ライフサイエンスコーパス: isoleucyl-tRNA

1 We have previously shown that limitation for isoleucyl-tRNA can initiate a ribosome bypass when an AU

2 t less error-prone and kinetically optimized isoleucyl-tRNA(Ile) synthesis under cellular conditions.

3 ity determinant for proper aminoacylation by isoleucyl tRNA synthetase (IleRS) and codon recognition

4 orf, whose function is unknown; divIVA; and isoleucyl tRNA synthetase (ileS).

5 In cattle, cytosolic isoleucyl-tRNA synthetase (IARS) missense mutations caus

6 For example, the close homologs isoleucyl-tRNA synthetase (IleRS) and valyl-tRNA synthet

7 Isoleucyl-tRNA synthetase (IleRS) catalyzes transfer of

8 Escherichia coli isoleucyl-tRNA synthetase (IleRS) exploits both the tRNA

9 Isoleucyl-tRNA synthetase (IleRS) is an aminoacyl-tRNA s

10 Isoleucyl-tRNA synthetase (IleRS) is unusual among amino

11 milar amino acids, valine and isoleucine, by isoleucyl-tRNA synthetase (IleRS) results, in part, from

12 he rate of activation of 5TFI by the E. coli isoleucyl-tRNA synthetase (IleRS) yielded a specificity

13 Leucyl-tRNA synthetase (LeuRS), isoleucyl-tRNA synthetase (IleRS), and valyl-tRNA synthe

14 Leucyl-tRNA synthetase (LeuRS), isoleucyl-tRNA synthetase (IleRS), and valyl-tRNA synthe

15 he Staphylococcus aureus ileS gene, encoding isoleucyl-tRNA synthetase (IleRS), contains a long mRNA

16 Here, it is shown that isoleucyl-tRNA synthetase (IleRS), which occasionally mi

17 e analog that inhibits the essential enzyme, isoleucyl-tRNA synthetase (IleRS).

18 Administration of mupirocin, an inhibitor of isoleucyl-tRNA synthetase activity, resulted in changes

19 Here I show that isoleucyl-tRNA synthetase aminoacylates CoA-SH with vali

20 ied small molecules that inhibit recombinant isoleucyl-tRNA synthetase and that are lethal to the par

21 , which are also conserved in the homologous isoleucyl-tRNA synthetase and valyl-tRNA synthetase edit

22 Together with prior analyses of isoleucyl-tRNA synthetase and valyl-tRNA synthetase, the

23 Using isoleucyl-tRNA synthetase as an example, we placed mutat

24 s reliance on post-transfer editing, whereas isoleucyl-tRNA synthetase differs in retaining a distinc

25 ese eukaryote-like features, M. tuberculosis isoleucyl-tRNA synthetase exhibited highly specific cros

26 As an example, discrete sites in isoleucyl-tRNA synthetase for amino acid activation and

27 y halted before isoleucine codon by reducing isoleucyl-tRNA synthetase from reaction mixture of in vi

28 Methanosarcina species by mutagenesis of the isoleucyl-tRNA synthetase gene (ileS) from Methanosarcin

29 In this study, a novel group of isoleucyl-tRNA synthetase gene (ileS) T box leader seque

30 The monomeric Escherichia coli isoleucyl-tRNA synthetase has a zinc-containing peptide

31 We showed by RNAi knockdown that T. brucei isoleucyl-tRNA synthetase is essential for the parasites

32 Escherichia coli isoleucyl-tRNA synthetase is one of five closely related

33 For example, isoleucyl-tRNA synthetase misactivates valine (to produc

34 In the absence of tRNA, isoleucyl-tRNA synthetase misactivates valine, while val

35 Substitution of a homologous CP1 domain from isoleucyl-tRNA synthetase or mutation within the LeuRS C

36 Here we report that a specific mutation in isoleucyl-tRNA synthetase prevents editing by blocking t

37 Recent mutational analysis of an isoleucyl-tRNA synthetase showed that discrimination of

38 mutations in a presumptive "hinge region" of isoleucyl-tRNA synthetase that is situated between the t

39 Valyl-tRNA synthetase, a close homolog of isoleucyl-tRNA synthetase, misactivates threonine, alpha

40 eukaryote-like features, and unlike E. coli isoleucyl-tRNA synthetase, the M. tuberculosis enzyme ch

41 For isoleucyl-tRNA synthetase, these errors are reduced by t

42 as demonstrated by its ability to complement isoleucyl-tRNA synthetase-deficient mutants of E. coli.

43 hromosomally encoded organellar (apicoplast) isoleucyl-tRNA synthetase.

44 parasites had a mutation in the cytoplasmic isoleucyl-tRNA synthetase.

45 were investigated with an editing-defective isoleucyl-tRNA synthetase.

46 yl adenylates by editing synthetases such as isoleucyl-tRNA synthetase.

47 m with p43, as well as cross-reactivity with isoleucyl-tRNA synthetase.

48 ase of the particle and maps the location of isoleucyl-tRNA synthetase.

49 mary structure of Mycobacterium tuberculosis isoleucyl-tRNA synthetase.

50 by bacterial-type but not by eukaryotic-type isoleucyl-tRNA synthetases and might also be a determina

51 Examples include isoleucyl-tRNA synthetases whose acquisition from eukary

52 or of Escherichia coli and other eubacterial isoleucyl-tRNA synthetases, but not of eukaryote cytopla

53 aryote cytoplasmic than to other eubacterial isoleucyl-tRNA synthetases.