ライフサイエンスコーパス: isoleucyl-tRNA synthetase

1 hromosomally encoded organellar (apicoplast) isoleucyl-tRNA synthetase.

2 parasites had a mutation in the cytoplasmic isoleucyl-tRNA synthetase.

3 were investigated with an editing-defective isoleucyl-tRNA synthetase.

4 yl adenylates by editing synthetases such as isoleucyl-tRNA synthetase.

5 m with p43, as well as cross-reactivity with isoleucyl-tRNA synthetase.

6 ase of the particle and maps the location of isoleucyl-tRNA synthetase.

7 mary structure of Mycobacterium tuberculosis isoleucyl-tRNA synthetase.

8 aryote cytoplasmic than to other eubacterial isoleucyl-tRNA synthetases.

9 Administration of mupirocin, an inhibitor of isoleucyl-tRNA synthetase activity, resulted in changes

10 Here I show that isoleucyl-tRNA synthetase aminoacylates CoA-SH with vali

11 ied small molecules that inhibit recombinant isoleucyl-tRNA synthetase and that are lethal to the par

12 , which are also conserved in the homologous isoleucyl-tRNA synthetase and valyl-tRNA synthetase edit

13 Together with prior analyses of isoleucyl-tRNA synthetase and valyl-tRNA synthetase, the

14 by bacterial-type but not by eukaryotic-type isoleucyl-tRNA synthetases and might also be a determina

15 Using isoleucyl-tRNA synthetase as an example, we placed mutat

16 or of Escherichia coli and other eubacterial isoleucyl-tRNA synthetases, but not of eukaryote cytopla

17 as demonstrated by its ability to complement isoleucyl-tRNA synthetase-deficient mutants of E. coli.

18 s reliance on post-transfer editing, whereas isoleucyl-tRNA synthetase differs in retaining a distinc

19 ese eukaryote-like features, M. tuberculosis isoleucyl-tRNA synthetase exhibited highly specific cros

20 As an example, discrete sites in isoleucyl-tRNA synthetase for amino acid activation and

21 y halted before isoleucine codon by reducing isoleucyl-tRNA synthetase from reaction mixture of in vi

22 Methanosarcina species by mutagenesis of the isoleucyl-tRNA synthetase gene (ileS) from Methanosarcin

23 In this study, a novel group of isoleucyl-tRNA synthetase gene (ileS) T box leader seque

24 The monomeric Escherichia coli isoleucyl-tRNA synthetase has a zinc-containing peptide

25 In cattle, cytosolic isoleucyl-tRNA synthetase (IARS) missense mutations caus

26 ity determinant for proper aminoacylation by isoleucyl tRNA synthetase (IleRS) and codon recognition

27 For example, the close homologs isoleucyl-tRNA synthetase (IleRS) and valyl-tRNA synthet

28 Isoleucyl-tRNA synthetase (IleRS) catalyzes transfer of

29 Escherichia coli isoleucyl-tRNA synthetase (IleRS) exploits both the tRNA

30 Isoleucyl-tRNA synthetase (IleRS) is an aminoacyl-tRNA s

31 Isoleucyl-tRNA synthetase (IleRS) is unusual among amino

32 milar amino acids, valine and isoleucine, by isoleucyl-tRNA synthetase (IleRS) results, in part, from

33 he rate of activation of 5TFI by the E. coli isoleucyl-tRNA synthetase (IleRS) yielded a specificity

34 Leucyl-tRNA synthetase (LeuRS), isoleucyl-tRNA synthetase (IleRS), and valyl-tRNA synthe

35 Leucyl-tRNA synthetase (LeuRS), isoleucyl-tRNA synthetase (IleRS), and valyl-tRNA synthe

36 he Staphylococcus aureus ileS gene, encoding isoleucyl-tRNA synthetase (IleRS), contains a long mRNA

37 Here, it is shown that isoleucyl-tRNA synthetase (IleRS), which occasionally mi

38 e analog that inhibits the essential enzyme, isoleucyl-tRNA synthetase (IleRS).

39 orf, whose function is unknown; divIVA; and isoleucyl tRNA synthetase (ileS).

40 We showed by RNAi knockdown that T. brucei isoleucyl-tRNA synthetase is essential for the parasites

41 Escherichia coli isoleucyl-tRNA synthetase is one of five closely related

42 For example, isoleucyl-tRNA synthetase misactivates valine (to produc

43 In the absence of tRNA, isoleucyl-tRNA synthetase misactivates valine, while val

44 Valyl-tRNA synthetase, a close homolog of isoleucyl-tRNA synthetase, misactivates threonine, alpha

45 Substitution of a homologous CP1 domain from isoleucyl-tRNA synthetase or mutation within the LeuRS C

46 Here we report that a specific mutation in isoleucyl-tRNA synthetase prevents editing by blocking t

47 Recent mutational analysis of an isoleucyl-tRNA synthetase showed that discrimination of

48 mutations in a presumptive "hinge region" of isoleucyl-tRNA synthetase that is situated between the t

49 eukaryote-like features, and unlike E. coli isoleucyl-tRNA synthetase, the M. tuberculosis enzyme ch

50 For isoleucyl-tRNA synthetase, these errors are reduced by t

51 Examples include isoleucyl-tRNA synthetases whose acquisition from eukary