ライフサイエンスコーパス: isonitrile

1 n treated with 2 equiv of 2,6-dimethylphenyl isonitrile.

2 of multicomponent reactions and convertible isonitriles.

3 nerated from the reactions of thioacids with isonitriles.

4 amily of proteins that produce small organic isonitriles.

5 s of a reaction between carboxylic acids and isonitriles.

6 otal synthesis of N-methylwelwitindolinone D isonitrile (1) has been achieved in 17 steps from a read

7 the natural product (+/-)-welwitindolinone A isonitrile (1) is described.

8 cyanate (2a), (-)-N-methylwelwitindolinone C isonitrile (2b), and (-)-3-hydroxy-N-methylwelwitindolin

9 he example reaction of beta-galactopyranosyl isonitrile (7) with a protected aspartic acid under micr

10 (99m)Tc-methoxyisobutyl isonitrile (99(m)Tc-MIBI) single-photon emission compute

11 f typical donor ligands (carbon monoxide, an isonitrile, a nitrile, THF-d8,) it forms the respective

12 By the careful choice of amino acid and isonitrile, an optional access to all possible enantiome

13 thesized in racemic form by employing indole-isonitrile and ammonium acetate in the Ugi 4-center-3-co

14 g system of the hapalindoles from cis-indole isonitrile and geranyl pyrophosphate through a presumed

15 rmodynamical stability of the nitrile versus isonitrile and silanitrile versus isosilanitrile isomer

16 nd N-terminal peptides, mediated by hindered isonitriles and hydroxybenzotriazole, gives rise to pept

17 The latter react with isonitriles and singlet carbenes giving (phosphino)phosp

18 lement of multicomponent reactions for which isonitriles are known and offer the desirable trait of g

19 o not have the objectionable odors for which isonitriles are typically known, making them more access

20 we report on the utilization of convertible isonitriles as effective synthetic tools for the ligatio

21 ones are essentially unknown as reactants in isonitrile-based multicomponent reactions.

22 One focus of the work is isonitriles bearing perfluorinated alkyl groups that ena

23 Selective addition of radicals to isonitriles can be harnessed for initiating reaction cas

24 onitriles proceed via an insertion of CO and isonitrile carbon into the B-Li bond followed by isomeri

25 center with isonitrile, whereas insertion of isonitrile carbon occurred at the B-Bi bond in 10 which

26 led through extension of recently discovered isonitrile chemistry to the domain of alpha,beta-unsatur

27 rein our recent explorations in the field of isonitrile chemistry.

28 n aryl migration process, producing a eta(1) isonitrile complex.

29 rboxylic acid isonitrile couplings, thioacid isonitrile couplings at ambient temperature, and isonitr

30 tility of microwave-mediated carboxylic acid isonitrile couplings, thioacid isonitrile couplings at a

31 ed with the results of 99mTc-methoxyisobutyl isonitrile, CT, MRI, or histology.

32 Moreover, the reactions of 3 with isonitrile derivatives RNC: under heating conditions gav

33 and the N-benzyl group and conversion of the isonitrile-derived amide (the Ugi product) into the corr

34 he strategy relies on the use of convertible isonitriles-derived from Fukuyama amines-and peptide car

35 Applications of the isonitrile/Diels-Alder logic to the IMDA reaction, as we

36 , the striking architectures and the unusual isonitrile functional groups of the isocyanoterpenes hav

37 or product is actually paerucumarin, a novel isonitrile functionalized cumarin.

38 duce rhabduscin, an amidoglycosyl- and vinyl-isonitrile-functionalized tyrosine derivative.

39 ever, we find that 14 and 2,6-dimethylphenyl isonitrile give instead a 2,5-diazahafnacyclopentane tha

40 ling (2CC) reaction of carboxylic acids with isonitriles gives rise to various N-formylamides.

41 let carbenes giving (phosphino)phosphinidene-isonitrile (>P-P<--:CNR) and -carbene adducts (>P-P<--:C

42 A new family of unsaturated isonitriles has been prepared by the base-promoted ring-

43 ling (2CC) reaction of carboxylic acids with isonitriles have been investigated.

44 Isocyanide (formerly isonitrile) hydratase (EC 4.2.1.103) is an enzyme of the

45 tration of reactants, arranging the acid and isonitrile in the appropriate orientations, isolating in

46 synthesis of (-)-N-methylwelwitindolinone C isonitrile, in addition to the total syntheses of the 3-

47 net O-H and C-H addition across, as well as isonitrile insertion into, the terminal platinum-amido l

48 sequential imine formation, decarboxylation, isonitrile insertion, and hydrolysis to afford the produ

49 le, the reaction with a second equivalent of isonitrile is also observed for smaller substituents.

50 l-proline or pipecolic acid, aldehydes, and isonitriles is described.

51 polypeptides on solid phase via mediation by isonitriles is described.

52 using combined native chemical ligation and isonitrile-mediated activation strategies.

53 The scope of isonitrile-mediated amide bond-forming reactions is furt

54 itrile couplings at ambient temperature, and isonitrile-mediated couplings of carboxylic acids and th

55 , aggregation-prone sequence, we advanced an isonitrile-mediated ligation method.

56 his study, we compared 99mTc-methoxyisobutyl isonitrile (MIBI) with 201Tl scintigraphy for the detect

57 usly constructs the spiro-oxindole and vinyl isonitrile moieties.

58 soxazolecarboxylic acid, and the convertible isonitrile N-(2-{[(tert-butyldimethylsilyl)oxy]methyl}ph

59 suggests that the reactions with CO and aryl isonitriles proceed via an insertion of CO and isonitril

60 ver the silanitrile and the nitrile over the isonitrile reaction products are favored, respectively.

61 We have investigated the reaction of isonitriles (RNC) with electronically unsaturated diene

62 ional 201TI and hexakis 2-methoxy-2-isobutyl isonitrile studies are less accurate as compared to FDG

63 Depending on the substituent of the isonitrile, the reaction with a second equivalent of iso

64 to contribute to background oxidation of the isonitrile, thereby explaining the improved performance

65 ms that are bridged with L = benzene bis-1,4-isonitrile to form polymer strands.

66 a thioacid, which presumably reacts with the isonitrile to generate a thio-formimidate carboxylate mi

67 ic acid function reacts with small aliphatic isonitriles to form N-acyl formamides inside the cavity.

68 Recent developments in the use of isonitriles to furnish secondary and tertiary amide bond

69 3 reacted with CO (1 atm) and various isonitriles under ambient condition, and mechanistic stu

70 lecule coordinating to the metal center with isonitrile, whereas insertion of isonitrile carbon occur

71 d in 6 was achieved by the treatment with an isonitrile, which led to the formation of a base-stabili

72 from an aldehyde, a secondary amine, and an isonitrile with excellent asymmetric induction.

73 On the contrary, in the reaction of isonitriles with 1, planar five-membered heterocycles (3

74 Thermolysis of isonitriles with carboxylic acids provides, in one step,

75 ion complexes are applied to the reaction of isonitriles with carboxylic acids.

76 hermolysis, carboxylic acids can couple with isonitriles without an external catalyst to form N-formy