ライフサイエンスコーパス: isomerase

1 on of a hydrophobic clamp in triosephosphate isomerase.

2 D) is a mitochondrial matrix peptidyl-prolyl isomerase.

3 by serving as an IKK scaffold as well as an isomerase.

4 M17 activity operated by a protein-disulfide isomerase.

5 .5 even in the presence of protein-disulfide isomerase.

6 oxidoreductases ERp57 and protein disulfide isomerase.

7 easome subunits, and isopentenyl diphosphate isomerase.

8 r microcrystals of both naproxen and glucose isomerase.

9 metabolism by inhibition of triose-phosphate isomerase.

10 e ER lumen is prevented by protein disulfide isomerase.

11 s and proteins and is present in other thiol isomerases.

12 ductin1 oxidoreductase and protein disulfide isomerases.

13 the Escherichia coli DsbC and DsbG disulfide isomerases.

14 ep is catalyzed by peptidyl-prolyl cis-trans isomerases.

15 enzymes, such as Delta(3),Delta(2)-enoyl-CoA isomerases.

16 m(7)GTP, and human peptidyl-prolyl cis-trans isomerase 1 (Pin1) in complex with the peptide derived f

17 for an interaction with the peptidyl prolyl isomerase 1 (Pin1), a critical component of PDPK-mediate

18 oring glycolysis (enolase 1, triosephosphate isomerase 1, and hexokinase 2), were reduced when the fu

19 the endomembrane proteins protein disulfide isomerase 5 (PDI5) and NAI2, with the PDI5 interaction b

20 des encoded by the peptidyl-prolyl cis-trans isomerase A (PPIA) gene whose abundance was increased in

21 n A, also known as peptidylprolyl cis-/trans-isomerase A (PPIA), as a foldase is beneficial intracell

22 n A, also known as peptidylprolyl cis-/trans-isomerase A (PPIA), is a mediator of the neuroinflammato

23 serve that the dual-substrate phosphoribosyl isomerase A or priA gene, at which these pathways conver

24 ired Golgi delivery of the protein disulfide isomerase A3 (PDIA3), an enzyme that catalyzes giantin d

25 ng calnexin, calreticulin, protein disulfide isomerase A3, tapasin, TAP1, and TAP2.

26 Protein disulfide isomerase A6 (PDIA6) interacts with protein kinase RNA-l

27 that in addition to its known histone prolyl isomerase activities, the Fpr4 FKBP domain binds to nucl

28 re oxidases, FipB exhibited both oxidase and isomerase activities.

29 R) and phenylpyruvate tautomerase/dopachrome isomerase activity (MIF and DDT genes).

30 ing strongly dependent on the peptidylprolyl-isomerase activity and also on the TPR domain of FKBP52,

31 hioredoxin domain was shown to modulate both isomerase activity and F. tularensis virulence.

32 d tested them against CypD using binding and isomerase activity assays.

33 itor of ACSLs, also potently inhibited RPE65 isomerase activity in cellulo.

34 n unfolding, inhibition of PDI reductase and isomerase activity in vitro and in vivo, and subsequent

35 the enzymatic center, and affected disulfide isomerase activity in vitro.

36 We report a thermal secondary isomerase activity of CRALBP when bound to 9-cis-retinal

37 imilarity with Mip proteins, potentiated the isomerase activity of FipB in an in vitro assay and with

38 mutation in P4HB that impairs the disulfide isomerase activity of PDI.

39 f FKBP51 requires neither the peptidylprolyl-isomerase activity of the immunophilin nor its associati

40 and influences its peptidyl-prolyl cis/trans isomerase activity on residue Pro(314) of NS5A-D2.

41 EBI2 signaling activated Pin1 isomerase activity through a cascade that was sensitive

42 ant TvCyP1 exhibited typical peptidyl-prolyl isomerase activity with kcat/Km of approximately 7.1 mum

43 ificity toward 9-cis-retinal and its thermal isomerase activity yielding 9,13-dicis-retinal.

44 to have an additional, unexpected oxidative isomerase activity, thus making it a trifunctional enzym

45 Using FK506, an inhibitor of the FKBP51 isomerase activity, we found that the IKK-regulatory rol

46 1 reduces the cellular levels of RUNX3 in an isomerase activity-dependent manner by inducing the ubiq

47 This activates CypD's isomerase activity.

48 thase FATP2/SLCA27A2 to test their effect on isomerase activity.

49 PE65 is not dependent on O2 for its cleavage/isomerase activity.

50 involves both its scaffold function and its isomerase activity.

51 are proteins with peptidyl-prolyl cis/trans isomerase activity.

52 a zinc finger and to have protein-disulfide isomerase activity.

53 ophosphorylase, fumarase, and phosphoglucose isomerase activity.

54 r- and substrate-binding mutase domains with isomerase activity.

55 Vascular thiol isomerases also act as redox sensors.

56 des with both CaBP1/P5 and protein disulfide isomerase, although these are generally viewed as compon

57 ion of the BCO-related outlier RPE65 retinol isomerase, an enzyme that does not utilize carotenoids a

58 fied as a secreted peptidyl-prolyl cis/trans isomerase and chaperone that is dispensable for bacteria

59 ER) and is accomplished by protein disulfide isomerase and ER oxidoreductin 1beta, generating stoichi

60 hPDI) is an endoplasmic reticulum (ER) based isomerase and folding chaperone.

61 This has led to the hypothesis that the isomerase and lyase activities performed by the MST enzy

62 has also been proposed that the ketosteroid isomerase and other enzyme active sites provide electros

63 It has been proposed for ketosteroid isomerase and other enzymes that active site hydrogen bo

64 hat include members of the protein-disulfide isomerase and peptidyl-prolyl isomerase families.

65 le isozyme, beta-enolase and triosephosphate isomerase and phosphoglucomutase-1.

66 d RpiB, distant homologs of triose phosphate isomerase and ribose 5-phosphate isomerase B, were neces

67 by this algorithm, genes (ribose 5-phosphate isomerase and ribulose 5-phosphate 3-epimerase) in the p

68 Calvin-Benson cycle enzymes triose-phosphate isomerase and sedoheptulose 1,7-bisphosphate phosphatase

69 ncoded DsbP protein is a bona fide disulfide isomerase and suggest that a dedicated oxidative folding

70 re we show that TaPIN1 is a bona fide prolyl isomerase and that it interacts with the host ubiquitin

71 Next, we expressed a fusion protein of IPP isomerase and the phosphatase (Idi1~NudB) along with a r

72 two genes (xylA and EcxylB) encoding xylose isomerase and xyloluse kinase.

73 m enabled through the introduction of xylose isomerase and xylulokinase.

74 lysis of the storage, and secretion of thiol isomerases and determination of the electron transfer pa

75 We conclude that thiol isomerases and thiol-disulfide exchange contribute to TG

76 protein structure via their oxidoreductase, isomerase, and chaperone activities.

77 by two proteins with homology to ketosteroid isomerases, and assisted by two proteins with homology t

78 Arabinose-5-phosphate isomerases (APIs) catalyze the interconversion of d-ribu

79 uding a dominant mutation, in RPE65 retinoid isomerase are associated with distinct forms of retinal

80 Thiol isomerases are multifunctional enzymes that influence pr

81 These vascular thiol isomerases are released following vessel injury and part

82 , ERp5, and ERp57, among perhaps other thiol isomerases, are important for the initiation of thrombus

83 on of biological catalysis using ketosteroid isomerase as a prototypic example.

84 e phosphate isomerase and ribose 5-phosphate isomerase B, were necessary, as previously shown for Rhi

85 rises a major (beta/alpha)8 triose-phosphate isomerase barrel domain and a small alpha + beta inserti

86 novel morbid gene TXNDC15, encoding a thiol isomerase, based on independent loss of function mutatio

87 fringens reveals a modified triose-phosphate isomerase (beta/alpha)8 barrel in which a stable dimer i

88 bridge leading to loss of protein disulfide isomerase binding and lipid transfer activities; however

89 domains are important for protein disulfide isomerase binding and lipid transfer activity.

90 ct types (racemases/epimerases and cis-trans isomerases), but reactions entailing structural isomeris

91 However, thiol isomerases can escape endoplasmic retention and be secre

92 d incomplete equilibrium by triose phosphate isomerase cannot break a (13)C-(13)C bond within the tri

93 Adenosylcobalamin-dependent isomerases catalyze carbon skeleton rearrangements using

94 lues of (k(cat)/K(m))GAP for triosephosphate isomerase-catalyzed reactions of (R)-glyceraldehyde 3-ph

95 RPE65 is the isomerase catalyzing conversion of all-trans-retinyl est

96 f the flavonoid biosynthetic enzyme chalcone isomerase (CHI), which catalyzes the conversion of narin

97 ibute to the terrestrial plants and chalcone isomerase (CHI)-catalyzed intramolecular and stereospeci

98 reatment with 17l in the glucose-6-phosphate isomerase chronic in vivo mouse model of arthritis yield

99 derstanding of the mechanisms by which thiol isomerases control vascular function, the clinical utili

100 tene isomers in the fruit due to a defective isomerase (CRTISO) and the old gold crimson (og(c) ) tom

101 ta-carotene isomerase [ZISO] and prolycopene isomerase [CrtISO]).

102 The peptidylprolyl isomerase, cyclophilin D (CypD, PPIF), is a positive reg

103 ontrol) and mice deficient in peptidylprolyl isomerase D (cyclophilin D, encoded by Ppid) by administ

104 ch as Escherichia coli KdsD, contain a sugar isomerase domain and a tandem cystathionine beta-synthas

105 The sugar isomerase domain of E. coli KdsD, lacking the two cystat

106 tion was located in the C-terminal disulfide isomerase domain of PDI, sterically close to the enzymat

107 als a central catalytic parvulin-type prolyl isomerase domain, which is inserted into a larger compos

108 ntly reported an API containing only a sugar isomerase domain.

109 omain and a C-terminal FKBP peptidyl-proline isomerase domain.

110 onversely, over-expression of the disulphide isomerase DsbA increases the colistin MIC of laboratory

111 Another thiol isomerase, endoplasmic reticulum protein 5 (ERp5), is in

112 nism whereby binding of a substrate to thiol isomerases enhances catalytic activity of remote domains

113 In bacteria and fungi one desaturase/isomerase enzyme completes the same series of reactions.

114 An isomerase enzyme is thought to be responsible for the tr

115 etinyl esters to 11-cis-retinol, is also the isomerase enzyme responsible for the production of meso-

116 Thus, a subclass of FKBP prolyl isomerase enzymes is recruited to linker regions of chro

117 The isomerase enzymes release isochorismate or aminodeoxycho

118 can be modulated by expression of the thiol isomerase ERp5.

119 thiol isomerases including protein disulfide isomerase, ERp57, and ERp5 are secreted by and localize

120 Regulation of thiol isomerase expression, analysis of the storage, and secre

121 tein-disulfide isomerase and peptidyl-prolyl isomerase families.

122 -regulated protein 78 kDa, protein disulfide isomerase family A, member 6, ER protein 44, and disulfi

123 the oxidation status of ER protein-disulfide isomerase family members revealed a shift to a more oxid

124 ving force for reoxidizing protein disulfide isomerase family members, thus efficiently contributing

125 the fourth member of the mammalian enoyl-CoA isomerase family.

126 d inhibition of the 12-kDa cis-trans proline isomerase FK506-binding protein (FKBP12).

127 The peptidylprolyl isomerase FKBP12 interacts with FK506 forming a complex

128 erium tuberculosis (Mtb) DprE1, an essential isomerase for the biosynthesis of the mycobacterial cell

129 The retinol isomerase for this noncanonical pathway is dihydrocerami

130 protein model of AMF, namely phosphoglucose isomerase from rabbit muscle (RmPGI).

131 p domains of FipB and FipA impart additional isomerase functionality to FipB, but only the DsbA-like

132 hared mutations: amplification of the xylose isomerase gene and inactivation of ISU1, a gene encoding

133 ry to identify multiple copies of the xylose isomerase gene as a genomic change contributing to high

134 Here we show that the bacterial heptose isomerase GmhA displays homotropic positive and negative

135 d these to show that while protein disulfide isomerase has little capacity for 2dCD4 reduction, Trx r

136 c disulfide bonds that are modified by thiol isomerases have been described in substrates such as alp

137 ines to leucines abolished protein disulfide isomerase heterodimerization, lipid transfer, and apoB s

138 by the cyclophilin family of peptidyl-prolyl isomerases, highlighting the potential for regulation of

139 Human protein disulphide isomerase (hPDI) is an endoplasmic reticulum (ER) based

140 reduced a domain of human protein disulfide isomerase (hPDI) with atomistic resolution.

141 The human protein disulfide isomerase (hPDI), is an essential four-domain multifunct

142 ent oncogenic event and a biomarker for Topo-isomerase I inhibitor based therapy.

143 Correspondingly, Topo-isomerase I inhibitors effectively and preferentially el

144 mic instability and hypersensitivity to Topo-isomerase I inhibitors.

145 events replication-dependent removal of Topo-isomerase I-DNA adducts at the step of strand cleavage,

146 The enzyme IDP isomerase (IDI) catalyzes the interconversion between ID

147 desaturase-1, the putative all-trans retinol isomerase in Muller cells, appears to be 9-cis retinol.

148 focal adhesion kinase, and protein-disulfide isomerase in proximity to actin filaments.

149 ransporter (floppase), and protein-disulfide isomerase in proximity to short actin filaments.

150 We have now investigated the role of thiol isomerases in the activation of LLC in platelet releasat

151 There are seven peptidyl-prolyl cis-trans isomerases in the rER, and so far, two of these enzymes,

152 Several thiol isomerases including protein disulfide isomerase, ERp57,

153 (ii) the DHAP analogue and triose-phosphate isomerase inhibitor phosphoglycolohydroxamate (PGH).

154 adient-2 (AGR2), a soluble protein-disulfide isomerase involved in ER protein folding and quality con

155 ERp57 is a disulfide isomerase involved in the folding of a subset of glycopr

156 tudy, we cloned an isopentenyl pyrophosphate isomerase (IPPI) cDNA, AaIPPI1, from Artemisia annua (Aa

157 A plasmid-encoded disulfide isomerase is associated with conjugation.

158 e active site base of the enzyme ketosteriod isomerase (KSI) allows efficient and saturable base resc

159 of an aspartate general base in ketosteroid isomerase (KSI) by exogenous rescue.

160 at the active site of the enzyme ketosteroid isomerase (KSI) exerts an extremely large electric field

161 in the active site of the enzyme ketosteroid isomerase (KSI) facilitates quantum proton delocalizatio

162 fluorotyrosines (F-Tyr's) in the ketosteroid isomerase (KSI) oxyanion hole to systematically vary the

163 r the naturally occurring enzyme ketosteroid isomerase (KSI).

164 tric field in the active site of ketosteroid isomerase (KSI).

165 Depletion of particular ERAD-associated isomerases, lectins, and translocon components, includin

166 we identified variants of PROTEIN DISULFIDE ISOMERASE LIKE 5-1 (HvPDIL5-1) as the cause of naturally

167 or in maize indicated that protein disulfide isomerase-like and phosphoglycerate kinase were required

168 tinct modules: an N-terminal sugar phosphate isomerase-like domain associated with DSD activity and a

169 n the adjacent gene PDILT (protein disulfide isomerase-like, testis expressed) also reached genome-wi

170 sly unappreciated role for Mannose phosphate isomerase (MPI) as a metabolic enzyme required to mainta

171 or CDG-Ib) have mutations in phosphomannose isomerase (MPI) that impair glycosylation and lead to st

172 derived from glucose through phosphomannose isomerase (MPI, Fru-6-P <--> Man-6-P) whose deficiency c

173 ase (MtnP), 5-(methylthio)ribose-1-phosphate isomerase (MtnA), and an annotated class II aldolase-lik

174 with binding of a peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) to p53-RS, but not t

175 ng carotenoid isomerase (yofi), a carotenoid-isomerase nonsense mutant, which arrests the turnover of

176 This study provides an overview of which isomerases occur in nature, how we should describe and c

177 pigment epithelium (RPE), is a key retinoid isomerase of the visual cycle necessary for generating 1

178 not an influence of either triose phosphate isomerase or the transaldolase reaction.

179 incomplete equilibration by triose phosphate isomerase, or the transaldolase reaction all interact to

180 ncy of a product analog bound to ketosteroid isomerase oxyanion hole mutants and concluded that the a

181 The mechanism by which thiol isomerases participate in thrombus generation is being e

182 ave shown that the peptidyl-prolyl cis/trans isomerase parvulin 17 (Par17) interacts with tubulin in

183 correct DSB errors through protein-disulfide isomerase (PDI) activity.

184 Protein disulfide isomerase (PDI) and endoplasmic reticulum protein 57 (ER

185 his model was dependent on protein disulfide isomerase (PDI) and TF expression by myeloid cells, but

186 gest that the catalysis by protein disulfide isomerase (PDI) and thiol-disulfide exchange is mostly e

187 Protein disulfide isomerase (PDI) derived from intravascular cells is requ

188 Thiol isomerases such as protein-disulfide isomerase (PDI) direct disulfide rearrangements required

189 mice generated by crossing protein disulfide isomerase (PDI) floxed mice with lysozyme-Cre transgenic

190 Protein disulfide isomerase (PDI) has two distinct CGHC redox-active sites

191 Protein disulfide isomerase (PDI) interacts with these early intermediates

192 Protein disulfide isomerase (PDI) is a chaperone protein in the endoplasmi

193 Protein-disulfide isomerase (PDI) is a ubiquitous dithiol-disulfide oxidor

194 Protein disulfide isomerase (PDI) is an oxidoreductase essential for foldi

195 udy was to explain whether protein disulfide isomerase (PDI) is responsible for the thiol-disulfide r

196 e previously reported that protein disulfide isomerase (PDI) is S-nitrosylated in brains of patients

197 ontains >20 members of the protein disulfide isomerase (PDI) superfamily, which ensure formation of t

198 increase in the levels of protein-disulfide isomerase (PDI), a multifaceted endoplasmic reticulum re

199 his enzyme cooperates with protein disulfide isomerase (PDI), a redox chaperone previously implicated

200 ule and lysosome cargo and protein disulfide isomerase (PDI), all of which serve to stabilize thrombu

201 e protein A (NusA), human protein disulphide isomerase (PDI), and the b'a' domain of PDI (PDIb'a').

202 Protein disulfide isomerase (PDI), ERp5, and ERp57, among perhaps other th

203 Protein disulfide isomerase (PDI), secreted by platelets and endothelial c

204 Protein disulfide isomerase (PDI), secreted from platelets and endothelial

205 Surprisingly, we find that protein disulfide isomerase (PDI), the major protein oxidase of the ER lum

206 s]), the gene that encodes protein disulfide isomerase (PDI).

207 translational oxidation of protein disulfide isomerase (PDI).

208 ization of Tom20/Nur77 and Protein Disulfide Isomerase (PDI)/Nur77.

209 Thus, inhibition of protein disulfide isomerases (PDI) required for protein folding in the end

210 mannosidase Htm1p and the protein disulfide isomerase Pdi1p (Htm1p-Pdi1p) acts as a folding-sensitiv

211 interaction of VWF and the protein disulfide isomerase PDIA1, which has previously been used to visua

212 A resident ER protein disulfide isomerase, PDIA6, limits the duration of IRE1alpha activ

213 Protein disulfide isomerases (PDIs) areERfoldases identified as possibleAL

214 Protein disulfide isomerases (PDIs) catalyze the correct folding of protei

215 Protein disulfide isomerases (PDIs) play a central role in this process.

216 Protein disulfide isomerases (PDIs) support endoplasmic reticulum redox pr

217 maintained through action of phosphoglucose isomerase (PGI) and phosphoglucose mutase interconvertin

218 te (OPP) pathway and the glucose-6-phosphate isomerase (PGI) reaction.

219 ycolysis cascade: hexokinase, phosphoglucose isomerase, phosphofructokinase and aldolase.

220 ation and degradation mediated by the prolyl isomerase Pin1 and the ubiquitin ligase KLHL20.

221 re we identify the peptidyl-prolyl cis-trans isomerase Pin1 as an important factor mediating CPEB des

222 The prolyl isomerase Pin1 enhanced p53-dependent BAX activation by

223 s of BRD4 are positively regulated by prolyl isomerase PIN1 in gastric cancer cells.

224 identify a homologue of the peptidyl-prolyl isomerase PIN1 in T. annulata (TaPIN1) that is secreted

225 and a unique therapeutic target, the prolyl isomerase Pin1 is overexpressed in a majority of HCCs, w

226 n was suppressed by inhibitors of the prolyl isomerase Pin1 or extracellular signal-regulated kinases

227 The prolyl isomerase Pin1 regulates multiple signaling cascades by

228 The prolyl isomerase PIN1, a critical modifier of multiple signalli

229 K, conformation of XPO5 is altered by prolyl isomerase Pin1, resulting in reduction of pre-miRNA load

230 regulated by the interaction with the prolyl-isomerase Pin1, via proteasome-mediated degradation; p63

231 ed up-regulation of the expression of prolyl isomerase PIN1, which in turn increases enzyme activity

232 tch3 is a novel target protein of the prolyl-isomerase Pin1, which is able to regulate Notch3 protein

233 al recognition sites for the peptidyl-prolyl isomerase Pin1.

234 catalyzed by the peptidyl-prolyl cis-/trans isomerase Pin1.

235 orylation-specific peptidyl-prolyl cis/trans isomerase Pin1.

236 thways in multiple tumor types is the unique isomerase Pin1.

237 h is further regulated by the unique proline isomerase Pin1.

238 catalyzed by the peptidyl-prolyl cis-/trans isomerase Pin1.

239 osphatase 1B and a peptidyl-prolyl cis-trans isomerase (Pin1) isomerase resulted in potent, selective

240 a substrate for the peptidylprolyl cis/trans isomerase, Pin1, as well as the ERK1/2 kinases.

241 lpha) is a substrate for the peptidyl prolyl isomerase, Pin1, which mediates cis-trans isomerization

242 We also show that a peptidyl-prolyl isomerase PINN-1 antagonizes SYDN-1 in the spatiotempora

243 cipate in the network pathways linking thiol isomerases, platelet receptor activation, and fibrin gen

244 h as thioredoxin (Trx) and protein disulfide isomerase, play an essential role in regulating the acti

245 not exposed to VCs, plastidic phosphoglucose isomerase (pPGI) acts as an important determinant of pho

246 n mesophyll cells (plastidial phosphoglucose isomerase [pPGI]).

247 tilized to confirm peptidyl-prolyl cis-trans-isomerase (PPIase) activity by a PPIase assay and the al

248 Here, we postulated that peptidyl prolyl isomerase (PPIase) activity of FKBP65 positively modulat

249 n A is a conserved peptidyl-prolyl cis-trans isomerase (PPIase) best known as the cellular receptor o

250 roxylase (LH) 2 or peptidyl-prolyl cis-trans isomerase (PPIase) FKBP65.

251 Human peptidyl-prolyl isomerase (PPIase) Pin1 plays key roles in developmental

252 RIN4 also interacts with the prolyl-peptidyl isomerase (PPIase) ROC1, which is reduced upon RIN4 Thr1

253 Peptidyl-proline isomerases (PPIases) are a chaperone superfamily compris

254 , the rER-resident peptidyl prolyl cis/trans isomerases (PPIases) play an important role in the zippe

255 rolling binding to peptidyl-prolyl cis/trans isomerases (PPIases).

256 es is regulated by cis/trans peptidyl-prolyl isomerases (PPIases).

257 milies of enzymes, known as "peptidyl-prolyl isomerases" (PPIases), catalyze this reaction, which inv

258 CypA (Cyclophilin A) is a peptidyl-prolyl isomerase previously shown to be required for chondrogen

259 ion, such as calreticulin, protein disulfide isomerase, proteasome subunits, and isopentenyl diphosph

260 racemase), TpiA2 (D-3-tetrulose-4-phosphate isomerase; renamed EryH), and RpiB (D-erythrose-4-phosph

261 med EryH), and RpiB (D-erythrose-4-phosphate isomerase; renamed EryI), a pathway fully consistent wit

262 e report that cyclophilin B (CypB), a prolyl isomerase residing in the endoplasmic reticulum (ER), pr

263 a peptidyl-prolyl cis-trans isomerase (Pin1) isomerase resulted in potent, selective, proteolytically

264 as been proposed to inhibit the visual cycle isomerase RPE65, thereby slowing regeneration of 11-cis-

265 We found that cone density in retinol isomerase RPE65-deficient and cone photoreceptor functio

266 Retinol isomerase RPE65-deficient mice [a model of Leber congeni

267 roduce the esterified substrate for retinoid isomerase (RPE65), which converts all-trans-retinyl este

268 expression of the retinal pigment epithelium isomerase, Rpe65.

269 comparing the electric field in ketosteroid isomerase's (KSI's) active site to zero overestimates th

270 ters for activation of yeast triosephosphate isomerase (ScTIM), yeast orotidine monophosphate decarbo

271 Current inhibitors of peptidylprolyl isomerases show no selectivity between the tightly conse

272 We demonstrate that tomato cyclopropyl isomerase (SlCPI), an enzyme involved in sterol biosynth

273 e more comprehensive identification of thiol isomerase substrates and better elucidation of their cel

274 mmalian cells but had little effect on other isomerases such as Pin4, FKBP12, or cyclophilin A.

275 Thiol isomerases such as protein-disulfide isomerase (PDI) dir

276 ehydrogenase, actually belongs to the xylose isomerase superfamily.

277 PIN1 is a peptidyl-prolyl isomerase that catalyzes the cis/trans isomerization of

278 n-bonding interaction present in ketosteroid isomerase that has been proposed to stabilize a developi

279 D) is a mitochondrial matrix peptidyl-prolyl isomerase that regulates the MPTP and is a drug target f

280 ugh most of the activities of vascular thiol isomerases that contribute to thrombus formation are yet

281 mutant forms to identify substrates of thiol isomerases that participate in the network pathways link

282 our results with those of protein disulfide-isomerase, the eukaryotic counterpart of DsbA, allowing

283 nt four case studies, focused on ketosteroid isomerase, the SH3 domain, dihydrofolate reductase, and

284 he toxin is transferred to protein disulfide isomerase; this ER redox chaperone is known to unfold CT

285 They adopt a partial triose-phosphate isomerase (TIM) barrel fold with N- and C-terminal exten

286 lase 1 family (alpha/beta)8 triose-phosphate isomerase (TIM) barrel structure with a highly conserved

287 end of the HydG (betaalpha)8 triosephosphate isomerase (TIM) barrel, a canonical [4Fe-4S] cluster bin

288 Y208 and S211 from loop 7 of triosephosphate isomerase (TIM) form hydrogen bonds to backbone amides a

289 Triosephosphate isomerase (TIM) is a proficient catalyst of the reversib

290 The tunnel region at triosephosphate isomerase (TIM)'s dimer interface, distant from its cata

291 of the cyclophilin subset of peptidyl-prolyl isomerases to protein folding and identified cyclophilin

292 nophilins, which function as peptidyl-prolyl isomerases, to regulate Crk proteins in human T lymphocy

293 d, namely cystatin B (CSTB), triosephosphate isomerase (TPI1), and deleted in malignant brain tumors

294 17, it was unable to bind protein disulfide isomerase, transfer lipids, and support apoB secretion.

295 In the glycolysis pathway, triosephosphate isomerase was up-regulated, whereas pyruvate kinase was

296 ibitor of the FKBP family of peptidyl prolyl isomerases, was shown to increase survival in animal mod

297 ts with the oxidoreductase protein-disulfide isomerase, we hypothesized that thioredoxin-1 (Trx1), a

298 n-dependent interaction with Pin1, a proline isomerase, which mediates cis-trans isomerization of the

299 ies with double mutants including carotenoid isomerase (yofi), a carotenoid-isomerase nonsense mutant

300 arotene desaturase [ZDS]), and two cis-trans isomerases (zeta-carotene isomerase [ZISO] and prolycope

301 and two cis-trans isomerases (zeta-carotene isomerase [ZISO] and prolycopene isomerase [CrtISO]).