and the pi* orbital of CO/isocyanide.

3 he ordered water molecule to hydrate organic isocyanides.

4 monoxide, nitric oxide, and methyl and ethyl isocyanides.

5 leaving the R-NC bond in a series of organic isocyanides.

6 a multicomponent reaction with peptides and isocyanides.

7 des an efficient, direct synthesis of alkene isocyanides.

8 eaction of 4 and 3, respectively, with CO or isocyanides.

9 yzed reaction of thiocarboxylic acids 2 with isocyanides 3.

10 Isocyanide 5 and synthetic diastereomers 5a and 5c showe

11 3, arylglyoxals 4, amine 5 (or without), and isocyanide 6 produced the 2,3-dihydro-1H-2-benzazepin-1-

12 role in controlling the stereoselectivity of isocyanide addition, and the carboxylate group of l-prol

13 f the reaction was found to be determined by isocyanide addition, while the rate-limiting step was fo

14 l structure of the more sterically demanding isocyanide adduct, [Ni(CNCy)(PCy2NBz2)2]2(BF4)2, 4.

15 withC bond and enhanced reactivity of phenyl isocyanide adsorbed at the Pd step edge compared with th

16 to the carbene nucleus with various organic isocyanides afforded a new class of ketenimines in yield

17 eir reactions with phenylacetylene and xylyl isocyanide, affording in the case of each reagent two di

18 The reaction is also successful for other isocyanides, albeit with reduced enantioselectivity.

19 2 react rapidly with representative cyanide, isocyanide, alkyne, N 2, alkene, diazene, azide, CO 2, c

20 The apparent transfer of the isocyanide alpha-carbon to protic solvents as a formyl g

21 rvations in multicomponent reactions between isocyanides, alpha-amino acids, and monofunctional aldeh

22 propylphenylisocyanide)tantalum is the first isocyanide analogue of the highly unstable Ta(CO)6 and r

23 antalum complex, Ta(CNXyl)(5)NO, which is an isocyanide analogue of the unknown Ta(CO)(5)NO.

24 I, or cis-[M(CNXyl)(4)(NO)(2)](+), which are isocyanide analogues of the unknown carbonyl complexes [

25 situ Bronsted acid-catalyzed reaction of the isocyanide and aldehyde to yield an imine that participa

26 with tighter binding by the more hydrophobic isocyanides and 200-300-fold tighter binding to the ferr

27 e gold species for the aldol condensation of isocyanides and aldehydes to form oxazolines.

28 Ru(H(2)IMes)(CH(i-PrOC(6)H(4)))Cl(2) by aryl isocyanides and small phosphites but only after initial

29 eaction between an aziridine aldehyde dimer, isocyanide, and l-proline to afford a chiral piperazinon

30 t reactions using a variety of beta-lactams, isocyanides, and amines.

31 mponent reaction that combines aryl halides, isocyanides, and diamines provides access to 2-aryl-2-im

32 ituted complexes by carbon monoxide and aryl isocyanides, and for the phosphine-free Hoveyda-Blechert

33 c aldehydes, primary amines, propiolic acid, isocyanides, and hydrazides has been developed in order

34 ree-component reaction among Z-chlorooximes, isocyanides, and hydroxylamines by exploiting the prefer

35 ticomponent reaction of 3-carbonylchromones, isocyanides, and nonsymmetric dienophiles.

36 rini three-component reactions of aldehydes, isocyanides, and strong carboxylic acids (i.e., pK(a) <

37 e report a three-component reaction in which isocyanides are able to open the epoxide intermediate of

38 The intermediate metalated isocyanides are efficiently trapped with electrophiles t

39 Isocyanides are exceptional building blocks, the wide de

40 The substituted isocyanides are ideally functionalized for elaboration i

41 r when it is treated with 2,6-dimethylphenyl isocyanide (ArNC), leading to the corresponding isothioc

42 t 3 nm resolution in real space using phenyl isocyanide as a probe molecule (Fig.

43 t 3 nm resolution in real space using phenyl isocyanide as a probe molecule.

44 tric assay for ICH activity using 2-naphthyl isocyanide as a substrate.

45 C that is trigonal bipyramidal with an axial isocyanide as demonstrated by X-ray crystallography.

46 c acids (alpha, beta, gamma), aldehydes, and isocyanides as reactants and alcohols as solvents, these

47 means of Ugi reactions incorporating lipidic isocyanides as surrogates of sphingolipids.

48 Complex 10 adds alkyl isocyanides as well as pivalonitrile at a lateral site a

49 An unusual Pd-catalyzed isocyanide assisted 5-exo-dig reductive cyclization of 1

50 Reactions of 2 and 3 with isocyanide at room temperature produced complexes 8-(CNB

51 These factors are similar to traditional isocyanide-based multicomponent reactions, such as the U

52 onally unstable in some synthetically useful isocyanide-based multicomponent reactions.

53 nd macrocyclization of peptides arising from isocyanide-based multicomponent reactions.

54 g step was found to deviate from traditional isocyanide-based multicomponent reactions.

55 an efficient activating agent for azines in isocyanide-based reactions, which then proceed through a

56 The heme ligand n-butyl isocyanide (BIC) was used to probe the mechanism of NO a

57 TIR spectroscopy for methyl through n-pentyl isocyanide bound to a series of 20 different distal pock

58 ructures of methyl, ethyl, propyl, and butyl isocyanide bound to sperm whale myoglobin (Mb) reveal tw

59 d exposure to the often toxic and malodorous isocyanide building blocks, the continuous approach was

60 of a dative bond to the surface through the isocyanide carbon.

61 e study has been carried out using different isocyanides, carboxylic acids, and phenols showing the s

62 d metal is observed to catalyze reactions of isocyanides (CN-R) with primary amines (H2N-R') and O2 t

63 hat are derivatives of 2,6-diisopropylphenyl isocyanide (CNdipp) have been developed; tungsten comple

64 The FTIR spectra for alkyl isocyanides (CNRs) change from a single nu(CN) band cent

65 Alkyl isocyanides (CNRs) identify pathways for diatomic ligand

66 p2))(2), which is the first stable monomeric isocyanide complex of zerovalent palladium.

67 but the components do not form a stable tris-isocyanide complex.

68 The ruthenium isocyanide complexes [PhBP(Ph)3]Ru(H)(CNXyl)(eta(2)-HSiH

69 prepared in two steps from the corresponding isocyanide complexes.

70 Isocyanides coordinate to both ferric and ferrous HO-bou

71 nd carbon monoxide and nitric oxide, but not isocyanide, cyanide, or azide.

72 R titrations of rHb (alphaH87G) with n-butyl isocyanide demonstrate the alpha-chains to be of high af

73 enching and removal of the catalyst using an isocyanide derivative afforded macrocyclic oligo(5-acety

74 l chlorides are proposed as stable and novel isocyanide dichloride synthetic equivalents.

75 olipid frameworks by condensation of lipidic isocyanides either with lipidic amines and oligosacchari

76 he oxidative coupling of bisnucleophiles and isocyanides, facilitating the further implementation of

77 ing opening of oxazolones by cupriomethylene isocyanides followed by sequential construction of two o

78 n ferulic (or lipoic acid), a melatonin-like isocyanide, formaldehyde, and tacrine derivatives, accor

79 clic compounds by integration of the in-line isocyanide formation and photochemical cyclization has b

80 Isocyanide (formerly isonitrile) hydratase (EC 4.2.1.103

81 d a novel oxidative coupling of diamines and isocyanides furnishing valuable guanidine-containing het

82 6)H(2)-2,4,6-(CH(3))(3))(2)] with tert-butyl isocyanide gave the Lewis adduct species (Ar(Me(6)))(2)G

83 sponding molecular junction terminated by an isocyanide group due to charge transport primarily throu

84 meta-terphenyl unit was substituted with an isocyanide group on each of its two terminal aryls to af

85 ylene]-5-oxazolones with activated methylene isocyanides has been reported.

86 Isocyanides have emerged as valuable C1 building blocks

87 The discovery of hydrogen isocyanide (HNC) in comet Hyakutake with an abundance (r

88 Here we report the detection of hydrogen isocyanide (HNC) in comet Hyakutake.

89 order to understand the structural basis for isocyanide hydratase (ICH) catalysis, we determined the

90 azine, followed by nucleophilic attack of an isocyanide in a Reissert-type process.

91 3-(tritylthio)propanoate as a novel class of isocyanide in MCR.

92 mmetric dialkylcarbodiimides from azides and isocyanides in a process involving the Nb(V)/Nb(III) red

93 In contrast, all four isocyanides in P6 crystals of wild-type recombinant Mb o

94 We have evaluated a range of functionalized isocyanides in the aziridine aldehyde-driven multicompon

95 l acetoacetate with 1:1 acetylenecarboxylate-isocyanides in toluene.

96 to those of amine reactions with coordinated isocyanides in transition metal complexes.

97 nctionalized isocyanides refers to all those isocyanides in which a neighbouring functional group can

98 In this manuscript, we have reviewed all the isocyanides in which the pendant functional group causes

99 ing hydrogen peroxide (H2O2) using rhodamine isocyanide incorporated calcium phosphate nanoparticles

100 d with electrophiles to generate substituted isocyanides incorporating contiguous tri- and tetra-subs

101 o-(pseudo)halobenzoates and hydrazines with isocyanide insertion allowing straightforward access to

102 We also achieved the isocyanide insertion between C(sp(2))-H and oxygen heter

103 and further nickel-catalyzed intramolecular isocyanide insertion has also been demonstrated.

104 ization of 2H-indazole at C3-position via an isocyanide insertion strategy for the synthesis of unpre

105 nickel-catalyzed ligand-/base-free oxidative isocyanide insertion under aerobic conditions with intra

106 second equivalent of the same or a different isocyanide inserts into the N-Si bond leading to the fin

107 then proceed through a key insertion of the isocyanide into a N-Si bond.

108 amino acids, aziridine aldehyde dimers, and isocyanides into chiral piperazinones have been investig

109 es form a mixture of aminonitrene complexes, isocyanide iridium(III) dihydride complexes, and ammonia

110 2-Nitrophenyl isocyanide is introduced as a convertible isocyanide wit

111 rst conjugate addition/alkylation to alkenyl isocyanides is described, which addresses this deficienc

112 rdination networks using ditopic m-terphenyl isocyanides is described.

113 5-dimethylpyrazolyl)borate and L = neopentyl isocyanide, is used to investigate C-H bond activation i

114 omponent reaction with alpha-amino acids and isocyanides, is described.

115 ve examined the equilibrium binding of three isocyanides, isopropyl, n-butyl, and benzyl, to the two

116 col to the coupling of anthranilic acids and isocyanides leading to medicinally relevant 2-aminobenzo

117 rcaptoethyl)amine (NS3)) and the monodentate isocyanide ligand (CN-peptide).

118 pecies (Ar(Me(6)))(2)GeCNBu(t), in which the isocyanide ligand displays a decreased C-N stretching fr

119 se Au...Au contact despite the fact that the isocyanide ligand has less steric bulk.

120 reaction in which a nitrene fragment from an isocyanide ligand is exchanged with a nitrene fragment o

121 ively charged carbon atom of the carbonyl or isocyanide ligand, and illustrate a novel (non-hydrogen

122 The encumbering m-terphenyl isocyanide ligand, CNAr(Mes2) (Mes = 2,4,6-Me(3)C(6)H(2)

123 ermanium atom and the C-N pi* orbital of the isocyanide ligand.

124 by the formation of an unusual chelating di(isocyanide) ligand, which suggests that other metal cent

125 ein, we show that two sterically encumbering isocyanide ligands can destabilize the MnMn bond leading

126 es precedent for an ensemble of carbonyl and isocyanide ligands to function in a redox non-innocent m

127 Complex 2 reacts with Me3SiN3 to make the isocyanide ligated azide complex {(C5Me5)2La[CNN(SiMe3)2

128 ects are attributed to sigma-donation of the isocyanide lone pair electrons to the surface.

129 Cr(0) complexes with carbonyl or monodentate isocyanides, manifesting in comparatively slow photodegr

130 nditions and replacement of the nucleophilic isocyanide moiety with different electrophiles (i.e., is

131 ew structure with respect to a mixed cyanide/isocyanide monolayer and propose a bonding scheme consis

132 d scope in terms of its amine, aldehyde, and isocyanide nature.

133 irect attachment of an C(O)OSiR3 group to an isocyanide nitrogen atom.

134 olled, solid-state preparation of Cu(I) tris-isocyanide nodes with a labile solvent ligand in a manne

135 x = 2, 3) affords a family of mixed carbonyl-isocyanides of the type [Fe(2)(S(2)C(n)H(2n)(CO)x(CNMe)(

136 sent the first detailed mechanistic study of isocyanide oligomerization by a p-block element species.

137 udies show that the adsorption of tert-butyl isocyanide on the (100) surface of germanium, measured u

138 ion occurs by initial eta1-adsorption of the isocyanide on the Au surface, which activates the isocya

139 er cleavage strategy, (p-tolysulfonyl)methyl isocyanide or ethyl isocyanoacetate was employed to reac

140 Bis-isocyanide Pd(CNAr(Dipp2))(2) is active for oxidative ad

141 vides the isolable, two-coordinate Pd(0) bis-isocyanide, Pd(CNAr(Dipp2))(2), which is the first stabl

142 Isocyanides possess a rich history in the world of synth

143 during imine formation is indicative of new isocyanide reactivity.

144 Complex 1c mediates a catalytic isocyanide reductive coupling to furnish an alkene produ

145 The term functionalized isocyanides refers to all those isocyanides in which a n

146 holate dianion in the presence of cyclohexyl isocyanide results in the formation of [(o-(Ph2P)C6H4)3(

147 enyl isocyanides to rapidly assemble diverse isocyanide scaffolds.

148 These correlations indicate that alkyl isocyanides serve as transition state analogues for the

149 saturated substrates such as isocyanates and isocyanides, suggesting the intermediacy of a "normal" F

150 from the reaction of 1 and cyclopropylmethyl isocyanide supports the notion of a radical-based mechan

151 In the case of the Ugi reaction with benzyl isocyanide, the N-substituted tetrazoles can be easily d

152 Using benzyl isocyanide, the prepared N-benzyl tetrazoles can be depr

153 and steric interactions, and, for the longer isocyanides, the unfavorable hydrophobic effect of placi

154 A novel one-step addition of an isocyanide to a hydrazine derived Schiff base affords un

155 selectivities for the addition of tert-butyl isocyanide to a wide range of aldehydes (aromatic, heter

156 anide on the Au surface, which activates the isocyanide to attack by the amine.

157 ydrin adduct) can be trapped with tert-butyl isocyanide to form an alpha-hydroxy lactone with good se

158 Complex 4a reacts with n-butyl isocyanide to give the coordination product 6, which has

159 alyst-promoted proton transfer from hydrogen isocyanide to imine to generate diastereomeric iminium/c

160 reeing rotation of His64, causes bound butyl isocyanide to point completely outward in P6 crystals.

161 (H)L(iPr)Cr]2 reductively couples cyclohexyl isocyanide to produce various novel nitrogen heterocycle

162 as completely stopped by coordination of the isocyanide to the verdoheme intermediate rather than to

163 talytic, enantioselective alpha-additions of isocyanides to aldehydes has been demonstrated (Passerin

164 hydrogenation of nitroarenes, nitriles, and isocyanides to corresponding amines with excellent activ

165 sed to measure the binding parameters of the isocyanides to ferrous hHO-1.

166 nes by exploiting the preferential attack of isocyanides to nitrile N-oxides via a [3 + 1] cycloaddit

167 beta,beta-disubstituted arylsulfonyl alkenyl isocyanides to rapidly assemble diverse isocyanide scaff

168 Addition of L = carbon monoxide or aryl isocyanides to the Grubbs second-generation carbene comp

169 enzyme of the DJ-1 superfamily that hydrates isocyanides to yield the corresponding N-formamide.

170 CO and a hydrophobic cyanide analogue, butyl isocyanide, to dithionite-reduced b(6) f complex perturb

171 lino)-alpha-methoxy acetate with tosylmethyl isocyanide (TosMIC) reagent to give 1-(o-nitrophenyl)imi

172 single pot from aryl-substituted tosylmethyl isocyanide (TosMIC) reagents and imines generated in sit

173 erent surface-binding chemistries (thiol and isocyanide) under three different preparation conditions

174 Ar(Dipp2) revealed that free and coordinated isocyanide undergo rapid exchange, but the components do

175 The products include imide, isocyanide, vinyl, alkyl, azide, triazenido, benzo[ c]ci

176 ns, particularly the rate of addition of the isocyanide was found to be crucial for good yields and h

177 This bifunctional isocyanide was found to undergo mild cyclodehydration to

178 High diasteroselectivity for each isocyanide was observed.

179 ady-state activity assays showed that benzyl isocyanide was the most potent uncompetitive inhibitor w

180 Benzyl isocyanide was the strongest ligand to ferrous heme in a

181 The cyclization of allenoates with activated isocyanides was reported for the first time.

182 To illustrate the broader applicability of isocyanides, we have recently developed a novel oxidativ

183 Substituted tosylmethyl isocyanides were found to be the key intermediates in co

184 yl imidazolylidene (NHC) does not react with isocyanides, whereas anti-Bredt di(amino)carbene (pyr-NH

185 yl isocyanide is introduced as a convertible isocyanide with demonstration of its feasibility and app

186 and copper complexes with phenanthroline and isocyanides with almost millesecond emission lifetimes t

187 The radical fluoroalkylation of isocyanides with fluorinated sulfones is enabled by visi

188 iphatic, dipeptidic, glucosidic, and lipidic isocyanides with several amino acids, thus giving access

189 bstituted oxazolones and activated methylene isocyanides, yielding bisoxazoles with three potential p

190 -2H-chromen-2-ones with acetylenecarboxylate-isocyanide zwitterionic intermediates through Michael ad