ライフサイエンスコーパス: isoenzyme

1 lfotranserases exist in mammals (up to seven isoenzymes).

2 that modulates the activity of MAT2A-encoded isoenzyme.

3 that modulates the activity of MAT2A-encoded isoenzyme.

4 inhibitors specific for the cyclooxygenase 2 isoenzyme.

5 de substrates were tested against each human isoenzyme.

6 N-1-methylheptylformamide inhibitor in this isoenzyme.

7 d not reduce the expression of any other PKC isoenzyme.

8 vity appear to be more dependent on the PLD2 isoenzyme.

9 ich had become fully dependent on the second isoenzyme.

10 ructure-activity relationships for each ALDH isoenzyme.

11 que and overlapping functions of the ALDH1/2 isoenzymes.

12 daidzin for selectivity against five ALDH1/2 isoenzymes.

13 specific pyruvate dehydrogenase kinase (PDK) isoenzymes.

14 failed to detect heterodimerization of these isoenzymes.

15 ween the beta(1)beta(1) and gamma(2)gamma(2) isoenzymes.

16 te preferences shown by these highly related isoenzymes.

17 ve inhibition of human alcohol dehydrogenase isoenzymes.

18 the tissue-specific expression of these two isoenzymes.

19 e amino acids have the same function in both isoenzymes.

20 substrate specificities and are, therefore, isoenzymes.

21 gesting a differential induction of distinct isoenzymes.

22 uggesting functional cooperation between the isoenzymes.

23 eta-hydroxysteroid dehydrogenase (17betaHSD) isoenzymes.

24 r human ALDH1A1 compared to eight other ALDH isoenzymes.

25 l as the alpha- and the gamma-subunit of NSE isoenzymes.

26 ynthesis, were transfected with human Has1-3 isoenzymes.

27 gulate all three nrd operons that encode RNR isoenzymes.

28 Plants commonly contain two AMADH isoenzymes.

29 12-fold selectivity for NEU2 over all other isoenzymes.

30 rkers as well as serum lactate dehydrogenase isoenzyme 1 (S-LD-1) may have value.

31 da parapsilosis-secreted aspartyl proteinase isoenzyme 1 (SAPP1) in virulence.

32 e solid tumors, the role of subtilisin-kexin isoenzyme-1 (SKI-1) in this context is unknown.

33 eased expression of steroid-5alpha-reductase isoenzyme-1 (SRD5A1) over SRD5A2, which is otherwise the

34 tumor markers, such as lactate dehydrogenase isoenzyme-1, may provide a greater risk stratification.

35 rt hairpin (sh) sequences for inhibiting PHD isoenzyme 2 and FIH were inserted into novel, nonviral,

36 (HIF), a potent governor of metabolism, with isoenzyme 2 being the main regulator.

37 ut not azithromycin, inhibit cytochrome P450 isoenzyme 3A4 (CYP3A4), and inhibition increases blood c

38 which have not been previously reported for isoenzyme A.

39 serum levels of creatine kinase muscle-brain isoenzyme, a myocardial-specific injury marker, and an i

40 Three isoenzymes (isoenzyme A1, A2 and B) were obtained upon ammonium sulf

41 pH optimum for enzyme activity was 4.98 for isoenzymes A1 and A2, and 5.8 for isoenzyme B.

42 The isoenzymes A1 and B had optimum temperature at 30 degree

43 analog of CCF642 defined binding to the PDI isoenzymes A1, A3, and A4 in MM cells.

44 rature at 30 degrees C in both years whereas isoenzyme A2 had maximum activity at 40 degrees C in 200

45 activators of the hyc-encoded hydrogenase 3 isoenzyme) activated hyf-lacZ.

46 three lines of evidence that the thioredoxin isoenzymes actually have redundant activities as antioxi

47 absolute protein expression level of an ADH isoenzyme, ADH1C1, in human liver.

48 ntial inhibition of hepatic cytochrome P-450 isoenzymes, affect CY metabolism and conditioning-relate

49 Akt isoenzymes (Akt1-3) are downstream of IRK and are activa

50 Moreover, the isoenzyme aldolase C [also known as zebrin II (ZII)] is

51 al analogues of the DMSO reductase family of isoenzymes allows mechanistic examination of the minimal

52 stained activation of protein kinase C (PKC) isoenzymes alpha and betaII leads to their translocation

53 sensitivity to MSA with Ca(2+)-dependent PKC isoenzymes (alpha, beta, and gamma) being the most susce

54 the selective translocation of classical PKC isoenzymes, alpha and betaII, to a juxtanuclear compartm

55 iological conditions, we have cloned rat ALT isoenzyme ALT1 and ALT2 complementary DNAs (cDNAs), exam

56 Isoenzyme analysis of cultured parasites is the conventi

57 logic approach (in vitro culture followed by isoenzyme analysis).

58 A content, species-specific surface markers, isoenzyme analysis, and karyotyping indicate that they a

59 n that contained each of the three described isoenzymes and 69 extended-spectrum beta-lactamase-produ

60 cells or HEK293 cells did not express any AP isoenzymes and did not display any NAADP 2'-phosphatase

61 ride is the first drug that can inhibit both isoenzymes and is soon to be available.

62 inhibit PG synthesis via COX-1 and/or COX-2 isoenzymes and may inhibit periodontal destruction.

63 xhibit brain-regional alterations in 5alphaR isoenzymes and neuroactive steroid levels; then, we asse

64 tudy provides evidence that in human TB, NOS isoenzymes and NO are present in specialized areas of th

65 a suppresses the activity of specific CYP450 isoenzymes and that this correlates with discrete toxici

66 causes of differences between catalytic GST isoenzymes and the effects of mutations and genetic poly

67 of help to determine the roles of different isoenzymes and the mining of genes involved in light res

68 We evaluated the roles of specific HDAC isoenzymes and their inhibition on both ER and PR signal

69 or proteins that recognize individual kinase isoenzymes and their state of activation.

70 rapid and accurate method to detect all KPC isoenzymes and was useful in documenting the presence an

71 Immunoblot, isoenzyme, and RT-PCR analyses indicate that AtGLR1.1 re

72 rly the promitogenic and prosurvival epsilon isoenzyme, and this inactivation causes growth inhibitio

73 A comparative analysis of the AOX isoenzymes AOX1A, AOX1C, and AOX1D from Arabidopsis (Ara

74 As such, the cytosolic AAT2 isoenzyme appears to serve a nonredundant function in pl

75 All isoenzymes are active in vitro, while some may be ineffi

76 s that the intracellular distribution of PKD isoenzymes are distinct, and suggests that their signali

77 Multiple PI3K and Akt isoenzymes are found in hepatocytes and whether isoform-

78 ased phosphorylated PKC, we suggest that PKC isoenzymes are involved in the neuroprotective action of

79 Phospholipase C-beta (PLC-beta) isoenzymes are key effectors in G protein-coupled signal

80 Two ALT isoenzymes are known to exist, but only one ALT gene has

81 pear in gene families, and the corresponding isoenzymes are located to the thylakoid lumen of chlorop

82 These isoenzymes are potential targets for anticancer therapy.

83 there differences in tissue expression of HO isoenzymes are unanswered questions?

84 a variant in PLA2G2A encoding the sPLA2-IIA isoenzyme, as an instrumental variable.

85 f and variation between all the isoforms and isoenzymes, as well as covarying results with the conven

86 2-kinase/fructose-2,6-biphosphatase (PFKFB2) isoenzyme at Ser-483.

87 s 4.98 for isoenzymes A1 and A2, and 5.8 for isoenzyme B.

88 isoenzymes, including glycogen phosphorylase isoenzyme BB (GPBB).

89 homodimerization of PLC-beta3 and PLC-beta1 isoenzymes but failed to detect heterodimerization of th

90 states are essentially the same for the two isoenzymes, but the S states are quite different, indica

91 s yeast's entire complement of 26 glycolytic isoenzymes by any alternative, functional glycolytic pat

92 ond dynamics of horseradish peroxidase (HRP) isoenzyme C in the free form and when ligated to a varie

93 catalytic alpha(I) subunit of the main C-P4H isoenzyme (C-P4H-I).

94 ne sulfation is mediated by one of two Golgi isoenzymes, called tyrosylprotein sulfotransferases (TPS

95 of the hemA gene, which codes for one of two isoenzymes catalyzing 5-aminolevulinic acid synthesis.

96 essive stent expansion on creatine kinase-MB isoenzyme (CK-MB) release and clinical restenosis.

97 s concept is applied here to creatine kinase isoenzyme (CK-MB), a cardiac biomarker in ischemic condi

98 o high affinity and selectivity toward MAO-A isoenzyme, compared to clorgyline and moclobemide, with

99 le non GB accumulators have low-BAL-affinity isoenzymes containing Ile.

100 hanges in expression of specific PDK and PDP isoenzymes contribute to hyperphosphorylation and theref

101 ble mutants revealed that each AHAS and IPMS isoenzyme contributes to homeostasis rather than being f

102 To compare the properties of these isoenzymes, COS-1 cells, with minor endogenous hyalurona

103 d the inhibition of the cyclooxygenase (COX) isoenzymes, COX-1 and COX-2, affect memory function and

104 Leu at position 141 in the gamma(2)gamma(2) isoenzyme create an environment with stereoselectivity f

105 tly coordinated CRR1-dependent regulation of isoenzymes Cth1 and Crd1 reinforces the notion that copp

106 Many of these tumors express the isoenzyme cycloxygenase-2 (COX-2), which is involved in

107 tat (COBI; an inactivator of cytochrome P450 isoenzyme CYP3A without anti-HIV activity) and a new int

108 mma) being the most susceptible, followed by isoenzymes delta and epsilon.

109 te (S1P), produced by two sphingosine kinase isoenzymes, denoted SphK1 and SphK2, is the ligand for a

110 Two separate isoenzymes, designated IMPDH types I and II, contribute

111 The Sorghum bicolor beta-glucosidase isoenzyme Dhr1 has a strict specificity for its natural

112 The HYD4 isoenzyme did not substitute for HYD3 in H(2) production

113 In addition, ALT isoenzymes distribute differentially at the subcellular

114 e) upon binding to these human and mouse NAT isoenzymes driven by a proton transfer event.

115 Mammalian genomes encode 2 DUOX isoenzymes (DUOX1/DUOXA1 and DUOX2/DUOXA2).

116 hologic Q waves or creatine phosphokinase-MB isoenzyme elevation >8 x upper limits of normal) was red

117 Creatine kinase-MB isoenzyme elevation occurred in 25.6% of the PPCP group

118 of stress cardiomyopathy, including cardiac isoenzyme elevation, QTc interval prolongation, and rapi

119 atohepatitis in which the gene for the MAT1A isoenzyme encoding AdoMet synthetase has been disrupted,

120 Three isoenzymes, ES10, ES4 and ES3, account for more than 95%

121 The isoenzymes exhibited different kinetic properties.

122 PKC isoenzymes exhibited variable sensitivity to MSA with Ca

123 over SRD5A2, which is otherwise the dominant isoenzyme expressed in the prostate.

124 The latter population contains isoenzymes for each step of TG synthesis.

125 abolism, involving differential synthesis of isoenzymes for many oxidation and reduction reactions.

126 We show that all HAS isoenzymes form homomeric and also heteromeric complexes

127 LDH isoenzyme fractionation confirmed predominance of LD1 an

128 ione anion to CDNB in the wild-type M1-1 GST isoenzyme from rat and in three single point mutant (Tyr

129 Amadoriases I and II are deglycation isoenzymes from Aspergillus sp. of potential relevance f

130 Here, two isoenzymes from tomato (Solanum lycopersicum), SlAMADHs,

131 KI isoforms, indicate that individual PIP5KI isoenzymes fulfill specific roles in embryonic developme

132 opsis (Arabidopsis thaliana) cytosolic GAPDH isoenzymes GAPC1 and GAPC2 to cadmium-induced stress in

133 ts close homolog, the maize beta-glucosidase isoenzyme Glu1, which shares 72% sequence identity, hydr

134 quential enzymatic reaction performed by two isoenzyme groups, cyclooxygenases (COX-1 and COX-2) and

135 There are two main bacterial GS isoenzymes, GSI-alpha and GSI-beta.

136 Two distinct GPAT isoenzymes had been identified in mammalian tissues, an

137 additional knowledge also suggests that each isoenzyme has evolved different collagen sequence-prefer

138 nctions of individual protein kinase C (PKC) isoenzymes has emerged as an important goal in the study

139 More than 30 human P450 isoenzymes have been characterized, with at least nine p

140 itochondrial branched chain aminotransferase isoenzyme (hBCATm) must be stored in a reducing environm

141 t hCA I isoform, whereas the other cytosolic isoenzyme, hCA II, was strongly affected.

142 data imply a very high degree of Na,K-ATPase isoenzyme heterogeneity in zebrafish, with the potential

143 i, noted for encoding the fourth hydrogenase isoenzyme (HYD4), is not expressed at a significant leve

144 derivatives were tested against human (h) CA isoenzymes I and II (cytosolic, ubiquitous isoforms) and

145 Of the two DHP isoenzymes identified to date, much of the recent focus

146 we established stable transfectants of this isoenzyme in CaCo-2 cells.

147 espiration of overexpressing a cytosolic GS1 isoenzyme in leaf mesophyll cells of tobacco.

148 C-P4H-I is the major isoenzyme in most cells, and inactivation of its catalyt

149 e we show that ACAT1 is the major functional isoenzyme in the mouse brain.

150 nderstanding of the role of tannins and soil isoenzymes in decomposition.

151 tes mellitus, but the role of individual COX isoenzymes in diabetic nephropathy remains unknown.

152 ported example is the loss of one of the two isoenzymes in glioblastoma cancer cells such that the us

153 ractions are those involving cytochrome P450 isoenzymes in hepatic metabolism.

154 endent dioxygenase family and comprise three isoenzymes in humans: TETs 1-3.

155 The potential diagnostic value of ALT isoenzymes in liver disease was evaluated in an obese an

156 This early increase in isoenzymes in nonkeratinized OCP epithelia is reduced as

157 egarding distinct functions for specific PPO isoenzymes in plants.

158 sing data from a study of the inheritance of isoenzymes in selfed progeny of octoploid strawberry cul

159 Here we report multiple CK isoenzymes in the diploid channel catfish (Ictalurus pun

160 The presence of GalNAc-T isoenzymes in the human corneal and conjunctival epithel

161 vessel formation, the role of individual PKC isoenzymes in these events is not defined.

162 e selectivity toward one of the five ALDH1/2 isoenzymes, including compound 36, a selective inhibitor

163 ted by several hepatic cytochrome P450 (CYP) isoenzymes, including CYP1A2.

164 of glycogen metabolism and consists of three isoenzymes, including glycogen phosphorylase isoenzyme B

165 l classes of drugs are known to affect IMPDH isoenzymes, including nucleotide and NAD analogs, sugges

166 sPLA2 activity encompasses several sPLA2 isoenzymes, including sPLA2-V.

167 In the absence of ATP, each isoenzyme increased actin's final anisotropy cooperative

168 n of enzyme subunits and weak association of isoenzymes independently catalyzing the same reaction.

169 ared, the true benefits of additional type 1 isoenzyme inhibition are unknown.

170 In addition, dual isoenzyme inhibition will soon be available.

171 BI-1 (BMP-1 isoenzyme inhibitor-1), a selective inhibitor of a small

172 ompound 8 showed remarkable HDAC 1, 2, and 6 isoenzymes inhibitory activities with IC(50) values of 1

173 glutathione S-transferases (GSTs), phase II isoenzymes involved in cellular detoxification, on risk

174 by sphingosine kinase (SK), of which the SK1 isoenzyme is activated by tumor necrosis alpha (TNF-alph

175 The AK2 isoenzyme is expressed in the mitochondrial intermembran

176 hough metabolism mediated by cytochrome P450 isoenzymes is known to play a major part in the biotrans

177 When a mixture of isoenzymes is present, S1A1 is dominant in its effects o

178 The hypoxia inducibility of the C-P4H isoenzymes is thus likely to ensure sufficient C-P4H act

179 One of these, a phospholipase A2 isoenzyme, is capable of releasing a number of the fatty

180 Three isoenzymes (isoenzyme A1, A2 and B) were obtained upon a

181 activity of PKM2, the major pyruvate kinase isoenzyme known to regulate cellular glutathione levels.

182 amplicon was designed so that the genes for isoenzymes KPC-1, -2, and -3 could be easily distinguish

183 otted protein ubiquitin C-terminal hydrolase isoenzyme L1 (UCH-L1) and have therefore been able to qu

184 ound that CCR5 2-18 is sulfated by both TPST isoenzymes leading to a final product with four sulfotyr

185 PMI was defined as creatine kinase-MB isoenzyme level > or = 10x upper limit of normal at 24 h

186 elevated troponin and creatine phosphokinase isoenzyme levels with mortality and organ failure in sub

187 of the high active site homology of the hNEU isoenzymes, little progress in the design and synthesis

188 mics analysis, we identified pyruvate kinase isoenzyme M2 (PKM2), a critical regulator of glycolysis

189 The monoamine oxidase isoenzymes (MAOs) A and B play important roles in the ho

190 modulates the activity of the MAT2A-encoded isoenzyme MATII.

191 We propose that fungal NAT isoenzymes may have evolved to perform diverse functions

192 th the variable activities of human aldolase isoenzymes modulated LacD.1's affinity for substrate.

193 d tested them against the full panel of hNEU isoenzymes (NEU1, NEU2, NEU3, NEU4).

194 sbuvir is not metabolized by cytochrome P450 isoenzymes, nor does it induce or inhibit the metabolism

195 -reductase inhibitor, acting upon the type 2 isoenzyme of 5-alpha reductase.

196 ows the greatest selectivity for this unique isoenzyme of any of the formamide inhibitors.

197 decreased the levels of creatine kinase, MB isoenzyme of creatine kinase, blood urea nitrogen, creat

198 GFAT2 is, therefore, an isoenzyme of GFAT1, but its regulation by cAMP is the op

199 ilated in the chloroplast by a chloroplastic isoenzyme of glutamine synthetase (GS2), the predominant

200 c mass was developed using purified AGX2, an isoenzyme of human UDP-GlcNAc pyrophosphorylase.

201 The inducible isoenzyme of nitric oxide synthase (iNOS) generates nitr

202 The crystal structure of HPTP-B, a human isoenzyme of the low molecular weight phosphotyrosyl pho

203 Two isoenzymes of malate dehydrogenase (MDH) operate as comp

204 Conventional and novel isoenzymes of PKC are activated by the membrane-embedded

205 ber of a family of genes that includes three isoenzymes of prolyl 3-hydroxylase (P3H), P3H1, P3H2, an

206 uggest that humans express two mitochondrial isoenzymes of tafazzin that have similar transacylase ac

207 lus, identifying three groups of homologues: Isoenzymes of the first group are found in all species a

208 indicate that parasites express multiple APD isoenzymes of various functions that can now be specific

209 The roles of individual HDAC isoenzymes on ER and PR expression and their functions w

210 Among the three HAS isoenzymes, only HAS2 mRNA increased after O-GlcNAcylati

211 Inhibition of protein kinase C (PKC) isoenzymes or metalloproteinase inhibition by batimastat

212 fascinating question whether individual ADT isoenzymes (or combinations thereof) differentially modu

213 dized by two transhydrogenation cycles, i.e. isoenzyme pairs of dehydrogenases with different cofacto

214 nity of PKC, it specifically inactivates PKC isoenzymes, particularly the promitogenic and prosurviva

215 tochemical assessment of phosphodiesterase-5 isoenzyme (PDE-5) and PDE-2 expression, which are the ta

216 Sildenafil, a type 5 phosphodiesterase isoenzyme (PDE5) inhibitor with a short half-life, incre

217 activation of PKC, particularly prosurvival isoenzyme PKCepsilon, resulting in preconditioning again

218 ontaining proteins, such as protein kinase C isoenzymes (PKCs), have been identified as molecular tar

219 eta-hydroxysteroid dehydrogenase (3beta-HSD) isoenzymes play a key role in cellular steroid hormone s

220 cular weight complexes of PORB with its twin isoenzyme, PORA, as encountered with (Cys303-->Ala)-PORB

221 Rifampin (RIF) upregulates CYP 450 isoenzymes, potentially lowering efavirenz (EFV) exposur

222 We analyzed a tetrameric PPO isoenzyme (PPO-6) from dandelion (Taraxacum officinale)

223 In a proteinase survey, all BMP-1 isoenzymes processed human laminin-5 gamma2 and alpha3 c

224 NSR1 suggest that two sulfide dehydrogenase isoenzymes provide a compensatory NADPH-dependent S(0) r

225 The classical PKCbetaI and PKCbetaII isoenzymes provide a unique opportunity because they are

226 fer reactions for analogue complexes and for isoenzymes provided the catalytic sites are isostructura

227 ion structure of the second human LMW PTPase isoenzyme provides the opportunity to examine the struct

228 lot and quantitative PCR survey of the BMP-1 isoenzymes revealed expression of mTLD in primary kerati

229 rioration, preangiography creatine kinase-MB isoenzyme rise >2 x normal, and time interval between pr

230 and the myosin head (S1) was separated into isoenzymes S1A1 and S1A2 by ion-exchange chromatography.

231 The two major forms of phospholipase A(2) isoenzymes, secretory phospholipase A(2) and cytosolic p

232 Isoenzyme-selective cAMP agonists and peptide disruptors

233 recently published by developing a class of isoenzyme-selective inhibitors using similar indole-2,3-

234 We have investigated the PKC isoenzyme selectivity for activation of two mammalian PL

235 4), showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.

236 -strands of EC domains, suggesting that each isoenzyme serves a different function.

237 s increased in MCK-PPARbeta/delta muscle, an isoenzyme shift that diverts pyruvate into the mitochond

238 However, we suggest that LDH isoenzymes should be studied in further research.

239 he present studies we demonstrate that these isoenzymes show high GPx activity toward phospholipid hy

240 emical reactions, many hundreds of metabolic isoenzymes show significant and tumor-specific expressio

241 uman pyruvate dehydrogenase complex, has two isoenzymes, somatic cell-specific PDH1 and testis-specif

242 c steatosis and provide evidence that an ALT isoenzyme-specific assay may have more diagnostic value

243 Our data indicate PI3K-C2gamma supports an isoenzyme-specific forking of insulin-mediated signal tr

244 Elucidation of isoenzyme-specific functions of individual protein kinas

245 SK1-I (BML-258), as a potent, water-soluble, isoenzyme-specific inhibitor of SphK1.

246 e basis for rational approach to design ALDH isoenzyme-specific inhibitors as research tools and perh

247 Isoenzyme-specific PKC inhibitors demonstrated that PKCe

248 n enzyme active site that is coupled with an isoenzyme-specific regulatory mechanism.

249 We used an isoenzyme-specific SphK1 inhibitor, SK1-I, to investigat

250 h can be distinguished by its sensitivity to isoenzyme-specific, substrate-competitive inhibitors.

251 103, differ from vorinostat in structure and isoenzyme specificity, and have shown activity against l

252 ipid mediator produced by sphingosine kinase isoenzymes (SphK1 and SphK2), regulates diverse cellular

253 h is produced by 2 sphingosine kinase (SphK) isoenzymes, SphK1 and SphK2, has been implicated in IgE-

254 e (S1P), is produced by 2 sphingosine kinase isoenzymes, SphK1 and SphK2.

255 , catalyzed by two sphingosine kinase (SphK) isoenzymes, SphK1 and SphK2.

256 metabolic redundancy given, for example, by isoenzymes, subcellular compartmentalization or the pres

257 useful for measurement of highly homologous isoenzymes such as ADHs where multiple signature peptide

258 Among several PKC isoenzymes tested, only PKCalpha and -delta were able to

259 two known articular chondrocyte-expressed TG isoenzymes (TG2) demonstrated that TG2 was essential for

260 However, the number of different isoenzymes that are expressed in the liver and their ret

261 e of localization for PKCalpha and PKCbetaII isoenzymes that arises with sustained stimulation of PKC

262 Sphingosine kinase 2 (SphK2), one of the isoenzymes that generates S1P, was associated with histo

263 to sphingosine kinase 1 (SphK1), one of the isoenzymes that generates the pro-survival lipid mediato

264 Interestingly, two human isoenzymes that play a special protective role, safeguar

265 is characterized by expression of glycolytic isoenzymes that play key roles in parasite metabolism.

266 Sphingosine kinase 1 (SphK1), one of the two isoenzymes that produce sphingosine-1-phosphate, is up-r

267 bstrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) an

268 ugh there may be contributions by both major isoenzymes, the effects on viral infectivity appear to b

269 uences indicates that plants have two ALDH10 isoenzymes: those known to be GB accumulators have a hig

270 man thymidine kinase-1 and the mitochondrial isoenzyme thymidine kinase-2, the highest phosphorylatio

271 The hydrolysis requires myrosinase isoenzyme to be present in sufficient activity; however,

272 h its proposed function in targeting the PKA isoenzyme to organelles rich in PBR, i.e. mitochondria,

273 hese data indicate a general tendency of HAS isoenzymes to form both homomeric and heteromeric comple

274 Finally, inhibiting the transketolase isoenzyme transketolase-like 1 (TKTL1) by siRNA reversed

275 Elevated serum levels of creatine kinase (MB isoenzyme), troponin I, and troponin T, usually in the p

276 cells, potential interactions among the HAS isoenzymes using fluorescence resonance energy transfer

277 quantify ProGRP, NSE, and their isoform and isoenzyme variants, respectively.

278 The sixth isoenzyme was a novel carboxylesterase and its complete

279 The GalNAc-T4 isoenzyme was found in the apical cell layers, whereas G

280 Each isoenzyme was identified by mass spectrometry of its try

281 Expression of AP isoenzymes was analyzed in HeLa cells.

282 ysiological affect of these mutations in AAT isoenzymes was determined by measuring growth and amino

283 ional (PKCbetaII) and novel (PKCepsilon) PKC isoenzymes were also observed which were synchronous wit

284 In contrast, creatine kinase isoenzymes were not significantly different between pati

285 However, both isoenzymes were required for efficient TNF-alpha secreti

286 gainst the GalNAc-T1, -T2, -T3, -T4, and -T6 isoenzymes, were used for immunofluorescence microscopic

287 of functionally distinct but highly similar isoenzymes which are >70% identical.

288 In plants, PPOs often occur as families of isoenzymes which are differentially expressed, but littl

289 ermined by serine palmitoyltransferase (SPT) isoenzymes, which are trimeric proteins composed of two

290 edly reduced hyaluronan synthesis by all HAS isoenzymes while raising its concentration from 5 to 25

291 ny one of the six different carboxylesterase isoenzymes will regulate the metabolism of retinyl palmi

292 be GB accumulators have a high-BAL-affinity isoenzyme with Ala or cysteine in this critical position

293 or rottlerin (3 microM) or knockdown of this isoenzyme with specific siRNA oligonucleotides blocked p

294 s with CaM is supported by pull-down of both isoenzymes with CaM-Sepharose beads from 1321N1 cell lys

295 CHS3 and CHS8, which encode chitin synthase isoenzymes with different biochemical properties and phy

296 rgeting multiple forms of phospholipase A(2) isoenzymes with DNA antisense oligomers.

297 d isolated and cloned the genes encoding the isoenzymes with plastidic localization: NbAsp5 and NbPAT

298 Surprisingly, the Sdh3p subunit can form SDH isoenzymes with Sdh4p or with Shh4p as well as be a subu

299 Therefore, we analyzed the different AOX isoenzymes with the aim to identify differences in their

300 s and nonsynonymous/synonymous rates for Pr1 isoenzymes within a lineage and between lineages showed