ライフサイエンスコーパス: isogenic

1 They are considered isogenic.

2 but the rhizobia compared were not otherwise isogenic.

3 diated genome editing, we created a panel of isogenic 22Rv1 prostate cancer cell lines representing a

4 By using isogenic A. baumannii mutants lacking expression of viru

5 ongoing survival of ABC cells, we developed isogenic ABC cells that differed solely with respect to

6 o characterize transcriptomes of time-staged isogenic and hybrid zygotes following fertilization.

7 Detailed behavioral studies on near-isogenic and knockout lines showed that SLI1 impairs phl

8 Notably, field tests with near-isogenic and transgenic lines confirmed that the japonic

9 it a bi-modal body-weight distribution, with isogenic animals randomly emerging as either normal or o

10 We grew isogenic Arabidopsis thaliana mutants with altered immun

11 Isogenic astrocytes from these mice showed activation no

12 , PMN recruitment to wounds infected with an isogenic AT-deficient S. aureus strain was unimpeded, ex

13 moter affect lifespan when expressed in a co-isogenic background.

14 the inorganic components of human cells with isogenic backgrounds in distinct states of cellular plur

15 anism for multiple phenotypes to arise in an isogenic bacterial population.

16 echanisms underlying phenotypic variation in isogenic bacterial populations remain poorly understood.

17 sters are phenotypic variants present within isogenic bacterial populations that exhibit extreme tole

18 eration backcrossing, and generated a nearly isogenic, blight-resistant 9311/Xa21 rice.

19 nts (epiHybrids), which we derived from near-isogenic but epigenetically divergent parents.

20 Supplementation of isogenic c-Rel-competent Treg cells from prediabetic NOD

21 ncy of the long reads in these aspects using isogenic C. elegans genome with no gap.

22 in MA high/low drinking mice, as well as in isogenic C57BL/6J mice that varied in their MA preferenc

23 tivity of TFs associated to mutant PIK3CA in isogenic cancer cell line models.

24 Starting from isogenic canola (Brassica napus) lines, epilines were ge

25 served significantly reduced survival of the isogenic carrier mutant compared to that of the parental

26 Elimination of pilus production in the isogenic carrier mutant decreased its ability to coloniz

27 Elimination of pilus in the isogenic carrier mutant increased the level of survival

28 ure for oncogenic KRAS derived from a murine isogenic cell line with a coexpression network derived b

29 l function by using genome editing to create isogenic cell lines followed by phenotypic characterizat

30 icacy of LINE-1 replication was increased in isogenic cell lines harboring inactivating mutations in

31 s, we performed a genome-wide RNAi screen in isogenic cell lines harboring wild-type or mutant PIK3CA

32 ively, and selectivities of >11.6 versus the isogenic cell lines transfected with and expressing func

33 more stable in KEAP1(+/+) than in KEAP1(-/-) isogenic cell lines, whereas NRF2 is dramatically stabil

34 utations using stably transfected, inducible isogenic cell lines.

35 .76-0.99) when using chromogenic staining in isogenic cell lines.

36 led by the GalNAc-T2 isoform both ex vivo in isogenic cell models and in vivo in mouse Galnt2 knockou

37 CR) genotyping technology to create scarless isogenic cell models of cancer variants in 1 month.

38 ariability in protein copy numbers across an isogenic cell population.

39 Isogenic cell populations possess heterogeneous gene exp

40 Using isogenic cells and a panel of colorectal and lung cell l

41 iency was markedly reduced (to 1-10%) in the isogenic cells deficient in Pol kappa, Pol iota or Pol z

42 Time lapse microscopy showed that isogenic cells express heterogeneous, dynamic levels of

43 I3K signalling by cancer-relevant mutations (isogenic cells expressing an oncomutant PI3Kalpha allele

44 the presence of lysozyme in comparison with isogenic cells expressing these genes individually.

45 significant phenotypic differentiation among isogenic cells frequently occurs, with the resulting het

46 Isogenic cells have different lengths of the early inter

47 synthase genes, suggesting that some of the isogenic cells in a population might produce autoinducer

48 The authors demonstrate that the majority of isogenic cells in bacterial populations survive lethal a

49 the PALB2 gene in HEK239 cells, resulting in isogenic cells representing all three genotypes for both

50 Isogenic cells show a large degree of variability in gro

51 Isogenic cells were analyzed by microarray, Western blot

52 conducted the replication experiments in the isogenic cells where individual translesion synthesis (T

53 creases were almost completely eliminated in isogenic cells with CASP3 gene ablation.

54 g and a higher frequency of fork collapse in isogenic cells, explaining their poorer proliferation ra

55 eens with multiple assay readouts in a human isogenic cellular model.

56 We used whole-genome sequencing of multiple isogenic chicken DT40 cell clones to precisely determine

57 To more fully examine these subjects, isogenic chimeric SK- and M-protein-containing GAS strai

58 of the Aprt gene at its endogenous locus in isogenic Chinese hamster ovary cell lines.

59 The ability of an isogenic ClfB-deficient mutant to adhere to AD corneocyt

60 Using isogenic, clonal cell lines with variable copy numbers o

61 An isogenic codY-null mutant of SM101 showed decreased leve

62 /eod1-2 mutants were already larger than the isogenic Col-0 wild type, but this phenotype was trigger

63 colorectal cancer progression, we used three isogenic colon cancer cell lines that differ only in KRA

64 r, we used precise gene targeting to produce isogenic colon cancer cell lines with a knockout/rescue

65 Isogenic colorectal cancer (CRC) cell lines with differe

66 utations and analyzed two different types of isogenic control and NRXN1 mutant neurons derived from t

67 ar profiling results show that NK603 and its isogenic control are not substantially equivalent.

68 press a long-acting analogue of GLP-1 or the isogenic control microbe which solely harbored the pNZ44

69 tal tract infection but, unlike a pathogenic isogenic control, is unable to elicit significant chroni

70 rived from one control individual and to the isogenic control.

71 -specific efflux pump (TetA) compared to the isogenic control.

72 ne editing of MECP2(R306C) cells to generate isogenic controls rescued HDAC3-FOXO-mediated impairment

73 odel of Rett syndrome are smaller than their isogenic controls.

74 esent in PGRN patient neurons as compared to isogenic controls.

75 (sprayed or unsprayed with Roundup) and the isogenic corn to reassess its substantial equivalence st

76 ssessed as 'substantially equivalent' to its isogenic counterpart by a nutrient composition analysis

77 metabolome differences between NK603 and its isogenic counterpart consisted of an increase in polyami

78 type C EN strain CN3758 were evaluated using isogenic cpb and cpe null mutants.

79 mall RNAs of cells and matched exosomes from isogenic CRC cell lines differing only in KRAS status.

80 In addition, we constructed isogenic csrA mutants in two widely used infectious B. b

81 Thus, the isogenic DC cell model provides a platform for therapeut

82 Here, we generate isogenic DC patient and disease allele-corrected intesti

83 In this study, we compared an isogenic deletion strain of S. pneumoniae TIGR4 in polya

84 se-dependent keratinocyte apoptosis than the isogenic Deltapvl mutant.

85 An isogenic derivative of hvKP1 (hvKP1Deltapeg-344) was con

86 An isogenic derivative of M1T1 strain MGAS5005 producing Ss

87 in restoration of capsule production in the isogenic derivative strain.

88 eriments involving inoculation of individual isogenic derivatives of NTHi strain 12, the parent strai

89 rt G1 phases load MCM much faster than their isogenic differentiated counterparts with long G1 phases

90 highly radiosensitive, in contrast to their isogenic differentiated progeny.

91 y of this improved approach, we generated an isogenic distribution of heteroplasmic cells with variab

92 DLC1-positive cancer cell line but not in an isogenic DLC1-negative cell line.

93 atin interactions, we established stable and isogenic Drosophila epilines that carry alternative epia

94 Populations of isogenic embryonic stem cells or clonal bacteria often e

95 s above those observed during challenge with isogenic empty vector controls.

96 are genome-wide methylation patterns between isogenic ESC and EGC lines to define epigenetic similari

97 Z in A/E pathogen virulence, we generated an isogenic espZ deletion strain (DeltaespZ) and correspond

98 An isogenic ETEC 1766a strain with a tleA mutation showed a

99 in naturally aneuploid isolates compared to isogenic euploid controls and found that 10-30% of ampli

100 n factors in developing mouse ES-DCs with an isogenic expression screen.

101 fluorescent protein (GFP)-expressing PAO1 or isogenic exsA mutants for 6 h ex vivo before bacterial t

102 A-seq) analysis of a wild-type strain and an isogenic fabT deletion mutant strain found that between

103 se FANCD2-dependent mechanisms, we generated isogenic FANCI-, FANCD2- and FANCI:FANCD2 double-null ce

104 ts in the linear sorting of a set of diverse isogenic female lines, unambiguously demonstrating the h

105 and virulence characteristics, and produced isogenic gene deletion mutants of important CA-MRSA viru

106 gnition and chemotropic interactions between isogenic germlings requires oscillation of the mitogen-a

107 Isogenic gonococcal mutants in which the lgt required fo

108 In summary, isogenic guinea pigs show promise as a model to investig

109 Strain 2 isogenic guinea pigs were inoculated with H1N1pdm09 infl

110 Here, we describe a study with isogenic guinea pigs, which would uniquely combine the a

111 Isogenic H pylori mutants were used to determine the rol

112 nstructed and characterized a large panel of isogenic H. pylori strains that differ primarily in the

113 resonance imaging also demonstrated that the isogenic H201R strain was significantly more virulent in

114 Using an isogenic HCT116 colon cancer model of oxaliplatin resist

115 Furthermore, an isogenic HDC-deficient L. reuteri mutant that was unable

116 of a proof-of-principle platform, which uses isogenic hESCs for functional evaluation of GWAS-identif

117 e, mice when compared with infection with an isogenic hla deletion mutant.

118 DM shared transcriptomic profiles with their isogenic HMDM counterparts while also revealing novel ma

119 since expression of lngA was up-regulated in isogenic hns and crp mutants.

120 Altered segregation ratios on near-isogenic host genotypes differing in the region carrying

121 s, response, and action in parental and near-isogenic Htg9.1 genotypes strongly implicate LsERF1 as t

122 measurements in poorly and highly metastatic isogenic human breast cancer lines.

123 oliferation and survival, we generated three isogenic human colorectal carcinoma cell line models in

124 Here, we created isogenic human ESCs (hESCs) with mutations in GWAS-ident

125 ar disease-associated mutations and in three isogenic human heart tissue and hiPSC-CM pairs showed gr

126 ong-QT syndrome and also supports the use of isogenic human induced pluripotent stem cell-derived car

127 We used an isogenic human mammary epithelial cell (HMEC) culture mo

128 roRNAs (miRNAs) in neurogenesis, we employed isogenic human RTT patient-derived induced pluripotent s

129 into oxidized chromatin we have established 'isogenic' human diploid cells in which PARP1 and/or PARP

130 geneity) leads to phenotypic diversity among isogenic individual cells.

131 Isogenic induced pluripotent stem cell lines showed grea

132 Through competition between otherwise isogenic intein-positive and intein-negative strains we

133 enesis of SNCA in these cells, generating an isogenic iPSC line with normalized SNCA gene dosage.

134 report comparative genomic analysis of nine isogenic iPSC lines generated using three reprogramming

135 301L mutation and generated P301L:Deltap35KI isogenic iPSC lines using CRISPR/Cas9 genome editing.

136 enic propensity influences the commitment of isogenic iPSCs and a specifically isolated pool of mesod

137 We created cerebral organoids from the isogenic iPSCs and found that blockade of p25 generation

138 found that differentiated cells derived from isogenic iPSCs and nt-ESCs showed comparable lineage gen

139 Having used this pair of isogenic iPSCs to define this phenotype, these cells can

140 ived from SCZ patient iPSCs and DISC1-mutant isogenic iPSCs.

141 In contrast, high binding to an isogenic K1 capsule-negative mutant (AB307.30) was shown

142 We derive del(7q)- and isogenic karyotypically normal induced pluripotent stem

143 We utilised isogenic keratinocytes, microvascular endothelial cells,

144 quantitative phosphoproteomic analysis using isogenic knockin cell lines containing 'driver' oncogeni

145 ypic clonal screening strategies to generate isogenic knockouts and knock-ins highly efficiently, wit

146 reater extent versus other MEK inhibitors in isogenic KRAS HCT116 and mutant KRAS SW620 colon cancer

147 Despite BIM and BIK induction, the isogenic KRAS mutant versus wild-type cells remained res

148 evelop a synthetic lethal chemical screen in isogenic KRAS-mutant and wild-type cells to identify cli

149 ncluding wild-derived populations and inbred isogenic laboratory strains.

150 TD2 mutations on chemotherapy sensitivity in isogenic leukemia cell lines and in murine leukemia gene

151 We used a near-isogenic line of the cultivar Bowman, BW316 (ert-m.34),

152 Four Arabidopsis (Arabidopsis thaliana) near isogenic lines (NILs) differing in g were grown at ambie

153 We used genetic mapping and near isogenic lines (NILs) to identify, validate and fine-map

154 s, genome-wide association studies, and near-isogenic lines enabled the identification of terpene syn

155 sensitive and resistant parasites, including isogenic lines expressing mutant or wild-type K13.

156 arrying the Tau P301L mutation and generated isogenic lines in which p35 is replaced with noncleavabl

157 (Triticum aestivum) genotypes and their near-isogenic lines with the VRN-A1 alleles swapped.

158 tance assays, using ZmTps21 and Zmtps21 near-isogenic lines, further support the endogenous antifunga

159 Major QTLs were confirmed using near-isogenic lines.

160 Isogenic lngR and lngS mutants were considerably affecte

161 comparison between heat-stressed LVS and the isogenic Lon-deficient mutant identified 29 putative Lon

162 Comparison of isogenic lung and pancreas tumor models suggests that us

163 Experiments with near-isogenic maize lines derived from crosses between B73 an

164 Isogenic MELAS and Leigh syndrome iPS cell lines were ge

165 nesis in serotype M59 GAS, we constructed an isogenic mga mutant strain.

166 SRSF2 in K562 leukemia cells, generating an isogenic model so that splicing alterations can be attri

167 The development of in vitro isogenic models of radioresistance through exposure to f

168 -type were significantly higher than that of isogenic modH5 OFF or DeltamodH5 mutants, indicating tha

169 Here, we have generated a stable and isogenic motor neuronal NSC34 cell model with inducible

170 ductions in leukemic burden, specifically in isogenic mouse leukemias and patient-derived xenograft A

171 Using isogenic mouse lines with distinct microbiota profiles,

172 We generated isogenic MR1(-/-) clonal derivatives of the A549 lung ca

173 or MTAP-null cancer cell lines compared with isogenic MTAP-expressing counterparts.

174 Our isogenic Mtb:DeltaRv2745c mutant expresses a significant

175 esentative epidemic M1 strain and a panel of isogenic mutant derivative strains, we evaluated the rel

176 rulence of a clinical ExPEC isolate with its isogenic mutant impaired for the production of colibacti

177 ngeles County clone (LAC) wild-type with the isogenic mutant LACpsmalpha, which lacks the psmalpha op

178 A nonhemolytic isogenic mutant of GBS 874391, Deltacyle9, was impaired

179 tatively determined using both wild-type and isogenic mutant Pseudomonas strains with different EPS-s

180 Compared to the wild-type strain, a H201R isogenic mutant strain caused significantly larger skin

181 Using isogenic mutant strains, we demonstrate that deleting on

182 An isogenic mutant was constructed in kdpE and complemented

183 ture of H. pylori strain 7.13 or its pgdA(-) isogenic mutant with AGS gastric epithelial cells or HEK

184 ) regulon as well as the dosR regulon in the isogenic mutant, Mtb:DeltaRv2745c.

185 ld-type strains and their corresponding CdtB isogenic mutants and by delivering CdtB directly into th

186 We found that isogenic mutants lacking SPN, SLO, and both toxins are e

187 sures, Alab49DeltafbaA was compared to other isogenic mutants lacking virulence genes known to be dis

188 We isolate lipopolysaccharides from isogenic mutants of Salmonella sp., one lacking the modi

189 Using isogenic mutants of strain H44/76 that differed only in

190 A screen of isogenic mutants revealed that the highly surface-expres

191 film produced by the parental strain and the isogenic mutants using static and dynamic systems.

192 wild-type strain was used in this study, and isogenic mutants were constructed with deletions in the

193 Isogenic mutants with straight-rod morphology showed 7-2

194 Using endocytosis inhibitors, bacterial isogenic mutants, and neutralizing antibodies against ho

195 Using isogenic mutants, we show in vitro and ex vivo that CotE

196 eted gene deletion, we generated a set of 28 isogenic mutants.

197 whole genome library that was delivered into isogenic neuroblastoma cell lines expressing or not expr

198 or intravenous injection with cryopreserved, isogenic NF54 P. falciparum sporozoites (PfSPZ) generate

199 N2-fixing symbionts progressively outcompete isogenic non-fixers within root nodules, where N2-fixati

200 nvironments - wild-type matrix-producing and isogenic non-producing strains can coexist.

201 e presents increased McTNs compared with its isogenic non-stem-like subpopulation.

202 eripheral blood mononuclear cells, while its isogenic nonmotile mutant lacking PF resulted in signifi

203 ral characteristics of the OPS moieties from isogenic nonmucoid strain 4095a and mucoid strain 4095c

204 In contrast, isogenic nontransformed cells were resistant to fatty ac

205 zymes in the resistance to TKIs, we used the isogenic NSCLC H1650 cell line and its erlotinib-resista

206 rent EGFR/KRAS mutational status and that of isogenic NSCLC lines expressing wild-type or mutant EGFR

207 (iPSC-CMs and iPSC-ECs) were more similar to isogenic nt-ESC counterparts than those derived from IVF

208 Isogenic NTHI strain 86-028NP mutants lacking hktE and p

209 mitochondrial haplotype placed alongside an isogenic nuclear background.

210 Isogenic P1 deletion mutants were used to reconstitute t

211 icient cells with camptothecin while sparing isogenic p53-positive cells.

212 e-wide loss-of-function genetic screen in an isogenic pair of human colorectal cancer cell lines harb

213 enetic screen to determine the phenotypes of isogenic pairs of clear cell renal cancer cells (ccRCC),

214 histone modifications genome-wide across an isogenic panel of mouse embryonic stem cell (ESC) and ne

215 ignificantly attenuated in comparison to the isogenic parental strain, TX82, in a mixed-inoculum UTI

216 ased NADPH levels compared with those in the isogenic parents.

217 Isogenic Parkin mutant iPSC-derived cardiomyocytes showe

218 booster immunization with their encapsulated isogenic partners.

219 alysis and heat map data correctly clustered isogenic phenotypes, highlighting the potential for hund

220 le to colonize mice colon as compared to the isogenic Pil3+ variant.

221 trait diversity in populations of otherwise isogenic plants.

222 In vitro attachment assays of isogenic plaque clone pairs with mutations in either TC0

223 Isogenic pluripotent stem cells are critical tools for s

224 n than in mice similarly challenged with the isogenic PNAG-defective M10 mutant.

225 a number of cells randomly selected from an isogenic population at a given time and condition, to ra

226 nhances noise in mRNA distribution across an isogenic population of cells.

227 d phenotypic variability within an otherwise isogenic population of cells.

228 Even within an isogenic population, the day-3 mitoflash frequency was n

229 bit heterogeneous responses within a clonal, isogenic population.

230 signaling variability, both across cells in isogenic populations and within individual cells over ti

231 bacteria to humans, individual cells within isogenic populations can show significant variation in s

232 natural populations to those made using near-isogenic populations derived from crosses between parent

233 An additional challenge is that isogenic populations exhibit significant phenotypic hete

234 Finally, analysis of daughter-cell pairs and isogenic populations indicates that the dynamics of the

235 RhoA controls cell-to-cell heterogeneity in isogenic populations of cells in vitro and epithelial mo

236 n addition, a fraction of individuals within isogenic populations raised in controlled environments h

237 able to transfer their amoeboid phenotype to isogenic primary cancer cells through exosomes, and that

238 fy phenotypes previously described in non-co-isogenic Prnp(-/-) mice.

239 cld was essential for chlorate reduction in isogenic pure culture experiments, but showed only minor

240 m four cytoreductive nephrectomies and SETD2 isogenic renal cell carcinoma (RCC) cell lines using chr

241 We show that this activity is triggered in isogenic renal cells upon their transformation independe

242 Here, we report the generation of an isogenic resource to test the direct impact of splicing

243 These chimeric but isogenic rNiVs replicated well in primary human endothel

244 cies of modified or unmodified plasmids into isogenic S.

245 lly into the chromosomal att site of both an isogenic S. aureus and a S. epidermidis recipient.

246 sed compared to that in cells exposed to the isogenic S. aureus wild-type strain, indicating that PSM

247 ructed an S. Typhi fliC mutant and otherwise isogenic S. Typhi strains expressing the Hj, Hd, Hz66 fl

248 structures vary from cell to cell even in an isogenic sample.

249 ique, treatment induced mutations in sets of isogenic samples with very low false positive rates.

250 Using 30 isogenic samples, reliable cohorts of validated mutation

251 experimentally induced mutations in multiple isogenic samples.

252 es in bone were significantly reduced in the isogenic sarA mutants.

253 LAC and the USA200 strain UAMS-1) and their isogenic sarA mutants.

254 timated differential gene expression between isogenic seedlings whose parents had, or had not, been s

255 %, 0.83 microg, and 27.9%, respectively, for isogenic segregants.

256 e interplay between SP-A and a collection of isogenic sequential isolates from 7 patients with CF.

257 enic stimulation of mTORC1 signaling in this isogenic setting or a panel of eight breast cancer cell

258 n, we used Zinc finger nucleases to generate isogenic SHANK3 knockout human embryonic stem (ES) cell

259 usly inoculated mice were challenged with an isogenic SpA-deficient S. aureus mutant, cells prolifera

260 nts of CORRECT to generate scarlessly edited isogenic stem cell lines with intended monoallelic and b

261 ed a high fat/sugar water-induced animal (an isogenic strain of C57BL/6 J:129S1/SvImJ mice) model of

262 A/J lacking T and NK cells), and SK(-/-) (an isogenic strain of strain C57BL6/J lacking SK1), to inve

263 L6/J (both immunocompetent), Tgepsilon26 (an isogenic strain of strain CBA/J lacking T and NK cells),

264 Notably, our results differ from non-isogenic strain studies, thus highlighting the importanc

265 Previous data generated using non-isogenic strains and transfection models suggest that va

266 However, in murine infection models, isogenic strains expressing the two delta-toxin variants

267 Infection studies with isogenic strains having defined toxin deletions have est

268 oach was applied to Tn-Seq libraries made in isogenic strains of Mycobacterium tuberculosis lacking t

269 Fluorescent protein-based differentiation of isogenic strains revealed that priority of gut colonizat

270 Our data obtained using isogenic strains suggest that the liaS(R135G) mutation i

271 Furthermore, we generated isogenic strains that allowed us to establish that Exigu

272 Comparing isogenic strains that differ only in their ability to in

273 s, thus highlighting the importance of using isogenic strains to study the role of CagA toxin polymor

274 d laboratory parasites as well as across non-isogenic strains.

275 enome editing mediated by TALENs to generate isogenic subject-specific mutant and gene-corrected iPSC

276 were analyzed, in comparison with their near-isogenic susceptible strain.

277 stitutions were introduced into the HA of an isogenic swine lineage virus.

278 Msh3-/- cells provide a single, isogenic system to add back Msh3 and test key biochemica

279 Over the last ten years, isogenic tagging (IT) has revolutionised the study of ba

280 produced a genome-wide collection of 15,000 isogenic targeting vectors for conditional mutagenesis i

281 ue for assaying large libraries of otherwise isogenic transposon mutants providing insight into gene

282 used with HDR donors in hESCs to generate an isogenic TS cell line in a scarless manner and to model

283 uces significant tumor control in aggressive isogenic tumor models via a concerted innate and adaptiv

284 +oxaliplatin+folinic acid), not only between isogenic tumors but also within the same tumor.

285 se may drive dynamic phenotypic mosaicism in isogenic unicellular organisms.

286 er of rrn operons in E. coli by constructing isogenic variants with 5-10 operons.

287 mbryonic fibroblasts (MEFs) compared with an isogenic virus encoding mitochondrial PB2, in a MAVS-ind

288 y observed in culture, providing potentially isogenic virus-free lines enabling studies probing the b

289 show that crossing these altered plants with isogenic wild type produces epi-lines with heritable, en

290 Compared with isogenic wild-type (WT) cells, PIK3CA mutant CRCs conver

291 logs) in the bclA1(-) mutant compared to the isogenic wild-type control, but that levels of toxins (A

292 o increase expression of NDRG1 compared with isogenic wild-type controls and TP53 R248W knockin cells

293 sceptibility to VEEV-induced cell death than isogenic wild-type MEFs, indicating that EGR1 modulates

294 es showed altered expression compared to the isogenic wild-type strain and included transcriptional r

295 a major CG methytransferase in rice) and its isogenic wild-type.

296 In this study we used FMR1 knockout and isogenic wildtype mice to systematically map the distrib

297 Engineered strains that are isogenic with B. thailandensis, except the DNA region en

298 TXBP1 loss-of-function mutations and studied isogenic WT and STXBP1-mutant human neurons derived from

299 mutant and undetectable in both LAC and its isogenic xerC mutant.

300 f enzymes increased biofilm formation in the isogenic xerC mutants.