ライフサイエンスコーパス: isoleucine

1 ous iron (Fe) or the amino acids leucine and isoleucine.

2 of Lys to the total amount of Met, Thr, and isoleucine.

3 e base-binding pocket, with bulky leucine or isoleucine.

4 h an increase of jasmonic acid and jasmonoyl-isoleucine.

5 l function is to aminoacylate tRNA(Ile) with isoleucine.

6 of one of these lysine residues, Lys-313, to isoleucine.

7 ch threonine 68 of TLR7 was substituted with isoleucine.

8 efficiently clears tRNA(Leu) mischarged with isoleucine.

9 ly in ligand binding, is substituted with an isoleucine.

10 tein triacylglycerol (1)H NMR resonances and isoleucine.

11 ne resolution of isomers such as leucine and isoleucine.

12 ed in intersubunit clashes among the mutated isoleucines.

13 1.44 (95% CI 1.26-1.65, p = 9.5 x 10-8) for isoleucine, 1.85 (95% CI 1.41-2.42, p = 7.3 x 10-6) for

14 P of pandemic A/BM/1/1918 (H1N1), comprising isoleucine-100, proline-283, and tyrosine-313, that is e

15 Compared with the control, isoleucine-10g reduced the blood glucose AUC and peak bl

16 Isoleucine-10g, but not isoleucine-5g, slowed gastric em

17 mics analyses showed higher levels of JA, JA-isoleucine, 12-oxo-phytodienoic acid, and arabidopsides

18 Thus, isoleucine-17 plays dual roles in determining the distri

19 Mutating SLN residue isoleucine-17 to alanine (I17A) decreased the binding af

20 Furthermore, we identified isoleucine-182 in transmembrane domain 3 of zDHHC3 as a

21 mutation of alanine 145, histidine 180, and isoleucine 191 on 14-3-3sigma isoform promotes GluN2C bi

22 val for IFG based on a fully adjusted model: isoleucine 2.29 (1.31-4.01), leucine 1.80 (1.10-2.96), v

23 elta subunit sequence from the N terminus to isoleucine 235 in M1.

24 ons at amino acid positions 260 (alanine for isoleucine), 261 (hydroxyproline for alanine), and 263 (

25 f novel conjugates of THC with alanine (2a), isoleucine (2b), proline (2c), valine (2d), phenylalanin

26 d (amino acid=L-valine (1), L-leucine (2), L-isoleucine (3), L-tryptophan (4), L-phenylalanine (5), L

27 A mutation of isoleucine 335 to valine (I355V) in hSLC2A9 can reduce f

28 he phosphatidylserine head group passes near isoleucine-364 (I364) and that I364 is critical to the r

29 Mutation of isoleucine-386 at the center of ER46's transmembrane hyd

30 human URAT1 serine-35, phenylalanine-365 and isoleucine-481 are necessary and sufficient to provide u

31 gene that includes the last cytosine (C) of isoleucine 507 (Ile507ATC) and the two thymidines (T) of

32 n (DeltaF508), a synonymous codon change for isoleucine 507 (Ile507ATT), and protein misfolding.

33 ltaF508) and a silent codon change (SCC) for isoleucine-507 (I507-ATC-->ATT).

34 +2 sequon position with PglB is modulated by isoleucine 572.

35 blood glucose (P < 0.01), whereas effects of isoleucine-5g were NS.

36 Isoleucine-10g, but not isoleucine-5g, slowed gastric emptying (P < 0.05), but g

37 We found that PA residue isoleucine 656 plays a critical role in PA binding to TE

38 lanine+tyrosine (32.6%), leucine (45.7%) and isoleucine (68%) are found less in haustorium.

39 The best peptide (IC50 =89 nm) replaces isoleucine 689 with an S-gamma-methyl stapled amino acid

40 It is isoleucine 75 in the case of thioredoxin.

41 olved in posttranslational transformation of isoleucine 8 to beta-methyl-delta-hydroxy-proline throug

42 adiolabeled antagonist ((125)I-sarcosine(1), isoleucine(8) Ang II) in brain homogenates and tissue se

43 n the FCSRT (0.43 points per year of age for isoleucine; 95% confidence interval [CI], -0.58 to -0.29

44 Mutation of this isoleucine abrogated VP2 incorporation into virus-like p

45 ens triggers higher jasmonic acid, jasmonoyl-isoleucine accumulation, and jasmonic acid-dependent gen

46 differ; leucine stimulated insulin, whereas isoleucine acted insulin independently.

47 tes with amino acids glutamine, tyrosine and isoleucine, along with serum cholesterol measures and at

48 rminal epitope of neuropeptide glutamic acid-isoleucine/alpha-melanocyte-stimulating hormone (NEI/alp

49 Isoleucine, alpha1-acid glycoprotein, and glucose were l

50 Thiaisoleucine, an isoleucine analog, also has antimalarial activity.

51 lucose, amino acids like histidine, leucine, isoleucine and alanine, and also 2,3-butanediol, methano

52 ociated with decreased levels of alanine and isoleucine and elevated levels of glutamine.

53 oc-protected alpha-amino diazoketones from L-isoleucine and L-threonine and to the preparation of a d

54 physical activity is associated lower serum isoleucine and leucine in peripubertal girls, independen

55 In addition, isoleucine and leucine levels increased significantly (

56 the valine pool and a 2-fold increase in the isoleucine and leucine pools.

57 CaBP7 NTD, these residues are replaced with isoleucine and leucine residues with branched side chain

58 parts higher fidelity, but replacements with isoleucine and leucine resulted in lower-fidelity phenot

59 hesis of branched-chain amino acids (valine, isoleucine and leucine) were also absent, but genes for

60 esulted in the accumulation of jasmonic acid-isoleucine and loss of dormancy in seeds of stressed pla

61 lly similar noncognate amino acids including isoleucine and methionine.

62 te is produced, conjugated to the amino acid isoleucine and perceived by a co-receptor complex compos

63 that mimics the plant hormone jasmonic acid isoleucine and promotes opening of stomata for bacterial

64 ric acid, 4-hydroxyproline, glycine, leucine+isoleucine and putrescine proved to be useful for differ

65 VimA mediated coenzyme A (CoA) transfer to isoleucine and reduced branched-chain amino acid metabol

66 the WPH components tested, the amino acid L-isoleucine and the peptide L-leucyl-L-isoleucine showed

67 he branched chain amino acids (BCAs) leucine/isoleucine and their deaminated metabolites, and lowered

68 leucine acquisition and, to a lesser extent, isoleucine and valine acquisition.

69 that were proline, hydroxyproline, leucine, isoleucine and valine on the negative side of PC1 and po

70 Branched-chain amino acids (BCAAs; leucine, isoleucine and valine) are elevated in the blood of obes

71 ivity and has reduced catabolic activity for isoleucine and valine.

72 nt with the zebrafish P2X4.1 structure, with isoleucines and threonines (Ile-332 and Thr-336) positio

73 (15)N-specific labeling of isoleucines and tryptophans, reporting on backbone and s

74 d degradation (named for leucine, valine and isoleucine) and seed development was limited to leucine

75 ffinity for DNA, more enhanced activation by isoleucine, and a lower propensity for nonspecific DNA b

76 l-leucine but also includes l-methionine, l-isoleucine, and l-valine.

77 ations of glycine, alanine, valine, leucine, isoleucine, and phenylalanine at six positions.

78 id biosynthetic machinery utilizing glucose, isoleucine, and serine.

79 ed to the identification of N-malonyl-D-allo-isoleucine, and the discovery of a novel amino acid race

80 metacluster formation of serine, asparagine, isoleucine, and tryptophan.

81 periplasmic binding protein of the leucine, isoleucine, and valine (LIV) branched-chain amino acid t

82 branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are elevated in maple syrup urine

83 s of the branched-chain amino acids leucine, isoleucine, and valine in this acute study.

84 Only alanine, glutamate, isoleucine, and valine, but not leucine, were increased

85 hain amino acids (BCAAs), including leucine, isoleucine, and valine, has shown potential benefits for

86 hain amino acids (BCAAs) valine, leucine and isoleucine are essential amino acids that play critical

87 supports queries where isobaric leucine and isoleucine are treated equivalent, and an option for sea

88 ly amino acids including methionine, lysine, isoleucine, arginine, and aromatics, tend to promote str

89 Infrequent residues (e.g. isoleucine, arginine, cysteine, proline, aspartate, and

90 nthesis of JA and the bioactive conjugate JA-isoleucine, as well as activation of the JA signaling pa

91 ting solely of leucines, except for a single isoleucine at a particular position, transformed cells.

92 R can result from substitution of valine for isoleucine at codon 122 of the transthyretin (TTR) gene

93 displayed a unique preference for valine and isoleucine at P2.

94 Substitution of methionine for isoleucine at position 148 markedly decreased the V(max)

95 cture-based mechanism for mismatching of the isoleucine at position 181 and the increased vaccine eff

96 by serine at position 281 and methionine by isoleucine at position 309.

97 ly) or non-functional (AVI: alanine, valine, isoleucine at positions 49, 262, and 296, respectively)

98 lting in an amino acid change from valine to isoleucine at residue 19 of Nsp1beta diminished its abil

99 /H(+) antiporter, even though it contains an isoleucine at the Glu(in) position that was previously t

100 interesting deviation is the decoding of the isoleucine AUA codon as methionine by the one mitochondr

101 ize the universal AUG and the unconventional isoleucine AUA codons for methionine.

102 Consequently, deletion of ilvA causes isoleucine auxotrophy.

103 GA and MYC2 binding motifs, MYC2, and the JA-isoleucine biosynthesis enzymes DDE2/AOS and JAR1 are fu

104 he threonine dehydratase IlvA is part of the isoleucine biosynthesis pathway in the Gram-positive mod

105 wth and specifically inhibits coenzyme A and isoleucine biosynthesis.

106 oteins consisting exclusively of leucine and isoleucine (called LIL traptamers) that specifically act

107 moiety is derived from an intermediate of l-isoleucine catabolism.

108 chaea is essential for this tRNA to read the isoleucine codon AUA and to differentiate between AUA an

109 Translation of the isoleucine codon AUA in most prokaryotes requires a modi

110 Bacteria decode the isoleucine codon AUA using a tRNA species that is posttr

111 oped very similar strategies for reading the isoleucine codon AUA while discriminating against the me

112 artificially and specifically halted before isoleucine codon by reducing isoleucyl-tRNA synthetase f

113 mans, sometimes initiates with the universal isoleucine codons AUU and AUC.

114 abled P-site codon binding to these normally isoleucine codons.

115 epend on signaling via (1) the jasmonic acid-isoleucine conjugate (JA-Ile) and (2) other octadecanoid

116 production of the stress hormones jasmonate-isoleucine conjugate and abscisic acid, which represents

117 in GA3 or the functional analog of jasmonoyl-isoleucine, coronatine.

118 ermeability transition (MPT) with N-methyl-4-isoleucine cyclosporine (NIM811) improves the outcome of

119 ransition pore (mPTP) opener, and N-methyl-4-isoleucine cyclosporine (NIM811), an mPTP inhibitor, wer

120 Asc-1 antiporter activity is enhanced by D-isoleucine (D-Ile), which releases D-serine and glycine

121 WPH components: (a) control; (b) WPH; (c) L-isoleucine; (d) L-leucine; (e) L-leucine plus L-isoleuci

122 uterated apart from (1)H/(13)C NMR probes at isoleucine delta1 methyl groups, which facilitated (1)H/

123 36-bp operator fragments are consistent with isoleucine-dependent binding of two CodY dimers per dupl

124 Transcription profiling during isoleucine depletion, which leads to gradual starvation

125 Isoleucine deprivation results in GCN2-mediated phosphor

126 xo-phytodienoic acid, jasmonic acid, and its isoleucine derivative increased in roots upon osmotic an

127 Isoleucine did not affect energy intake.

128 soleucyl-L-leucine dipeptide; (g) L-leucyl-L-isoleucine dipeptide.

129 tory MREI (methionine-arginine-glutamic acid-isoleucine) domain, highly expressed in the central nerv

130 emoglobin; however the parasite must acquire isoleucine exogenously, because this amino acid is not p

131 leucine; (d) L-leucine; (e) L-leucine plus L-isoleucine; (f) L-isoleucyl-L-leucine dipeptide; (g) L-l

132 embranes and lipid droplets; substitution of isoleucine for methionine at position 148 did not alter

133 (apoCaM) is already pre-associated with the isoleucine-glutamine (IQ) domain on the channel carboxy

134 ggest that apoCaM interacts with a conserved isoleucine-glutamine (IQ) motif in the C terminus of the

135 interacts with calmodulin via its N-terminal isoleucine-glutamine (IQ) motif.

136 pon binding of Ca(2+)/calmodulin (CaM) to an isoleucine-glutamine motif in the carboxy tail of Ca(V)1

137 CaM interacts with an IQ (isoleucine-glutamine) motif in the large intracellular C

138 h recent implication of short glycine-serine-isoleucine (GSI) containing motifs.

139 tion of the isomeric amino acids leucine and isoleucine had markedly different effects on ethanol sen

140 ive gene expression by the bioactive form JA-isoleucine have been well-studied, knowledge on JA metab

141 cid substitutions at D1416 in the IHD motif (isoleucine-histidine-aspartic acid) in the NBARC domain

142 Compared with isoleucine homozygotes, valine homozygotes had significa

143 te these proteins containing leucine (L) and isoleucine (I) as LIL proteins.

144 group 1 dandelion PPOs possess a hydrophobic isoleucine (I) at position HB2+1, group 2 PPOs exhibit a

145 mV, respectively, by the size of a conserved isoleucine (I126) in the S1 segment, thus indicating the

146 While T had no effect on the uptake of isoleucine (Ile) and alpha-methylaminoisobutyric acid (M

147 emization of Asp, as well as racemization of isoleucine (Ile) and phenylalanine (Phe) after 100 s of

148 ate family of growth regulators includes the isoleucine (Ile) conjugate of jasmonic acid (JA-Ile) and

149 n ALDH10s with low BADH activity, because an isoleucine (Ile) pushes the Trp against the Tyr.

150 e-chain dihedral angles of leucine (Leu) and isoleucine (Ile), and identify those conformations that

151 branched-chain amino acids (BCAAs) leucine, isoleucine (Ile), and valine (Val) in the mitochondria e

152 f isobaric residues (Xle): leucine (Leu) and isoleucine (Ile).

153 as the committed step in the biosynthesis of isoleucine (Ile).

154 re heavily influenced by Asp(399) and the di-isoleucines, Ile(402) and Ile(403).

155 Our data show that alteration of the isoleucine (Ile172) did not affect the basal ATPase acti

156 an in-frame deletion of a conserved Galpha11 isoleucine (Ile200del), and one of the nine unrelated pa

157 s revealed a possible role for valine and/or isoleucine in CI tolerance.

158 Wounded pho1 leaves hyperaccumulated JA/JA-isoleucine in comparison with the wild type.

159 directly controls biosynthesis of jasmonoyl-isoleucine in JA-mediated defense responses and interact

160 The prominence of isoleucine in mcfp-1, however, distinguished it from hom

161 ults in a replacement of methionine-475 with isoleucine in nonstructural protein 3 (nsp3), was respon

162 differentiation between isomeric leucine and isoleucine in peptide sequencing utilizes multistage ele

163 to contain 4 or 5 basic residues as well as isoleucine in the +2 position: (RRQKR downward arrowFI)

164 utation of the well-conserved lysine 48 into isoleucine in the SOR from Desulfoarculus baarsii dramat

165 Lys), methionine (Met), threonine (Thr), and isoleucine involves monofunctional Asp kinases (AKs) and

166 Acyl chloride of N-phthaloyl-(S)-isoleucine is an efficient chiral auxiliary for the reso

167 s active during phototrophic growth and that isoleucine is mainly synthesized from the citramalate pa

168 We report that when isoleucine is withdrawn from the culture medium of intra

169 functions both as a receptor for jasmonoyl-l-isoleucine (JA-Ile) and as the component of an E3-ubiqui

170 We found that the COR and jasmonate isoleucine (JA-Ile) co-receptor JAZ2 is constitutively e

171 Jasmonoyl-isoleucine (JA-Ile) has been identified as a specific li

172 The phytohormone jasmonoyl-L-isoleucine (JA-Ile) signals through the COI1-JAZ corecep

173 The binding of jasmonoyl-L-isoleucine (JA-Ile) to the F-box of CORONATINE INSENSITI

174 es the bioactive hormone (3R,7S)-jasmonoyl-l-isoleucine (JA-Ile) with high specificity.

175 The main hormonal signal, jasmonoyl-L-isoleucine (JA-Ile), has been found recently to undergo

176 e responses to the plant hormone jasmonoyl-L-isoleucine (JA-Ile).

177 nd mutations of K176 to threonine (K176T) or isoleucine (K176I) produced similar fusion phenotypes as

178 ine, glycine, histidine, total homocysteine, isoleucine, kynurenine, leucine, lysine, methionine, met

179 Branched-chain amino acids L-isoleucine, L-leucine, and L-valine (ILV) activate CodY

180 Changes in beta-hydroxybutyrate, isoleucine, lactate, and pyridoxate were blunted in thos

181 (positive association), followed by leucine/isoleucine (Leu/Ile) (negative association).

182 We found that isoleucine, leucine and tyrosine levels were significant

183 associated with a pair of large clusters of isoleucine, leucine and valine (ILV) side chains located

184 us aureus in response to the availability of isoleucine, leucine and valine (ILV), and GTP.

185 sheep, including branched chain amino acids (isoleucine, leucine and valine) that have been identifie

186 i.e., the branched-chain amino acids (BCAAs) isoleucine, leucine, and valine (ILV) and the nucleoside

187 clusters of branched aliphatic amino acids [isoleucine, leucine, and valine (ILV) clusters] were fou

188 ture appears to correlate with the number of isoleucine, leucine, and valine (ILV) side chains that f

189 e cluster of branched aliphatic side chains, isoleucine, leucine, and valine (ILV).

190 sma levels of the branched-chain amino acids isoleucine, leucine, and valine are associated with Alzh

191 BCAAs (i.e., isoleucine, leucine, and valine) and their downstream me

192 the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and valine) are strongly associated

193 re optimized for the resolution of the BCAAs isoleucine, leucine, and valine, as well as 13 other ami

194 etection (LOD) were 400, 200, and 100 nM for isoleucine, leucine, and valine, respectively.

195 tor specific for the hydrophobic amino acids isoleucine, leucine, and valine.

196 Arginine, lysine, isoleucine, leucine, methionine, phenylalanine, valine,

197 tiation, whereas replacement with threonine, isoleucine, leucine, or proline, which maintain the stru

198 anine, tyrosine, valine, methionine, lysine, isoleucine, leucine, phenylalanine, taurine, cysteine, a

199 With Cc0300, substrates terminating in isoleucine, leucine, phenylalanine, tyrosine, valine, me

200 rum values for a-amino-butyric acid, valine, isoleucine, leucine, tyrosine, phenylalanine, ornithine

201 higher levels of stress-related amino acids (isoleucine, leucine, valine, and proline), sugars, inter

202 gnificant associations with future diabetes: isoleucine, leucine, valine, tyrosine and phenylalanine.

203 The 5-amino acid (AA) signature, including isoleucine, leucine, valine, tyrosine, and phenylalanine

204 ation between baseline circulating levels of isoleucine, leucine, valine, tyrosine, and phenylalanine

205 ll-surface CXCR4 in neuroblastoma cells: the isoleucine-leucine motif at residues 328 and 329 and res

206 leotide polymorphisms (SNPs) associated with isoleucine levels and one SNP associated with both leuci

207 to 114.16 (92.89-143.52) microM (P = .004), isoleucine levels increased from 20.43 (10.92-27.41) mic

208 at a genetic predisposition to raised plasma isoleucine levels is positively associated with AD.

209 ally predicted one standard deviation higher isoleucine levels was 1.35 (95% CI, 1.08-1.69; p = 0.007

210 interaction site to amino acid 52 of VP1, an isoleucine located within a sequence motif IDPWI in the

211 The branched-chain amino acids leucine and isoleucine lower blood glucose after oral glucose ingest

212 biosynthesis of histidine, valine, leucine, isoleucine, lysine and proline pre-determines the relian

213 3 tail: the segment at residues 11-27 and an isoleucine-lysine nuclear localization signal (IK-NLS) m

214 The growth trends of tryptophan and isoleucine metaclusters, along with serine, asparagine,

215 n the RYGB surgery group, changes in leucine/isoleucine, methionine, phenylalanine, and glucagon-like

216 er transitions using 17 isotopically labeled isoleucine methyl groups and three tryptophan side chain

217 s independently from JA-isoleucine or any JA-isoleucine mimic.

218 ine kinase inhibitor-refractory threonine-to-isoleucine mutation at position 315 (T315I).

219 Gene sequencing revealed a phenylalanine-->isoleucine mutation in the 33rd position of exon 2 of TT

220 e bulkier phenylalanine (fingers domain) and isoleucine (N-terminal domain) could induce a tendency t

221 ophobic pocket in the apple 2 domain and the isoleucine occupies a flanking minor pocket.

222 tic side chains such as valine, leucine, and isoleucine of putative substrates.

223 est this assumption, we examined the role of isoleucine on DNA binding, bending and catalytic activit

224 e intragastric administration of leucine and isoleucine on the gastric emptying of, and blood glucose

225 in the roots that acts independently from JA-isoleucine or any JA-isoleucine mimic.

226 striction with medical food and supplemental isoleucine or valine (n = 5 of 29), or the use of natura

227 eveals DinB2-like polymerases, with leucine, isoleucine or valine steric gates, in many taxa of the p

228 ch methionines 150 and 154 were converted to isoleucines or in which histidine 139 was converted to a

229 t hemoglobin (Hb A) was replaced by leucine, isoleucine, or phenylalanine.

230 acid signature composed of arginine, leucine/isoleucine, phenylalanine, tyrosine, valine and proline

231 o recycling endosomes via a novel N-terminal isoleucine-proline (IP) motif.

232 a conserved four amino acid motif, (serine-X-isoleucine-proline) which exists within an intrinsically

233 In healthy subjects, both leucine and isoleucine reduced blood glucose in response to a mixed-

234 In particular, the methionine-to-isoleucine replacement at amino acid residue 867 (M867I)

235 nding PDZ domains is the accommodation of an isoleucine residue at the C-terminal position (P(0)), a

236 biophysical approaches, we have uncovered an isoleucine residue in the kinase domain of the Tec famil

237 Rho GTPases due to a distinctive switch one isoleucine residue reminiscent of the constitutively act

238 an allosteric communication with a conserved isoleucine residue that lines the binding channel for hi

239 impacts were specific to substitutions with isoleucine residues because functional modulation was pa

240 that the first layer of the highly conserved isoleucine residues in the filter is primarily responsib

241 d w-type ions, 45 of 50 detected leucine and isoleucine residues were successfully distinguished and

242 f helix-destabilizing, ss-branched valine or isoleucine residues within the TMD restores normal secre

243 To mimic interacting leucine and isoleucine residues, we have created new amino acids tha

244 formation with a hinge region around the two isoleucine residues.

245 lkyl aryl ether linkage between the dopa and isoleucine residues.

246 The structure of CodY in complex with isoleucine revealed a reorganized GAF domain.

247 ne, alanine, valine, leucine, phenylalanine, isoleucine, serine, tryptophan, methionine, and cysteine

248 acid L-isoleucine and the peptide L-leucyl-L-isoleucine showed greater efficiency in translocating GL

249 We suggest that this isoleucine side chain in the Tec family kinases acts as

250 ergetic barrier to activation imposed by the isoleucine side chain.

251 tope labeling of the delta1 methyl groups of isoleucine side chains demonstrates that, in solution, N

252 g kinetic CPMG NMR spectroscopic data for 17 isoleucine side chains distributed over all parts of GCK

253 ay does not directly promote survival during isoleucine starvation.

254 Isoleucine-starved parasites remain viable for 72 h and

255 (8a-8c) requires the involvement of an allo-isoleucine stereoisomer and suggests the intriguing poss

256 tely 4% of black Americans carry a valine-to-isoleucine substitution (V122I) in the transthyretin pro

257 the majority of U.S. subjects with valine-to-isoleucine substitution at position 122 (Val122Ile) (n =

258 is entirely dependent on a phenylalanine-to-isoleucine substitution at position 427 in the fusion su

259 beta receptor mutant containing a leucine-to-isoleucine substitution in its transmembrane domain, whi

260 mino acids revealed an alternate pathway for isoleucine synthesis (via citramalate synthase, CimA, CT

261 oncurrent reduction of the BCAAs leucine and isoleucine, the AAAs tyrosine and phenylalanine, and 4 o

262 hen it is supplemented with 50 mug/ml l-allo-isoleucine, the starting unit for CMA production.

263 s supported the transformation of valine and isoleucine to isobutylamine and 2-methylbutylamine as re

264 mine to leucine substitution (Q4594L) and an isoleucine to methionine substitution (I4790M) in highly

265 hypomorphic allele, mitfa(z25) results in an isoleucine to phenylalanine substitution in the first he

266 ge-gated potassium channel Kv1.1 converts an isoleucine to valine codon for amino acid 400, speeding

267 with an amino acid change at residue 19 from isoleucine to valine induced KPNA1 degradation.

268 cing showed that noddy mutant mice harbor an isoleucine-to-asparagine (I108N) mutation in the EC1 rep

269 TERF6 and an RNA sequence in the chloroplast isoleucine transfer RNA gene (trnI.2) located in the rRN

270 The hormone JA-isoleucine triggers the interaction of JAZ repressor pro

271 Change of alanine 383 of TpeL to isoleucine turns the sugar donor preference from UDP-Glc

272 llowed by specific sequences of leucines and isoleucines, two hydrophobic amino acids that differ onl

273 Alanine, leucine, isoleucine, tyrosine, and glutamine predicted incident t

274 The serum levels of valine, leucine, isoleucine, tyrosine, and phenylalanine were measured in

275 ended pattern except for cystine/methionine, isoleucine, tyrosine/phenylalanine, lysine and threonine

276 Our study shows that isoleucine utilization is an essential pathway that can

277 pounds for their potential to interfere with isoleucine utilization.

278 oproteins, citrate, tyrosine, phenylalanine, isoleucine, valine and glucose were identified and consi

279 t levels of glucose at 120 min, and leucine, isoleucine, valine and proline at 90 and 120 min, wherea

280 through reduced branched-chain AAs (leucine, isoleucine, valine).

281 The branched chain amino acids leucine, isoleucine, valine, and alloisoleucine were significantl

282 glycine, histidine, phenylalanine, leucine, isoleucine, valine, and tyrosine) were assessed with the

283 5 essential amino acids 3 times/d (leucine, isoleucine, valine, lysine, and threonine) (HFrAA) or wi

284 strongly require supplementation of leucine, isoleucine, valine, methionine, and threonine and modest

285 The essential amino acids: tryptophan, isoleucine, valine, phenylalanine, leucine, threonine, l

286 accumulation of many amino acids, including isoleucine, valine, threonine, and 4-aminobutanoate, whi

287 of the neighboring LRRFIP2, and marked by an isoleucine-valine missense variant in MLH1.

288 mino acid moieties, such as methyl groups of isoleucines, valines, or leucines.

289 clopropylglycine residue that may arise from isoleucine via a cryptic chlorination pathway.

290 required for the biosynthesis of leucine and isoleucine, were decreased in strains lacking BSH.

291 thetical isomer pairs, including leucine and isoleucine, whereas their stereoisomers (d- and l-forms)

292 DNA by as much as 150 degrees ; an invariant isoleucine, which has been seen structurally to intercal

293 The sole exception is isoleucine, which is not present in adult human hemoglob

294 In ATP8A2, the corresponding residue is an isoleucine, which recently was found mutated in patients

295 or more conserved lysines or replacement of isoleucine with alanine or valine alters the ability of

296 cell lines, valine with high expression and isoleucine with low expression.

297 domains, such as the widely used GCN4-based isoleucine zipper (IZ) and the T4 bacteriophage fibritin

298 F TM domain revealed a heptad repeat leucine-isoleucine zipper motif (LIZ).

299 des molecular details of this unique leucine/isoleucine zipper, revealing specific hydrophobic and io

300 ng cancer cells as highly active recombinant isoleucine-zipper-tagged TRAIL (iz-TRAIL).