ライフサイエンスコーパス: isoflavonoid

1 e of dietary Se and as an upgraded source of isoflavonoids.

2 ors of ecologically important flavonoids and isoflavonoids.

3 opanoid pathway that produces flavonoids and isoflavonoids.

4 the various important bioactive lignans and isoflavonoids.

5 iogenetic relationships between the modified isoflavonoids 1-11 are proposed, and a cyclization react

6 Isoflavonoids 26-28 showed moderate (IC50 7-30 microM) b

7 methylation that converts the pterocarpanoid isoflavonoid 6a-hydroxymaackiain to pisatin.

8 vestigate the role of the small intestine in isoflavonoid absorption and metabolism in humans.

9 Isoflavonoid absorption from the gut requires deconjugat

10 ere fed a single soy meal containing 64.8 mg isoflavonoid aglycone equivalents (95% as glucosides).

11 Chyme contained 36.7% of ingested isoflavonoid aglycone equivalents, primarily (95.8%) as

12 To determine the contents of these isoflavonoids, an efficient analytical LC-MS (TOF) techn

13 ption was assessed indirectly by quantifying isoflavonoids and several metabolites in 24-h urine pool

14 Extracts rich in prenylated isoflavonoids and stilbenoids showed potent antibacteria

15 In flavonoid, isoflavonoid, and anthocyanin biosynthesis, chalcone iso

16 edicago truncatula) glycosylates flavonoids, isoflavonoids, and triterpenes.

17 asmid to increase anti-tumor efficacy of the isoflavonoid apigenin (APG) in human malignant neuroblas

18 Isoflavonoids are a class of phenylpropanoids made by le

19 Isoflavonoids are a group of secondary metabolites commo

20 In soybean, isoflavonoids are a key rhizodeposit component that aid

21 Isoflavonoids are commonly found in leguminous plants, w

22 ds, whereas the isoflavone reductase-derived isoflavonoids are mainly restricted to the Fabaceae, it

23 Flavonoids and isoflavonoids are major plant secondary metabolites that

24 Isoflavonoids are thought to play an important role in s

25 s consistent with the physiological roles of isoflavonoids as defense compounds against pathogens and

26 transcription factors involved in regulating isoflavonoid biosynthesis in Lotus (Lotus japonicus).

27 ct O-methyltransferases (OMTs) implicated in isoflavonoid biosynthesis in Medicago species, a 7-OMT m

28 Isoflavonoid biosynthesis was silenced via RNA interfere

29 nzyme catalyzing the first committed step of isoflavonoid biosynthesis, various chalcone substrates a

30 Our aim is to understand the regulation of isoflavonoid biosynthesis.

31 o the main subgroup 2 have roles in inducing isoflavonoid biosynthesis.

32 to P. sojae; furthermore, the expression of isoflavonoid biosynthetic genes was drastically reduced

33 ytoalexin in alfalfa, is synthesized via the isoflavonoid branch of phenylpropanoid metabolism.

34 arpus, were investigated for inducibility of isoflavonoids by germination with or without subsequent

35 Isoflavonoid compositions, phenylalanine ammonia lyase (

36 None of the 3 isoflavonoid compounds administered orally affected live

37 Puerarin, daidzin, and daidzein are 3 major isoflavonoid compounds isolated from Pueraria lobata, an

38 romyces cerevisiae) to produce flavonoid and isoflavonoid compounds.

39 made by legumes, and consumption of dietary isoflavonoids confers benefits to human health.

40 of Rhizopus onto the seedlings increased the isoflavonoid content considerably (in the range of 0.5-3

41 ect against oxidative stress due to its high isoflavonoid content.

42 Exposure to the isoflavonoid coumestrol increased beta-glucuronidase act

43 HPLC analysis of isoflavonoid-derived metabolites of the phenylpropanoid

44 e 3-O-methylation of the 6a-hydroxymaackiain isoflavonoid-derived pterocarpanoid intermediate found i

45 tocopherol, polyunsaturated fatty acids, and isoflavonoids did not differ significantly between dieta

46 ld be normalized to the aglycone mass (or an isoflavonoid equivalent) rather than a simple sum of all

47 > glycitein > genistein) and the quantity of isoflavonoid equivalents were not significantly differen

48 d of each treatment period was analyzed for isoflavonoid (equol, O-desmethylangolensin, genistein, a

49 protection has not been determined, urinary isoflavonoid excretion appears linear at low-to-moderate

50 oducts, and a dose-response study of urinary isoflavonoid excretion at the low end of soy consumption

51 in previous studies--and to compare urinary isoflavonoid excretion between equol excreters and nonex

52 purpose of our study was to measure urinary isoflavonoid excretion in response to daily consumption

53 Qualitative profiles (x +/- SEM) of isoflavonoid excretion in urine (daidzein > glycitein >

54 Our results indicate that urinary isoflavonoid excretion is dose dependent in humans at lo

55 careful design and interpretation of urinary isoflavonoid excretion studies, particularly bacterial m

56 there was a linear dose response of urinary isoflavonoid excretion to soy consumption that did not d

57 was a highly linear dose response of urinary isoflavonoid excretion to soy consumption, which did not

58 asurements, with adjustment for body weight, isoflavonoid exposure is 4-6 times higher in infants fed

59 eporter was also induced by the alfalfa root isoflavonoids formononetin and medicarpin but not by two

60 roots deficient for a subset of flavonoids, isoflavonoids (formononetin and biochanin A) and flavone

61 Genistein, a natural isoflavonoid found in soybean products, has been propose

62 molecule Bcl-2 inhibitor HA14-1 (HA) and the isoflavonoid genistein (GST) in human malignant neurobla

63 Among them, the soybean isoflavonoid genistein received much attention due to it

64 tro seed exudates and by the addition of the isoflavonoids genistein and daidzein.

65 Ileostomy subjects efficiently deglycosylate isoflavonoid glucosides in the small intestine and appea

66 Isoflavonoids had a small effect on bacterial community

67 Although soy isoflavonoids have a number of health-promoting benefits

68 utionary significance since both lignans and isoflavonoids have comparable plant defense properties,

69 In addition, flavonoids and isoflavonoids have direct but complex effects on human h

70 oid cases and 173 controls were analyzed for isoflavonoids (ie, daidzein, genistein, equol, and O-des

71 Genistein is a prominent isoflavonoid in soy products and has been proposed as th

72 array ultraviolet scanning to quantitate soy isoflavonoids in foods and in human plasma, urine, and b

73 Despite the importance of plant lignans and isoflavonoids in human health protection (e.g. for both

74 This observation suggests novel roles for isoflavonoids in nodulation.

75 ntial involvement of 2'- and 3'-hydroxylated isoflavonoids in pathogen defense and insect-induced res

76 lant by reducing the accumulation of alfalfa isoflavonoids in the bacterial cells.

77 The cytotoxic effect of isoflavonoids in the development of different forms of c

78 Metabolism of isoflavonoids in the upper gastrointestinal tract was ex

79 species that also produce B-ring methylated isoflavonoids in vivo.

80 Mutant strain I-1 was isolated by its isoflavonoid-inducible neomycin resistance following mut

81 c parameters for the 4'-O-methylation of the isoflavonoid intermediate 2,7,4'-trihydroxyisoflavanone

82 4'-O-Methylation of an isoflavonoid intermediate is a key reaction in the biosy

83 , the production of microbial metabolites of isoflavonoids is limited in ileostomy subjects.

84 Nematode infection had no effect on isoflavonoid levels.

85 ys, and Medicago-specific pathways including isoflavonoid, lignin and triterpene saponin biosynthesis

86 induction of phenylpropanoid, flavonoid and isoflavonoid metabolic pathway genes involved in the pro

87 avone reductase, a key branchpoint enzyme in isoflavonoid metabolism and primarily found in the Fabac

88 id pathway, suggest new pathways for complex isoflavonoid metabolism, and indicate differential mecha

89 ckpea (Cicer arietinum), 4'-O-methylation of isoflavonoid natural products occurs early in the biosyn

90 ty for the 4' and 7-hydroxyl moieties of the isoflavonoid nucleus.

91 The bioactive isoflavonoids of the Leguminosae often are methylated on

92 ochemical biosensor for studying the role of isoflavonoids on A549 lung adenocarcinoma cell line.

93 y the type, level, and specific influence of isoflavonoids on cells.

94 Compared to untreated sprouts, total isoflavonoid, PAL activity and antioxidant capacity show

95 empting to speculate that this branch of the isoflavonoid pathway arose via evolutionary divergence f

96 ts in increased induction of phenylpropanoid/isoflavonoid pathway gene transcripts after infection bu

97 ghlight the metabolic flexibility within the isoflavonoid pathway, suggest new pathways for complex i

98 nges in expression of confirmed genes of the isoflavonoid pathway.

99 es to endomembranes after elicitation of the isoflavonoid pathway.

100 bolic channeling at the entry point into the isoflavonoid pathway.

101 in vivo reconstruction of the flavonoid and isoflavonoid pathways in yeast provides a unique platfor

102 d enzymes in the general phenylpropanoid and isoflavonoid pathways.

103 scription rates of genes encoding enzymes of isoflavonoid phytoalexin biosynthesis and related pathwa

104 firm that daidzein is not an intermediate in isoflavonoid phytoalexin biosynthesis in alfalfa.

105 metabolic channeling at the entry point into isoflavonoid phytoalexin biosynthesis protects an unstab

106 l legume Medicago truncatula accumulated the isoflavonoid phytoalexin medicarpin in response to yeast

107 one in the biosynthesis of the antimicrobial isoflavonoid phytoalexin medicarpin.

108 ymbiosis), and in defense against pathogens (isoflavonoid phytoalexins).

109 he wide individual variation seen in urinary isoflavonoid phytoestrogen excretion, we conducted a ser

110 Isoflavonoids play important roles in plant defense and

111 Prenylated flavonoids and isoflavonoids possess antimicrobial activity against fun

112 oalexin medicarpin, coordinated increases in isoflavonoid precursors were only observed for YE and no

113 In this study, an isoflavonoid prenyltransferase gene, designated as LaPT1

114 However, only a few plant flavonoid and isoflavonoid prenyltransferase genes have been identifie

115 red high homologies with known flavonoid and isoflavonoid prenyltransferases.

116 ional domains similar to other flavonoid and isoflavonoid prenyltransferases; it has a predicted chlo

117 Pisatin is a fungistatic isoflavonoid produced by garden pea (Pisum sativum), a h

118 Germination alone poorly induced isoflavonoid production (in the range of 0.2-0.7 mg repr

119 The induction of isoflavonoid production in L. japonicus also involves th

120 ted during four days at 24 degrees C and the isoflavonoid profiles and concentrations evaluated by HP

121 of the product fed but increased the urinary isoflavonoid recovery, suggesting that fermentation incr

122 bstrates, are coordinately regulated with an isoflavonoid-specific gene and specifically activated by

123 The inducibility of different isoflavonoid subclasses in seedlings with Rhizopus varie

124 viously identified as showing preference for isoflavonoid substrates in vitro, was strongly up-regula

125 ic activity against a range of flavonoid and isoflavonoid substrates using a high-throughput HPLC ass

126 IOMT) in the biosynthesis of 4'-O-methylated isoflavonoids such as the phytoalexin medicarpin in vivo

127 nary excretion of daidzein, genistein, total isoflavonoids (TIFLs), and equol (measured by HPLC/photo

128 protein intake from 24-h recalls and urinary isoflavonoids were 0.72 (0.43, 0.96) for daidzein, 0.67

129 erence returned to baseline levels after the isoflavonoids were discontinued.

130 Urinary isoflavonoids were measured by isotope-dilution gas chro

131 action condition for the maximum recovery of isoflavonoids with high cyto-protective effect was optim